Entrepreneurship and the MBA : an analysis of selected MBA entrepreneurial programs including the University of Michigan Business School

http://deepblue.lib.umich.edu/bitstream/2027.42/96901/1/MBA_Jauchius-W_1998Final.pd

Relaxed and active thin filament structures; a new structural basis for the regulatory mechanism

The structures of muscle thin filaments reconstituted using skeletal actin and cardiac troponin and tropomyosin have been determined with and without bound Ca2+ using electron microscopy and reference-free single particle analysis. The resulting density maps have been fitted with atomic models of actin, tropomyosin and troponin showing that: (i) the polarity of the troponin complex is consistent with our 2009 findings, with large shape changes in troponin between the two states; (ii) without Ca2+ the tropomyosin pseudo-repeats all lie at almost equivalent positions in the 'blocked' position on actin (over subdomains 1 and 2); (iii) in the active state the tropomyosin pseudo-repeats are all displaced towards subdomains 3 and 4 of actin, but the extent of displacement varies within the regulatory unit depending upon the axial location of the pseudo-repeats with respect to troponin. Individual pseudo-repeats with Ca2+ bound to troponin can be assigned either to the 'closed' state, a partly activated conformation, or the 'M-state', a fully activated conformation which has previously been thought to occur only when myosin heads bind. These results lead to a modified view of the steric blocking model of thin filament regulation in which cooperative activation is governed by troponin-mediated local interactions of the pseudo-repeats of tropomyosin with actin

Exploring the relationship between aboriginal tourism and community development

Aboriginal communities are increasingly turning toward aboriginal tourism develop- ment to diversify their economic base, validate their claims related to proprietary rights over traditional lands and re-connect youth with elders and the community to their land and their culture. Oftentimes, these development initiatives are tied to broader commu- nity development goals, yet the success of the tourism project is generally measured by its market readiness, revenue generation and job creation. The purpose of this article is to provide insight into the breadth of aboriginal community development benefits from tourism development through a review of literature of selected international case studies on aboriginal tourism development. Framing our approach is Bell’s typology of aboriginal community development that is conceptualized as consisting of five dimen- sions that include community empowerment, community wellness, community economic development, community learning and community stewardship [Bell, M. (1999). The changing face of community development in the north: From the power paradigm to the spirit paradigm. Yellowknife, NWT: Inukshuk Management Consultants]. The analy- sis provided insight into how aboriginal tourism initiatives benefit broader community development dimensions beyond the economic and that to develop tourism that extends its benefits to the community, issues that relate to community empowerment, wellness and healing and stewardship should be addressed

Monitoring the Myosin Crossbridge Cycle in Contracting Muscle:Steps towards ‘Muscle the Movie’.

Some vertebrate muscles (e.g. those in bony fish) have a simple lattice A-band which is so well ordered that low-angle X-ray diffraction patterns are sampled in a simple way amenable to crystallographic techniques. Time-resolved X-ray diffraction through the contractile cycle should provide a movie of the molecular movements involved in muscle contraction. Generation of ‘Muscle—The Movie’ was suggested in the 1990s and since then efforts have been made to work out how to achieve it. Here we discuss how a movie can be generated, we discuss the problems and opportunities, and present some new observations. Low angle X-ray diffraction patterns from bony fish muscles show myosin layer lines that are well sampled on row-lines expected from the simple hexagonal A-band lattice. The 1st, 2nd and 3rd myosin layer lines at d-spacings of around 42.9 nm, 21.5 nm and 14.3 nm respectively, get weaker in patterns from active muscle, but there is a well-sampled intensity remnant along the layer lines. We show here that the pattern from the tetanus plateau is not a residual resting pattern from fibres that have not been fully activated, but is a different well-sampled pattern showing the presence of a second, myosin-centred, arrangement of crossbridges within the active crossbridge population. We also show that the meridional M3 peak from active muscle has two components of different radial widths consistent with (i) active myosin-centred (probably weak-binding) heads giving a narrow peak and (ii) heads on actin in strong states giving a broad peak

Letter from Squire Gray Eyes & John M. Armstrong to James B. Finley

Squire Gray Eyes and John M. Armstrong write to Finley reporting that the enemy is at work at the mission in Wyandot City. Evidently, the Southern missionaries are dividing the Indians concerning membership in the MEC North vs. the MEC South. Our slave dealing missionaries are willing to resort to any means whatever to maintain their grasp upon the Indians. A meeting was recently held attended by nonprofessors, slave dealers, infidels, inebriates, and backsliders. This group sent a letter to the Ohio Conference stating that the Indians in the Kansas Mission had decided to align themselves with the MEC South, in direct opposition to the previous letter sent by the valid congregation requesting alignment with the MEC North. Squire Gray Eyes and John Armstrong bewail the actions of this unofficial, invalid group. Abstract Number - 783https://digitalcommons.owu.edu/finley-letters/2289/thumbnail.jp

Learning Local Immigration History In and Out of the Museum

In this article we utilize three case studies from the US as models for structuring historical inquiry in museum education programs focused on local immigration history. We focus on how models of practice from museums can be utilized as part of authentic history education pedagogy – in particular conducting historical inquiry with archival material and creating engaging exhibits. The three cases we draw from are the Tenement Museum (New York City), the Open House exhibit at the Minnesota History Center (St Paul, Minnesota), and a middle grades project in the Greenbush neighborhood (Madison, Wisconsin)

Literature and sustainability

Sustainability has become a key socio-political issue over recent years. However, whilst the literary-critical community has advanced enthusiastically on an exciting range of environmentally-based analyses (most obviously through the work of ecocriticism), its response specifically to sustainability—as an attempt to reconceptualise the way we live, as an idea with a particular history, and as a ubiquitous term driven through over-use to near meaninglessness—has been extremely limited. The basic idea of the volume is to make a start on filling this gap. Split into four sections: Historicising sustainability, Discourses of sustainability, The sustainability of literature, Sustainability in literature – it has some very good contributors, and starts off with an introduction about the history of the term, looks at its beginnings in the C19th, and goes onto show how contemporary authors are dealing with it including Jeanette Winterson, Michel Houellebecq, Margaret Atwood and Amitav Ghosh