Synthesis of finite displacements and displacements in continental margins

The scope of the project is the analysis of displacement-rate fields in the transitional regions between cratonal and oceanic lithospheres over Phanerozoic time (last 700 ma). Associated goals are an improved understanding of range of widths of major displacement zones; the partition of displacement gradients and rotations with position and depth in such zones; the temporal characteristics of such zones-the steadiness, episodicity, and duration of uniform versus nonunifrom fields; and the mechanisms and controls of the establishment and kinematics of displacement zones. The objective is to provide a context of time-averaged kinematics of displacement zones. The initial phase is divided topically among the methodology of measurement and reduction of displacements in the lithosphere and the preliminary analysis from geologic and other data of actual displacement histories from the Cordillera, Appalachians, and southern North America

Patients as researchers - innovative experiences in UK National Health Service research

Consumer involvement is an established priority in UK health and social care service development and research. To date, little has been published describing the process of consumer involvement and assessing ‘consumers’ contributions to research. This paper provides a practical account of the effective incorporation of consumers into a research team, and outlines the extent to which they can enhance the research cycle; from project development and conduct, through data analysis and interpretation, to dissemination. Salient points are illustrated using the example of their collaboration in a research project. Of particular note were consumers’ contributions to the development of an ethically enhanced, more robust project design, and enriched data interpretation, which may not have resulted had consumers not been an integral part of the research team

Maximum Likelihood Estimation in Gaussian Chain Graph Models under the Alternative Markov Property

The AMP Markov property is a recently proposed alternative Markov property for chain graphs. In the case of continuous variables with a joint multivariate Gaussian distribution, it is the AMP rather than the earlier introduced LWF Markov property that is coherent with data-generation by natural block-recursive regressions. In this paper, we show that maximum likelihood estimates in Gaussian AMP chain graph models can be obtained by combining generalized least squares and iterative proportional fitting to an iterative algorithm. In an appendix, we give useful convergence results for iterative partial maximization algorithms that apply in particular to the described algorithm.Comment: 15 pages, article will appear in Scandinavian Journal of Statistic

A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma.

MicroRNAs (miRNAs) are small ∼22nt single stranded RNAs that negatively regulate protein expression by binding to partially complementary sequences in the 3' untranslated region (3' UTRs) of target gene messenger RNAs (mRNA). Recently, mutations have been identified in both miRNAs and target genes that disrupt regulatory relationships, contribute to oncogenesis and serve as biomarkers for cancer risk. KIT, an established oncogene with a multifaceted role in melanogenesis and melanoma pathogenesis, has recently been shown to be upregulated in some melanomas, and is also a target of the miRNA miR-221. Here, we describe a genetic variant in the 3' UTR of the KIT oncogene that correlates with a greater than fourfold increased risk of acral melanoma. This KIT variant results in a mismatch in the seed region of a miR-221 complementary site and reporter data suggests that this mismatch can result in increased expression of the KIT oncogene. Consistent with the hypothesis that this is a functional variant, KIT mRNA and protein levels are both increased in the majority of samples harboring the KIT variant. This work identifies a novel genetic marker for increased heritable risk of melanoma

The Health and Social Care Act for England 2012: The extension of ‘new professionalism’

The 2012 Health and Social Care Act, introduced by the coalition government, has been seen as fundamentally changing the form and content of publicly funded health care provision in England. The legislation was hugely controversial and widely criticized. Much of this criticism pointed to the ways in which the reforms undermined the funding of the National Health Service, and challenged the founding principle of free universal provision. In this commentary we take issue with the argument that the Act represented a radical break with the past and instead suggest that it was an extension of the previous Labour government’s neo-liberal reforms of the public sector. In particular, the Act invoked the principles of ‘new professionalism’ to undermine professional dominance, and attract private providers into statutory health care at the expense of public providers. In turn, this extension of new professionalism may encourage public distrust in the medical profession and absolve the state of much of its statutory health care obligation. </jats:p

The potential area of occupancy of non-native plants across a warming high-Arctic archipelago: Implications for strategic biosecurity management

The terrestrial high-Arctic has, so far, escaped the worst impacts of non-native plant establishment. However, increasing human activity and changing climate raise the risk of introductions and establishment, respectively. The lack of biosecurity in the terrestrial Arctic is thus of concern. To facilitate the development of biosecurity measures on the rapidly warming and highly trafficked archipelago of Svalbard, we generated ecological niche models to map the bioclimatic niche potential of 27 non-native established or door-knocker vascular plant species across Svalbard, identify species with a high risk of widespread occupancy, and locate hotspots of potential current and future invasions. Under the current climate the three species with the highest threat in terms of broad potential area of occupancy and known invasion potential were Deschampsia cespitosa, Ranunculus subborealis subsp. villosus and Saussurea alpina. However, under future climate, most of the considered species have potentially wide distributions across the archipelago. Remote eastern islands were a hotspot region for broader potential establishment of non-native species under the current climate. Our results suggest that many non-native plant species have a broader macroclimatic niche on Svalbard than they currently occupy, and that other factors probably limit both dispersal and establishment outside their current localised distributions. Environmental management on Svalbard has a limited window of opportunity to act early in containing and preventing the spread of non-native plant species beyond the few settlements where they currently exist. Moreover, preventing introductions and establishments on the remote and rarely visited islands of Edgeøya, Barentsøya and Bjørnøya could be also a priority action to safeguard sanctuaries of the archipelago’s natural ecosystems