Comparative Compositional Analysis and Pesticidal Efficacy of Essential Oils from Leaves of Skimmia Aanquetilia N.P. Taylor and Airy Shaw

The objective of the current study was to re-examine the chemical components of the essential oil (EO) from the aerial parts of Skimmia anquetilia N.P. Taylor & Airy Shaw in two different seasons designated as Skimmia anquetilia rainy season essential oil (SKREO) and Skimmia anquetilia winter season essential oil (SKWEO). The GC-MS analysis of SKREO and SKWEO resulted in the identification of 42 and 48 constituents, comprising of 95.3 % and 95.4 % of the total composition respectively. Both SKREO and SKWEO varied in their chemical composition in terms of quantity viz: linalyl acetate (15.8% - 17.6%), linalool (13.2% - 13.9%), geijerene (11.6% - 11.7%), α-thujene (11.3% - 11.1%), α-terpineol (6.1% - 6.1%), geranyl acetate (5.0% - 5.1%), α-terpinyl acetate (3.3% - 3.1%), myrcene (3.0% - 3.1%), geraniol (2.6% - 1.9%), α-pinene (2.1% - 2.2%), trans-β-ocimene (2.1% - 2.3%), cis-β-ocimene (2.0% - 2.2%) and neryl acetate (2.3% - 2.4%). Besides qualitative differences SKREO and SKWEO, both were studied for their pesticidal activities. The study exhibited potent antifeedant activity against Spodoptera litura and nematicidal activity against Meloidogyne incognita. Based on the present observations, it was found that besides its academic importance, shrub Skimmia anquetilia can be a good source of phytochemicals like linalyl acetate, linalool, geijerene, thujene and can be used for the development of herbal source for antifeedant and nematicidal activity after proper clinical trials

Part 3. A Novel Stereocontrolled, In Situ, Solution- and Solid-Phase, Aza Michael Approach for High-Throughput Generation of Tetrahydroaminoquinoline-Derived Natural-Product-like Architectures

With the goal of rapidly accessing tetrahydroquinoline-based natural-product-like polycyclic architectures, herein, we report an unprecedented, in situ, stereocontrolled Aza Michael approach in solution and on the solid phase. The mild reaction conditions required to reach the desired target are highly attractive for the use of this method in library generation. To our knowledge, this approach has not been used before, and it opens a novel route leading to a wide variety of tetrahydroquinoline-derived bridged tricyclic derivatives.NRC publication: Ye

Use of <i>S</i>-proline as chiral auxiliary in α-alkylations of carboxylic acids^†

2628-2631Use of S-proline as auxiliary in α-alkylations of carboxylic acids results in Se-face approach of the electrophile

Preparation of nanocrystalline Pd/SnO2 thin films deposited on alumina substrate by reactive magnetron sputtering for efficient CO gas sensing

We have prepared nanocrystalline Pd/SnO2 thin films deposited on alumina substrate by reactive magnetron sputtering for highly sensitive and selective CO gas sensing. The deposited thin films have a nanocrystalline nature and uniform granular morphologies as characterized by GIXRD and FESEM, respectively. The oxidation states and defect states were measured using XPS and PL spectra, respectively. The sensing performance of samples for CO gas was recorded at different conditions. An enhanced sensing performance of Pd/SnO2 (sensor response, SR -90.5% with fast response/recovery time -15 s/34 s) was achieved compared to pristine-SnO2 film (SR -81.7% and response/recovery time -60 s/98 s) for 91 ppm CO gas at 200 ? operating temperature. Further, Pd/SnO2 film exhibits an excellent SR -65.5% even at 100 C operating temperature. Thus, the prepared nanocrystalline Pd/SnO2 thin films can be used for the fabrication of CO gas sensors with efficient sensing performance

A new method for the synthesis of ethyl (1α, 5α<i>, </i>6α)-3-benzyl-3-azabicyclo[3.1.0.]hexane-2,4-dione-6-carboxylate: An intermediate for the trovafloxacin side chain^$

873-875A convenient and high yield process for ethyl (1α, 5α, 6α)-3-benzyl-3-azabicyclo[3.1.0.]hexane-2,4-dione-6-carboxylate using a facile endo-exo conversion by DBU is described

Room temperature sputtered nanocrystalline SnO2 thin films sensitized with Pd nanoparticles for high performance CO gas sensing application

In the present work, we have reported that Pd sensitized nanocrystalline SnO2 thin films sputtered at room temperature are quite promising for development of CO gas sensors. The investigation of materials quality and to understand the sensing mechanism, various characterization techniques such as the GIXRD, FESEM, PL and XPS were used. The sensing characteristics of prepared samples have been measured for different concentration of CO gas and at different temperatures. An excellent sensor response (similar to 94.5%) has been achieved for Pd sensitized SnO2 at 100 degrees C temperature for CO gas of 91 ppm concentration than SnO2 thin film (sensor response similar to 13.6%). The maximum sensor responses similar to 99.5% and similar to 84.3% were observed at 200 degrees C temperature, respectively for both samples. Also, a very fast response and recovery time of about similar to 8 s and similar to 15 s was achieved for Pd sensitized SnO2 thin film. Further, it was observed that Pd sensitized SnO2 thin film was highly selective for CO gas compared to NH3, H2S, NO2 and NO gases and highly stable even after preserved for about six months. Thus, rough surface or nano-pillars/cracks on the surface can also improve the gas sensing

Therapeutic potential of cyanobacterial pigment protein phycoerythrin: in silico and in vitro study of BACE1 interaction and in vivo Aβ reduction

Cyanobacteria are an immense source of innovative classes of pharmacologically active compounds exhibiting various biological activities ranging from antioxidants, antibiotics, anticancer, anti-inflammatory to anti-Alzheimer's disease. In the present study, we primarily targeted the inhibition of Beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) by a naturally occurring cyanobacterial protein phycoerythrin (C-PE). BACE1 cleaves amyloid-β precursor protein (APP) and leads to accumulation of neurotoxic amyloid beta (Aβ) plaques in the brain, as an attribute of Alzheimer's disease (AD). Inhibition of BACE1 was measured in terms of their association and dissociation rate constants, thermodynamics of binding using surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC). The kinetic parameters for enzyme activity were also measured using synthetic decapeptide as a substrate. We further validated the potential of PE by in-vivo histopathological staining of Aβ aggregate mutant Caenorhabditis elegans CL4176 by Thioflavin-T. The present studies pave the way for the application of naturally occurring C-PE as a putative therapeutic drug for the AD

Therapeutic potential of cyanobacterial pigment protein phycoerythrin: in silico and in vitro study of BACE1 interaction and in vivo Aβ reduction

Cyanobacteria are an immense source of innovative classes of pharmacologically active compounds exhibiting various biological activities ranging from antioxidants, antibiotics, anticancer, anti-inflammatory to anti-Alzheimer's disease. In the present study, we primarily targeted the inhibition of Beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) by a naturally occurring cyanobacterial protein phycoerythrin (C-PE). BACE1 cleaves amyloid-β precursor protein (APP) and leads to accumulation of neurotoxic amyloid beta (Aβ) plaques in the brain, as an attribute of Alzheimer's disease (AD). Inhibition of BACE1 was measured in terms of their association and dissociation rate constants, thermodynamics of binding using surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC). The kinetic parameters for enzyme activity were also measured using synthetic decapeptide as a substrate. We further validated the potential of PE by in-vivo histopathological staining of Aβ aggregate mutant Caenorhabditis elegans CL4176 by Thioflavin-T. The present studies pave the way for the application of naturally occurring C-PE as a putative therapeutic drug for the AD