6 research outputs found
Psychological Attributes of Mergers — Part 2
- Author
- Publication venue
- 'Emerald'
- Publication date
- Field of study
Learning about forest futures under climate change through transdisciplinary collaboration across traditional and western knowledge systems
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
We provide an overview of a transdisciplinary project about sustainable forest management under climate change. Our project is a partnership with members of the Menominee Nation, a Tribal Nation located in northern Wisconsin, United States. We use immersive virtual experiences, translated from ecosystem model outcomes, to elicit human values about future forest conditions under alternative scenarios. Our project combines expertise across the sciences and humanities as well as across cultures and knowledge systems. Our management structure, governance, and leadership behaviors have both fostered and constrained our work and must be continuously responsive to changing group dynamics. Our project presents opportunities for substantial contributions to society, including insights and knowledge about complementary ways of knowing, skills training, and professional development, and opportunities for reflexive learning about effective transdisciplinary, translational, and transformative scientific processes
The development of British accountancy in the nineteenth century: A technological determinist approach
- Author
- Abbott Andrew
- Anderson Malcolm
- Bessemer Henry
- Briston Richard J.
- Brown Richard
- Bywater Michael
- Carr-Saunders Alexander M.
- Cohen Gerald A.
- Cohen Gerald A.
- Cottrell P. L.
- Cottrell P. L.
- de Paula Frederic R.M.
- Deane Phyllis
- Derek Matthews
- Dicksee Lawrence R.
- Edwards John Richard
- Edwards John Richard
- Edwards John Richard
- Gourvish Terry
- Grace Darbyshire
- Hobsbawm Eric
- Howard Michael C.
- Howitt Sir Harold
- Hudson Pat
- Johnson Terry
- Jones Edgar
- Jones Edgar
- Kedslie Moyra J.M.
- Kedslie Moyra J.M.
- Kirkham Linda M.
- Kirkham Linda M.
- Larson Magali S.
- Lawson Philip
- Locke Robert
- Lockwood David
- Macdonald Keith M.
- Mathias Peter
- Matthews Derek
- Matthews Derek
- McDougall E. H.V.
- McKinlay John B.
- McLennan Gregor
- Mitchell Brian R.
- Nixon Alfred
- Parker Robert H.
- Pevsner Norman
- Pixley Francis W.
- Rigby Stephen H.
- Roslender Robin
- Sayers Richard S.
- Shaw William H.
- Spicer Eulalie E.
- Stacey Nicholas A.H.
- Stewart James C.
- Walker Stephen P.
- Walker Stephen P.
- West Brian P.
- Worthington Beresford
- Wright Eric O.
- Publication venue
- Publication date
- 01/01/2006
- Field of study
This article argues that some of the most popular treatments of the development of accountancy in Britain do not accord with the historical evidence. This is true of the functionalist's altruistic view of the profession and of the predominant paradigm�-�the Weberian 'professional project'. There is no evidence in the early history of British accountancy to support the concepts of, for example: monopolistic closure, credentialism, or the social construction of skill. Instead, using a model based on technological determinism, the article reasserts the importance of the industrialisation process in forming the accountancy profession, and sees the formation of the chartered societies as largely set up to brand the accountants' training and thereby preserve the value of their human capital.Professions, Accounting History, Chartered Accountancy, Technological Determinism,
Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans (Nature, (2020), 581, 7809, (434-443), 10.1038/s41586-020-2308-7)
- Author
- Aguilar Salinas C.A.
- Ahmad T.
- Albert C.M.
- Alföldi J.
- Ardissino D.
- Armean Irina M.
- Atzmon G.
- Banks Eric
- Barnard J.
- Beaugerie L.
- Benjamin E.J.
- Bergelson Louis
- Birnbaum Daniel P.
- Boehnke M.
- Bonnycastle L.L.
- Bottinger E.P.
- Bowden D.W.
- Bown M.J.
- Brand Harrison
- Chambers J.C.
- Chan J.C.
- Chasman D.
- Cho J.
- Chong Jessica X.
- Chung M.K.
- Cibulskis Kristian
- Cohen B.
- Collins Ryan L.
- Connolly Kristen M.
- Correa A.
- Covarrubias Miguel
- Cummings Beryl B.
- Dabelea D.
- Daly Mark J.
- Daly Mark J.
- Darbar D.
- Donnelly Stacey
- Duggirala R.
- Dupuis J.
- Ellinor P.T.
- Elosua R.
- England Eleina M.
- Erdmann J.
- Esko T.
- Farjoun Yossi
- Ferriera Steven
- Florez J.
- Francioli Laurent C.
- Franke A.
- Färkkilä M.
- Gabriel Stacey
- Ganna Andrea
- Gauthier Laura D.
- Genome Aggregation Database Consortium.
- Gentry Jeff
- Getz G.
- Glaser B.
- Glatt S.J.
- Goldstein D.
- Gonzalez C.
- Groop L.
- Gupta Namrata
- Haiman C.
- Hanis C.
- Harms M.
- Hiltunen M.
- Holi M.M.
- Hultman C.M.
- Jeandet Thibault
- Kallela M.
- Kaplan Diane
- Kaprio J.
- Karczewski Konrad J.
- Kathiresan S.
- Kim B.-J.
- Kim Y.J.
- Kirov G.
- Kooner J.
- Koskinen S.
- Kosmicki Jack A.
- Krumholz H.M.
- Kugathasan S.
- Kwak S.H.
- Laakso M.
- Laricchia Kristen M.
- Lehtimäki T.
- Lek Monkol
- Llanwarne Christopher
- Loos R.J.F.
- Lubitz S.A.
- Ma R.C.W.
- MacArthur Daniel G.
- MacArthur Daniel G.
- Marrugat J.
- Mattila K.M.
- McCarroll S.
- McCarthy M.I.
- McGovern D.
- McPherson R.
- Meigs J.B.
- Melander O.
- Metspalu A.
- Minikel Eric Vallabh
- Munshi Ruchi
- Neale Benjamin M.
- Neale Benjamin M.
- Nilsson P.M.
- Novod Sam
- Ongur D.
- Orozco L.
- Owen M.J.
- O’Donnell-Luria A.H.
- O’Donovan M.C.
- Palmer C.N.A.
- Palotie A.
- Park K.S.
- Pato C.
- Petrillo Nikelle
- Pierce-Hoffman Emma
- Poterba Timothy
- Pulver A.E.
- Rahman N.
- Remes A.M.
- Rhodes Daniel
- Rioux J.D.
- Ripatti S.
- Roazen David
- Roden D.M.
- Ruano-Rubio Valentin
- Saleheen D.
- Salomaa V.
- Saltzman Andrea
- Samani N.J.
- Samocha Kaitlin E.
- Scharf J.
- Schleicher Molly
- Schunkert H.
- Seaby Eleanor G.
- Seed Cotton
- Shoemaker M.B.
- Singer-Berk Moriel
- Sklar P.
- Soininen H.
- Sokol H.
- Solomonson Matthew
- Soto Jose
- Spector T.
- Sullivan P.F.
- Suvisaari J.
- Tai E.S.
- Talkowski Michael E.
- Tashman Katherine
- Teo Y.Y.
- Tiao Grace
- Tibbetts Kathleen
- Tiinamaija T.
- Tolonen Charlotte
- Tsuang M.
- Turner D.
- Tusie-Luna T.
- Vartiainen E.
- Vawter M.P.
- Vittal Christopher
- Wade Gordon
- Walters Raymond K.
- Wang Arcturus
- Wang Qingbo
- Ware James S.
- Watkins H.
- Watts Nicholas A.
- Weersma R.K.
- Weisburd Ben
- Wessman M.
- Whiffin Nicola
- Wilson J.G.
- Xavier R.J.
- Zappala Zachary
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 03/02/2021
- Field of study
10.1038/s41586-020-03174-8Nature590784
IL-17–high asthma with features of a psoriasis immunophenotype
- Author
- A. Bautmans
- A. Bedding
- A. Berglind
- A. Berton
- A. Bush
- A. Chaiboonchoe
- A. D'Amico
- A. Manta
- A. Mazein
- A. Meiser
- A. Menzies-Gow
- A. Roberts
- A. Rowe
- A. Selby
- A. Sogbessan
- A. Vyas
- A.-S. Lantz
- A.F. Behndig
- A.H. Wagener
- A.H. Zwinderman
- A.J. James
- A.J. Knox
- A.R. Sousa
- A.T. Bansal
- Aleksandra Draper
- Alexander Manta
- Alnahas
- Ana R. Sousa
- Anne Petrén
- Annemiek Dijkhuis
- Anthony Postle
- Anton Vink
- Antonio Pacino
- Antonios Aliprantis
- Armin Braun
- B. Dahlén
- B. De Meulder
- B. Nordlund
- B. Thornton
- Barbara Smids
- Bart Lambrecht
- Ben Nicholas
- Besnard
- Bigler
- Breda Flood
- Busse
- C. Auffray
- C. Casaulta
- C. Faulenbach
- C. Holweg
- C. Pison
- C. Rossios
- C. von Garnier
- C.E. Wheelock
- C.H. Compton
- C.M. van Drunen
- C.S. Murray
- Caroline Mathon
- Caroline Smith
- Chambers
- Charles Auffray
- Choy
- Christopher Larminie
- Clair Barber
- Coen Wiegman
- Corinna Schoelch
- Corren
- Cristina Gomez
- D. Burg
- D. Campagna
- D. Erzen
- D. Garissi
- D. Gibeon
- D. Lefaudeux
- D. Myles
- D.E. Shaw
- David Allen
- David Balgoma
- Djukanovic
- Dominick E. Shaw
- Doroteya Staykova
- Dyson Kerry
- E. Bucchioni
- E. Formaggio
- E. Guillmant-Farry
- E. Henriksson
- E. Jeyasingham
- E.H. Bel
- Egeberg
- Elizabeth Yeyasingham
- Emma Ray
- Erika J. Kennington
- F. Baribaud
- F. Singer
- F. Spycher
- Fahy
- Fang
- Frans Wald
- G. Galffy
- G. Hedlin
- G. Kerry
- G. Praticò
- G. Roberts
- G. Santini
- Giorgio Pennazza
- Grazyna Bochenek
- Green
- Guerra
- Gurczynski
- H. Ahmed
- H. Bisgaard
- Hector Gallart
- Hinks
- Hugo Knobel
- I. Horváth
- I. Pandis
- I.M. Adcock
- Ian M. Adcock
- Ildikó Horváth
- imothy Davison
- Inge De Lepeleire
- Ingrid Delin
- Ioannis Pandis
- J. Bigler
- J. Brandsma
- J. Corfield
- J. Gent
- J. Haughney
- J. Musial
- J. Pellet
- J. Riley
- J. Stokholm
- J. Vestbo
- J.M. Hohlfeld
- J.P. Rocha
- J.R. Konradsen
- James P.R. Schofield
- James P.R. Schofield
- Jane Martin
- Jeanette Bigler
- Jenny Versnel
- Jessica Edwards
- Jessica Smith
- Johan Kolmert
- John-Olof Thörngren
- Jonathan Thorsen
- Jonathan Van Eyll
- Jonathan Ward
- Jonathan Ward
- Jorge Beleta
- Jorge De Alba
- Juliette Kamphuis
- Jörgen Östling
- K. Bønnelykke
- K. Dyson
- K. Fichtner
- K. Johnson
- K. Nething
- K. Riemann
- K. Strandberg
- K. Sun
- K. Tariq
- K.F. Chung
- Kai Sun
- Katherine M. Smith
- Kerry Gove
- Kian Fan Chung
- Kirsty Russell
- Kjell Alving
- Kolbinger
- Kosmas Kretsos
- Kristiane Wetzel
- Kumlin
- Kuo
- L. El Hadjam
- L. Krueger
- L. McEvoy
- L. Pahus
- L. Tamasi
- L.A. Lowe
- L.J. Fleming
- L.X. Larsson
- Lambrecht
- Lara Ravanetti
- Le Rouzic
- Leanne Metcalf
- Leanne Reynolds
- Leon Carayannopoulos
- Lindegard
- Lisa Marouzet
- Lorraine Hewitt
- Lotvall
- M. Caruso
- M. Gahlemann
- M. Gerhardsson de Verdier
- M. Klüglich
- M. Miralpeix
- M. Puig N. Rao
- M. Saqi
- M. Sunther
- M. Szentkereszty
- M. van Geest
- M.J. Boedigheimer
- M.J. Loza
- Maciej Kupczyk
- Magnus Ericsson
- Makihara
- Malayka Rahman-Amin
- Manohara Kanangana Batuwitage
- Marco Santoninco
- Marcus Sjödin
- Marek Sanak
- Maria Mikus
- Marianne van de Pol
- Marleen van Geest
- Martin
- Martine Robberechts
- Massimo Caruso
- Maxim Kots
- McAleer
- Michael Rutgers
- N. Fitch
- N. Jullian
- N. Krug
- N. Lazarinis
- N. Lemonnier
- N. Mores
- N. Sehgal
- N.H. Vissing
- Nagai
- Neil Gozzard
- Norbert Krug
- Oosaki
- Outi Vaarala
- P. Badorrek
- P. Bakke
- P. Brinkman
- P. Chanez
- P. Dennison
- P. Howarth
- P. Latzin
- P. Montuschi
- P. Powell
- P. Söderman
- P.J. Skipp
- P.J. Sterk
- P.W. Hekking
- Paolo Montuschi
- Pappu
- Parulekar
- Paul Dodson
- Paul J. Skipp
- Pavord
- Per S. Bakke
- Peter Howarth
- Peter J. Sterk
- Peter Nilsson
- Petsky
- Philip Monk
- R. Djukanovic
- R. Knowles
- R. Lutter
- R. Niven
- R. Sigmund
- R.J.M. Middelveld
- Rathore
- Ratko Djukanović
- Rene Lutter
- Ricciardolo
- Richard Hu
- Romanas Chaleckis
- Roos
- Rosalia Emma
- Russell
- S. Ballereau
- S. Bates
- S. Hashimoto
- S. Masefield
- S. Nsubuga
- S. Pavlidis
- S. Scott
- S. Stephan
- S. Valente
- S.E. Dahlen
- S.J. Fowler
- S.J. Wilson
- S.S. Wagers
- Saeeda Lone-Latif
- Sally Meah
- Samantha Walker
- Sandy Pink
- Scott Kuo
- Shama Naz
- Shaw
- Siew
- Sile Hu
- Siân Williams
- Stacey Reinke
- Stephen J. Fowler
- Susan Wilson
- Susanna Palkonen
- Sven-Erik Dahlen
- T. Geiser
- T. Higenbottam
- T. Sandström
- Tamara Dekker
- Taylor
- Thomas Sandström
- U. Frey
- U. Hoda
- U. Nihlén
- Ueharaguchi
- V.J. Erpenbeck
- W. Seibold
- W. Yu Amgen
- W. Zetterquist
- W.M. van Aalderen
- Wang
- Wenzel
- Woodruff
- X. Hu
- Xian Yang
- Y. Guo
- Yike Guo
- Z. Weiszhart
- Z. Zolkipli
- Zala Jevnikar
- Zhao
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Zoe
- Allen L.
- Allen Meryem
- Allen Schvearn
- Allibone S.
- Allison K.S.
- Allos R.
- Ally S.M.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- Altabaibeh A.
- Alvaro A.
- AlZahrani D.
- Amin V.
- Amirsavadkouhi Ali
- Amitrano Sara
- Anastasescu E.
- Anderson F.
- Anderson J.
- Anderson Madeleine
- Anderson Peter
- Anderson S.
- Anderson S.
- Anderson T.
- Andolfo I.
- Andretta F.
- Andreucci E.
- Andrew Angela
- Andrew B.
- Andrew Gratrix
- Andrews E.
- Andrews Shea J.
- Anedda F.
- Anemoli V.
- Annis A.
- Antcliffe David
- Antinori Andrea
- Antoni M.D.
- Anumakonda V.
- Apetri E.
- Aquino Maia
- Arabi Y.M.
- Aravindan Latha
- Arbane Gill
- Archer Katie
- Arden T.
- Arias Sonia Sousa
- Arif S.
- Armstrong Jacob
- Armstrong Lisa
- Armstrong Ruth
- Arning N.
- Arnold Sophie
- Arranz María Jesús
- Arribas E.
- Artuso R.
- Arumugam Prabhu
- Ascolillo Steven
- Ashraf Saima
- Ashton L.
- Aslibekyan S.
- Astin-Chamberlain Raine
- Atkinson E.G.
- Attwood B.
- Aucella F.
- Auld D.
- Auld F.
- Austin Karen
- Austin Pauline
- Auton A.
- Ayers A.
- Azarzar S.
- Bachetti T.
- Baikady R.R.
- Baillie John Kenneth
- Baines Balvinder
- Baines D.
- Baines K.
- Baird Yolanda
- Bakthavatsalam Dhanalakshmi
- Balaconis Mary K.
- Baldassarri M.
- Ball C.A.
- Baltzell A.H.
- Bamford A.
- Bamford Peter
- Banach Dorota
- Bancroft Hollie
- Band G.
- Bandini M.
- Bandla Nageswar
- Bano S.
- Baptista David
- Barakeh D.
- Baras Aris
- Baratti S.
- Barber R.
- Barberis L.
- Barbieri C.
- Barclay Lucy
- Bargagli E.
- Barhoush E.
- Barker J.
- Barnes K.C.
- Baroni S.
- Barrett F.
- Barron A.
- Barry P.
- Bartels M.
- Bartley Shauna
- Baruah R.
- Bashyal Archana
- Basikolo C.
- Bassetti M.
- Bastion V.
- Bates H.
- Bates Michelle
- Batini Chiara
- Battle Ceri
- Bauchmuller K.
- Baxter N.
- Baya N.
- Bayo L.A.
- Beadle Jane
- Bean S.
- Beaumont K.
- Beavis S.
- Beck A.
- Beckmann Noam D.
- Bedini J. L.
- Bee Catherine E.
- Beech E.
- Beech Valerie
- Beekes M.
- Beesley K.
- Begg Colin
- Beguin Y.
- Behan T.
- Beith C.M.
- Belagodu Zakaula
- Belbin Gillian Morven
- Belfield H.
- Belhaj Y.
- Beligni G.
- Belisle A.
- Bell D.
- Bell G.
- Bell M.
- Bell S.
- Bellamy Mary
- Belli M.A.
- Bellini A.
- Bellwood R.
- Below Jennifer
- Bemand T.
- Benetti E.
- Benham Leonie
- Bennett D.
- Bennett Sara
- Bentley David
- Bentley M.
- Benyon S.
- Beranova E.
- Bercades G.
- Bergantini L.
- Bergomi P.
- Berkowitz Nathan
- Bernardo D.
- Bevan E.
- Bewley J.
- Bhatia Nikhil
- Bhatterjee Ravi
- Bhuie Parminder
- Bi R.
- Biagio A.D.
- Bianchi F.
- Bibert S.
- Bibi Fatima
- Biddle Jack
- Biggs Heather
- Birch J.
- Birch J.
- Birch Sophie.
- Birchall K.
- Birchall K.
- Bird S.
- Birkinshaw Isobel
- Birt M.
- Biscarini F.
- Black E.
- Black K.
- Blackledge B.
- Blackman H.
- Blakemore H.
- Blay Natalia
- Blow Sara
- Blunt M.
- Board S.
- Bochud P.Y.
- Bociek Aneta
- Boezen M.
- Boillat N.
- Bokhari M.
- Bolton Matthew
- Bolton Rachel
- Bonner Stephen
- Booker L.
- Borislavova B.
- Borra Catherine
- Botello A.
- Botfield Liam
- Bottà G.
- Bouab M.
- Bough L.
- Boughton A.P.
- Bowes A.
- Bowles Ruth
- Boyle P.
- Boyle R.
- Boz Ceilia
- Bradford Y.
- Bradley C.
- Bradley P.
- Bradley-Potts Joanne
- Bradshaw Zena
- Brady A.
- Brady M.
- Brady R.
- Brandwood C.
- Branney D.
- Brantwood Craig
- Brassard N.
- Brayne A.
- Brealey D.
- Bremmer P.
- Brenner B.
- Bretherick Andrew D.
- Brett Michael
- Brett Stephen
- Brickell K.
- Bridgett V.
- Brimfield Lutece
- Brinkworth Elaine
- Briton Kate
- Britvan Bari
- Bromley M.
- Brooke Hollie
- Brooks S.
- Brown A.
- Brown Adam
- Brown C.W.
- Brown Ellen
- Brown Joanna
- Bruce M.
- Brumpton Ben M.
- Bruno Raffaele
- Brunton Mark
- Bruttini M.
- Bryant J.
- Bryant S.
- Buckley C.
- Buckley Sarah
- Bunni L.
- Burda D.
- Buring Julie E
- Burn I.
- Burnett C.
- Burns K.
- Burt K.
- Burtenshaw Andrew
- Burton Maudrian
- Busani S.
- Bussotti M.
- Butcher D.
- Butler Aaron
- Butler Joanna
- Butler S.
- Butler-Laporte G.
- Butterworth A.S.
- Butterworth-Cowin N.
- Button H.
- Buxbaum Joseph D
- Cabrelli Louise
- Cagova L.
- Caldarelli G.P.
- Callaghan Marie
- Callier S.
- Cameli Paolo
- Campbell Archie
- Campbell Archie
- Campbell Helen
- Campbell Rachael
- Campbell Suzanne
- Campos Sara
- Camsooksai J.
- Canaccini A.
- Cantarini L.
- Cantor M.N.
- Capasso M.
- Capitani K.
- Cappelli S.
- Capps N.
- Carbral-Ortega L.
- Carella M.
- Carey D.J.
- Carmody Margaret
- Carmody S.
- Carnahan M.
- Carreras A.
- Carriero M.L.
- Carter A.
- Carter David
- Carter E.
- Carter Joseph
- Carter S.
- Carungcong J.
- Casey Matt
- Castaño-Vinyals G.
- Castelli F.
- Castle K.
- Castori M.
- Caswell Melanie
- Catena E.
- Caterson Jess
- Cathcart Susanne
- Catlow L.
- Caulfield Mark J.
- Cavazza Anna
- Cawley Kathryn
- Cawthron K.
- Ceri S.
- Chablani M.
- Chadbourn Indra
- Chamnanphon Monpat
- Chan Georgia
- Chan R.
- Chandler B.
- Chang Xiao
- Chapman Susan
- Chariyavilaskul Pajaree
- Charles B.
- Charlesworth Ruth
- Charney Alexander W.
- Charnock R.
- Chasman D.I.
- Chassé M.
- Chaudhary Kumardeep
- Chavan S.
- Cheema Yusuf
- Chen Hung-Hsin
- Chen Jiantao
- Cheng N.
- Cherian Shiney
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- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease