21 research outputs found
Assessment of technology-based ventures, complexity and viability : toward early-stage, technology-based venture screening and assessment decision aids
Using Stories in Coach Education
The purpose of this paper is to illustrate how storied representations of research can be used as an effective pedagogical tool in coach education. During a series of continuing professional development seminars for professional golf coaches, we presented our research in the form of stories and poems which were created in an effort to evoke and communicate the lived experiences of elite professional golfers. Following these presentations, we obtained written responses to the stories from 53 experienced coaches who attended the seminars. Analysis of this data revealed three ways in which coaches responded to the stories: (i) questioning; (ii) summarising; and (iii) incorporating. We conclude that these responses illustrate the potential of storied forms of representation to enhance professional development through stimulating reflective practice and increasing understanding of holistic, person-centred approaches to coaching athletes in high-performance sport
The "Jock Body" and the social construction of space: the performance and positioning of cultural identity
This article draws on data generated from a 3-year ethnographic study of "jock culture" at one university setting in England to illuminate the ways that specific kinds of bodies are located in social space so as to construct a range of identity positions that facilitate the maintenance of this culture over time. These positions are as follows: the jocks, sport scholars, also-rans, anti-jocks, wannabes, and the non-jocks. The analysis revealed how individuals negotiate an embodied identity within a network of power relations, with the performing jock body occupying the most highly visible, yet taken for granted, central space around which all other bodies are positioned according to their ability to meet the combined sporting and social requirements of this culture. The findings have significance for how we understand the ways in which bodies and space are reciprocally constituted along with the dilemmas this poses for individuals within a cultural setting
Steroid Hormone Control of Cell Death and Cell Survival: Molecular Insights Using RNAi
The insect steroid hormone ecdysone triggers programmed cell death of obsolete larval tissues during metamorphosis and provides a model system for understanding steroid hormone control of cell death and cell survival. Previous genome-wide expression studies of Drosophila larval salivary glands resulted in the identification of many genes associated with ecdysone-induced cell death and cell survival, but functional verification was lacking. In this study, we test functionally 460 of these genes using RNA interference in ecdysone-treated Drosophila l(2)mbn cells. Cell viability, cell morphology, cell proliferation, and apoptosis assays confirmed the effects of known genes and additionally resulted in the identification of six new pro-death related genes, including sorting nexin-like gene SH3PX1 and Sox box protein Sox14, and 18 new pro-survival genes. Identified genes were further characterized to determine their ecdysone dependency and potential function in cell death regulation. We found that the pro-survival function of five genes (Ras85D, Cp1, CG13784, CG32016, and CG33087), was dependent on ecdysone signaling. The TUNEL assay revealed an additional two genes (Kap-α3 and Smr) with an ecdysone-dependent cell survival function that was associated with reduced cell death. In vitro, Sox14 RNAi reduced the percentage of TUNEL-positive l(2)mbn cells (p<0.05) following ecdysone treatment, and Sox14 overexpression was sufficient to induce apoptosis. In vivo analyses of Sox14-RNAi animals revealed multiple phenotypes characteristic of aberrant or reduced ecdysone signaling, including defects in larval midgut and salivary gland destruction. These studies identify Sox14 as a positive regulator of ecdysone-mediated cell death and provide new insights into the molecular mechanisms underlying the ecdysone signaling network governing cell death and cell survival
Modeling Ozone Reaction Rate Constants of Micropollutants Using Quantitative Structure-Property Relationships
Alkyl dehydrogenation in a Rh(i) complex via an isolated agostic intermediate
A well-characterised 14-electron rhodium phosphine complex, [Rh(P(i)Pr(3))(3)][BAr(4)(F)], which contains a beta-CH agostic interaction, is observed to undergo spontaneous dehydrogenation to afford [Rh(P(i)Pr(3))(2)(P(i)Pr(2)(C(3)H(5)))][BAr(4)(F)]; calculations on a model system show that while C-H activation is equally accessible from the beta-CH agostic species or an alternative gamma-CH agostic isomer, subsequent beta-H-transfer can only be achieved along pathways originating from the beta-CH agostic form
Teachers’ views on the construction, management and delivery of an externally prescribed physical education curriculum: higher grade physical education
There is strong agreement that teachers are central to curriculum planning and development as it is teachers who ultimately decide whether or not, or to what extent, to implement innovations. By applying Basil Bernstein’s (1990) theoretical framework on the social construction of pedagogic discourse, this paper examines teachers’ views towards the process of a particular curriculum innovation in physical education in Scotland, Higher Grade Physical Education (HGPE). Also examined are teachers’ views on the consequent subject content and the management of the subject in schools, in an attempt to identify factors that aided or hindered teachers from supporting and delivering HGPE. It is suggested that as a consequence of teachers being expected to deliver an externally prescribed curriculum, de-professionalisation and de-skilling are probable teacher experiences
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An atlas of genetic influences on osteoporosis in humans and mice.
Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound in 426,824 individuals, identifying 518 genome-wide significant loci (301 novel), explaining 20% of its variance. We identified 13 bone fracture loci, all associated with estimated BMD (eBMD), in ~1.2 million individuals. We then identified target genes enriched for genes known to influence bone density and strength (maximum odds ratio (OR) = 58, P = 1 × 10-75) from cell-specific features, including chromatin conformation and accessible chromatin sites. We next performed rapid-throughput skeletal phenotyping of 126 knockout mice with disruptions in predicted target genes and found an increased abnormal skeletal phenotype frequency compared to 526 unselected lines (P < 0.0001). In-depth analysis of one gene, DAAM2, showed a disproportionate decrease in bone strength relative to mineralization. This genetic atlas provides evidence linking associated SNPs to causal genes, offers new insight into osteoporosis pathophysiology, and highlights opportunities for drug development
An atlas of genetic influences on osteoporosis in humans and mice.
Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound in 426,824 individuals, identifying 518 genome-wide significant loci (301 novel), explaining 20% of its variance. We identified 13 bone fracture loci, all associated with estimated BMD (eBMD), in ~1.2 million individuals. We then identified target genes enriched for genes known to influence bone density and strength (maximum odds ratio (OR) = 58, P = 1 × 10-75) from cell-specific features, including chromatin conformation and accessible chromatin sites. We next performed rapid-throughput skeletal phenotyping of 126 knockout mice with disruptions in predicted target genes and found an increased abnormal skeletal phenotype frequency compared to 526 unselected lines (P < 0.0001). In-depth analysis of one gene, DAAM2, showed a disproportionate decrease in bone strength relative to mineralization. This genetic atlas provides evidence linking associated SNPs to causal genes, offers new insight into osteoporosis pathophysiology, and highlights opportunities for drug development