Microfluidics: Fluid physics at the nanoliter scale

Microfabricated integrated circuits revolutionized computation by vastly reducing the space, labor, and time required for calculations. Microfluidic systems hold similar promise for the large-scale automation of chemistry and biology, suggesting the possibility of numerous experiments performed rapidly and in parallel, while consuming little reagent. While it is too early to tell whether such a vision will be realized, significant progress has been achieved, and various applications of significant scientific and practical interest have been developed. Here a review of the physics of small volumes (nanoliters) of fluids is presented, as parametrized by a series of dimensionless numbers expressing the relative importance of various physical phenomena. Specifically, this review explores the Reynolds number Re, addressing inertial effects; the Péclet number Pe, which concerns convective and diffusive transport; the capillary number Ca expressing the importance of interfacial tension; the Deborah, Weissenberg, and elasticity numbers De, Wi, and El, describing elastic effects due to deformable microstructural elements like polymers; the Grashof and Rayleigh numbers Gr and Ra, describing density-driven flows; and the Knudsen number, describing the importance of noncontinuum molecular effects. Furthermore, the long-range nature of viscous flows and the small device dimensions inherent in microfluidics mean that the influence of boundaries is typically significant. A variety of strategies have been developed to manipulate fluids by exploiting boundary effects; among these are electrokinetic effects, acoustic streaming, and fluid-structure interactions. The goal is to describe the physics behind the rich variety of fluid phenomena occurring on the nanoliter scale using simple scaling arguments, with the hopes of developing an intuitive sense for this occasionally counterintuitive world

Effective pseudo-potentials of hydrodynamic origin

It is shown that low Reynolds number fluid flows can cause suspended particles to respond as though they were in an equilibrium system with an effective potential. This general result follows naturally from the fact that different methods of moving particles in viscous fluids give rise to very different long-range flows. Two examples are discussed: electrophoretic `levitation' of a heavy charged sphere, for which a hydrodynamic `pseudo-potential' can be written in closed form, and quasi-two dimensional crystals of like-charged colloidal spheres which form near charged walls, whose apparent attraction arises not from a force but from persistent fluid flows.Comment: 10 pages, 3 figures, submitted to J. Fluid Mec

Kinematic irreversibility in surfactant-laden interfaces

The surface shear viscosity of an insoluble surfactant monolayer often depends strongly on its surface pressure. Here, we show that a particle moving within a bounded monolayer breaks the kinematic reversibility of low-Reynolds-number flows. The Lorentz reciprocal theorem allows such irreversibilities to be computed without solving the full nonlinear equations, giving the leading-order contribution of surface-pressure-dependent surface viscosity. In particular, we show that a disk translating or rotating near an interfacial boundary experiences a force in the direction perpendicular to that boundary. In unbounded monolayers, coupled modes of motion can also lead to non-intuitive trajectories, which we illustrate using an interfacial analog of the Magnus effect. This perturbative approach can be extended to more complex geometries, and to 2D suspensions more generally

Schematic Models for Active Nonlinear Microrheology

We analyze the nonlinear active microrheology of dense colloidal suspensions using a schematic model of mode-coupling theory. The model describes the strongly nonlinear behavior of the microscopic friction coefficient as a function of applied external force in terms of a delocalization transition. To probe this regime, we have performed Brownian dynamics simulations of a system of quasi-hard spheres. We also analyze experimental data on hard-sphere-like colloidal suspensions [Habdas et al., Europhys. Lett., 2004, 67, 477]. The behavior at very large forces is addressed specifically

Induced-charge Electrokinetic Phenomena: Theory and Microfluidic Applications

We give a general, physical description of ``induced-charge electro-osmosis'' (ICEO), the nonlinear electrokinetic slip at a polarizable surface, in the context of some new techniques for microfluidic pumping and mixing. ICEO generalizes ``AC electro-osmosis'' at micro-electrode arrays to various dielectric and conducting structures in weak DC or AC electric fields. The basic effect produces micro-vortices to enhance mixing in microfluidic devices, while various broken symmetries -- controlled potential, irregular shape, non-uniform surface properties, and field gradients -- can be exploited to produce streaming flows. Although we emphasize the qualitative picture of ICEO, we also briefly describe the mathematical theory (for thin double layers and weak fields) and apply it to a metal cylinder with a dielectric coating in a suddenly applied DC field.Comment: 4 pages, 4 figs; revsion with more refs, one new fig, and more emphasis on microfluidic

Induced-Charge Electro-Osmosis

We describe the general phenomenon of `induced-charge electro-osmosis' (ICEO) -- the nonlinear electro-osmotic slip that occurs when an applied field acts on the ionic charge it {\sl induces} around a polarizable surface. Motivated by a simple physical picture, we calculate ICEO flows around conducting cylinders in steady (DC), oscillatory (AC), and suddenly-applied electric fields. This picture, and these systems, represent perhaps the clearest example of nonlinear electrokinetic phenomena. We complement and verify this physically-motivated approach using a matched asymptotic expansion to the electrokinetic equations in the thin double-layer and low potential limits. ICEO slip velocities vary like $u_s \propto E_0^2 L$, where $E_0$ is the field strength and $L$ is a geometric length scale, and are set up on a time scale $\tau_c = \lambda_D L/D$, where $\lambda_D$ is the screening length and $D$ is the ionic diffusion constant. We propose and analyze ICEO microfluidic pumps and mixers that operate without moving parts under low applied potentials. Similar flows around metallic colloids with fixed total charge have been described in the Russian literature (largely unnoticed in the West). ICEO flows around conductors with fixed potential, on the other hand, have no colloidal analog and offer further possibilities for microfluidic applications.Comment: 36 pages, 8 figures, to appear in J. Fluid Mec

Improvement of Renormalization-Scale Uncertainties Within Empirical Determinations of the b-Quark Mass

Accurate determinations of the MS-bar b-quark mass $m_b(m_b)$ from $\sigma(e^+e^-\to{\rm hadrons})$ experimental data currently contain three comparable sources of uncertainty; the experimental uncertainty from moments of this cross-section, the uncertainty associated with $\alpha_s(M_z)$, and the theoretical uncertainty associated with the renormalization scale. Through resummation of all logarithmic terms explicitly determined in the perturbative series by the renormalization-group (RG) equation, it is shown that the renormalization-scale dependence is virtually eliminated as a source of theoretical uncertainty in $m_b(m_b)$. This resummation also reduces the estimated effect of higher-loop perturbative contributions, further reducing the theoretical uncertainties in $m_b(m_b)$. Furthermore, such resummation techniques improve the agreement between the values of the MS-bar b-quark mass extracted from the various moments of $R(s)=\sigma(e^+e^-\to{\rm hadrons})/\sigma_{pt}$ [$\sigma_{pt}=4\pi\alpha^2/(3s)$], obviating the need to choose an optimummoment for determining $m_b(m_b)$. Resummation techniques are also shown to reduce renormalization-scale dependence in the relation between b-quark MS-bar and pole mass and in the relation between the pole and $1S$ mass.Comment: 19 pages, latex2e, 6 eps figures contained in latex file. Errors corrected in equations (20)--(22

Collective Modes in the Loop Ordered Phase of Cuprates

We show that the two branches of collective modes discovered recently in under-doped Cuprates with huge spectral weight are a necessary consequence of the loop-current state. Such a state has been shown in earlier experiments to be consistent with the symmetry of the order parameter competing with superconductivity in four families of Cuprates. We also predict a third branch of excitations and suggest techniques to discover it. Using parameters to fit the observed modes, we show that the direction of the effective moments in the ground state lies in a cone at an angle to the c-axis as observed in experiments