16 research outputs found
Regulation of sclerostin production in human male osteocytes by androgens: Experimental and clinical evidence
No full textD-Aspartic acid stimulates steroidogenesis through the delay of LH receptor internalization in a mammalian Leydig cell line
No full textRecent experimental evidence on non-mammalian animal models showed that D-Aspartic acid (d-Asp) administration increases testosterone levels through upregulation of StAR in Leydig cells. In this study, we aimed to investigate in vitro the signaling pathway associated with d-Asp stimulation in MA-10 murine Leydig cells
Regulation of sclerostin production in human male osteocytes by androgens: Experimental and clinical evidence
No full textThe Klinefelter syndrome is associated with high recurrence of copy number variations on the X chromosome with a potential role in the clinical phenotype
No full textMolecular karyotyping of single sperm with nuclear vacuoles identifies more chromosomal abnormalities in patients with testiculopathy than fertile controls: Implications for ICSI
No full textPolymorphism rs2274911 of GPRC6A as a Novel Risk Factor for Testis Failure
No full textThe G protein-coupled receptor GPRC6A is an emerging effector with multiple endocrine roles, including stimulation of T production from the testis. Recently, two men with an inactivating mutation (F464Y) of GPRC6A have been identified, and they showed primary testicular failure and deranged spermatogenesis. Furthermore, one of them also reported cryptorchidism at birth. In addition, a polymorphism (rs2274911, Pro91Ser) in GPRC6A is associated with prostate cancer, a typical androgen-sensitive cancer
Polymorphism rs2274911 of GPRC6A as a Novel Risk Factor for Testis Failure
No full textThe G protein-coupled receptor GPRC6A is an emerging effector with multiple endocrine roles, including stimulation of T production from the testis. Recently, two men with an inactivating mutation (F464Y) of GPRC6A have been identified, and they showed primary testicular failure and deranged spermatogenesis. Furthermore, one of them also reported cryptorchidism at birth. In addition, a polymorphism (rs2274911, Pro91Ser) in GPRC6A is associated with prostate cancer, a typical androgen-sensitive cancer
WGA analysis and aCGH of single sperm.
No full text<p><b>a</b>. Gel electrophoresis of WGA products from single human sperm. Ct: cycle threshold as determined by Real-Time PCR with SYBR Green. <b>b</b>. Real-Time PCR of the same WGA products. The difference in fluorescence (fluorescence at the end of each cycle minus baseline fluorescence level) is plotted against the cycle number. Hybridization failed for samples with a cycle threshold >10. <b>c</b>. Molecular karyotype of a normal 23,X sperm co-hybridized with female (upper panel) and male reference (lower panel). <b>d</b>. Molecular karyotype of a normal 23,Y sperm co-hybridized with a female (upper panel) and a male reference (lower panel).</p
Subject characteristics and summary of aCGH results on single sperm.
No full text<p>Subject characteristics and summary of aCGH results on single sperm.</p
