A Determination of the 27Si(P,y) Reaction Rate Using its Mirror and its Importance in X-Ray Burst Nucleosynthesis

X-ray bursts are the most frequent thermonuclear explosions occurring in the universe and represent one of the sources of heavier element nucleosynthesis. In order to determine how much X-ray bursts influence the abundances of these heavier nuclei there is a need for critical nuclear information such as: nuclear masses, ß-decay rates and reaction rates. Due to this need, the field of experimental nuclear physics has been focusing on developing unstable beams and new or improved indirect methods of studying nuclei and reactions, as well as detection systems of higher capability. In light of this perspective, the focus of this dissertation was twofold. One part involved performing a low-cost, low-modification upgrade to the Oxford focal plane detector using Micromegas technology. The upgrade was very successful in improving the total energy loss resolution by as high as a factor of 3 and thus improving the particle identification ability of the detector. This leads to an increase in the mass range of nuclei possible to study from A=16 to A=32. The other part of this dissertation project was aimed at studying the proton-capture reaction ^27Si(p, γ)^28P using an experimental indirect method called the Asymptotic Normalization Coefficient method. This reaction is part of the thermonuclear runaway network of an X-ray burst suggested by the theoretical models. The spectroscopic factor of ^28P was evaluated for the first time in literature at Sv2s½= 1:11±0:56. The direct capture reaction rate was found to be in agreement with the theoretical predictions, and it was confirmed experimentally that at astrophysical energies, the non-resonant component is overwhelmed by the contributions of the resonances

A Determination of the 27Si(P,y) Reaction Rate Using its Mirror and its Importance in X-Ray Burst Nucleosynthesis

X-ray bursts are the most frequent thermonuclear explosions occurring in the universe and represent one of the sources of heavier element nucleosynthesis. In order to determine how much X-ray bursts influence the abundances of these heavier nuclei there is a need for critical nuclear information such as: nuclear masses, ß-decay rates and reaction rates. Due to this need, the field of experimental nuclear physics has been focusing on developing unstable beams and new or improved indirect methods of studying nuclei and reactions, as well as detection systems of higher capability. In light of this perspective, the focus of this dissertation was twofold. One part involved performing a low-cost, low-modification upgrade to the Oxford focal plane detector using Micromegas technology. The upgrade was very successful in improving the total energy loss resolution by as high as a factor of 3 and thus improving the particle identification ability of the detector. This leads to an increase in the mass range of nuclei possible to study from A=16 to A=32. The other part of this dissertation project was aimed at studying the proton-capture reaction ^27Si(p, γ)^28P using an experimental indirect method called the Asymptotic Normalization Coefficient method. This reaction is part of the thermonuclear runaway network of an X-ray burst suggested by the theoretical models. The spectroscopic factor of ^28P was evaluated for the first time in literature at Sv2s½= 1:11±0:56. The direct capture reaction rate was found to be in agreement with the theoretical predictions, and it was confirmed experimentally that at astrophysical energies, the non-resonant component is overwhelmed by the contributions of the resonances

A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson's disease

Background: Hallucinations occur in 20-40% of PD patients and have been associated with unfavorable clinical outcomes (i.e., nursing home placement, increased mortality). Hallucinations, like other non-motor features of PD, are not well recognized in routine primary/secondary clinical practice. So far, there has been no instrument for uniform characterization of hallucinations in PD. To this end, we developed the University of Miami Parkinson's disease Hallucinations Questionnaire (UM-PDHQ) that allows comprehensive assessment of hallucinations in clinical or research settings.Methods: The UM-PDHQ is composed of 6 quantitative and 14 qualitative items. For our study PD patients of all ages and in all stages of the disease were recruited over an 18-month period. The UPDRS, MMSE, and Beck Depression and Anxiety Inventories were used for comparisons.Results and Discussion: Seventy consecutive PD patients were included in the analyses. Thirty-one (44.3%) were classified as hallucinators and 39 as non-hallucinators. No significant group differences were observed in terms of demographics, disease characteristics, stage, education, depressive/anxiety scores or cognitive functioning (MMSE) between hallucinators and non-hallucinators. Single mode hallucinations were reported in 20/31 (visual/14, auditory/4, olfactory/2) whereas multiple modalities were reported in 11/31 patients. The most common hallucinatory experience was a whole person followed by small animals, insects and reptiles.Conclusion: Using the UM-PDHQ, we were able to define the key characteristics of hallucinations in PD in our cohort. Future directions include the validation of the quantitative part of the questionnaire than will serve as a rating scale for severity of hallucinations

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Transfer reactions as an Indirect Method in Nuclear Astrophysics

In my presentation, I will discuss the use of transfer reactions as an indirect method of determining information important for nuclear astrophysics. Specifically, I will focus on peripheral reactions and their analysis with the Asymptotic Normalization Coefficients (ANC) method. I will present results from related experiments that have been conducted at the Cyclotron Institute, Texas A&M University with focus on the 0ptical Model Parameters obtained and the need for reliable calculations. Additionally, I will describe the im- provements in the measured data that we obtained after upgrading the detection system used

GIST and Ghrelin: To Be or Not to Be?

Background: Ghrelin is the orexigenic hormone secreted mainly by the stomach. Its involvement in neoplastic development has been studied in gastrointestinal adenocarcinomas. Our paper aims to evaluate the influence of the ghrelin axis in gastrointestinal stromal tumors (GISTs). Materials and Methods: The study design included two groups of patients, 46 with gastric GISTs and 30 with obesity. Archived tissue samples were evaluated for the presence of gastritis and H. pylori. Immunohistochemical expression of ghrelin and its receptor (GHS-R) was assessed. Results: All GISTs showed absent immunohistochemical expression for ghrelin, while GHS-R displayed a particular pattern, with notable differences in intensity (p = 0.0256) and percentage of stained cells (p < 0.00001) in the periphery vs. core of tumors. Positive ghrelin expression was lower in the gastric mucosa of the first group compared to the second group (p < 0.001). Conclusion: The ghrelin axis can influence GISTs carcinogenesis through activation of GHS-R. A previously described direct autocrine/paracrine mechanism is not supported by our findings

Insight into Potential Biomedical Application of Mesoporous Materials

The physicochemical properties of many drugs have a decisive impact on their bioavailability, as well as the pharmacokinetic efficiency in various disease therapeutics. That is why mesoporous materials have attracted a special interest in the drug delivery field, facilitating the loading of drugs into their pores due to their high surface area and porosity. The interfacial interactions established with drug molecules represent the driving force for efficient drug loading and controlled release kinetics. Moreover, these materials offer an optimal design for implantable local-delivery devices or for improving the accuracy of imaging techniques in clinical diagnosis. Their use is validated by improvements in therapeutic outcome and prevention of side effects. This review discusses the role of mesoporous materials in different biomedical applications

Probiotic Properties of Weissella confusa PP29 on Hibiscus sabdariffa L. Media

To date, there are very few data regarding new efficient probiotics’ development with their own prebiotic substrate. All commercial products contain prebiotic substrate that was previously purified from external sources and added to the final product. The present study describes Weissella confusa strain fermentations in media with different anthocyanin concentrations from Hibiscus sabdariffa L., in order to increase the exopolysaccharide (EPS) yield, leading to augmented probiotic and prebiotic properties. The extracted and purified EPS were characterized by Gel permeation chromatography, Fourier-transform infrared, and nuclear magnetic resonance spectroscopy; thermal analysis measurements and the whole fermented media’s probiotic properties were evaluated by testing low pH and bile salt resistance, along with hydrophobicity and auto-aggregation capacity. The anthocyanins increased biomass and EPS yields and the high EPS molecular mass improved nutrient access by allowing a good microbial suspension in media. The confirmed dextran structure provides media biocompatibility and very good probiotic properties compared with existing literature. Simultaneously, the anthocyanins in media protected the strain cells against low pH and bile salt compared with the control fermentation. These very good results show that the whole fermented culture media is suitable for further in-vitro and in-vivo studies regarding its probiotic and prebiotic activity

Transcutaneous Drug Delivery Systems Based on Collagen/Polyurethane Composites Reinforced with Cellulose

Designing composites based on natural polymers has attracted attention for more than a decade due to the possibility to manufacture medical devices which are biocompatible with the human body. Herein, we present some biomaterials made up of collagen, polyurethane, and cellulose doped with lignin and lignin-metal complex, which served as transcutaneous drug delivery systems. Compared with base material, the compressive strength and the elastic modulus of biocomposites comprising lignin or lignin-metal complex were significantly enhanced; thus, the compressive strength increased from 61.37 to 186.5 kPa, while the elastic modulus increased from 0.828 to 1.928 MPa. The release of ketokonazole from the polymer matrix follows a Korsmeyer–Peppas type kinetics with a Fickian diffusion. All materials tested were shown to be active against pathogenic microorganisms. The mucoadhesiveness, bioadhesiveness, mechanical resistance, release kinetic, and antimicrobial activity make these biocomposites to be candidates as potential systems for controlled drug release