Dynamics of concurrent and sequential Central European and Scandinavian heatwaves

In both 2003 and 2018 a heatwave in Scandinavia in July was followed by a heatwave in Central Europe in August. Whereas the transition occurred abruptly in 2003, it was gradual in 2018 with a 12-day period of concurrent heatwaves in both regions. This study contrasts these two events in the context of a heatwave climatology to elucidate the dynamics of both concurrent and sequential heatwaves. Central European and, in particular, concurrent heatwaves are climatologically associated with weak pressure gradient (WPG) events over Central Europe, which indicate the absence of synoptic activity over this region. One synoptic pattern associated with such events is Scandinavian blocking. This pattern is at the same time conducive to heatwaves in Scandinavia, thereby providing a mechanism by which Scandinavian and Central European heatwaves can co-occur. Further, the association of WPG events with Scandinavian blocking constitutes a mechanism that allows heatwaves to grow beyond the perimeter of the synoptic system from which they emanated. A trajectory analysis of the source regions of the low-level air incorporated in the heatwaves indicates rapidly changing air mass sources throughout the heatwaves in both regions, but no recycling of heat from one heatwave to the other. This finding is line with a composite analysis indicating that transitions between Scandinavian and Central European heatwaves are merely a random coincidence of heatwave onset and decay

Mapping and Functional Characterisation of a CTCF-Dependent Insulator Element at the 3′ Border of the Murine Scl Transcriptional Domain

The Scl gene encodes a transcription factor essential for haematopoietic development. Scl transcription is regulated by a panel of cis-elements spread over 55 kb with the most distal 3′ element being located downstream of the neighbouring gene Map17, which is co-regulated with Scl in haematopoietic cells. The Scl/Map17 domain is flanked upstream by the ubiquitously expressed Sil gene and downstream by a cluster of Cyp genes active in liver, but the mechanisms responsible for delineating the domain boundaries remain unclear. Here we report identification of a DNaseI hypersensitive site at the 3′ end of the Scl/Map17 domain and 45 kb downstream of the Scl transcription start site. This element is located at the boundary of active and inactive chromatin, does not function as a classical tissue-specific enhancer, binds CTCF and is both necessary and sufficient for insulator function in haematopoietic cells in vitro. Moreover, in a transgenic reporter assay, tissue-specific expression of the Scl promoter in brain was increased by incorporation of 350 bp flanking fragments from the +45 element. Our data suggests that the +45 region functions as a boundary element that separates the Scl/Map17 and Cyp transcriptional domains, and raise the possibility that this element may be useful for improving tissue-specific expression of transgenic constructs

Front–orography interactions during landfall of the 1992 New Year's Day Storm

Although following a common synoptic evolution for this region, the 1992 New Year's Day Storm was associated with some of the strongest winds observed along the Norwegian west coast. The narrow wind band along its bent-back front became famous as the “poisonous tail” and paved the way towards today's sting jet terminology. This article re-examines the storm's landfall with a particular focus on the interaction with the orography. Sensitivity analyses based on WRF simulations demonstrate that the formation and the evolution of the warm-air seclusion and its poisonous tail are largely independent of orography. In contrast, the warm sector of the storm undergoes considerable orographically induced modifications. While moving over the orography, both warm and cold fronts are eroded rapidly. This development fits neither the cold-air-damming paradigm nor the passive-advection paradigm describing front–orography interactions. The warm sector is lifted over the orography, thereby accelerating the occlusion process. The insensitivity of the warm-air seclusion to the orographic modifications of the warm sector raises the question of to which extent these entities are still interacting after the onset of the occlusion process.</p

Daily to decadal modulation of jet variability

The variance of a jet’s position in latitude is found to be related to its average speed: when a jet becomes stronger its variability in latitude decreases. This relationship is shown to hold for observed midlatitude jets around the world and also across a hierarchy of numerical models. North Atlantic jet variability is shown to be modulated on decadal timescales, with decades of a strong, steady jet being interspersed with decades of a weak, variable jet. These modulations are also related to variations in the basin-wide occurrence of high-impact blocking events. A picture emerges of complex multidecadal jet variability in which recent decades do not appear unusual. We propose an underlying barotropic mechanism to explain this behaviour, related to the change in refractive properties of a jet as it strengthens, and the subsequent effect on the distribution of Rossby wave breaking

Beyond cold and warm: an objective classification for maritime midlatitude fronts

This study introduces a detailed and objective classification for midlatitude maritime fronts. The classification is based on a principal component analysis (PCA) to determine the dominant patterns of variability between fronts. Here, fronts are defined as three-dimensional frontal volumes, which are detected in the ERA-Interim dataset for a large number of locations in the Atlantic, Pacific and Indian oceans during both winter and summer. In addition to the well-established distinction between warm and cold fronts, the PCA exposes several new dimensions of variability: (i) front intensity, (ii) surface fluxes and (iii) along-front transports, linked to the intensity of the associated conveyor belts. These new dimensions of variability are regionally and seasonally robust and a lagged composite analysis demonstrates that each of the new front types evolves in a dynamically characteristic way. Further, the new front types can be related to established ones like katafronts and anafronts. The new front types are finally redefined based on simple parameter thresholds to simplify their application in future studies.ISSN:0035-9009ISSN:1477-870

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

Gene-modified autologous hematopoietic stem cells (HSC) can provide ample clinical benefits to subjects suffering from X-linked chronic granulomatous disease (X-CGD), a rare inherited immunodeficiency characterized by recurrent, often life-threatening bacterial and fungal infections. Here we report on the molecular and cellular events observed in two young adults with X-CGD treated by gene therapy in 2004. After the initial resolution of bacterial and fungal infections, both subjects showed silencing of transgene expression due to methylation of the viral promoter, and myelodysplasia with monosomy 7 as a result of insertional activation of ecotropic viral integration site 1 (EVI1). One subject died from overwhelming sepsis 27 months after gene therapy, whereas a second subject underwent an allogeneic HSC transplantation. Our data show that forced overexpression of EVI1 in human cells disrupts normal centrosome duplication, linking EVI1 activation to the development of genomic instability, monosomy 7 and clonal progression toward myelodysplasia