A blood based 12-miRNA signature of Alzheimer disease patients

Background: Alzheimer disease (AD) is the most common form of dementia but the identification of reliable, early and non-invasive biomarkers remains a major challenge. We present a novel miRNA-based signature for detecting AD from blood samples. Results: We apply next-generation sequencing to miRNAs from blood samples of 48 AD patients and 22 unaffected controls, yielding a total of 140 unique mature miRNAs with significantly changed expression levels. Of these, 82 have higher and 58 have lower abundance in AD patient samples. We selected a panel of 12 miRNAs for an RT-qPCR analysis on a larger cohort of 202 samples, comprising not only AD patients and healthy controls but also patients with other CNS illnesses. These included mild cognitive impairment, which is assumed to represent a transitional period before the development of AD, as well as multiple sclerosis, Parkinson disease, major depression, bipolar disorder and schizophrenia. miRNA target enrichment analysis of the selected 12 miRNAs indicates an involvement of miRNAs in nervous system development, neuron projection, neuron projection development and neuron projection morphogenesis. Using this 12-miRNA signature, we differentiate between AD and controls with an accuracy of 93%, a specificity of 95% and a sensitivity of 92%. The differentiation of AD from other neurological diseases is possible with accuracies between 74% and 78%. The differentiation of the other CNS disorders from controls yields even higher accuracies. Conclusions: The data indicate that deregulated miRNAs in blood might be used as biomarkers in the diagnosis of AD or other neurological diseases

An Autonomous Lunar Geophysical Experiment Package (ALGEP) for future space missions

Geophysical observations will provide key information about the inner structure of the planets and satellites and understanding the internal structure is a strong constraint on the bulk composition and thermal evolution of these bodies. Thus, geophysical observations are a key to uncovering the origin and evolution of the Moon. In this article, we propose the development of an autonomous lunar geophysical experiment package, composed of a suite of instruments and a central station with standardized interface, which can be installed on various future lunar missions. By fixing the interface between instruments and the central station, it would be possible to easily configure an appropriate experiment package for different missions. We describe here a series of geophysical instruments that may be included as part of the geophysical package: a seismometer, a magnetometer, a heat flow probe, and a laser reflector. These instruments will provide mechanical, thermal, and geodetic parameters of the Moon that are strongly related to the internal structure. We discuss the functionality required for future geophysical observations of the Moon, including the development of the central station that will be used commonly by different payloads

Performance report of the RHUM-RUM ocean bottom seismometer network around La Réunion, western Indian Ocean

International audienceRHUM-RUM is a German-French seismological experiment based on the sea floor surrounding the island of La Réunion, western Indian Ocean (Barruol and Sigloch, 2013). Its primary objective is to clarify the presence or absence of a mantle plume beneath the Reunion volcanic hotspot. RHUM-RUM's central component is a 13-month deployment (October 2012 to November 2013) of 57 broad-band ocean bottom seismometers (OBS) and hydrophones over an area of 2000 ⇥ 2000 km 2 surrounding the hotspot. The array contained 48 wideband OBS from the German DE-PAS pool and 9 broadband OBS from the French INSU pool. It is the largest deployment of DEPAS and INSU OBS so far, and the first joint experiment. This article reviews network performance and data quality: of the 57 stations, 46 and 53 yielded good seismome-ter and hydrophone recordings, respectively. The 19 751 total deployment days yielded 18 735 days of hydrophone recordings and 15 941 days of seismometer recordings, which are 94 and 80 % of the theoretically possible yields. The INSU seismic sensors stand away from their OBS frames, whereas the DEPAS sensors are integrated into their frames. At long periods (> 10 s), the DEPAS seismome-ters are affected by significantly stronger noise than the INSU seismometers. On the horizontal components, this can be explained by tilting of the frame and buoy assemblage, e.g. through the action of ocean-bottom currents, but in addition the DEPAS intruments are affected by significant self-noise at long periods, including on the vertical channels. By comparison, the INSU instruments are much quieter at periods > 30 s and hence better suited for long-period signals studies. The trade-off of the instrument design is that the integrated DEPAS setup is easier to deploy and recover, especially when large numbers of stations are involved. Additionally , the wideband sensor has only half the power consumption of the broadband INSU seismometers. For the first time, this article publishes response information of the DE-PAS instruments, which is necessary for any project where true ground displacement is of interest. The data will become publicly available at the end of 2017

Seasonal seismic activity on Mars

International audienc

Newly formed craters on Mars located using seismic and acoustic wave data from InSight

Meteoroid impacts shape planetary surfaces by forming new craters and alter atmospheric composition. During atmospheric entry and impact on the ground, meteoroids excite transient acoustic and seismic waves. However, new crater formation and the associated impact-induced mechanical waves have yet to be observed jointly beyond Earth. Here we report observations of seismic and acoustic waves from the NASA InSight lander’s seismometer that we link to four meteoroid impact events on Mars observed in spacecraft imagery. We analysed arrival times and polarization of seismic and acoustic waves to estimate impact locations, which were subsequently confirmed by orbital imaging of the associated craters. Crater dimensions and estimates of meteoroid trajectories are consistent with waveform modelling of the recorded seismograms. With identified seismic sources, the seismic waves can be used to constrain the structure of the Martian interior, corroborating previous crustal structure models, and constrain scaling relationships between the distance and amplitude of impact-generated seismic waves on Mars, supporting a link between the seismic moment of impacts and the vertical impactor momentum. Our findings demonstrate the capability of planetary seismology to identify impact-generated seismic sources and constrain both impact processes and planetary interiors

Largest recent impact craters on Mars: Orbital imaging and surface seismic co-investigation

Two >130-meter-diameter impact craters formed on Mars during the later half of 2021. These are the two largest fresh impact craters discovered by the Mars Reconnaissance Orbiter since operations started 16 years ago. The impacts created two of the largest seismic events (magnitudes greater than 4) recorded by InSight during its 3-year mission. The combination of orbital imagery and seismic ground motion enables the investigation of subsurface and atmospheric energy partitioning of the impact process on a planet with a thin atmosphere and the first direct test of martian deep-interior seismic models with known event distances. The impact at 35°N excavated blocks of water ice, which is the lowest latitude at which ice has been directly observed on Mars

On the Detectability and Use of Normal Modes for Determining Interior Structure of Mars

ISSN:1572-9672ISSN:0038-630