378 research outputs found
A new diagrammatic representation for correlation functions in the in-in formalism
In this paper we provide an alternative method to compute correlation
functions in the in-in formalism, with a modified set of Feynman rules to
compute loop corrections. The diagrammatic expansion is based on an iterative
solution of the equation of motion for the quantum operators with only retarded
propagators, which makes each diagram intrinsically local (whereas in the
standard case locality is the result of several cancellations) and endowed with
a straightforward physical interpretation. While the final result is strictly
equivalent, as a bonus the formulation presented here also contains less graphs
than other diagrammatic approaches to in-in correlation functions. Our method
is particularly suitable for applications to cosmology.Comment: 14 pages, matches the published version. includes a modified version
of axodraw.sty that works with the Revtex4 clas
Measurement of Permanent Electric Dipole Moments of Charged Hadrons in Storage Rings
Permanent Electric Dipole Moments (EDMs) of elementary particles violate two
fundamental symmetries: time reversal invariance (T) and parity (P). Assuming
the CPT theorem this implies CP-violation. The CP-violation of the Standard
Model is orders of magnitude too small to be observed experimentally in EDMs in
the foreseeable future. It is also way too small to explain the asymmetry in
abundance of matter and anti-matter in our universe. Hence, other mechanisms of
CP violation outside the realm of the Standard Model are searched for and could
result in measurable EDMs.
Up to now most of the EDM measurements were done with neutral particles. With
new techniques it is now possible to perform dedicated EDM experiments with
charged hadrons at storage rings where polarized particles are exposed to an
electric field. If an EDM exists the spin vector will experience a torque
resulting in change of the original spin direction which can be determined with
the help of a polarimeter. Although the principle of the measurement is simple,
the smallness of the expected effect makes this a challenging experiment
requiring new developments in various experimental areas.
Complementary efforts to measure EDMs of proton, deuteron and light nuclei
are pursued at Brookhaven National Laboratory and at Forschungszentrum Juelich
with an ultimate goal to reach a sensitivity of 10^{-29} e cm.Comment: 8 pages, 2 figure
Thermal production of axino Dark Matter
We reconsider thermal production of axinos in the early universe, adding: a)
missed terms in the axino interaction; b) production via gluon decays
kinematically allowed by thermal masses; c) a precise modeling of reheating. We
find an axino abunance a few times larger than previous computations.Comment: 6 pages, 2 figures. Final version, to appear on JHE
Dietary elimination of children with food protein induced gastrointestinal allergy – micronutrient adequacy with and without a hypoallergenic formula?
Background:
The cornerstone for management of Food protein-induced gastrointestinal allergy (FPGIA) is dietary exclusion; however the micronutrient intake of this population has been poorly studied. We set out to determine the dietary intake of children on an elimination diet for this food allergy and hypothesised that the type of elimination diet and the presence of a hypoallergenic formula (HF) significantly impacts on micronutrient intake.
Method:
A prospective observational study was conducted on children diagnosed with FPIGA on an exclusion diet who completed a 3 day semi-quantitative food diary 4 weeks after commencing the diet. Nutritional intake where HF was used was compared to those without HF, with or without a vitamin and mineral supplement (VMS).
Results:
One-hundred-and-five food diaries were included in the data analysis: 70 boys (66.7%) with median age of 21.8 months [IQR: 10 - 67.7]. Fifty-three children (50.5%) consumed a HF and the volume of consumption was correlated to micronutrient intake. Significantly (p <0.05) more children reached their micronutrient requirements if a HF was consumed. In those without a HF, some continued not to achieve requirements in particular for vitamin D and zinc, in spite of VMS.
Conclusion:
This study points towards the important micronutrient contribution of a HF in children with FPIGA. Children, who are not on a HF and without a VMS, are at increased risk of low intakes in particular vitamin D and zinc. Further studies need to be performed, to assess whether dietary intake translates into actual biological deficiencies
The Role of TSLP in IL-13-Induced Atopic March
Although atopic dermatitis (AD) is the initial step of the “atopic march”, a progression from AD to asthma, the underlying mechanism remains unknown. Selective expression of IL-13 in the skin of mice caused an AD phenotype resembling human AD, and the disorder was associated with enhanced production of thymic stromal lymphopoietin (TSLP) in the AD skin with a systemic Th2 immunity. Here we show that IL-13 transgenic mice with AD had significantly enhanced lung inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR) when sensitized and challenged by allergen. In addition, the level of TSLP was significantly higher in acute AD than in chronic AD. Furthermore, elimination of TSLP signaling significantly diminished the allergic asthma responses, immune cell production of Th2 cytokines (IL-4, IL-13), and serum IgE. These studies indicate that IL-13 induces AD and atopic march via a TSLP dependent mechanism
Vaccine-associated enhanced disease : case definition and guidelines for data collection, analysis, and presentation of immunization safety data
This is a Brighton Collaboration Case Definition of the term & ldquo;Vaccine Associated Enhanced Disease & rdquo; to be utilized in the evaluation of adverse events following immunization. The Case Definition was developed by a group of experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of vaccines for SARS-CoV-2 vaccines and other emerging pathogens. The case definition format of the Brighton Collaboration was followed to develop a consensus definition and defined levels of certainty, after an exhaustive review of the literature and expert consultation. The document underwent peer review by the Brighton Collaboration Network and by selected Expert Reviewers prior to submission.
(c) 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Is Our Universe Natural?
It goes without saying that we are stuck with the universe we have.
Nevertheless, we would like to go beyond simply describing our observed
universe, and try to understand why it is that way rather than some other way.
Physicists and cosmologists have been exploring increasingly ambitious ideas
that attempt to explain why certain features of our universe aren't as
surprising as they might first appear.Comment: Invited review for Nature, 11 page
Semi-analytical approach to magnetized temperature autocorrelations
The cosmic microwave background (CMB) temperature autocorrelations, induced
by a magnetized adiabatic mode of curvature inhomogeneities, are computed with
semi-analytical methods. As suggested by the latest CMB data, a nearly
scale-invariant spectrum for the adiabatic mode is consistently assumed. In
this situation, the effects of a fully inhomogeneous magnetic field are
scrutinized and constrained with particular attention to harmonics which are
relevant for the region of Doppler oscillations. Depending on the parameters of
the stochastic magnetic field a hump may replace the second peak of the angular
power spectrum. Detectable effects on the Doppler region are then expected only
if the magnetic power spectra have quasi-flat slopes and typical amplitude
(smoothed over a comoving scale of Mpc size and redshifted to the epoch of
gravitational collapse of the protogalaxy) exceeding 0.1 nG. If the magnetic
energy spectra are bluer (i.e. steeper in frequency) the allowed value of the
smoothed amplitude becomes, comparatively, larger (in the range of 20 nG). The
implications of this investigation for the origin of large-scale magnetic
fields in the Universe are discussed. Connections with forthcoming experimental
observations of CMB temperature fluctuations are also suggested and partially
explored.Comment: 40 pages, 13 figure
Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation
<p>Abstract</p> <p>Background</p> <p>Allergic proctocolitis (APC) in exclusively breast-fed infants is caused by food proteins, deriving from maternal diet, transferred through lactation. In most cases a maternal cow milk-free diet leads to a prompt resolution of rectal bleeding, while in some patients a multiple food allergy can occur. The aim of this study was to assess whether the atopy patch test (APT) could be helpful to identify this subgroup of patients requiring to discontinue breast-feeding due to polisensitization. Additionally, we assessed the efficacy of an amino acid-based formula (AAF) when multiple food allergy is suspected. amino acid-based formula</p> <p>Methods</p> <p>We have prospectively enrolled 14 exclusively breast-fed infants with APC refractory to maternal allergen avoidance. The diagnosis was confirmed by endoscopy with biopsies. Skin prick tests and serum specific IgE for common foods, together with APTs for common foods plus breast milk, were performed. After a 1 month therapy of an AAF all patients underwent a follow-up rectosigmoidoscopy.</p> <p>Results</p> <p>Prick tests and serum specific IgE were negative. APTs were positive in 100% infants, with a multiple positivity in 50%. Sensitization was found for breast milk in 100%, cow's milk (50%), soy (28%), egg (21%), rice (14%), wheat (7%). Follow-up rectosigmoidoscopy confirmed the remission of APC in all infants.</p> <p>Conclusions</p> <p>These data suggest that APT might become a useful tool to identify subgroups of infants with multiple gastrointestinal food allergy involving a delayed immunogenic mechanism, with the aim to avoid unnecessary maternal dietary restrictions before discontinuing breast-feeding.</p
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