Correlation between temporomandibular joint dysfunction and Eichner classification

Introduction: The Dental Prosthetics Department's most common patients are elderly who have lost their teeth. Dental deficiencies not only impair the functions of the stomatognathic system but can also be the cause of temporomandibular disorders (TMD). Deficiencies in the lateral sections lead to a decrease in the occlusion height in patients, which negatively affects the aesthetics of the face by shortening the lower floor and overloading the remaining teeth, eventually leading to their pathological wear. Loss of occlusion height changes the spatial arrangement of the lower jaw to the upper jaw, which can lead to changes in the temporomandibular joint. The loss of a tooth or group of teeth is an indication for proper prosthetic treatment. The dentist should be able to take into account, evaluate and, if necessary, cure TMD, but this is not a common skill among dentists. Such treatment requires an appropriate comprehensive approach. There are currently no standards for such treatment. We presented one of the methods as part of our study.Purpose of work:The aim of the study was to check the correlation between the occurrence of temporomandibular disorders and missing teeth and used prosthetic restorations. Material and methods:Medical history records of 58 patients under the care of the Department of Dental Prosthetics at Medical University of Lublin were analyzed. Factors such as age and gender, occlusion height, distribution of missing teeth according to the Eichner classification and symptoms of temporomandibular joint disorders, i.e. crackling, pain, limited and excessive abduction of the jaw were checked. Before starting prosthetic treatment, every patient underwent comprehensive conservative, surgical and periodontics treatment in accordance with existing needs. Results:The study group consisted of 38 women and 20 men. The average age of all patients was 69.6 years; - average for men - 70.45 years, women 68.16 years. The oldest patient was an 88-year-old man, and the youngest was a 43-year-old woman. 31% of patients were toothless. 25.9% of patients had pain within the stomatognathic system, of which 86.7% were women and 13.3% men. Relaxation splint was made in 24.1% of patients.Summary:The study showed that the ailments associated with the stomatognathic system are correlated with a reduction in occlusion height. Larger dental deficits are more common in older people. Pain symptoms are the most common cause of making relaxation splints. Women more often than men complain of pain. The correct treatment scheme for patients with missing teeth and long-term loss of support zones is staggered treatment - two-stage. The first stage of treatment is to restore the correct occlusion height by using the occlusal splint. Then, after the adaptation period, there is a transition to the second stage of treatment - the use of proper prosthetic restoration maintaining the correct height of occlusio

MikroRNA w chorobach układu sercowo-naczyniowego

MikroRNA to endogenne, małe, niekodujące cząsteczki RNA, które odgrywają kluczową rolę w regulacji ekspre- sji genów. MikroRNA biorą udział w wielu procesach bio- logicznych, takich jak proliferacja, różnicowanie komó- rek, angiogeneza czy apoptoza. Doniesienia naukowe wskazują, że mikroRNA znamiennie determinują fizjolo- gię i patofizjologię serca; mogą również mieć znaczenie diagnostyczne jako nowe biomarkery użyteczne w roz- poznawaniu i przebiegu na przykład zawału serca. Choroby Serca i Naczyń 2011, 8 (3), 158–16

MicroRNAs in cardiovascular diseases

MikroRNA to endogenne, małe, niekodujące cząsteczki RNA, które odgrywają kluczową rolę w regulacji ekspresji genów. MikroRNA biorą udział w wielu procesach biologicznych, takich jak proliferacja, różnicowanie komórek, angiogeneza czy apoptoza. Doniesienia naukowe wskazują, że mikroRNA znamiennie determinują fizjologię i patofizjologię serca; mogą również mieć znaczenie diagnostyczne jako nowe biomarkery użyteczne w rozpoznawaniu i przebiegu na przykład zawału serca.MicroRNAs are endogenous small non-codig RNA, that they play crucial roles in the regulation of gene expression. MicroRNAs participate in many essential biological process, such as cell proliferation, differentiation, angiogenesis and apoptosis. Emerging evidence has indicated that microRNAs are involved in cardiac physiology and pathophysiology, including the regulation of cardiac physiological function and participation in the genesis of cardiac diseases. MikroRNAs are also recognized as a new diagnostic biomarkers of myocardial injury

Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level

Duży śluzak lewego przedsionka o przebiegu sugerującym początkowo zatorowość płucną

Cardiac myxomas are rare. They usually appear as a sporadic isolated mass in the left atrium of women with no other pathology. Our patient had symptoms which may suggest pulmonary embolism (PE)-TTE, D-dimers, ECG, laboratory findings seemed to confirm acute PE. Physical examination was unremarkable. Signs of pulmonary hypertension and shortened acceleration time also suggested PE. However, angio-CT excluded it. The patient was transfered to surgical department. During the operation the big myxoma filling the whole space of the left atrium and blocking the entrance to the left ventricle was found and easily removed. Kardiol Pol 2010; 68, 6: 695-69

Selected Applications of Chitosan Composites

Chitosan is one of the emerging materials for various applications. The most intensive studies have focused on its use as a biomaterial and for biomedical, cosmetic, and packaging systems. The research on biodegradable food packaging systems over conventional non-biodegradable packaging systems has gained much importance in the last decade. The deacetylation of chitin, a polysaccharide mainly obtained from crustaceans and shrimp shells, yields chitosan. The deacetylation process of chitin leads to the generation of primary amino groups. The functional activity of chitosan is generally owed to this amino group, which imparts inherent antioxidant and antimicrobial activity to the chitosan. Further, since chitosan is a naturally derived polymer, it is biodegradable and safe for human consumption. Food-focused researchers are exploiting the properties of chitosan to develop biodegradable food packaging systems. However, the properties of packaging systems using chitosan can be improved by adding different additives or blending chitosan with other polymers. In this review, we report on the different properties of chitosan that make it suitable for food packaging applications, various methods to develop chitosan-based packaging films, and finally, the applications of chitosan in developing multifunctional food packaging materials. Here we present a short overview of the chitosan-based nanocomposites, beginning with principal properties, selected preparation techniques, and finally, selected current research