Wave energy extraction from device arrays : experimental investigation in a large wave facility

Multiple wave energy devices supported by a common structure represent one possible method of efficiently converting ocean wave energy into electricity. In this study, experimental measurements of multiple small-scale wave energy devices are reported to assist the development and validation of numerical models. Through observation and measurement, the response of two float geometries subjected to a range of wave conditions and device settings were determined. A range of regular wave conditions were identified that caused a linear relationship to occur between the heave displacement amplitude of the float and the incident wave amplitude. These test cases will enable comparisons to be made with linear simulations of response. Tests conducted in various wave conditions have highlighted the capability of altering the device response by changing the equilibrium draft of one float geometry. Additional damping on the upper surface of the float, due to wave overtopping, could be exploited as a method of limiting the heave response of the device in large amplitude waves. The influence of hydrodynamic interactions on arrays of closely spaced devices has been experimentally investigated for devices subjected to regular and irregular wave conditions. The magnitude and occurrence of interactions and their affect on the individual device response is demonstrably dependent on the incident wave frequency and device separation distance. Compared to an isolated device, positive interactions result in higher average power outputs for an array of devices at certain wave frequencies. Positive interactions occuring at particular wave frequencies are balanced by negative interactions at other wave frequencies, in agreement with published numerical studies of array performance. Varying the level of mechanical damping applied to the float through the power take-off system results in a frequency shift of the calculated power transfer function and alters the motion path of the float. This finding implies that the level of generator torque could be used as an alternative method to tune the response of the device based on the measured incident wave-field. Several time-averaged and time-varying approaches to simulating the response of a wave energy device subjected to wave-field forcing and undergoing free response have been studied. By comparing the simulated and measured responses, the feasibility of using linear and non-linear force terms in a time-varying model has been assessed. In general, single degree-of-freedom simulations based on linear hydrodynamic parameters tend to over-predict device response amplitudes, requiring the application of additional damping. The simulation approach which resulted in the closest agreement with measured responses required the combination of linear diffraction force and radiation added mass terms with non-linear drag and buoyancy force terms, as well as body inertia and gravity forces. This approach goes part way to simulating the complex time-varying hydrodynamics associated with a wave energy device subjected to wave-field forcing.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Investigation of the response of groups of wave energy devices

Placing wave energy devices within close proximity to each other can be beneficial as the costs of deployment, maintenance and infrastructure are reduced significantly compared to if the devices are deployed in isolation. A mathematical model is presented in this thesis which combines linear wave theory with a series of linear driven harmonic oscillators to model an array (group) of floating wave energy devices which move predominantly in heave (vertically) in a train of incident regular waves. Whilst similar mathematical models have been used previously to investigate interactions between fluids and groups of structures, much of the published work does not address array configurations or device constraints that are relevant to designers of structure-supported array devices. The suitability of linear theory for application to closely spaced arrays is assessed in this thesis through comparison to small-scale experimental data and by evaluation of the magnitude of second-order hydrodynamic forces. Values of mechanical damping and mass are determined for each element of an array in order to achieve the maximum power from an array of floats without requiring the knowledge of the motion of every float within the array in order to apply the forces to any one float. Further to this, the analysis of floats of varying geometry is performed in order to assess the possibility of array optimisation through the variation of float geometries within a closely spaced array.It is shown in this thesis that linear theory provides a reasonable prediction of the response of floats that are sufficiently close together to interact for most wave frequencies to which the arrays are likely to be subjected. Under the assumption of easily implementable mechanical damping, it is determined that the power output from an array of floats of equal geometry can be increased by specifying different magnitudes of mechanical damping on each float independently of the radiation damping. Variations in submerged float geometries for the purpose of manipulating array characteristics according to the incident wave frequency are best applied through the variation in draft of a single geometry. Variations in submerged float geometry which occur close to the free surface are found to be of the greatest significance. Where the float is uniform in cross-section, the most appropriate method to select float drafts within an array is found to be based on the evaluation of the total damping on each float.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

EVALUATION OF ANTHELMINTIC FISHMEAL POLYMER BAITS FOR THE CONTROL OF \u3ci\u3eBAYLISASCARIS PROCYONIS\u3c/i\u3e IN FREE-RANGING RACCOONS (\u3ci\u3ePROCYON LOTOR\u3c/i\u3e)

Baylisascaris procyonis is a common gastrointestinal parasite of raccoons (Procyon lotor) and is a zoonotic helminth with the potential to cause severe or fatal infection. Raccoons thrive in human-dominated landscapes, and the fecal-oral transmission pathway and lack of effective treatment make B. procyonis a serious threat to public health. The distribution of medicinal baits has emerged as a socially acceptable and cost-effective method for managing disease in free-ranging wildlife. We assessed the suitability of a mass-producible anthelmintic bait for B. procyonis mitigation by evaluating the willingness of free-ranging raccoons to consume anthelmintic baits and determining whether bait consumption successfully cleared B. procyonis infections from raccoons. Anthelmintic baits were modified from standard fishmeal polymer baits, the food attractant commonly used in oral rabies vaccine baits, with the introduction of 220 mg of pyrantel pamoate into the fishmeal mixture. We captured 16 naturally infected raccoons, presented one anthelmintic bait, and monitored B. procyonis infection over 90 d by screening feces for eggs. Treatment cleared B. procyonis infections for nine of 12 raccoons that consumed \u3e10 g of the 15 g bait. We used remote cameras to monitor in situ patterns of bait consumption for anthelmintic baits relative to standard baits. Both anthelmintic and standard baits were rapidly consumed, with no differences in the rate of consumption between bait types. However, after bait contact, raccoons demonstrated a greater willingness to consume standard baits while ignoring anthelmintic baits more frequently (P=0.06). Initial trials of anthelmintic baits show promise, although refinement in both dose and palatability is needed. At mass production scales, the addition of pyrantel pamoate to fishmeal polymer baits would be inexpensive, potentially making anthelmintic baits a viable management option when coupled with an oral rabies vaccine or used independently for B. procyonis mitigation

EVALUATION OF ANTHELMINTIC FISHMEAL POLYMER BAITS FOR THE CONTROL OF \u3ci\u3eBAYLISASCARIS PROCYONIS\u3c/i\u3e IN FREE-RANGING RACCOONS (\u3ci\u3ePROCYON LOTOR\u3c/i\u3e)

Baylisascaris procyonis is a common gastrointestinal parasite of raccoons (Procyon lotor) and is a zoonotic helminth with the potential to cause severe or fatal infection. Raccoons thrive in human-dominated landscapes, and the fecal-oral transmission pathway and lack of effective treatment make B. procyonis a serious threat to public health. The distribution of medicinal baits has emerged as a socially acceptable and cost-effective method for managing disease in free-ranging wildlife. We assessed the suitability of a mass-producible anthelmintic bait for B. procyonis mitigation by evaluating the willingness of free-ranging raccoons to consume anthelmintic baits and determining whether bait consumption successfully cleared B. procyonis infections from raccoons. Anthelmintic baits were modified from standard fishmeal polymer baits, the food attractant commonly used in oral rabies vaccine baits, with the introduction of 220 mg of pyrantel pamoate into the fishmeal mixture. We captured 16 naturally infected raccoons, presented one anthelmintic bait, and monitored B. procyonis infection over 90 d by screening feces for eggs. Treatment cleared B. procyonis infections for nine of 12 raccoons that consumed \u3e10 g of the 15 g bait. We used remote cameras to monitor in situ patterns of bait consumption for anthelmintic baits relative to standard baits. Both anthelmintic and standard baits were rapidly consumed, with no differences in the rate of consumption between bait types. However, after bait contact, raccoons demonstrated a greater willingness to consume standard baits while ignoring anthelmintic baits more frequently (P=0.06). Initial trials of anthelmintic baits show promise, although refinement in both dose and palatability is needed. At mass production scales, the addition of pyrantel pamoate to fishmeal polymer baits would be inexpensive, potentially making anthelmintic baits a viable management option when coupled with an oral rabies vaccine or used independently for B. procyonis mitigation

Brief Educational Workshops in Secondary Schools Trial (BESST): Protocol for a school-based cluster randomised controlled trial of open-access psychological workshop programme for 16–18-year-olds

Anxiety and depression are increasingly prevalent in adolescents, often causing daily distress and negative long-term outcomes. Despite significant and growing burden, less than 25% of those with probable diagnosis of anxiety and depression are receiving help in England. Significant barriers to help-seeking exist in this population, with a scarcity of easily accessible, effective, and cost-effective interventions tailored specially for this age group. One intervention that has been shown to be feasible to deliver and with the promise of reducing stress in this age group is a school-based stress workshop programme for 16-18-year-olds (herein called DISCOVER). The next step is to rigorously assess the effectiveness, and cost-effectiveness, of the DISCOVER intervention in a fully powered cluster randomised controlled trial (cRCT). If found to be clinically and cost effective, DISCOVER could be scaled up as a service model UK-wide and have a meaningful impact on the mental health of adolescents across the country

16th Annual Environmental Law Institute

Materials from the 16th Annual Environmental Law Institute held by UK/CLE in May 2000

Clinical trials in amyotrophic lateral sclerosis:a systematic review and perspective

Amyotrophic lateral sclerosis is a progressive and devastating neurodegenerative disease. Despite decades of clinical trials, effective disease modifying drugs remain scarce. To understand the challenges of trial design and delivery, we performed a systematic review of phase II, phase II/III and phase III amyotrophic lateral sclerosis clinical drug trials on trial registries and PubMed between 2008 and 2019. We identified 125 trials, investigating 76 drugs and recruiting more than 15000 people with amyotrophic lateral sclerosis. 90% of trials used traditional fixed designs. The limitations in understanding of disease biology, outcome measures, resources and barriers to trial participation in a rapidly progressive, disabling and heterogenous disease hindered timely and definitive evaluation of drugs in two-arm trials. Innovative trial designs, especially adaptive platform trials may offer significant efficiency gains to this end. We propose a flexible and scalable multi-arm, multi-stage trial platform where opportunities to participate in a clinical trial can become the default for people with amyotrophic lateral sclerosis