Social Media in Emergent Brazil

Since the birth of the internet, low-income Brazilians have received little government support to help them access it. In response, they have largely self-financed their digital migration. Internet cafés became prosperous businesses in working-class neighbourhoods and rural settlements, and, more recently, families have aspired to buy their own home computer with hire purchase agreements. As low-income Brazilians began to access popular social media sites in the mid-2000s, affluent Brazilians ridiculed their limited technological skills, different tastes and poor schooling, but this did not deter them from expanding their online presence. Young people created profiles for barely literate older relatives and taught them to navigate platforms such as Facebook and WhatsApp. Based on 15 months of ethnographic research, this book aims to understand why low-income Brazilians have invested so much of their time and money in learning about social media. Juliano Spyer explores this question from a number of perspectives, including education, relationships, work and politics. He argues that the use of social media reflects contradictory values. Low-income Brazilians embrace social media to display literacy and upward mobility, but the same technology also strengthens traditional networks of support that conflict with individualism.

Mίdias sociais no Brasil emergente

Mesmo tendo menor escolaridade e menos dinheiro, os brasileiros das classes populares ajudaram a pagar por sua inclusão digital. Quando os brasileiros de baixa renda começaram a acessar redes sociais, pessoas de alto poder aquisitivo ridicularizaram o conhecimento tecnológico limitado, o gosto diferente e a baixa escolaridade desses usuários mais pobres, mas isso não os intimidou, e eles continuaram a expandir sua presença nos serviços on-line. Jovens criaram perfis para parentes mais velhos, quase analfabetos, e os ensinaram a navegar em plataformas como Facebook e WhatsApp. Juliano Spyer procura entender por que brasileiros de baixa renda investiram tanto tempo e dinheiro para incorporar o uso das mídias sociais a seu cotidiano. Explora essa questão por uma variedade de temas, incluindo educação, relacionamentos, trabalho e política e argumenta que o uso das mídias sociais reflete valores e motivações contraditórias. Brasileiros de baixa renda abraçam as mídias sociais para exibir sua crescente escolaridade e mobilidade social, mas a mesma tecnologia também fortalece redes de apoio mútuo tradicionais que rejeitam atitudes individualistas

Sensitive HIV-1 DNA Pol Next-Generation Sequencing for the Characterisation of Archived Antiretroviral Drug Resistance

Modern HIV-1 treatment effectively suppresses viral amplification in people living with HIV. However, the persistence of HIV-1 DNA as proviruses integrated into the human genome remains the main barrier to achieving a cure. Next-generation sequencing (NGS) offers increased sensitivity for characterising archived drug resistance mutations (DRMs) in HIV-1 DNA for improved treatment options. In this study, we present an ultra-sensitive targeted PCR assay coupled with NGS and a robust pipeline to characterise HIV-1 DNA DRMs from buffy coat samples. Our evaluation supports the use of this assay for Pan-HIV-1 analyses with reliable detection of DRMs across the HIV-1 Pol region. We propose this assay as a new valuable tool for monitoring archived HIV-1 drug resistance in virologically suppressed individuals, especially in clinical trials investigating novel therapeutic approaches

The virological durability of first-line ART among HIV-positive adult patients in resource limited settings without virological monitoring: a retrospective analysis of DART trial data

BACKGROUND: Few low-income countries have virological monitoring widely available. We estimated the virological durability of first-line antiretroviral therapy (ART) after five years of follow-up among adult Ugandan and Zimbabwean patients in the DART study, in which virological assays were conducted retrospectively. METHODS: DART compared clinically driven monitoring with/without routine CD4 measurement. Annual plasma viral load was measured on 1,762 patients. Analytical weights were calculated based on the inverse probability of sampling. Time to virological failure, defined as the first viral load measurement ≥200 copies/mL after 48 weeks of ART, was analysed using Kaplan-Meier plots and Cox regression models. RESULTS: Overall, 65% of DART trial patients were female. Patients initiated first-line ART at a median (interquartile range; IQR) age of 37 (32-42) and with a median CD4 cell count of 86 (32-140). After 240 weeks of ART, patients initiating dual-class nucleoside reverse-transcriptase inhibitor (NRTI) -non-nucleoside reverse-transcriptase (NNRTI) regimens containing nevirapine + zidovudine + lamivudine had a lower incidence of virological failure than patients on triple-NRTI regimens containing tenofovir + zidovudine + lamivudine (21% vs 40%; hazard ratio (HR) =0.48, 95% CI:0.38-0.62; p < 0.0001). In multivariate analyses, female patients (HR = 0.79, 95% CI: 0.65-0.95; p = 0.02), older patients (HR = 0.73 per 10 years, 95% CI: 0.64-0.84; p < 0.0001) and patients with a higher pre-ART CD4 cell count (HR = 0.64 per 100 cells/mm(3), 95% CI: 0.54-0.75; p < 0.0001) had a lower incidence of virological failure after adjusting for adherence to ART. No difference in failure rate between the two randomised monitoring strategies was observed (p= 0.25). CONCLUSIONS: The long-term durability of virological suppression on dual-class NRTI-NNRTI first-line ART without virological monitoring is remarkable and is enabled by high-quality clinical management and a consistent drug supply. To achieve higher rates of virological suppression viral-load-informed differentiated care may be required. TRIAL REGISTRATION: Prospectively registered on 18/10/2000 as ISRCTN13968779

உலகம் சமூக ஊடகங்களை எப்படி மாற்றியிருக்கிறது

ஒன்பது மானுடவியலாளர்கள் பிரேசில், சீனா, இந்தியா, துருக்கி, இங்கிலாந்து, சிலி, டிரினிடாட், இத்தாலி போன்ற ஒன்பது வெவ்வேறு சமூகங்களில் 15 மாதங்களை தங்கியிருந்து நடத்திய ஆய்வின் கண்டுபிடிப்புகளை ஆராயும் "நாம் ஏன் பதிவிடுகிறோம்" என்ற புத்தக வரிசையின் முதல் புத்தகம் தான் உலகம் சமூக ஊடகங்களை எப்படி மாற்றியிருக்கிறது என்ற இந்தப் புத்தகம். இது மேற்கூறிய ஆராய்ச்சியின் முடிவுகளை தொகுத்து வழங்கியும், அரசியல், கல்வி, பாலினம், வணிகம் ஆகியவற்றின் மீது சமூக ஊடகங்களின் தாக்கத்தைப் பற்றி ஆராய்ந்தும், ஒரு ஒப்பீட்டு ஆய்வினை வழங்குகிறது. காட்சிக்குரிய தகவல் பரிமாற்றத்தின் மீதான அதிக முக்கியத்துவத்தின் விளைவுகள் என்ன? நாம் அதிக தனிமையானவர்களாக ஆகிவருகிறோமா அல்லது அதிக சமூகமயமானவர்களாக ஆகிவருகிறோமா? பொதுநோக்கிய சமூக ஊடகங்கள் ஏன் மிகவும் பழமைவாதம் நிறைந்ததாக இருக்கிறது? நிகழ்நிலையில் உள்ள சமத்துவத்தால், இயல்புநிலையில் உள்ள சமத்துவமின்மையை ஏன் மாற்ற முடியவில்லை? மீம்கள் எப்படி இணையத்தின் மரபுக் காவலர்களாக மாறின? போன்றவை தான் அவை. செயல்திட்டத்தை கல்விக் கட்டமைப்பு மற்றும் கண்டுபிடிப்புகளுக்கு பொறுப்பேற்க உதவும் கருத்தியல் கூறுகள் ஆகியவற்றிற்கான அறிமுகவுரையின் துணையுடன், இந்தப் புத்தகம், சமூக ஊடகங்கள் போன்ற எங்குமுளத்தன்மையுள்ள, மிகவும் நெருக்கமான ஒன்றை புரிந்து கொண்டு பாராட்ட ஒரே வழி, அதில் பதிவிடும் மக்களின் வாழ்வில் மூழ்கிப் பார்ப்பது தான் என்று வாதிடுகிறது. அப்போது தான் நம்மால், உலகெங்கிலும் உள்ள மக்கள் சமூக ஊடகங்களை எவ்வாறு எதிர்பாராத வழிகளில் மாற்றியிருக்கின்றனர் என்று கண்டறிந்து அதன் விளைவுகளை எடைபோட முடியும்

Como o Mundo Mudou as Mídias Sociais

Como o Mundo as Mídias Sociais é o primeiro livro da Why We Post, uma série de livros que investiga as descobertas de nove antropólogos, que passaram 15 meses vivendo em comunidades em diferentes partes do mundo, incluindo Brasil, Chile, China, Inglaterra, Índia, Itália, Trinidad e Turquia. Este livro oferece uma análise comparativa que resume os resultados da pesquisa e a análise do impacto das mídias sociais sobre política e gênero, educação e comércio. Qual é o resultado do aumento da ênfase na comunicação visual? Estamos nos tornando mais individualistas ou mais sociais? Por que as mídias sociais públicas são tão conservadoras? Por que a igualdade na internet não consegue anular a desigualdade? Como os memes se tornaram a polícia moral da internet? Apoiado por uma introdução à estrutura acadêmica do projeto e aos termos teóricos que ajudam a analisar as descobertas, o livro argumenta que a única maneira de se apreciar e entender algo tão privado e ubíquo como as mídias sociais deve se dar a partir da imersão nas vidas das pessoas que ali postam. Só então podemos descobrir como diferentes indivíduos em todo o mundo já transformaram as mídias sociais de maneiras tão inesperadas e avaliar suas conseqüências

The virological durability of first-line ART among HIV-positive adult patients in resource limited settings without virological monitoring: a retrospective analysis of DART trial data.

BACKGROUND: Few low-income countries have virological monitoring widely available. We estimated the virological durability of first-line antiretroviral therapy (ART) after five years of follow-up among adult Ugandan and Zimbabwean patients in the DART study, in which virological assays were conducted retrospectively. METHODS: DART compared clinically driven monitoring with/without routine CD4 measurement. Annual plasma viral load was measured on 1,762 patients. Analytical weights were calculated based on the inverse probability of sampling. Time to virological failure, defined as the first viral load measurement ≥200 copies/mL after 48 weeks of ART, was analysed using Kaplan-Meier plots and Cox regression models. RESULTS: Overall, 65% of DART trial patients were female. Patients initiated first-line ART at a median (interquartile range; IQR) age of 37 (32-42) and with a median CD4 cell count of 86 (32-140). After 240 weeks of ART, patients initiating dual-class nucleoside reverse-transcriptase inhibitor (NRTI) -non-nucleoside reverse-transcriptase (NNRTI) regimens containing nevirapine + zidovudine + lamivudine had a lower incidence of virological failure than patients on triple-NRTI regimens containing tenofovir + zidovudine + lamivudine (21% vs 40%; hazard ratio (HR) =0.48, 95% CI:0.38-0.62; p < 0.0001). In multivariate analyses, female patients (HR = 0.79, 95% CI: 0.65-0.95; p = 0.02), older patients (HR = 0.73 per 10 years, 95% CI: 0.64-0.84; p < 0.0001) and patients with a higher pre-ART CD4 cell count (HR = 0.64 per 100 cells/mm3, 95% CI: 0.54-0.75; p < 0.0001) had a lower incidence of virological failure after adjusting for adherence to ART. No difference in failure rate between the two randomised monitoring strategies was observed (p= 0.25). CONCLUSIONS: The long-term durability of virological suppression on dual-class NRTI-NNRTI first-line ART without virological monitoring is remarkable and is enabled by high-quality clinical management and a consistent drug supply. To achieve higher rates of virological suppression viral-load-informed differentiated care may be required. TRIAL REGISTRATION: Prospectively registered on 18/10/2000 as ISRCTN13968779

Defining Potential Therapeutic Targets in Coronavirus Disease 2019: A Cross-Sectional Analysis of a Single-Center Cohort

OBJECTIVES: Multiple mechanisms have been proposed to explain disease severity in coronavirus disease 2019. Therapeutic approaches need to be underpinned by sound biological rationale. We evaluated whether serum levels of a range of proposed coronavirus disease 2019 therapeutic targets discriminated between patients with mild or severe disease. DESIGN: A search of ClinicalTrials.gov identified coronavirus disease 2019 immunological drug targets. We subsequently conducted a retrospective observational cohort study investigating the association of serum biomarkers within the first 5 days of hospital admission relating to putative therapeutic biomarkers with illness severity and outcome. SETTING: University College London, a tertiary academic medical center in the United Kingdom. PATIENTS: Patients admitted to hospital with a diagnosis of coronavirus disease 2019. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Eighty-six patients were recruited, 44 (51%) with mild disease and 42 (49%) with severe disease. We measured levels of 10 cytokines/signaling proteins related to the most common therapeutic targets (granulocyte-macrophage colony-stimulating factor, interferon-α2a, interferon-β, interferon-γ, interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, interleukin-7, interleukin-8, tumor necrosis factor-α), immunoglobulin G antibodies directed against either coronavirus disease 2019 spike protein or nucleocapsid protein, and neutralization titers of antibodies. Four-hundred seventy-seven randomized trials, including 168 different therapies against 83 different pathways, were identified. Six of the 10 markers (interleukin-6, interleukin-7, interleukin-8, interferon-α2a, interferon-β, interleukin-1 receptor antagonist) discriminated between patients with mild and severe disease, although most were similar or only modestly raised above that seen in healthy volunteers. A similar proportion of patients with mild or severe disease had detectable spike protein or nucleocapsid protein immunoglobulin G antibodies with equivalent levels between groups. Neutralization titers were higher among patients with severe disease. CONCLUSIONS: Some therapeutic and prognostic biomarkers may be useful in identifying coronavirus disease 2019 patients who may benefit from specific immunomodulatory therapies, particularly interleukin-6. However, biomarker absolute values often did not discriminate between patients with mild and severe disease or death, implying that these immunomodulatory treatments may be of limited benefit