Are online auction markets efficient? An empirical study of market liquidity and abnormal returns

Technological advances have facilitated investment in collectibles through online auction markets, where information regarding product characteristics, current and historical prices, and product availability is available to millions of market participants. However, market inefficiencies may still exist, where prices do not reflect market information and where savvy speculators can profit. Using unit root and variance ratio tests, we examine 8538 rare stamp and 56,997 rare coin auctions to evaluate the efficiency of online markets. In particular, we study market liquidity, abnormal returns and weak-form efficiency. We find an inverse relationship between market efficiency and liquidity. Bidder competition intrinsic to liquidity increases the chances that uninformed bidders drive up item prices, leading to the observed market inefficiencies

Event sequence modeling of IT adoption in healthcare

Information systems research is replete with examples of the importance of business processes defining IT adoption. Business processes are influenced by both organizational and operational concerns. We evaluate the comparative importance of operational and organizational influences for complementary IT systems. In the context of acute-care hospitals the analysis shows that an organizational approach to automating a process is related to different financial outcomes than an operational approach. Six complementary systems supporting a three-stage medication management process are studied: prescribing, dispensing, and administration. The analysis uses firm-level, panel data extracted from the HIMSS Analytics database spanning ten years of IT adoption for 140 hospitals. We have augmented the HIMSS dataset with matching demographic and financial details from the American Hospital Association and the Centers for Medicare and Medicaid Services. Using event sequence analysis we explore whether organizations are more likely to adopt organization boundary spanning systems and if the sequence of adoption follows the temporal ordering of the business process steps. The research also investigates if there is a relationship between the paths to IT adoption and financial performance. Comparison of the two measures suggests that the organizational model of adoption is observed more often in the data. Following the organizational model of adoption is associated with approximately $155 dollar increase in net income per patient day; whereas the operational model of adoption is associated with approximately$225 dollars decrease in net income per patient day. However, this effect diminishes with the adoption of each additional system thus demonstrating that the adoption path effects may only be relevant in the short-term

AN EMPIRICAL ANALYSIS OFTHE FACTORS THAT AFFECT NURSE RETENTION

Investigate the effects of stress, economic factors, altruism and value congruence on intentions to leave the profession in nursing. As the demand for nurses increases retaining nurses will be critical for healthcare organizations and the healthcare industry. We draw from a mature body of research on nurse retention to build the research model. We analyze data from a survey of 861 registered nurses in the southeastern United States. Structural equation modeling was used to analyze the survey. Results confirm the importance of stress and salaries. Strong evidence supports the importance of the fit between employer and nurse values. Finally, the analysis provides unexpected evidence of the reduction of opportunities nurses have to fulfill altruistic desires at work

How can virtual communities create value for business?

Virtual communities include everything from discussion boards to massive multiplayer online role-playing games and virtual realities such as Second Life. The business world has assumed that virtual communities can be leveraged to provide access to consumers and consumer data. The benefits of this assumption have not always been realized. The purpose of this article is to understand why some business ventures into virtual communities fail and others succeed. Why do virtual communities support certain types of business activities and not others? Which firm activities are the best candidates to benefit from being positioned in virtual communities? The theories of social contracts and trust explain how firms can successfully participate in virtual communities. The theories have implications in the context of transaction-oriented, interest-oriented, relationship-oriented, and fantasy-oriented communities. The value chain provides an instructive background to understand which firm activities are candidates for being included in virtual communities. Success in virtual communities depends on an attitude of contribution, dedication of resources, building a critical mass, and matching community and business needs. Because many social technologies are in the disillusionment stage of the hype cycle, further research in the business use of virtual communities is needed to guide business practices as we move to full adoption

Glucose Metabolism through Pentose Phosphate Pathway: Effects on the Development of Congenital Heart Defects

Several studies have shown that genes related to cardiac muscle and function thrive in low glucose concentrations, whereas cells over actively replicate and do not reach full maturation in high glucose concentrations. Data suggests that blocking the pentose phosphate pathway induces cardiac maturation. The pentose phosphate pathway is responsible for generating ribose sugars that contribute to making nucleotides and NADP+/NADPH. Prolonged activation of the pentose phosphate pathway leads to excess nucleotide synthesis resulting in immature cardiomyocytes leading to congenital heart defects. This paper discussed how the pentose phosphate pathway is involved in the inhibition of fetal cardiomyocytes in high glucose conditions

Pictorial composition and plant forms

A correlation exists between design elements and the plant world; for example, the natural structure or the linear growth pattern may be visually interpreted as pure line which carries the viewer's eye from the tip of a leaf to the stem; it may change direction or bring attention to another area thus offering variety by setting up visual rhythms within a composition. The same may be stated with the other design elements, color, volume, and space. These elements may be called characteristics or growth patterns by which each plant establishes its own identity. The composition or view sought in presenting a plant consists of all these elements working together to achieve a visually stimulating variety. These natural relationships are retained in my works much as they appear because I feel they are interesting and offer many visual possibilities. I, therefore, am attempting to achieve a work that is more than just a botanical representation or illustration. All of the works in the exhibit are in several media: oil on canvas, water color, pencil, pastel, and colored ink. Various types of plants were used with design emphasis on their natural structure. The variety of angles or views allowed for many possibilities of composition. Some of the works place more emphasis on linear elements, while others emphasize volume, space, and color. Thus, the use of plants offered a means of exploring the various design elements three dimensionally on the flat picture plane

Jamaica, Three Years Later: Effects of Intensified Pro-Gay Activism on Severe Prejudice Against Lesbians and Gay Men

Jamaica has developed an international reputation for severe anti-gay prejudice. However, in the past few years, between 2012 and 2015, intensified waves of activism have increased the visibility of lesbian, gay, bisexual, and transgender (LGBT) Jamaicans, and supported their social and legal inclusion in Jamaican society. This research investigated the effects of that activism by taking advantage of two large, representative surveys of Jamaicans' attitudes toward lesbians and gay men: one in 2012 and one in 2015. Over the three-year period there were significant reductions in desire for social distance and opposition to gay rights. However, there was no significant change in anti-gay attitudes, and there was evidence of an increase in anti-gay behaviors. There was also no evidence of polarization of responses to gay men and lesbians; rather, the most prejudiced Jamaicans showed the largest reductions in bias. Implications of these findings for activism in Jamaica and other anti-gay countries are discussed

Improved HIV and Substance Abuse Treatment Outcomes for Released HIV-Infected Prisoners: The Impact of Buprenorphine Treatment

HIV-infected prisoners fare poorly after release. Though rarely available, opioid agonist therapy (OAT) may be one way to improve HIV and substance abuse treatment outcomes after release. Of the 69 HIV-infected prisoners enrolled in a randomized controlled trial of directly administered antiretroviral therapy, 48 (70%) met DSM-IV criteria for opioid dependence. Of these, 30 (62.5%) selected OAT, either as methadone (N = 7, 14.5%) or buprenorphine/naloxone (BPN/NLX; N = 23, 48.0%). Twelve-week HIV and substance abuse treatment outcomes are reported as a sub-study for those selecting BPN/NLX. Retention was high: 21 (91%) completed BPN/NLX induction and 17 (74%) remained on BPN/NLX after 12 weeks. Compared with baseline, the proportion with a non-detectable viral load (61% vs 63% log10 copies/mL) and mean CD4 count (367 vs 344 cells/mL) was unchanged at 12 weeks. Opiate-negative urine testing remained 83% for the 21 who completed induction. Using means from 10-point Likert scales, opioid craving was reduced from 6.0 to 1.8 within 3 days of BPN/NLX induction and satisfaction remained high at 9.5 throughout the 12 weeks. Adverse events were few and mild. BPN/NLX therapy was acceptable, safe and effective for both HIV and opioid treatment outcomes among released HIV-infected prisoners. Future randomized controlled trials are needed to affirm its benefit in this highly vulnerable population

Retention on Buprenorphine Is Associated with High Levels of Maximal Viral Suppression among HIV-Infected Opioid Dependent Released Prisoners

HIV-infected prisoners lose viral suppression within the 12 weeks after release to the community. This prospective study evaluates the use of buprenorphine/naloxone (BPN/NLX) as a method to reduce relapse to opioid use and sustain viral suppression among released HIV-infected prisoners meeting criteria for opioid dependence (OD).From 2005-2010, 94 subjects meeting DSM-IV criteria for OD were recruited from a 24-week prospective trial of directly administered antiretroviral therapy (DAART) for released HIV-infected prisoners; 50 (53%) selected BPN/NLX and were eligible to receive it for 6 months; the remaining 44 (47%) selected no BPN/NLX therapy. Maximum viral suppression (MVS), defined as HIV-1 RNA<50 copies/mL, was compared for the BPN/NLX and non-BPN/NLX (N = 44) groups.The two groups were similar, except the BPN/NLX group was significantly more likely to be Hispanic (56.0% v 20.4%), from Hartford (74.4% v 47.7%) and have higher mean global health quality of life indicator scores (54.18 v 51.40). MVS after 24 weeks of being released was statistically correlated with 24-week retention on BPN/NLX [AOR = 5.37 (1.15, 25.1)], having MVS at the time of prison-release [AOR = 10.5 (3.21, 34.1)] and negatively with being Black [AOR = 0.13 (0.03, 0.68)]. Receiving DAART or methadone did not correlate with MVS.In recognition that OD is a chronic relapsing disease, strategies that initiate and retain HIV-infected prisoners with OD on BPN/NLX is an important strategy for improving HIV treatment outcomes as a community transition strategy

HAE therapies: past present and future

Advances in understanding the pathophysiology and mechanism of swelling in hereditary angioedema (HAE) has resulted in the development of multiple new drugs for the acute and prophylactic treatment of patients with HAE. This review will recap the past treatment options, review the new current treatment options, and discuss potential future treatment options for patients with HAE