Variations of health check attendance in later life: results from a British birth cohort study

Background:Older adults are advised to attend a number of preventive health checks to preserve health andidentify risk factors for disease. Previous research has identified a number of health and social factors, labelled aspredisposing, enabling and need factors, using Andersen’s Behavioural Model of Health Service Use, that areassociated with health care utilisation. We aimed to assess associations between factors from childhood andadulthood, and health check attendance in later life in a British birth cohort study.Methods:For 2370 study members from the MRC National Survey of Health and Development (NSHD), healthcheck attendance was assessed at age 68. Study members were asked if they: attended blood pressure andcholesterol checks, had their eyes tested, received the influenza vaccine, attended colon cancer screening anddental checks. Health and social factors from childhood and adulthood were used in binomial regression models totest associations with health check attendance in men and women.Results:Health check attendance was high; 41% reported attending all six health checks within the recommendedtime frame. In multivariable models, being a non-smoker and having more health conditions in adulthood wereassociated with greater health check attendance in men and women. In women, childhood socioeconomicadvantage, being more physically active in midlife and previously attending screening procedures, and in men,greater self-organisation in adolescence and being married were associated with attending more health checks inlater life, following adjustments for childhood and adulthood factors.Conclusions:A number of predisposing, enabling and need factors from childhood and adulthood were found tobe associated with health check attendance at age 68, demonstrating the relevance of applying a life courseperspective to Andersen’s model in investigating health check attendance in later life. Health related factors werefound to be stronger correlates of health check attendance than socioeconomic factors

Employment and Disability Policy: the role of the psychologist

Persons with minor or major disabilities represent a significant portion of the U.S. working-age population. Based on the 1993 Survey of Income and Program Participation (SIPP), approximately 30 million (19%) men and women 18 to 64 years of age report some type of physical or mental limitation. For approximately 55% of these individuals (about 10% of those 18 to 64), the limitations are severe

GuiTope: an application for mapping random-sequence peptides to protein sequences

BACKGROUND: Random-sequence peptide libraries are a commonly used tool to identify novel ligands for binding antibodies, other proteins, and small molecules. It is often of interest to compare the selected peptide sequences to the natural protein binding partners to infer the exact binding site or the importance of particular residues. The ability to search a set of sequences for similarity to a set of peptides may sometimes enable the prediction of an antibody epitope or a novel binding partner. We have developed a software application designed specifically for this task. RESULTS: GuiTope provides a graphical user interface for aligning peptide sequences to protein sequences. All alignment parameters are accessible to the user including the ability to specify the amino acid frequency in the peptide library; these frequencies often differ significantly from those assumed by popular alignment programs. It also includes a novel feature to align di-peptide inversions, which we have found improves the accuracy of antibody epitope prediction from peptide microarray data and shows utility in analyzing phage display datasets. Finally, GuiTope can randomly select peptides from a given library to estimate a null distribution of scores and calculate statistical significance. CONCLUSIONS: GuiTope provides a convenient method for comparing selected peptide sequences to protein sequences, including flexible alignment parameters, novel alignment features, ability to search a database, and statistical significance of results. The software is available as an executable (for PC) at http://www.immunosignature.com/software and ongoing updates and source code will be available at sourceforge.net

De-standardization and gender convergence in work–family life courses in Great Britain: A multi-channel sequence analysis

This study addresses the question of de-standardized life courses from a gender perspective. Multi-channel sequence analysis is used to characterise the domains of work, partnership and parenthood in combination across the adult life courses of three birth cohorts of British men and women between the ages of 16 and 42. Three research questions are addressed. First, we examine whether there is evidence of increasing between-person de-standardization (diversity) and within-person differentiation (complexity) in work and family life courses across cohorts during the main childrearing years. Second, we investigate whether men's and women's work–family life courses are converging over time. Finally, we assess the link between educational attainment and work–family life courses across cohorts. Data are from the MRC National Survey of Health and Development 1946 birth cohort (n = 3012), the National Child Development Study 1958 birth cohort (n = 9616), and the British Cohort Study 1970 birth cohort (n = 8158). We apply multi-channel sequence analysis to group individuals into twelve conceptually-based work–family life course types. We find evidence of growing between-person diversity, across cohorts, for both women and men. In addition, partnership trajectories are growing more complex for both genders, while parental biographies and women's work histories are becoming less so. Women's and men's work–family life courses are becoming increasingly similar as more women engage in continuous full-time employment; however, life courses involving part-time employment or a career break remain common for women in the most recent cohort. Continuous, full-time employment combined with minimal family ties up to age 42 emerged as the most common pattern for women and the second most common for men in the 1970 cohort

Robots with Display Screens: A Robot with a More Humanlike Face Display Is Perceived To Have More Mind and a Better Personality

It is important for robot designers to know how to make robots that interact effectively with humans. One key dimension is robot appearance and in particular how humanlike the robot should be. Uncanny Valley theory suggests that robots look uncanny when their appearance approaches, but is not absolutely, human. An underlying mechanism may be that appearance affects users’ perceptions of the robot’s personality and mind. This study aimed to investigate how robot facial appearance affected perceptions of the robot’s mind, personality and eeriness. A repeated measures experiment was conducted. 30 participants (14 females and 16 males, mean age 22.5 years) interacted with a Peoplebot healthcare robot under three conditions in a randomized order: the robot had either a humanlike face, silver face, or no-face on its display screen. Each time, the robot assisted the participant to take his/her blood pressure. Participants rated the robot’s mind, personality, and eeriness in each condition. The robot with the humanlike face display was most preferred, rated as having most mind, being most humanlike, alive, sociable and amiable. The robot with the silver face display was least preferred, rated most eerie, moderate in mind, humanlikeness and amiability. The robot with the no-face display was rated least sociable and amiable. There was no difference in blood pressure readings between the robots with different face displays. Higher ratings of eeriness were related to impressions of the robot with the humanlike face display being less amiable, less sociable and less trustworthy. These results suggest that the more humanlike a healthcare robot’s face display is, the more people attribute mind and positive personality characteristics to it. Eeriness was related to negative impressions of the robot’s personality. Designers should be aware that the face on a robot’s display screen can affect both the perceived mind and personality of the robot

The cellular basis of distinct thirst modalities

Fluid intake is an essential innate behaviour that is mainly caused by two distinct types of thirst. Increased blood osmolality induces osmotic thirst that drives animals to consume pure water. Conversely, the loss of body fluid induces hypovolaemic thirst, in which animals seek both water and minerals (salts) to recover blood volume. Circumventricular organs in the lamina terminalis are critical sites for sensing both types of thirst-inducing stimulus. However, how different thirst modalities are encoded in the brain remains unknown. Here we employed stimulus-to-cell-type mapping using single-cell RNA sequencing to identify the cellular substrates that underlie distinct types of thirst. These studies revealed diverse types of excitatory and inhibitory neuron in each circumventricular organ structure. We show that unique combinations of these neuron types are activated under osmotic and hypovolaemic stresses. These results elucidate the cellular logic that underlies distinct thirst modalities. Furthermore, optogenetic gain of function in thirst-modality-specific cell types recapitulated water-specific and non-specific fluid appetite caused by the two distinct dipsogenic stimuli. Together, these results show that thirst is a multimodal physiological state, and that different thirst states are mediated by specific neuron types in the mammalian brain

Novel therapeutic targets in salivary duct carcinoma uncovered by comprehensive molecular profiling.

Salivary duct carcinoma (SDC) is a rare, aggressive salivary gland malignancy, which often presents at an advanced stage. A proportion of SDC are characterized by HER2 amplification and/or overexpression of androgen receptor (AR), which could be targeted in a subset of patients, but the presence of AR splice variant-7 (AR-V7) in some SDC cases could result in resistance to anti-androgen therapy. We evaluated a cohort of 28 cases of SDC for potentially targetable biomarkers and pathways using immunohistochemistry (IHC) and next-generation sequencing (DNA and RNA) assays. Pathogenic genetic aberrations were found in all but 1 case and affected TP53 (n = 19), HRAS (n = 7), PIK3CA, ERBB2 (HER2), and NF1 (n = 5 each); KMT2C (MLL3) and PTEN (n = 3 each); BRAF (p.V600E), KDM5C and NOTCH1 (n = 2 each). Androgen receptor was expressed in all cases and 13 of 27 harbored the AR-V7 splice variant (including a case without any other detectable genetic alteration). HER2 IHC was expressed in 11 of 28 cases. The majority of SDC cases had no biomarkers predictive of immunotherapy response: 5 cases exhibited low (1%-8%) programmed death ligand 1 (PD-L1) expression in tumor cells, 2 cases exhibited elevated TMB, and no samples exhibited microsatellite instability. Notably, the pre-treatment biopsies from 2 patients with metastatic disease, who demonstrated clinical responses to anti-androgen therapy, showed AR expression and no AR splice variants. We conclude that comprehensive molecular profiling of SDCs can guide the selection of patients for targeted therapies involving AR, HER2, PD-L1, mitogen-activated protein kinase, and PIK3CA pathways