Polygenic Study of Endurance-Associated Genetic Markers NOS3 (Glu298Asp), BDKRB2 (-9/+9), UCP2 (Ala55Val), AMPD1 (Gln45Ter) and ACE (I/D) in Polish Male Half Marathoners

The purpose of this study was to investigate individually and in combination the association between the ACE (I/D), NOS3 (Glu298Asp), BDKRB2 (-9/+9), UCP2 (Ala55Val) and AMPD1 (Gln45Ter) variants with endurance performance in a large, performance-homogenous cohort of elite Polish half marathoners. The study group consisted of 180 elite half marathoners: 76 with time 100 minutes. DNA of the subjects was extracted from buccal cells donated by the runners and genotyping was carried out using an allelic discrimination assay with a C1000 Touch Thermal Cycler (Bio-Rad, Germany) instrument with TaqMan® probes (NOS3, UCP2, and AMPD1) and a T100™ Thermal Cycler (Bio-Rad, Germany) instrument (ACE and BDKRB2). We found that the UCP2 Ala55Val polymorphism was associated with running performance, with the subjects carrying the Val allele being overrepresented in the group of most successful runners (100 min group (84.2 vs. 55.8%; OR = 4.23, p 100 min group (73.7 vs. 51.9%; OR = 2.6, p = 0.0034). These data suggest that the likelihood of becoming an elite half marathoner partly depends on the carriage of a high number of endurance-related alleles

Podiatric and stabilographic examinations of the effects of school bag carrying in children aged 11 to 15 years

Background: The issues raised in this study were inspired by the concern for the musculoskeletal status of school children. Carrying excess weight in the form of a school bag in this period of life affects the correct body posture of school children. The aim of the study was to analyze the influence of school bags on the feet force distribution on the ground and postural balance in children of both sexes between 11 and 15 years of age. Methods: The study investigated the distribution of pressure forces on the sole of the foot and its arch. The center of pressure for both feet and the whole body was also examined. The participants were 100 students from primary schools in Gdańsk, aged 11 to 15, including 54 girls and 46 boys. The research used a podobarographic platform that measures the distribution of foot pressure to the ground. The examinations included two measurements: in the first, the children stood on the platform in a natural position. Then, a 5 kg backpack was put on and they stood on the platform again. Results: Statistically significant differences were found in the distribution of the foot pressure on the ground in the left metatarsus (p = 0.000) and heel (p = 0.000) after putting on the backpack in both girls and boys. However, in the right foot, these differences concerned the metatarsal area (p = 0.001). The results of the balance tests were only statistically significant in the group of girls in the right foot sway area (p = 0.020). Conclusions: The school backpack load led to an increase in the values of the heel and metatarsal area measured in the students, causing its flattening