721 research outputs found
Chains of Viscoelastic Spheres
Given a chain of viscoelastic spheres with fixed masses of the first and last
particles. We raise the question: How to chose the masses of the other
particles of the chain to assure maximal energy transfer? The results are
compared with a chain of particles for which a constant coefficient of
restitution is assumed. Our simple example shows that the assumption of
viscoelastic particle properties has not only important consequences for very
large systems (see [1]) but leads also to qualitative changes in small systems
as compared with particles interacting via a constant restitution coefficient.Comment: 11 pages, 6 figure
A model of ballistic aggregation and fragmentation
A simple model of ballistic aggregation and fragmentation is proposed. The
model is characterized by two energy thresholds, Eagg and Efrag, which
demarcate different types of impacts: If the kinetic energy of the relative
motion of a colliding pair is smaller than Eagg or larger than Efrag, particles
respectively merge or break; otherwise they rebound. We assume that particles
are formed from monomers which cannot split any further and that in a
collision-induced fragmentation the larger particle splits into two fragments.
We start from the Boltzmann equation for the mass-velocity distribution
function and derive Smoluchowski-like equations for concentrations of particles
of different mass. We analyze these equations analytically, solve them
numerically and perform Monte Carlo simulations. When aggregation and
fragmentation energy thresholds do not depend on the masses of the colliding
particles, the model becomes analytically tractable. In this case we show the
emergence of the two types of behavior: the regime of unlimited cluster growth
arises when fragmentation is (relatively) weak and the relaxation towards a
steady state occurs when fragmentation prevails. In a model with mass-dependent
Eagg and Efrag the evolution with a cross-over from one of the regimes to
another has been detected
Amyloid-beta Leads to Impaired Cellular Respiration, Energy Production and Mitochondrial Electron Chain Complex Activities in Human Neuroblastoma Cells
Evidence suggests that amyloid-beta (Aβ) protein is a key factor in the pathogenesis of Alzheimer's disease (AD) and it has been recently proposed that mitochondria are involved in the biochemical pathway by which Aβ can lead to neuronal dysfunction. Here we investigated the specific effects of Aβ on mitochondrial function under physiological conditions. Mitochondrial respiratory functions and energy metabolism were analyzed in control and in human wild-type amyloid precursor protein (APP) stably transfected human neuroblastoma cells (SH-SY5Y). Mitochondrial respiratory capacity of mitochondrial electron transport chain (ETC) in vital cells was measured with a high-resolution respirometry system (Oxygraph-2k). In addition, we determined the individual activities of mitochondrial complexes I-IV that compose ETC and ATP cellular levels. While the activities of complexes I and II did not change between cell types, complex IV activity was significantly reduced in APP cells. In contrast, activity of complex III was significantly enhanced in APP cells, as compensatory response in order to balance the defect of complex IV. However, this compensatory mechanism could not prevent the strong impairment of total respiration in vital APP cells. As a result, the respiratory control ratio (state3/state4) together with ATP production decreased in the APP cells in comparison with the control cells. Chronic exposure to soluble Aβ protein may result in an impairment of energy homeostasis due to a decreased respiratory capacity of mitochondrial electron transport chain which, in turn, may accelerate neurons demis
How reliable is MRI in diagnosing cartilaginous lesions in patients with first and recurrent lateral patellar dislocations?
<p>Abstract</p> <p>Background</p> <p>Lateral dislocation of the patella (LPD) leads to cartilaginous injuries, which have been reported to be associated with retropatellar complaints and the development of patellofemoral osteoarthritis. Therefore, the purpose of this study was to determine the reliability of MRI for cartilage diagnostics after a first and recurrent LPD.</p> <p>Methods</p> <p>After an average of 4.7 days following an acute LPD, 40 patients (21 with first LPDs and 19 with recurrent LPDs) underwent standardized 1.5 Tesla MRI (sagittal T1-TSE, coronal STIR-TSE, transversal fat-suppressed PD-TSE, sagittal fat-suppressed PD-TSE). MRI grading was compared to arthroscopic assessment of the cartilage.</p> <p>Results</p> <p>Sensitivities and positive predictive values for grade 3 and 4 lesions were markedly higher in the patient group with first LPDs compared to the group with recurrent LPDs. Similarly, intra- and inter-observer agreement yielded higher kappa values in patients with first LPDs compared to those with recurrent LPDs. All grade 4 lesions affecting the subchondral bone (osteochondral defects), such as a fissuring or erosion, were correctly assessed on MRI.</p> <p>Conclusions</p> <p>This study demonstrated a comparatively good diagnostic performance for MRI in the evaluation of first and recurrent LPDs, and we therefore recommend MRI for the cartilage assessment after a LPD.</p
Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates
The heterotrimeric NatC complex, comprising the catalytic Naa30 and the two auxiliary subunits Naa35 and Naa38, co-translationally acetylates the N-termini of numerous eukaryotic target proteins. Despite its unique subunit composition, its essential role for many aspects of cellular function and its suggested involvement in disease, structure and mechanism of NatC have remained unknown. Here, we present the crystal structure of the Saccharomyces cerevisiae NatC complex, which exhibits a strikingly different architecture compared to previously described N-terminal acetyltransferase (NAT) complexes. Cofactor and ligand-bound structures reveal how the first four amino acids of cognate substrates are recognized at the Naa30–Naa35 interface. A sequence-specific, ligand-induced conformational change in Naa30 enables efficient acetylation. Based on detailed structure–function studies, we suggest a catalytic mechanism and identify a ribosome-binding patch in an elongated tip region of NatC. Our study reveals how NAT machineries have divergently evolved to N-terminally acetylate specific subsets of target proteins
Cooling dynamics of a dilute gas of inelastic rods: a many particle simulation
We present results of simulations for a dilute gas of inelastically colliding
particles. Collisions are modelled as a stochastic process, which on average
decreases the translational energy (cooling), but allows for fluctuations in
the transfer of energy to internal vibrations. We show that these fluctuations
are strong enough to suppress inelastic collapse. This allows us to study large
systems for long times in the truely inelastic regime. During the cooling stage
we observe complex cluster dynamics, as large clusters of particles form,
collide and merge or dissolve. Typical clusters are found to survive long
enough to establish local equilibrium within a cluster, but not among different
clusters. We extend the model to include net dissipation of energy by damping
of the internal vibrations. Inelatic collapse is avoided also in this case but
in contrast to the conservative system the translational energy decays
according to the mean field scaling law, E(t)\propto t^{-2}, for asymptotically
long times.Comment: 10 pages, 12 figures, Latex; extended discussion, accepted for
publication in Phys. Rev.
Self-diffusion in granular gases
The coefficient of self-diffusion for a homogeneously cooling granular gas
changes significantly if the impact-velocity dependence of the restitution
coefficient is taken into account. For the case of a constant
the particles spread logarithmically slow with time, whereas the
velocity dependent coefficient yields a power law time-dependence. The impact
of the difference in these time dependences on the properties of a freely
cooling granular gas is discussed.Comment: 6 pages, no figure
Localized and Cellular Patterns in a Vibrated Granular Layer
We propose a phenomenological model for pattern formation in a vertically
vibrated layer of granular material. This model exhibits a variety of stable
cellular patterns including standing rolls and squares as well as localized
objects (oscillons and worms), similar to recent experimental
observations(Umbanhowar et al., 1996). The model is an amplitude equation for
the parametrical instability coupled to the mass conservation law. The
structure and dynamics of the solutions resemble closely the properties of
localized and cellular patterns observed in the experiments.Comment: 4 pages, 4 figures, submitted to Phys. Rev. Let
Nanoassembly of Polydisperse Photonic Crystals Based on Binary and Ternary Polymer Opal Alloys
Ordered binary and ternary photonic crystals, composed of different sized
polymer-composite spheres with diameter ratios up to 120%, are generated using
bending induced oscillatory shearing (BIOS). This viscoelastic system creates
polydisperse equilibrium structures, producing mixed opaline colored films with
greatly reduced requirements for particle monodispersity, and very different
sphere size ratios, compared to other methods of nano-assembly
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