Hard x-ray broad band Laue lenses (80 - 600 keV): building methods and performances

We present the status of the laue project devoted to develop a technology for building a 20 meter long focal length Laue lens for hard x-/soft gamma-ray astronomy (80 - 600 keV). The Laue lens is composed of bent crystals of Gallium Arsenide (GaAs, 220) and Germanium (Ge, 111), and, for the first time, the focusing property of bent crystals has been exploited for this field of applications. We show the preliminary results concerning the adhesive employed to fix the crystal tiles over the lens support, the positioning accuracy obtained and possible further improvements. The Laue lens petal that will be completed in a few months has a pass band of 80 - 300 keV and is a fraction of an entire Laue lens capable of focusing X-rays up to 600 keV, possibly extendable down to 20 - 30 keV with suitable low absorption crystal materials and focal length. The final goal is to develop a focusing optics that can improve the sensitivity over current telescopes in this energy band by 2 orders of magnitude

Laue Lens Development for Hard X-rays (>60 keV)

Results of reflectivity measurements of mosaic crystal samples of Cu (111) are reported. These tests were performed in the context of a feasibility study of a hard X-ray focusing telescope for space astronomy with energy passband from 60 to 600 keV. The technique envisaged is that of using mosaic crystals in transmission configuration that diffract X-rays for Bragg diffraction (Laue lens). The Laue lens assumed has a spherical shape with focal length $f$. It is made of flat mosaic crystal tiles suitably positioned in the lens. The samples were grown and worked for this project at the Institute Laue-Langevin (ILL) in Grenoble (France), while the reflectivity tests were performed at the X-ray facility of the Physics Department of the University of Ferrara.Comment: 6 pages, 12 figures, accepted for publication in IEEE Transactions on Nuclear Scienc

Proliferative cell nuclear antigen (PCNA) expression in the intestine of Salmo trutta trutta naturally infected with an acanthocephalan

Background: Changes in the production of proliferating cell nuclear antigen (PCNA), a 36 kd protein involved in protein synthesis, within intestinal epithelia can provide an early indication of deviations to normal functioning. Inhibition or stimulation of cell proliferation and PCNA can be determined through immunohistochemical staining of intestinal tissue. Changes in the expression of PCNA act as an early warning system of changes to the gut and this application has not been applied to the fields of aquatic parasitology and fish health. The current study set out to determine whether a population of wild brown trout, Salmo trutta trutta (L.) harbouring an infection of the acanthocephalan Dentitruncus truttae Sinzar, 1955 collected from Lake Piediluco in Central Italy also effected changes in the expression of PCNA. Methods: A total of 29 brown trout were investigated, 19 of which (i.e. 65.5%) were found to harbour acanthocephalans (5-320 worms fish-1). Histological sections of both uninfected and infected intestinal material were immunostained for PCNA. Results: The expression of PCNA was observed in the epithelial cells in the intestinal crypts and within the mast cells and fibroblasts in the submucosa layer which is consistent with its role in cell proliferation and DNA synthesis. The number of PCNA-positive cells in both the intestinal epithelium and the submucosa layer in regions close to the point of parasite attachment were significantly higher than the number observed in uninfected individuals and in infected individuals in zones at least 0.7 cm from the point of parasite attachment (ANOVA, p < 0.05). Conclusions: An infection of the acanthocephalan D. truttae within the intestinal tract of S. t. trutta effected a significant increase in the number of PCNA positive cells (mast cells and fibroblasts) at the site of parasite attachment when compared to the number of positive cells found in uninfected conspecifics and in tissue zones away from the point of parasite attachment

New results on focusing of gamma-rays with Laue lenses

We report on new results on the development activity of broad band Laue lenses for hard X-/gamma-ray astronomy (70/100-600 keV). After the development of a first prototype, whose performance was presented at the SPIE conference on Astronomical Telescopes held last year in Marseille (Frontera et al. 2008), we have improved the lens assembling technology. We present the development status of the new lens prototype that is on the way to be assembled.Comment: 8 pages, 11 figures, to be Published in SPIE Proceedings, vol.7437-19, 200

Development status of the LAUE project

We present the status of LAUE, a project supported by the Italian Space Agency (ASI), and devoted to develop Laue lenses with long focal length (up to 100 meters), for hard X--/soft gamma--ray astronomy (80-600 keV). Thanks to their focusing capability, the design goal is to improve the sensitivity of the current instrumention in the above energy band by 2 orders of magnitude, down to a few times $10^{-8}$ photons/(cm$^2$ s keV).Comment: 9 pages, 9 figures, presented at the Space Telescopes and Instrumentation Symposium in Amsterdam, 2012: Ultraviolet to Gamma Ray Conference. Published in the Proceedings of the SPIE, Volume 8443, id. 84430B-84430B-9 (2012

Development status of a Laue lens project for gamma-ray astronomy

We report the status of the HAXTEL project, devoted to perform a design study and the development of a Laue lens prototype. After a summary of the major results of the design study, the approach adopted to develop a Demonstration Model of a Laue lens is discussed, the set up described, and some results presented.Comment: 11 pages, 11 figures, 2007 SPIE Conference on Optics for EUV, X-Ray, and Gamma-Ray Astronomy II

The side chain of glutamine 13 is the acyl-donor amino acid modified by type 2 transglutaminase in subunit T of the native rabbit skeletal muscle troponin complex.

Subunit T of the native muscle troponin complex is a recognised substrate of transglutaminase both in vitro and in situ with formation of isopeptide bonds. Using a proteomic approach, we have now determined the precise site of in vitro labelling of the protein. A preparation of troponin purified from ether powder from mixed rabbit skeletal muscles was employed as transglutaminase substrate. The only isoform TnT2F present in our preparation was recognised as acyl-substrate by human type 2 transglutaminase which specifically modified glutamine 13 in the N-terminal region. During the reaction, the troponin protein complex was polymerized. Results are discussed in relation to the structure of the troponin T subunit, in the light of the role of troponins in skeletal and cardiac muscle diseases, and to the rules governing glutamine side chain selection by tissue transglutaminase

Test of the CLAS12 RICH large scale prototype in the direct proximity focusing configuration

A large area ring-imaging Cherenkov detector has been designed to provide clean hadron identification capability in the momentum range from 3 GeV/c up to 8 GeV/c for the CLAS12 experiments at the upgraded 12 GeV continuous electron beam accelerator facility of Jefferson Laboratory. The adopted solution foresees a novel hybrid optics design based on aerogel radiator, composite mirrors and high-packed and high-segmented photon detectors. Cherenkov light will either be imaged directly (forward tracks) or after two mirror reflections (large angle tracks). We report here the results of the tests of a large scale prototype of the RICH detector performed with the hadron beam of the CERN T9 experimental hall for the direct detection configuration. The tests demonstrated that the proposed design provides the required pion-to-kaon rejection factor of 1:500 in the whole momentum range.Comment: 15 pages, 23 figures, to appear on EPJ

Focusing of gamma-rays with Laue lenses: first results

We report on the first results obtained from our development project of focusing gamma-rays ($>$60 keV) by using Laue lenses. The first lens prototype model has been assembled and tested. We describe the technique adopted and the lens focusing capabilities at about 100 keV.Comment: 8 pages 9 figures, to be published in SPIE Procs. 7011, 200

The large-area hybrid-optics RICH detector for the CLAS12 spectrometer

A large area imaging Cherenkov detector is under construction to provide hadron identification in the momentum range between 3 and 8 GeV/c for the CLAS12 exeperiment at the new 12 GeV electron beam of the Jefferson Laboratory (JLab). The detector adopts a hybrid optics solution with aerogel radiator, light planar and spherical mirrors and highly-segmented photon detectors. Cherenkov photons will be imaged either directly (for forward tracks) or after two mirror reflections (large angle tracks). The status of the detector construction is here reported