23 research outputs found

    Weaber Plain aquifer test results

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    As a part of the environmental planning and approvals process, the state government was required to prepare Groundwater Management and Hydrodynamic Plans. These plans are to address potential issues of salinity and water quality that could result from the development of irrigated agriculture on the Weaber Plain. The Weaber Plain groundwater modelling report (KBR 2010a) identified several options to manage watertables and salinity Production bores 10WP35PB and 10WP36PB were drilled in the palaeochannel on sites selected from the interpretation of airborne geophysics

    Groundwater trend analysis and salinity risk assessment for the south-west agricultural region of Western Australia, 2007–12

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    Dryland salinity is a hydrologically driven land degradation hazard in the south-west agricultural region of Western Australia (WA). Shallow-rooted annual crops and pastures transpire significantly less water than the native vegetation they replaced, leading to an increase in recharge, rising groundwater levels and the development of shallow watertables in areas where often none existed previously. Rising groundwater levels mobilise soluble salts, naturally stored at high concentrations in the regolith. These salts can be concentrated in the root zone of vegetation by evapotranspiration

    Parenteral immunization of mice with a genetically inactivated pertussis toxin DNA vaccine induces cell-mediated immunity and protection

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    The immunogenicity and protective efficacy of a DNA vaccine encoding a genetically inactivated S1 domain of pertussis toxin was evaluated using a murine respiratory challenge model of Bordetella pertussis infection. It was found that mice immunized via the intramuscular route elicited a purely cell-mediated immune response to the DNA vaccine, with high levels of gamma interferon (IFN-c) and interleukin (IL)-2 detected in the S1-stimulated splenocyte supernatants and no serum IgG. Despite the lack of an antibody response, the lungs of DNA-immunized mice were cleared of B. pertussis at a significantly faster rate compared with mock-immunized mice following an aerosol challenge. To gauge the true potential of this S1 DNA vaccine, the immune response and protective efficacy of the commercial diphtheria–tetanus–acellular pertussis (DTaP) vaccine were included as the gold standard. Immunization with DTaP elicited a typically strong T-helper (Th)2-polarized immune response with significantly higher titres of serum IgG than in the DNA vaccine group, but a relatively weak Th1 response with low levels of IFN-c and IL-2 detected in the supernatants of antigen-stimulated splenocytes. DTaP-immunized mice cleared the aerosol challenge more efficiently than DNA-immunized mice, with no detectable pathogen after day 7 post-challenge
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