Publications of the space physiology and countermeasures program, regulatory physiology discipline: 1980 - 1990

A 10-year cumulative bibliography of publications resulting from research supported by the Regulatory Physiology discipline of the Space Physiology and Countermeasures Program of NASA's Life Sciences Division is provided. Primary subjects included in this bibliography are circadian rhythms, endocrinology, fluid and electrolyte regulation, hematology, immunology, metabolism and nutrition, temperature regulation, and general regulatory physiology. General physiology references are also included. Principal investigators whose research tasks resulted in publication are identified by asterisk. Publications are identified by a record number corresponding with their entry in the Life Sciences Bibliographic Database, maintained at the George Washington University

Space medicine research publications: 1983-1984

A list of publications supported by the Space Medicine Program, Office of Space Science and Applications is given. Included are publications entered into the Life Sciences Bibliographic Database by The George Washington University as of October 1, 1984

Factores pronósticos en el tratamiento del condrosarcoma

Los autores 30 condrosarcomas tratados en su Departamento. Estudiando la distribución por sexos, edad, localización, supervivencia y los factores pronósticos respecto a la relación entre el tipo histológico, localización, tratamiento, origen y tiempo de evolución. Concluyen que son factores de mal pronóstico el grado histológico III, localización central, especialmente en ilíaco, origen primario de la enfermedad y un tiempo mayor de 6 meses entre el diagnóstico y el tratamientoThe authors are reviewed 30 chondrosarcomas seen at their department of orthopaedics surgery. They studied the age distribution, sex, localization, survival and the prognostic factors between histopathology, localization, origin, treatment and evolution times. It is concluyed that the grade III, central localization (specially in pelvis), primary origin and evolution times more than six months between diagnosis and treatment are bad prognostic factors in chondrosarcoma of bone

Sarcoma de Partes Blandas como Hallazgo Casual: a Propósito de Cuatro Observaciones

Se presentan en este trabajo cuatro pacientes con sarcoma s de partes blandas que fueron diagnosticados de fibrohistiocitoma maligno, osteosarcoma extraesquelético, sarcoma sinovial y sarcoma indiferenciado. En todos ellos el tumor fué un hallazgo casual apreciado en exploraciones orientadas hacia otros procesos por los que acudieron al hospital. Se insiste en el diagnóstico precoz y en el correcto tratamiento de este tipo de sarcomas y se recomienda la punción biopsia ante la presencia de tumoraciones blandas con crecimiento progresivo, aún sin otro tipo de sintomatología.Th e author s hav e colecte d fou r patients diagnose d o f Soft tissu e Sar - comas. Th e histologica l diagnosis was, malignan t fibrou s histiocytoma , extraskele - t a l osteosarcoma , synovia l sarcom a an d no-differentiate d sarcoma . Al l o f the m th e tu m o r wa s a casua l findin g durin g th e exploratio n suspectin g othe r pathology . The y emphasiz e a t th e earl y diagnosis an d correc t managemen t o f this typ e o f sarcomas, a s wel l a s th e needl e biops y (close d biopsy ) o f soft tumor s wit h progresiv e growth , even without clinical symptoms

A Transmission Electron Microscopic Study of Some Bronchiolar-Alveolar Reactions in Sheep and Cattle

The two main objectives of this thesis were firstly to study the morphological features of the alveolar macrophages (AM's) in normal sheep and in normal cattle and secondly to study AM's in sheep pulmonary adenomatosis (SPA) and in calves infected with the lungworm, Dictvocaulus vivioarus. in order to compare their morphological characteristics in the two diseases. The history and development of the transmission electron microscope (TEM)are outlined in Chapter 1. The use of the TEM in diagnostic pathology and research into animal and human diseases is also discussed with some examples relevant to studies in animals. A review of the ultrastructure of the cell types in the normal bronchiolar and alveolar epithelium in sheep and cattle is presented in Chapter 2. The AM in normal lungs in introduced and considered in this chapter. The structure of the lungs of normal sheep were studied to provide comparisons for subsequent examinations of SPA lungs at both light microscopic and electron microscopic levels. This work is reported in Chapter 4. Ciliated cells and Clara cells were identified in the bronchiolar epithelium while type I and type II pneumonocytes were recognised in the alveolar epithelium. The morphology of these different cells were described. Ewes with SPA were studied by light microscopy (LM) and TEM. The results confirmed that the proliferating tumour cells were due to the transformation of the type II pneumonocytes. No viral particles were identified in the cases examined. The AM's were consistently found in the alveolar lumen and their morphological characteristics revealed that they were activated. These activated AM's could be classified into two groups, based on their morphological features. The possible roles of the AM's in the pathogenesis of SPA is discussed. The histologic and ultrastructural appearance of cattle lungs were studied and compared with the lungs of calves that had been infected with lungworms; this is reported in Chapter 5. Ciliated cells and Clara cells were found in the bronchiolar epithelium while type I and type II pneumonocytes were noted in the alveolar epithelium. Alterations were observed both in the cell types of the bronchiolar epithelium and in the alveolar epithelium in calves with lungworms. In the bronchiolar epithelium, moderate to severe degenerative changes were recognised in the Clara cells and there was a loss of cilia from the ciliated cells. There was severe degeneration and type II pneumonocyte proliferation with hydropic swelling of the cytoplasm of the type I pneumonocytes. Inflammatory cells were a frequent finding in the bronchiolar and alveolar lumen. Interalveolar septa were markedly thickened in many cases. Alveolar macrophages were commonly found in the inflammatory exudate. They were similarly activated as the AM's in SPA. Morphologically, only one group of AM's could be identified. Some aspects of the cell kinetics of the lung, in particular the AM's, are discussed in Chapter 6. The morphological differences of the AM's in the two diseases are presented and discussed at the end of this chapter