Squark and Gluino Production at Hadron Colliders

We have determined the theoretical predictions for the cross-sections of squark and gluino production at \ppb and $pp$ colliders (Tevatron and LHC) in next-to-leading order of supersymmetric QCD. By reducing the dependence on the renormalization/factorization scale considerably, the theoretically predicted values for the cross-sections are much more stable if these higher-order corrections are implemented. If squarks and gluinos are discovered, this improved stability translates into a reduced error on the masses, as extracted experimentally from the size of the production cross-sections. The cross-sections increase significantly if the next-to-leading order corrections are included at a renormalization/factorization scale near the average mass of the produced massive particles. This rise results in improved lower bounds on squark and gluino masses. By contrast, the shape of the transverse-momentum and rapidity distributions remains nearly unchanged when the next-to-leading order corrections are included.Comment: 60 pages, Latex2e, 24 figures (uses epsfig.sty

Sequential model to describe the nicotinic synaptic current

An analytical formula is derived to describe the synaptic end plate current (epc) at the nicotinic receptor. Various concurrently occurring underlying processes, including (a) diffusion, (b) hydrolysis of acetylcholine, and (c) its binding to the dimeric receptor, were considered in order to develop the equation. Numeric solution of the equations that describe the events underlying the epc showed that these events occur in sequence, rather than concurrently. This sequential occurrence of the processes allowed for simplifications, which were used as the basis for the new description of the epc. The resulting formula serves as a tool for evaluating the relative contribution of the various processes in formation of the natural occurring transient epc

QCD Corrections to SUSY Higgs Production: The Role of Squark Loops

We calculate the two-loop QCD corrections to the production of the neutral supersymmetric Higgs bosons via the gluon fusion mechanism at hadron colliders, including the contributions of squark loops. To a good approximation, these additional contributions lead to the same QCD corrections as in the case where only top and bottom quark loops are taken into account. The QCD corrections are large and increase the Higgs production cross sections significantly.Comment: 5 pages, latex, 2 figure

Formation and Decay of Scalar Leptoquarks/Squarks in ep collisions

The cross sections for the formation of scalar resonances, leptoquarks or squarks, in electron/positron-proton collisions at HERA are presented including next-to-leading order QCD corrections. Depending mildly on the mass of the resonances, the K-factors increase the production cross sections by up to 30% if the target quarks are valence quarks. The QCD corrections to the partial decay widths of leptoquarks/squarks to leptons and quarks are small. The electron spectrum in the decays is softened nevertheless by perturbative gluon radiation at a level of 3.4 GeV for a leptoquark/squark mass of 200 GeV.Comment: 10 pages, LaTex file with 3 figures, uses axodraw.sty (included

Top quark associated production of topcolor pions at hadron colliders

We investigate the associated production of a neutral physical pion with top quarks in the context of topcolor assisted technicolor. We find that single-top associated production does not yield viable rates at either the Tevatron or LHC. tt-associated production at the Tevatron is suppressed relative to Standard Model ttH, but at the LHC is strongly enhanced and would allow for easy observation of the main decay channels to bottom quarks, and possible observation of the decay to gluons.Comment: 13 pages, 4 figures, submitted to PR

Cabozantinib in hepatocellular carcinoma: results of a phase 2 placebo-controlled randomized discontinuation study.

BackgroundCabozantinib, an orally bioavailable inhibitor of tyrosine kinases including MET, AXL, and VEGF receptors, was assessed in patients with hepatocellular carcinoma (HCC) as part of a phase 2 randomized discontinuation trial with nine tumor-type cohorts.Patients and methodsEligible patients had Child-Pugh A liver function and ≤1 prior systemic anticancer regimen, completed ≥4 weeks before study entry. The cabozantinib starting dose was 100 mg daily. After an initial 12-week cabozantinib treatment period, patients with stable disease (SD) per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.0 were randomized to cabozantinib or placebo. The primary endpoint of the lead-in stage was objective response rate (ORR) at week 12, and the primary endpoint of the randomized stage was progression-free survival (PFS).ResultsAmong the 41 HCC patients enrolled, the week 12 ORR was 5%, with 2 patients achieving a confirmed partial response (PR). The week 12 disease control rate (PR or SD) was 66% (Asian subgroup: 73%). Of patients with ≥1 post-baseline scan, 78% had tumor regression, with no apparent relationship to prior sorafenib therapy. Alpha-fetoprotein (AFP) response (>50% reduction from baseline) occurred in 9 of the 26 (35%) patients with elevated baseline AFP and ≥1 post-baseline measurement. Twenty-two patients with SD at week 12 were randomized. Median PFS after randomization was 2.5 months with cabozantinib and 1.4 months with placebo, although this difference was not statistically significant. Median PFS and overall survival from Day 1 in all patients were 5.2 and 11.5 months, respectively. The most common grade 3/4 adverse events, regardless of attribution, were diarrhea (20%), hand-foot syndrome (15%), and thrombocytopenia (15%). Dose reductions were utilized in 59% of patients.ConclusionsCabozantinib has clinical activity in HCC patients, including objective tumor responses, disease stabilization, and reductions in AFP. Adverse events were managed with dose reductions.Trial registration numberNCT00940225

Roots of the derivative of the Riemann zeta function and of characteristic polynomials

We investigate the horizontal distribution of zeros of the derivative of the Riemann zeta function and compare this to the radial distribution of zeros of the derivative of the characteristic polynomial of a random unitary matrix. Both cases show a surprising bimodal distribution which has yet to be explained. We show by example that the bimodality is a general phenomenon. For the unitary matrix case we prove a conjecture of Mezzadri concerning the leading order behavior, and we show that the same follows from the random matrix conjectures for the zeros of the zeta function.Comment: 24 pages, 6 figure

Distinct roles for strigolactones in cyst nematode parasitism of Arabidopsis roots

Phytohormones play an essential role in different stages of plant-nematode interactions. Strigolactones (SLs) are a novel class of plant hormones which play an important role in plant development. Furthermore, certain soil-inhabiting organisms exploit this plant molecule as allelochemical. However, whether SLs play a role in plant parasitism by nematodes is as yet unknown. This prompted us to investigate the potential role of SLs in different stages of the nematode life cycle using the beet cyst nematode Heterodera schachtii and Arabidopsis as a model system. We analyzed the effect of SLs on cyst nematode hatching, host attraction and invasion, and the establishment of a feeding relation upon infection of the SL deficient mutant max4-1 and the SL signaling mutant max2-1. In addition, infection assays were performed under phosphate shortage to enhance SL production and in the presence of the synthetic SL analog GR24. From this study, we can conclude that SLs do not contribute to cyst nematode hatching at the levels tested but that they do play a role in host attraction and subsequent invasion in a MAX2 dependent manner. Furthermore, we observed that increased levels of exogenous and endogenous SLs change the root invasion zone. Upon root infection, cyst nematode development was enhanced in both the max2-1 and max4-1 mutants due to the formation of enlarged feeding cells. These data provide evidence for distinct roles of SLs during cyst nematode parasitism of plant roots