<i>Aporosa</i> Blume from the paleoequatorial rainforest of Bikaner, India: Its evolution and diversification in deep time

The Gondwanan origin, northward migration and subsequent collision with Asia means that the Indian subcontinent is of particular interest regarding the origin and dispersal of numerous plants and animal species. With this in mind, we describe a fossil leaf of Aporosa Blume (Phyllanthaceae) from the Paleogene of the Indian subcontinent and discuss its evolution and diversification with respect to the moving Indian plate and its connection with Southeast Asia since the early Cenozoic. At present, Aporosa Blume is confined to Southeast Asia with a few species in India and New Guinea. It is represented by six endemic species growing in the evergreen forests of India and Sri Lanka, including Aporosa acuminata Thwaites, which is morphologically close to the here described fossil from Bikaner, Rajasthan, India. From the age of the fossil and the distribution of its modern comparable form, it is assumed that Aporosa originated on the Indian subcontinent and then was distributed to Southeast Asia, supporting the ‘Out of India’ hypothesis. Diversification of the genus might have taken place either in the Paleogene or Neogene. Our fossil leaf material also indicates the existence of palaeoequatorial (< 10° N) tropical rain forests in western India during the Paleogene in contrast to dry and desertic climate occurring today

(Im)possibilities of Autonomy: Social Movements In and Beyond Capital, the State and Development

Recently, we have witnessed the emergence of what appears to be a new set of claims in contemporary social movements based around the idea of autonomy. In this paper we interrogate this demand for autonomy. In order to do this, we first engage with existing literatures, identifying three main conceptions of autonomy: 1) autonomous practices vis-à-vis capital, or, what Negri calls, the ‘self-valorization’ of labour; 2) self-determination and independence from the state; and 3) alternatives to hegemonic discourses of development. We will then problematize and point out the central potentials, weaknesses and antagonisms at the heart of the concept of autonomy. We argue that social movements’ demands for autonomy point to, what Laclau and Mouffe call, the impossibility of society, the idea that society can never be complete. That is, there will always be resistances, such as those expressed by autonomous social movements. However, this also lets us understand the conception of autonomy to be incomplete. Autonomy itself is hence an impossibility. To point to these limits of the discourses of autonomy, we discuss how demands for autonomy are tied up with contemporary re-organizations of: 1) the capitalist workplace, characterized by discourses of autonomy, creativity and self-management; 2) the state, which increasingly outsources public services to independent, autonomous providers, which often have a more radical, social movement history; and 3) regimes of development, which today often emphasize local practices, participation and self-determination. Behind these critical reflections on the conception and practice of autonomy is the idea that autonomy should always be seen as something relational. That is, autonomy can never be fixed; there is no definite ground for demands for autonomy to stand on. Instead, social movements’ demands for autonomy are embedded in specific social, economic, political and cultural contexts, giving rise to possibilities as well as impossibilities of autonomous practices

Learning Together 1: an educational model for training GPs, paediatricians: initial findings.

Learning Together is primarily an educational intervention, where paediatric registrars [SpRs] and General Practice (GP) registrars [GPSTs] see children together in a primary care setting. Over a six month period in 2013/2014, 44 learning pairs were set up mainly in North East and Central London. Proof of concept for the model at scale was achieved. Reported learning demonstrated: clinical learning themes of new knowledge, skill and communication skills; and collaborative themes of ongoing collaboration, satisfaction with team working and change in attitudes. These themes were identified in both sets of trainees. The self-reported learning is backed up by the results of a retrospective notes review of four common conditions based on NICE guidelines; constipation, asthma, feverish illness and eczema (CAFE). Guidance adherence improved from 57% before the intervention in solo GP training consultations to 72% during the joint clinic intervention (p < 0.01). After the intervention when the GP registrars returned to normal consultations, guidance adherence was 77% compared to before the intervention (p < 0.01). In addition 99% of the parents, who handed in feedback forms or took part in interviews, reported a good experience of care, and 87% reported increased confidence to manage their children's health following the consultation. A second, linked article examines the cost utility of Learning Together in its South London extension

Synthesis of hetero-bifunctional, end-capped oligo-EDOT derivatives

Conjugated oligomers of 3,4-ethylenedioxythiophene (EDOT) are attractive materials for tissue engineering applications, and as model systems for studying the properties of the widely used polymer PEDOT. We report here the facile synthesis of a series of keto-acid end-capped oligo-EDOT derivatives (n = 2-7) through a combination of a glyoxylation end capping strategy and iterative direct arylation chain extension. Importantly, these structures not only represent the longest oligo-EDOTs reported, but are also bench stable in contrast to previous reports on such oligomers. The constructs reported here can undergo subsequent derivatization for integration into higher order architectures, such as those required for tissue engineering applications. The synthesis of hetero-bifunctional constructs, as well as those containing mixed monomer units is also reported, allowing further complexity to be installed in a controlled manner. Finally, we describe the optical and electrochemical properties of these oligomers and demonstrate the importance of the keto-acid in determining their characteristics

MMP for co-rank one foliation on threefolds

We prove existence of flips, special termination, the base point free theorem and, in the case of log general type, the existence of minimal models for F-dlt foliated log pairs of co-rank one on a projective threefold. As applications, we show the existence of F-dlt modifications and F-terminalisations for foliated log pairs and we show that foliations with canonical or F-dlt singularities admit non-dicritical singularities. Finally, we show abundance in the case of numerically trivial foliated log pairs

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

Peptide– and protein–nanoparticle conjugates have emerged as powerful tools for biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In this review, we focus on the key roles played by peptides and proteins in improving, controlling, and defining the performance of nanotechnologies. Within this framework, we provide a comprehensive overview of the key sequences and structures utilised to provide biological and physical stability to nano-constructs, direct particles to their target and influence their cellular and tissue distribution, induce and control biological responses, and form polypeptide self-assembled nanoparticles. In doing so, we highlight the great advances made by the field, as well as the challenges still faced in achieving the clinical translation of peptide- and protein-functionalised nano-drug delivery vehicles, imaging species, and active therapeutics

Electron Detectors for Electron-Beam Testing of Ultra Large Scale Integrated Circuits

The increasing density of components in integrated circuits imposes severe constraints on conventional electron beam testers. The use of electron detectors consisting of combined electrostatic and magnetic fields has demonstrated improved performance over conventional electrostatic detectors. Such detectors also ease many of the practical difficulties associated with electron beam testing of Ultra Large Scale Integration (ULSI) circuits. A detector using a single pole magnetic lens will be described and compared to detectors which use only electrostatic fields. The single pole lens detector has demonstrated superior performance to the electrostatic detector in terms of local field error and imaging resolution, allowing accurate measurements to be made on sub-micron structures

Tax evasion and exchange equity: a reference-dependent approach

The standard portfolio model of tax evasion with a public good produces the perverse conclusion that when taxpayers perceive the public good to be under-/overprovided, an increase in the tax rate increases/decreases evasion. The author treats taxpayers as thinking in terms of gains and losses relative to an endogenous reference level, which reflects perceived exchange equity between the value of taxes paid and the value of public goods supplied. With these alternative behavioral assumptions, the author overturns the aforementioned result in a direction consistent with the empirical evidence. The author also finds a role for relative income in determining individual responses to a change in the marginal rate of tax