Methodical approach to conducting a comprehensive pharmacoeconomic study of drug care in medical organizations

The problem of rational pharmacotherapy in outpatient and inpatient therapy is one of the most significant to date, due to the occurrence and progression of most pathologie

Methodical approach to conducting a multi-aspect matrix analysis of the drug range

The purpose of our study is to develop a methodology for multi-aspect matrix analysis of the drug range prescribed in outpatient clinic

Improving the competitiveness of pharmacies by means of informational technologies

The article presents the results of sociological research of the consumers of pharmaceutical services and the structure of the main reasons of the consumers’ visiting the pharmacies. The aspects of the informational activity of the pharmacists have been analyzed. The approach to the improvement of a pharmacy’s competitiveness by means of informational technologies that is the touch information terminals placed in trade area has been worked out. The unique pharmaceutical informational basis for the customers of the pharmacies and the software for the touch information terminals have been worked outyesBelgorod State National Research Universit

Optimization of information support for pharmacies in the field of pharmaceutical aid to children with arthropathy

The paper presents an analysis of information awareness of pharmaceutical personnel on aspects of pharmaceutical aid to children with joint diseases; we analyzed the product portfolio of medicines for treating children with juvenile arthritis in the ambulatory outpatient conditions, taking into account consumer preferences and economic opportunities of their families; we developed a materials bank for pharmaceutical information counseling of pharmacy personnel in terms of pharmaceutical aid to children with joint disease

Medico-social rationale for adaptation of regional drug supply systems to personalized pharmaceutical care for persons of different ages

In this study, we identified indicators of the state of personalized pharmaceutical care for target population groups at the regional level, in a model region, with the aim to develop a differentiated approach to such care. The rationale for the choice of Moscow Region as a model region is based on its specific socioeconomic indicators and a comparison of these with respective average Russian values. A need was shown to modernize patient-oriented pharmaceutical care, especially for certain population groups, such as children, women of working age (mothers), and the elderl

Quasi-exactly solvable quartic Bose Hamiltonians

We consider Hamiltonians, which are even polynomials of the forth order with the respect to Bose operators. We find subspaces, preserved by the action of Hamiltonian These subspaces, being finite-dimensional, include, nonetheless, states with an \QTR{it}{infinite} number of quasi-particles, corresponding to the original Bose operators. The basis functions look rather simple in the coherent state representation and are expressed in terms of the degenerate hypergeometric function with respect to the complex variable labeling the representation. In some particular degenerate cases they turn (up to the power factor) into the trigonometric or hyperbolic functions, Bessel functions or combinations of the exponent and Hermit polynomials. We find explicitly the relationship between coefficients at different powers of Bose operators that ensure quasi-exact solvability of Hamiltonian.Comment: 21 pages, REVTeX 3.0, no figures. In v.2 couple of misprints in English corrected. To be published in J. Phys. A: Math. Ge

Symmetries and modelling functions for diffusion processes

A constructive approach to theory of diffusion processes is proposed, which is based on application of both the symmetry analysis and method of modelling functions. An algorithm for construction of the modelling functions is suggested. This algorithm is based on the error functions expansion (ERFEX) of experimental concentration profiles. The high-accuracy analytical description of the profiles provided by ERFEX approximation allows a convenient extraction of the concentration dependence of diffusivity from experimental data and prediction of the diffusion process. Our analysis is exemplified by its employment to experimental results obtained for surface diffusion of lithium on the molybdenum (112) surface pre-covered with dysprosium. The ERFEX approximation can be directly extended to many other diffusion systems.Comment: 19 pages, 8 figure

Групповая классификация нелинейных уравнений колмогоровского типа

Розглядаються нелінійні рівняння колмогорівського типу, в які входить довільна функція. Одним із методів розв’язування диференціальних рівнянь з частинними похідними є теоретико-груповий метод. За допомогою цього методу вдається проінтегрувати ті рівняння, які мають нетривіальну групу симетрії. Тому задача групової класифікації є актуальною. Проведено групову класифікацію нелінійних рівнянь колмогорівського типу. За допомогою знайдених неперервних перетворень еквівалентності виділені нееквівалентні підкласи цих рівнянь. Для всіх підкласів обчислені максимальні алгебри інваріантності. З використанням знайдених підалгебр алгебри інваріантності для деяких нелінійних рівнянь зроблено симетрійну редукцію до рівнянь з меншою кількістю незалежних змінних. Вдалося проінтегрувати редуковані рівняння та отримати точні розв’язки відповідних нелінійних рівнянь.We consider Kolmogorov nonlinear equations with an arbitrary function. The group-theoretical method is one of the methods for solving partial differential problem. Using this method, we integrate equations with a non-trivial symmetry group. Therefore, group classification is high priority. Specifically, we conduct the group classification of Kolmogorov nonlinear equations. Using obtained continuous equivalence transformations, we present nonequivalent subclasses of these equations. We calculate maximum invariance algebras for all these subclasses. By employing the obtained subalgebras of invariance algebras for some nonlinear equations, symmetry is reduced to equations with a smaller number of independent variables. The reduced equations are integrated and exact solutions of the corresponding nonlinear equations are obtained.Рассматриваются нелинейные уравнения колмогоровского типа, в которые входит произвольная функция. Одним из методов решения дифференциальных уравнений с частными производными является теоретико-групповой метод. С помощью этого метода удается проинтегрировать уравнения, имеющие нетривиальную группу симметрии. Поэтому задача групповой классификации является актуальной. Проведена групповая классификация нелинейных уравнений колмогоровского типа. С помощью полученных непрерывных преобразований эквивалентности выделены неэквивалентные подклассы этих уравнений. Для всех подклассов вычислены максимальные алгебры инвариантности. С использованием найденных подалгебр алгебры инвариантности для некоторых нелинейных уравнений проведена симметрийная редукция к уравнениям с меньшим числом независимых переменных. Удалось проинтегрировать редуцированные уравнения и получить точные решения соответствующих нелинейных уравнений

The microbiota-gut-brain axis

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis. This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders. The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enteric nervous system, involving microbial metabolites such as short-chain fatty acids, branched chain amino acids, and peptidoglycans. Many factors can influence microbiota composition in early life, including infection, mode of birth delivery, use of antibiotic medications, the nature of nutritional provision, environmental stressors, and host genetics. At the other extreme of life, microbial diversity diminishes with aging. Stress, in particular, can significantly impact the microbiota-gut-brain axis at all stages of life. Much recent work has implicated the gut microbiota in many conditions including autism, anxiety, obesity, schizophrenia, Parkinson's disease, and Alzheimer's disease. Animal models have been paramount in linking the regulation of fundamental neural processes, such as neurogenesis and myelination, to microbiome activation of microglia. Moreover, translational human studies are ongoing and will greatly enhance the field. Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders

Optimization of pharmaceutical care for children with joint diseases

The article presents the results of optimization of pharmaceutical care (PC) for children with joint diseases (DJ) in conditions of inpatient and outpatient treatment, at the regional level, which allow to improve the quality of PC for children with DJ; to rationalize the doctors’ prescriptions; to determine the medicinal budget and to optimize the medical supply of children's medical organization