527 research outputs found
Diachronic and Synchronic Analysis for Knowledge Creation: Architectural Representation Geared to XR Building Archaeology (Claudius-Anio Novus Aqueduct in Tor Fiscale, the Appia Antica Archaeological Park)
This study summarises research progress to identify appropriate quality methodologies for representing, interpreting, and modelling complex contexts such as the Claudian Aqueduct in the Appian Way Archaeological Park. The goal is to intrinsically integrate (embed) geometric survey (Laser scanning and photogrammetric) with the materials and construction techniques (Stratigraphic Units-SU), semantic models in order to support the design with a better understanding of the artefact considered, and also to give indications that can be implemented in the future in a continuous cognitive process. Volume stratigraphic units in the form of architectural drawings, heritage building information modelling (HBIM) and extended reality (XR) environments have been oriented to comparative analyses based on the research case study's complex morphology. Analysis of geometries' intersection, construction techniques and materials open up new cognitive scenarios, self-feeding a progressive knowledge and making different studies correlatable, avoiding diaspora or incommunicability. Finally, an extended reality (XR) platform aims to enhance tangible and intangible values through new human-computer interaction and information sharing levels
Immersive Appian Way health infrastructure: human centric Digital Twin (The PAAA Archeological Park of the Appian Way 12km State-Own Section, Unesco Candidature)
From Rome to Benevento, the Appian Way (Via Appia Antica) was born as a military road, 'Regina Viarum'. In 312 b.C., consul Appio Claudio extended the infrastructure for 132 miles to Capua. Many transformations and integration occurred across the centuries, resulting in a unique multi-stratified world heritage (landscape, architecture, archaeological remains and tombs along the military way). In the 19th century, Luigi Canina conceived the Appian Way as an outdoor museum, realizing a first state-own section along the 12km here surveyed and described. This year, the Ministry of Culture (MIC) has launched the UNESCO nomination for the road. The article discusses aspects of the mass digitization undertaken by the Parco Archeologico dell'Appia Antica (PAAA, the Archaeological Park of the Appian Way). The aim is to build a Digital Twin of the infrastructure supporting knowledge enhancement, preservation, design, communication and fruition. A virtual space where digital technologies and eXtended Reality are the digital arms of the contemporary Vitruvian humanistic mission and vision of the PAAA Appian Way as a source of wealth and healthiness for all the users and visitors
Northern JHK Standard Stars for Array Detectors
We report J, H and K photometry of 86 stars in 40 fields in the northern
hemisphere. The fields are smaller than or comparable to a 4x4 arcmin
field-of-view, and are roughly uniformly distributed over the sky, making them
suitable for a homogeneous broadband calibration network for near-infrared
panoramic detectors. K magnitudes range from 8.5 to 14, and J-K colors from
-0.1 to 1.2. The photometry is derived from a total of 3899 reduced images;
each star has been measured, on average, 26.0 times per filter on 5.5 nights.
Typical errors on the photometry are about 0.012.Comment: 10 pages including 3 figures, one separate figure on four pages. The
finding chart of the AS-30 field and a few coordinates have been corrected.
GIF finding charts can also be found at
http://www.arcetri.astro.it/~hunt/std.htm
The cost-effectiveness of the Argus II retinal prosthesis in Retinitis Pigmentosa patients
This is the final version of the article. Available from the publisher via the DOI in this record.BACKGROUND: Retinitis Pigmentosa (RP) is a hereditary genetic disease causing bilateral retinal degeneration. RP is a leading cause of blindness resulting in incurable visual impairment and drastic reduction in the Quality of life of the patients. Second Sight Medical Products Inc. developed Argus II, a retinal prosthesis system for treating RP. Argus II is the world's first ever-commercial implant intended to restore some vision in the blind patients. The objective of this study was to assess the cost-effectiveness of the Argus® II Retinal Prosthesis System (Argus II) in Retinitis Pigmentosa (RP) patients. METHOD: A multi -state transition Markov model was developed to determine the cost-effectiveness of Argus II versus usual care in RP from the perspective of healthcare payer. A hypothetical cohort of 1000 RP patients aged 46 years followed up over a (lifetime) 25-year time horizon. Health outcomes were expressed as quality adjusted life years (QALYs) and direct healthcare costs expressed in 2012 €. Results are reported as incremental cost per ratios (ICERs) with outcomes and costs discounted at an annual rate of 3.5%. RESULTS: The ICER for Argus II was €14,603/QALY. Taking into account the uncertainty in model inputs the ICER was €14,482/QALY in the probabilistic analysis. In the scenarios of an assumption of no reduction on cost across model visual acuity states or a model time horizon as short as 10 years the ICER increased to €31,890/QALY and €49,769/QALY respectively. CONCLUSION: This economic evaluation shows that Argus II is a cost-effective intervention compared to usual care of the RP patients. The lifetime analysis ICER for Argus II falls below the published societal willingness to pay of EuroZone countries
REPRESENTING INTANGIBLE CULTURAL HERITAGE OF HUMANITY: FROM THE DEEP ABYSS OF THE PAST TO DIGITAL TWIN AND XR OF THE NEANDERTHAL MAN AND LAMALUNGA CAVE (ALTAMURA, APULIA)
The Altamura Man and the paleontological remains are situated within a complex context encompassing logistical, geological, paleoenvironmental, and cultural perspectives. This context is exceptionally well-preserved but also fragile, requiring its preservation due to its unique nature. Unresolved inquiries exist in various disciplines, such as archaeology, biocultural studies, ecology, and geology, pertaining to karst formation, taphonomic dynamics, and the cultural and ecological context of the Neanderthal individual found in the cave. Interdisciplinary research was necessary to address these complex questions and understand the broader context of the Lamalunga Cave. Climate change also necessitated attention to preserving the cave’s microclimate and monitoring potential biodegradation. Digital technologies, including photogrammetry and laser scanning, were crucial for monitoring and safeguarding the cave’s cultural heritage. Digital representation, 3D modelling and Digital Twin were essential for managing the cave’s intricacies, analysing its values, and enhancing visual communication. The management of the Lamalunga cave aimed to promote scientific interpretation, safeguard the cave, and provide tools for understanding, storytelling, and further investigation. It was essential to utilise available methodologies and technologies while avoiding destructive interventions. Contemporary technologies have revolutionised the archaeological and paleoanthropological domains, enabling remote study and preservation. Protecting and comprehending the cultural heritage of the cave is linked to its usability, which can be enhanced through digital documentation methodologies to inform visitors about the karst context and promote social and economic development
The cost-effectiveness of the Argus II retinal prosthesis in Retinitis Pigmentosa patients
Background:
Retinitis Pigmentosa (RP) is a hereditary genetic disease causing bilateral retinal degeneration. RP is a leading cause of blindness resulting in incurable visual impairment and drastic reduction in the Quality of life of the patients. Second Sight Medical Products Inc. developed Argus II, a retinal prosthesis system for treating RP. Argus II is the world’s first ever-commercial implant intended to restore some vision in the blind patients. The objective of this study was to assess the cost-effectiveness of the Argus® II Retinal Prosthesis System (Argus II) in Retinitis Pigmentosa (RP) patients.
Method:
A multi -state transition Markov model was developed to determine the cost-effectiveness of Argus II versus usual care in RP from the perspective of healthcare payer. A hypothetical cohort of 1000 RP patients aged 46 years followed up over a (lifetime) 25-year time horizon. Health outcomes were expressed as quality adjusted life years (QALYs) and direct healthcare costs expressed in 2012 €. Results are reported as incremental cost per ratios (ICERs) with outcomes and costs discounted at an annual rate of 3.5%.
Results:
The ICER for Argus II was €14,603/QALY. Taking into account the uncertainty in model inputs the ICER was €14,482/QALY in the probabilistic analysis. In the scenarios of an assumption of no reduction on cost across model visual acuity states or a model time horizon as short as 10 years the ICER increased to €31,890/QALY and €49,769/QALY respectively.
Conclusion:
This economic evaluation shows that Argus II is a cost-effective intervention compared to usual care of the RP patients. The lifetime analysis ICER for Argus II falls below the published societal willingness to pay of EuroZone countries
Morphology of the 12-micron Seyfert Galaxies: II. Optical and Near-Infrared Image Atlas
We present 263 optical and near-infrared (NIR) images for 42 Seyfert 1s and
48 Seyfert 2s, selected from the Extended 12-micron Galaxy Sample.
Elliptically-averaged profiles are derived from the images, and isophotal radii
and magnitudes are calculated from these. We also report virtual aperture
photometry, that judging from comparison with previous work, is accurate to
roughly 0.05mag in the optical, and 0.07mag in the NIR. Our B-band isophotal
magnitude and radii, obtained from ellipse fitting, are in good agreement with
those of RC3. When compared with the B band, V, I, J, and K isophotal diameters
show that the colors in the outer regions of Seyferts are consistent with the
colors of normal spirals. Differences in the integrated isophotal colors and
comparison with a simple model show that the active nucleus+bulge is stronger
and redder in the NIR than in the optical. Finally, roughly estimated Seyfert
disk surface brightnesses are significantly brighter in B and K than those in
normal spirals of similar morphological type.Comment: 17 pgs including figures; Table 2 is a separate file. Complete Figure
1 is available by contacting the authors. Accepted for publication in ApJ
On line power spectra identification and whitening for the noise in interferometric gravitational wave detectors
In this paper we address both to the problem of identifying the noise Power
Spectral Density of interferometric detectors by parametric techniques and to
the problem of the whitening procedure of the sequence of data. We will
concentrate the study on a Power Spectral Density like the one of the
Italian-French detector VIRGO and we show that with a reasonable finite number
of parameters we succeed in modeling a spectrum like the theoretical one of
VIRGO, reproducing all its features. We propose also the use of adaptive
techniques to identify and to whiten on line the data of interferometric
detectors. We analyze the behavior of the adaptive techniques in the field of
stochastic gradient and in the
Least Squares ones.Comment: 28 pages, 21 figures, uses iopart.cls accepted for pubblication on
Classical and Quantum Gravit
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