Pivotal response treatment for school-aged children and adolescents with autism spectrum disorder: a randomized controlled trial

Pivotal Response Treatment (PRT) is promising for children with Autism Spectrum Disorder (ASD), but more methodologically robust designed studies are needed. In this randomized controlled trial, forty-four children with ASD, aged 9-15 years, were randomly allocated to PRT (n = 22) or treatment-as-usual (TAU; n = 22). Measurements were obtained after 12- and 20-weeks treatment, and 2-month follow-up. PRT resulted in significant greater improvements on parent-rated social-communicative skills after 12 weeks treatment (p = .004, partial eta(2) = 0.22), compared to TAU. Furthermore, larger gains in PRT compared to TAU were observed on blindly rated global functioning, and parent-rated adaptive socialization skills and attention problems. Implications for clinical practice and suggestions for future research are discussed.Education and Child Studie

International consensus statement for the screening, diagnosis, and treatment of adolescents with concurrent Attention-Deficit/Hyperactivity Disorder and substance use disorder

Education and Child Studie

[Genes, environment and autism spectrum disorders]

Contains fulltext : 136167.pdf (publisher's version ) (Open Access

Erop uit!

Contains fulltext : 204481.pdf (publisher's version ) (Open Access)Rede uitgesproken bij de aanvaarding van het ambt van hoogleraar Psychiatrie aan de Radboud Universiteit/het Radboudumc op 14 juni 201918 p

Autisme, de noodzaak tot integratie van kennis, organisatie en perspectieven

Oratie uitgesproken door Prof.dr. W.G. Staal bij de aanvaarding van het ambt van hoogleraar op het gebied van Autismespectrumstoornissen: Neurobiologie, Neurocognitie en Behandeling aan de Universiteit Leiden op vrijdag 4 mei 2018Oratie uitgesproken door Prof.dr. W.G. Staal bij de aanvaarding van het ambt van hoogleraar op het gebied van Autismespectrumstoornissen: Neurobiologie, Neurocognitie en Behandeling aan de Universiteit Leiden op vrijdag 4 mei 2018Development Psychopathology in context: clinical setting

The genetic overlap of attention deficit hyperactivity disorder and autistic spectrum disorder

Contains fulltext : 126118.pdf (publisher's version ) (Open Access)Autistic spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD) are classified as distinct disorders within the DSM-IV-TR (1994). The manual excludes simultaneous use of both diagnoses in case of overlap on a symptomatic level. However this does not always represent clinical observations and findings of previous studies. This review explores the genetic basis of the phenomenological overlap between ADHD and ASD. Based on an extensive review of twin-, linkage-, association studies, and reported structural genomic abnormalities associated with these disorders, we have identified seventeen regions on the human genome that can be related to both disorders. These regions of shared genetic association are: 2q35, 3p14, 4p16.1, 4p16.3, 5p15.31, 5p15.33, 7p12.3, 7p22, 7q21, 8q24.3, 14q12, 15q11-12, 16p13, 17q11, 18q21-23, 22q11.2, Xp22.3. The presented data are of interest for future genetic studies and appear to suggest the existence of a phenotype partition that may differ from the current classification of psychiatric disorders