57 research outputs found
Futureproofing [18F]Fludeoxyglucose manufacture at an Academic Medical Center
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2018
- Field of study
Abstract
Background
We recently upgraded our [18F]fludeoxyglucose (FDG) production capabilities with the goal of futureproofing our FDG clinical supply, expanding the number of batches of FDG we can manufacture each day, and improving patient throughput in our nuclear medicine clinic. In this paper we report upgrade of the synthesis modules to the GE FASTLab 2 platform (Phase 1) and cyclotron updates (Phase 2) from both practical and regulatory perspectives. We summarize our experience manufacturing FDG on the FASTLab 2 module with a high-yielding self-shielded niobium (Nb) fluorine-18 target.
Results
Following installation of Nb targets for production of fluorine-18, a 55 μA beam for 22 min generated 1330 ± 153 mCi of [18F]fluoride. Using these cyclotron beam parameters in combination with the FASTLab 2, activity yields (AY) of FDG were 957 ± 102 mCi at EOS, corresponding to 72% non-corrected AY (n = 235). Our workflow, inventory management and regulatory compliance have been greatly simplified following the synthesis module and cyclotron upgrades, and patient wait times for FDG PET have been cut in half at our nuclear medicine clinic.
Conclusions
The combination of FASTlab 2 and self-shielded Nb fluorine-18 targets have improved our yield of FDG, and enabled reliable and repeatable manufacture of the radiotracer for clinical use.https://deepblue.lib.umich.edu/bitstream/2027.42/145727/1/41181_2018_Article_48.pd
Development of Positron Emission Tomography Radiotracers for the GABA Transporter 1
- Author
- Publication venue
- Publication date
- Field of study
In
vivo positron emission tomography (PET) imaging of the γ-aminobutyric
acid (GABA) receptor complex has been accomplished using radiolabeled
benzodiazepine derivatives, but development of specific presynaptic
radioligands targeting the neuronal membrane GABA transporter type
1 (GAT-1) has been less successful. The availability of new structure–activity
studies of GAT-1 inhibitors and the introduction of a GAT-1 inhibitor
(tiagabine, Gabatril) into clinical use prompted us to reinvestigate
the syntheses of PET ligands for this transporter. Initial synthesis
and rodent PET studies of N-[<sup>11</sup>C]methylnipecotic acid confirmed
the low brain uptake of that small and polar molecule. The common
design approach to improve blood–brain barrier permeability
of GAT-1 inhibitors is the attachment of a large lipophilic substituent.
We selected an unsymmetrical bis-aromatic residue attached to the
ring nitrogen by a vinyl ether spacer from a series recently reported
by Wanner and coworkers. Nucleophilic aromatic substitution of an
aryl chloride precursor with [<sup>18</sup>F]fluoride was used to
prepare the desired candidate radiotracer (<i>R</i>,<i>E</i>/<i>Z</i>)-1-(2-((4-fluoro-2-(4-[<sup>18</sup>F]fluorobenzoyl)styryl)oxy)ethyl)piperidine-3-carboxylic acid ((<i>R</i>,<i>E</i>/<i>Z</i>)-<b>[</b><sup><b>18</b></sup><b>F]10</b>). PET studies in rats showed
no brain uptake, which was not altered by pretreatment of animals
with the P-glycoprotein inhibitor cyclosporine A, indicating efflux
by Pgp was not responsible. Subsequent PET imaging studies of (<i>R</i>,<i>E</i>/<i>Z</i>)-[<sup><b>18</b></sup><b>F]10</b> in rhesus monkey brain showed very low brain
uptake. Finally, to test if the free carboxylic acid group was the
likely cause of poor brain uptake, PET studies were done using the
ethyl ester derivative of (<i>R</i>,<i>E</i>/<i>Z</i>)-<b>[</b><sup><b>18</b></sup><b>F]10</b>. Rapid and significant monkey brain uptake of the ester was observed,
followed by a slow washout over 90 min. The blood–brain barrier
permeability of the ester supports a hypothesis that the free acid
function limits brain uptake of nipecotic acid-based GAT-1 radioligands,
and future radiotracer efforts should investigate the use of carboxylic
acid bioisosteres
Use of 55 PET radiotracers under approval of a Radioactive Drug Research Committee (RDRC)
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 10/08/2022
- Field of study
Abstract
Background
In the US, EU and elsewhere, basic clinical research studies with positron emission tomography (PET) radiotracers that are generally recognized as safe and effective (GRASE) can often be conducted under institutional approval. For example, in the United States, such research is conducted under the oversight of a Radioactive Drug Research Committee (RDRC) as long as certain requirements are met. Firstly, the research must be for basic science and cannot be intended for immediate therapeutic or diagnostic purposes, or to determine the safety and effectiveness of the PET radiotracer. Secondly, the PET radiotracer must be generally recognized as safe and effective. Specifically, the mass dose to be administered must not cause any clinically detectable pharmacological effect in humans, and the radiation dose to be administered must be the smallest dose practical to perform the study and not exceed regulatory dose limits within a 1-year period. In our experience, the main barrier to using a PET radiotracer under RDRC approval is accessing the required information about mass and radioactive dosing.
Results
The University of Michigan (UM) has a long history of using PET radiotracers in clinical research studies. Herein we provide dosing information for 55 radiotracers that will enable other PET Centers to use them under the approval of their own RDRC committees.
Conclusions
The data provided herein will streamline future RDRC approval, and facilitate further basic science investigation of 55 PET radiotracers that target functionally relevant biomarkers in high impact disease states.http://deepblue.lib.umich.edu/bitstream/2027.42/174047/1/41181_2020_Article_110.pd
Inhibition of USP10 induces degradation of oncogenic FLT3
- Author
- A Hershko
- AA Warkentin
- Alexandra Christodoulou
- Amanda Christie
- Anthony Letai
- Atsushi Nonami
- B Sargin
- BM Kessler
- C Lavagna-Sévenier
- C Ndubaku
- C Reverdy
- Chengcheng Meng
- CM Pickart
- D Chauhan
- David M Weinstock
- Dharminder Chauhan
- E Weisberg
- E Weisberg
- E Weisberg
- E Weisberg
- E Weisberg
- Ellen L Weisberg
- G Oshikawa
- Hong Tiv
- Hyuk-Soo Seo
- I De Kouchkovsky
- Ilaria Lamberto
- J Heideker
- J Liu
- J Montero
- J Yuan
- James D Griffin
- Jing Yang
- Kenneth C Anderson
- Laura Doherty
- LM Kelly
- M Altun
- M Levis
- Maria Stella Ritorto
- Martin Sattler
- Matthias Trost
- ME Sowa
- MJ Clague
- MJ Clague
- MP Martelli
- MS Ritorto
- Nathan J Schauer
- Nathanael S Gray
- Prafulla C Gokhale
- R Pan
- Renee Wright
- Richard Stone
- RM Stone
- RS Atwal
- SA Abdul Rehman
- SA Armstrong
- SA Williams
- Sara J Buhrlage
- Shruti Bhatt
- Sirano Dhe-Paganon
- Sophia Adamia
- TC Chou
- Virginia De Cesare
- Y Matsuo
- YH Fan
- YM Báez-Santos
- Z Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 02/10/2017
- Field of study
Inhibition of USP10 induces degradation of oncogenic FLT3
- Author
- A Hershko
- AA Warkentin
- Alexandra Christodoulou
- Amanda Christie
- Anthony Letai
- Atsushi Nonami
- B Sargin
- BM Kessler
- C Lavagna-Sévenier
- C Ndubaku
- C Reverdy
- Chengcheng Meng
- CM Pickart
- D Chauhan
- David M Weinstock
- Dharminder Chauhan
- E Weisberg
- E Weisberg
- E Weisberg
- E Weisberg
- E Weisberg
- Ellen L Weisberg
- G Oshikawa
- Hong Tiv
- Hyuk-Soo Seo
- I De Kouchkovsky
- Ilaria Lamberto
- J Heideker
- J Liu
- J Montero
- J Yuan
- James D Griffin
- Jing Yang
- Kenneth C Anderson
- Laura Doherty
- LM Kelly
- M Altun
- M Levis
- Maria Stella Ritorto
- Martin Sattler
- Matthias Trost
- ME Sowa
- MJ Clague
- MJ Clague
- MP Martelli
- MS Ritorto
- Nathan J Schauer
- Nathanael S Gray
- Prafulla C Gokhale
- R Pan
- Renee Wright
- Richard Stone
- RM Stone
- RS Atwal
- SA Abdul Rehman
- SA Armstrong
- SA Williams
- Sara J Buhrlage
- Shruti Bhatt
- Sirano Dhe-Paganon
- Sophia Adamia
- TC Chou
- Virginia De Cesare
- Y Matsuo
- YH Fan
- YM Báez-Santos
- Z Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Validation of the collaborative outcomes study on health and functioning during infection times (COH-FIT) questionnaire for adults
- Author
- Afridi Muhammad Iqbal
- Agorastos Agorastos
- Aizberg Oleg
- Aksu Hatice
- Alexinschi Ovidiu
- Altynbekov Kuanysh
- Andreu-Bernabeu Alvaro
- Andrlíková Eva
- Anselmi Alejandro
- Aparicio Luana V.
- Arango Celso
- Arellano Ramon
- Arrondo Gonzalo
- Aschauer Elena
- Aschauer Harald
- Balazs Judit
- Bauer Michael
- Bechdolf Andreas
- Berk Michael
- Bitter Istvan
- Bolos Alexandra
- Borgwardt Stefan
- Boscutti Andrea
- Bourgin Julie
- Bozikas Vasilios P.
- Brahim Takoua
- Brambilla Paolo
- Brand Serge
- Brissos Sofia
- Brondino Natascia
- Brunoni Andre R.
- Carvalho Andre F.
- Cereda Guido
- Chi Xinli
- Ciappolino Valentina
- Ciuhodaru Tudor
- Colizzi Marco
- Conus Philippe
- Correll Christoph U.
- Cortese Samuele
- Costardi Carlos Gustavo
- Cracco Cecilia
- Croatto Giovanni
- Crossley Nicolas
- Curtis Jackie
- Czobor Pal
- Cáceres Antonia San José
- Dahdouh Aïcha
- Darcin Asli Enez
- Daskalakis Jeff
- De Leo Diego
- de Timary Philippe
- Demurtas Jacopo
- Dilbaz Nesrin
- Do Cuénod Kim Q.
- Domschke Katharina
- Dragioti Elena
- Díaz-Caneja Covadonga M.
- Efthymiou Dimitris
- Enrico Paolo
- Errazuriz Antonia
- Estrade Natalia
- Estradé Andrés
- Fan Jialin
- Favaro Angela
- Fiedorowicz Jess
- Firth Joseph
- Fonseca Lais
- Fortea Lydia
- Fullana Miquel A.
- Fusar-Poli Paolo
- Gadelha Ary
- Gaha Lotfi
- Gerdle Björn
- Gerunda Cristiano
- Gonzalez-Peñas Javier
- Gorwood Philip
- Guinart Daniel
- Guu Ta-wei
- Hadi Samira
- Hamilton Jane
- Haque Ariful
- Hasler Gregor
- Heuss Sabina
- Hidalgo-Mazzei Diego
- Hoffmann Sofie Have
- Honciuc Mihaela
- Horodnic Adrian Vasile
- Huber Christian G.
- Ifteni Petru
- Jamei Yasser Abu
- James Bawo
- Janků Karolina
- Javed Afzal
- Jiao Can
- Kahl Kai G.
- Kallivayalil Roy Abraham
- Kamiński Karol
- Kane John
- Kim Minah
- Kishimoto Taishiro
- Kiszkiel Łukasz
- Kitazawa Momoko
- Koutsouleris Nikolaos
- Koyanagi Ai
- Krebs Marie-Odile
- Krinitski Damir
- Kurokawa Shunya
- Kuttichira Praveenlal
- Kwon Jun Soo
- Lee Jinhee
- Lee Tae Young
- Leisch Friedrich
- Llorca Pierre-Michel
- Luiz Jhoanne Merlyn
- López-Jaramillo Carlos
- Machado Ana Inés
- Maes Michael
- Manková Denisa
- Marlicz Maria
- Marlicz Wojciech
- Marx Wolfgang
- Matei Valentin
- Matthews Evan
- Mavridis Dimitris
- Meyer-Lindenberg Andreas
- Mhalla Ahmed
- Millan Mark John
- Moghadasin Maryam
- Monaco Francesco
- Moniuszko-Malinowska Anna
- Morgado Pedro
- Mosina Anna
- Movina Larisa
- Mugisha James
- Negay Nikolay
- Ng Bernardo
- Nieman Dorien H.
- Nordentoft Merete
- Noyan Onur
- Nurmagambetova Saltanat
- Okasha Tarek
- Oprea Liviu
- Papsuev Oleg
- Parellada Mara
- Pena Edilberto
- Pfennig Andrea
- Polanczyk Guilherme
- Politi Pierluigi
- Rabbani Golam
- Radua Joaquim
- Righi Elena
- Ristic Dragana Ignjatovic
- Roman Raquel
- Rosenbaum Simon
- Rubio Jose
- Rungnirundorn Teerayuth
- Saccon Diego
- Sadeghi Masoud
- Sadeghi-Bahmani Dena
- Samochowiec Jerzy
- Sanchez Thelma
- Sand Michael
- Sartorius Norman
- Scanferla Elisabetta
- Schloegelhofer Monika
- Schneeberger Andres
- Schuch Felipe Barreto
- Seb-Akahomen Omonefe Joy
- Seedat Soraya
- Sehli Jihed
- Sheybani Farshad
- Shin Jae Il
- Skonieczna-Żydecka Karolina
- Solanes Aleix
- Solmi Marco
- Sommer Iris
- Sowa Paweł
- Spies Georgina
- Stubbs Brendon
- Su Kuan-Pin
- Sullivan Sarah
- Sun Ching-Fang
- Supasitthumrong Thitiporn
- Takamiya Akihiro
- Tazawa Yuki
- Teasdale Scott
- Thompson Trevor
- Thygesen Lau Caspar
- Tiihonen Jari
- Tsamakis Konstantinos
- Tunvirachaisakul Chavit
- Turliuc Serban
- Unoka Zsolt
- Valvassori Samira S.
- van Amelsvoort Therese
- van Os Jim
- van Winkel Ruud
- Vancampfort Davy
- Vassilopoulou Emilia
- Vendsborg Per
- Verdolini Norma
- Veronese Nicola
- Vieta Eduard
- von Känel Roland
- Ward Philip
- Weiser Mark
- Wells John
- Winter Sibylle
- Yang Lin
- Yatham Lakshmi N.
- Yu Xin
- Zhang Jieting
- Zoccante Leonardo
- Zou Liye
- Łoniewski Igor
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background. The Collaborative Outcome study on Health and Functioning during Infection Times (COH-FIT; www.coh-fit.com) is an anonymous and global online survey measuring health and functioning during COVID-19 pandemic. The aim of this study was to test concurrently the validity of COH-FIT items and the internal validity of the co-primary outcome, a composite psychopathology “P-score”.
Methods. The COH-FIT survey has been translated into 30 languages (two blind forward-translations, consensus, one independent English back-translation, final harmonization). To measure mental health, 1-4 items (“COH-FIT items”) were extracted from validated questionnaires (e.g. Patient Health Questionnaire 9). COH-FIT items measured anxiety, depressive, post-traumatic, obsessive-compulsive, bipolar and psychotic symptoms, as well as stress, sleep and concentration. COH-FIT Items which correlated r≥0.5 with validated companion questionnaires, were initially retained. A P-score factor structure was then identified from these items using exploratory factor analysis (EFA) and confirmatory factor analyses (CFA) on data split into training and validation sets. Consistency of results across languages, gender and age was assessed.
Results. From >150,000 adult responses by May 6th, 2022, a subset of 22,456 completed both COH-FIT items and validated questionnaires. Concurrent validity was consistently demonstrated across different languages for COH-FIT items. CFA confirmed EFA results of five first-order factors (anxiety, depression, post-traumatic, psychotic, psychophysiologic symptoms) and revealed a single second-order factor P-score, with high internal reliability (ω=0.95). Factor structure was consistent across age and sex.
Conclusions. COH-FIT is a valid instrument to globally measure mental health during infection times. The P-score is a valid measure of multidimensional mental health
Recommended from our members
Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: results from the international COH-FIT Study
- Author
- Afridi Muhammad Iqbal
- Agorastos Agorastos
- Aizberg Oleg
- Aksu Hatice
- Alexinschi Ovidiu
- Altynbekov Kuanysh
- Andreu-Bernabeu Alvaro
- Andrlíková Eva
- Anselmi Alejandro
- Aparicio Luana V.
- Arango Celso
- Arellano Ramon
- Arrondo Gonzalo
- Aschauer Elena
- Aschauer Harald
- Balazs Judit
- Bauer Michael
- Bechdolf Andreas
- Berk Michael
- Bitter Istvan
- Bolos Alexandra
- Borgwardt Stefan
- Boscutti Andrea
- Bourgin Julie
- Bozikas Vasilios P.
- Brahim Takoua
- Brambilla Paolo
- Brand Serge
- Brissos Sofia
- Brondino Natascia
- Brunoni Andre R.
- Carvalho Andre F.
- Cereda Guido
- Chi Xinli
- Ciappolino Valentina
- Ciuhodaru Tudor
- Colizzi Marco
- Conus Philippe
- Correll Christoph U.
- Cortese Samuele
- Costardi Carlos Gustavo
- Cracco Cecilia
- Croatto Giovanni
- Crossley Nicolas
- Curtis Jackie
- Cuénod Kim Q. Do
- Czobor Pál
- Cáceres Antonia San José
- Dahdouh Aïcha
- Darcin Asli Enez
- Daskalakis Jeff
- De Leo Diego
- de Timary Philippe
- Demurtas Jacopo
- Dilbaz Nesrin
- Domschke Katharina
- Dragioti Elena
- Díaz-Caneja Covadonga M.
- Efthymiou Dimitris
- Enrico Paolo
- Errazuriz Antonia
- Estrade Natalia
- Estradé Andrés
- Fan Jialin
- Favaro Angela
- Fiedorowicz Jess
- Firth Joseph
- Fonseca Lais
- Fortea Lydia
- Fullana Miquel A.
- Fusar-Poli Paolo
- Gadelha Ary
- Gaha Lotfi
- Gerdle Björn
- Gerunda Cristiano
- Gonzalez-Peñas Javier
- Gorwood Philip
- Guinart Daniel
- Guu Ta-wei
- Hadi Samira
- Hamilton Jane
- Haque Ariful
- Hasler Gregor
- Heuss Sabina
- Hidalgo-Mazzei Diego
- Hoffmann Sofie Have
- Honciuc Mihaela
- Horodnic Adrian Vasile
- Huber Christian G.
- Ifteni Petru
- Jamei Yasser Abu
- James Bawo
- Janků Karolina
- Javed Afzal
- Jiao Can
- Kahl Kai G.
- Kallivayalil Roy Abraham
- Kamiński Karol
- Kane John
- Kim Minah
- Kishimoto Taishiro
- Kiszkiel Łukasz
- Kitazawa Momoko
- Koutsouleris Nikolaos
- Koyanagi Ai
- Krebs Marie-Odile
- Krinitski Damir
- Kurokawa Shunya
- Kuttichira Praveenlal
- Kwon Jun Soo
- Lee Jinhee
- Lee Tae Young
- Leisch Friedrich
- Llorca Pierre-Michel
- Luiz Jhoanne Merlyn
- López-Jaramillo Carlos
- Machado Ana Inés
- Maes Michael
- Manková Denisa
- Marlicz Maria
- Marlicz Wojciech
- Marx Wolfgang
- Matei Valentin
- Matthews Evan
- Mavridis Dimitris
- Meyer-Lindenberg Andreas
- Mhalla Ahmed
- Millan Mark J.
- Moghadasin Maryam
- Monaco Francesco
- Moniuszko-Malinowska Anna
- Morgado Pedro
- Mosina Anna
- Movina Larisa
- Mugisha James
- Negay Nikolay
- Ng Bernardo
- Nieman Dorien H.
- Nordentoft Merete
- Noyan Onur
- Nurmagambetova Saltanat
- Okasha Tarek
- Oprea Liviu
- Papsuev Oleg
- Parellada Mara
- Pena Edilberto
- Pfennig Andrea
- Polanczyk Guilherme
- Politi Pierluigi
- Rabbani Golam
- Radua Joaquim
- Righi Elena
- Ristic Dragana Ignjatovic
- Roman Raquel
- Rosenbaum Simon
- Rubio Jose
- Rungnirundorn Teerayuth
- Saccon Diego
- Sadeghi Masoud
- Sadeghi-Bahmani Dena
- Samochowiec Jerzy
- Sanchez Thelma
- Sand Michael
- Sartorius Norman
- Scanferla Elisabetta
- Schlögelhofer Monika
- Schneeberger Andres
- Schuch Felipe Barreto
- Seb-Akahomen Omonefe Joy
- Seedat Soraya
- Sehli Jihed
- Sheybani Farshad
- Shin Jae Il
- Skonieczna-Żydecka Karolina
- Solanes Aleix
- Solmi Marco
- Sommer Iris
- Sowa Paweł
- Spies Georgina
- Stubbs Brendon
- Su Kuan-Pin
- Sullivan Sarah
- Sun Ching-Fang
- Supasitthumrong Thitiporn
- Takamiya Akihiro
- Tazawa Yuki
- Teasdale Scott
- Thompson Trevor
- Thygesen Lau Caspar
- Tiihonen Jari
- Tsamakis Konstantinos
- Tunvirachaisakul Chavit
- Turliuc Serban
- Unoka Zsolt
- Valvassori Samira S.
- van Amelsvoort Therese
- van Os Jim
- van Winkel Ruud
- Vancampfort Davy
- Vassilopoulou Emilia
- Vendsborg Per
- Verdolini Norma
- Veronese Nicola
- Vieta Eduard
- von Känel Roland
- Ward Philip
- Weiser Mark
- Wells John
- Winter Sibylle
- Yang Lin
- Yatham Lakshmi N.
- Yu Xin
- Zhang Jieting
- Zoccante Leonardo
- Zou Liye
- Łoniewski Igor
- Publication venue
- Elsevier
- Publication date
- 23/05/2024
- Field of study
International studies measuring wellbeing/multidimensional mental health before/ during the COVID-19 pandemic, including representative samples for >2 years, identifying risk groups and coping strategies are lacking. COH-FIT is an online, international, anonymous survey measuring changes in well-being (WHO-5) and a composite psychopathology P-score, and their associations with COVID-19 deaths/restrictions, 12 a-priori defined risk individual/cumulative factors, and coping strategies during COVID-19 pandemic (26/04/2020-26/06/2022) in 30 languages (representative, weighted non-representative, adults). T-test, χ2, penalized cubic splines, linear regression, correlation analyses were conducted. Analyzing 121,066/142,364 initiated surveys, WHO-5/P-score worsened intra-pandemic by 11.1±21.1/13.2±17.9 points (effect size d=0.50/0.60) (comparable results in representative/weighted non-probability samples). Persons with WHO-5 scores indicative of depression screening (2 years. The most subjectively effective coping strategies were exercise, internet use, social contacts. Identified risk groups, coping strategies and outcome trajectories can inform global public health strategies
Contributory presentations/posters
- Author
- A. A. Tikhomirov
- A. Amadei
- A. Bhattacharya
- A. Bogdanov
- A. C. Campos de Carvalho
- A. C. Mauricio
- A. C. Mauricio
- A. Cole
- A. D. Beniaminov
- A. D. Kaulen
- A. Di Nola
- A. Di Nola
- A. Emanuele
- A. Faraone
- A. G. Degermendzhy
- A. G. Sizykh
- A. G. Tonevitsky
- A. German
- A. Gries
- A. H. Parola
- A. Holzenburg
- A. I. El-Awadi
- A. I. Kuzmenko
- A. Ishino
- A. J. W. G. Visser
- A. J. Wein
- A. Jellali
- A. Johnson
- A. K. Bandyopadhyay
- A. K. Basak
- A. K. Basak
- A. K. Bera
- A. K. Bera
- A. K. Mishra
- A. K. Mishra
- A. K. Pal
- A. K. Pal
- A. K. Sharma
- A. K. Singh
- A. K. Tonkikh
- A. Khachatryan
- A. Kumar
- A. L. Barker
- A. L. Shvaleva
- A. M. Eissa
- A. M. Lynn
- A. M. Rebelo da Costa
- A. N. Antonovich
- A. Nandy
- A. Ongarbaev
- A. Pande
- A. Pramanik
- A. S. Dukhin
- A. S. Ghatpande
- A. Saitoh
- A. Sarai
- A. Sarai
- A. Spisni
- A. Srinivasan
- A. Srintvasan
- A. Surolia
- A. Surolia
- A. Takahashi
- A. Tikhonov
- A. V. Avetisyan
- A. Yayon
- A. Zanina
- Abdalla S. Ahmed
- Abraham H. Parola
- Achintya Das
- Adrian Neagu
- Adrian Neagu
- Adriana Solovicova
- Akira Goto
- Akira R. Kinjo
- Alan J. Waring
- Alberto Furia
- Alex Ninaber
- Alexander A. Yaroslavov
- Alexander V. Chalyi
- Alexandra Dinu
- Alexandra T. Balaban
- Alexandra Zahradniková
- Alexei N. Vasil’ev
- Alexey Surin
- Alfred Pingoud
- Alfredo Di Nola
- Almeida Rodrigo
- Amal K. Bera
- Amita Joshi
- Amitabha Chattopadhyay
- Amitabha Chattopadhyay
- Amy B. Heagle
- Ana Damjanović
- Andrew Badley
- Andrew Thompson
- Andrey V. Krylov
- András Dér
- András Hámori
- András Szilágyi
- Anil K. Singh
- Anil K. Singh
- Anil Kumar
- Anil Saran
- Anirban Ghosh
- Anjana Sen
- Anna Gabrielian
- Annie Morin
- Antonella Bandiera
- Anunay Samanta
- Anurae Varshney
- Anwer Mujeeb
- Araken S. Werneck
- Arghya Ray
- Arghya Ray
- Arijitt Borthakur
- Arima Fukunishi
- Arun Gidwani
- Arvi Freiberg
- Ashesh Nandy
- Ashish Arora
- Ashoke Ranjan Thakur
- Ashoke Ranjan Thakur
- Asok Baneriee
- Asok Baneriee
- Astrid Gräslund
- Astushi Nakagawa
- Atsushi Ohnishi
- Atta Ahmad
- Atta Ahmad
- Atta Ahmad
- Avadhesha Surolia
- Ayumu Saito
- B. -L. Johansson
- B. A. Feniouk
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- Vikas Chandra
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- Vinod Bhakuni
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- Vivian Stojanoff
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- Wang Bao Han
- Wang Jushuo
- Wang Zhi Xin
- Wei-ying Cheng
- Wen-rui Chang
- Werner Kühlbrandt
- William A. Eaton
- Wolfgang Höhne
- Wolfgang Jahnke
- Wolfgang Wende
- Xiao-jian Hu
- Xun Shen
- Y-M. Zheng
- Y. -H. Sanejouand
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- Y. Kishimoto
- Y. Kyogoku
- Y. Lin
- Y. M. Allakhverdieva
- Y. Nakato
- Y. Pesotskaya
- Y. Rubin
- Y. Shibata
- Y. Suezaki
- Y. U. Sasidhar
- Ya. I. Estrin
- Yasuhiro Kumaki
- Yasunori Yokoyama
- Yogesh Kumar
- Yoichi Hayakawa
- Yoichiro Ito
- Yoshihiro Kobashigawa
- Yoshitoshi
- Yoshiyuki Amemiya
- Yosiyuki Sowa
- Yu. Babayan
- Yu. P. Blagoy
- Yu. P. Chukova
- Yu. S. Babayan
- Yuan Zheng
- Yuji Kimura
- Yuki Fukuoka
- Yuki Nakagawa
- Yuling Yan
- Yuri Mukai
- Yuri Mukai
- Yuri N. Antonenko
- Yuriko Yamagata
- Yuriko Yamagata
- Yusuke Iguchi
- Yuzuru Husimi
- Yves Blouquit
- Z. B. Li
- Z. Combos
- Z. Cseh
- Z. Földes-Papp
- Z. Gombos
- Z. Guttenberg
- Z. Lobo
- Z. S. Várkonyi
- Z. Stolič
- Z. Tronteli
- Zeno Földes-Papp
- Zhao Nanming
- Zhi-hong Zhang
- Zs. Várkonyi
- Zvi Priel
- Á. Bódi
- Éric Quinjou
- Ü. Mets
- Č. N. Radenović
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Transverse momentum and pseudorapidity distributions of charged hadrons in pp collisions at (s) = 0.9 and 2.36 TeV
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Acosta Darin
- Acosta Jhon Gabriel
- Actis Oxana
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Agapitos Antonis
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Muhammad
- Ahmad Wael Haj
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alexander James
- Aliev Takhmasib
- Allfrey Philip
- Almeida Nuno
- Altsybeev Igor
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Ambroglini Filippo
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Yuri
- Andres Carrillo Montoya Camilo
- Andres Ocampo Rios Alberto
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Asaadi Jonathan
- Asghar Muhammad Irfan
- Askew Andrew
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Aumeyr Thomas
- Autermann Christian
- Avery Paul
- Avetisyan Aram
- Ayhan Aydin
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ballin Jamie
- Ban Yong
- Bandurin Dmitry
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Banzuzi Kukka
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Barfuss Anne-fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
- Bauer Gerry
- Bauer Julia
- Bauerdick Lothar A.T.
- Baumgartel Darin
- Baur Ulrich
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beccati Barbara
- Bedjidian Marc
- Behrens Ulf
- Belforte Stefano
- Beliy Nikita
- Bell Alan James
- Bell Ken W.
- Bell Peter
- Bellan Paolo
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- Bellinger James Nugent
- Belotelov Ivan
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Bender Walter
- Benedetti Daniele
- Benelli Gabriele
- Beni Noemi
- Benucci Leonardo
- Beretvas Andrew
- Bergauer Thomas
- Beri Suman Bala
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Berzano Umberto
- Besancon Marc
- Besson Auguste
- Betchart Burton
- Betts Russell Richard
- Beuselinck Raymond
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialas Wojciech
- Biallass Philipp
- Bianchini Lorenzo
- Bianco Stefano
- Biasini Maurizio
- Biasotto Massimo
- Biino Cristina
- Bilei Gian Mario
- Bilki Burak
- Bilmis Selcuk
- Binkley Morris
- Biselli Angela
- Bitioukov Sergei
- Blekman Freya
- Bloch Daniel
- Bloch Ingo
- Bloch Philippe
- Bloom Kenneth
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- Blume Michael
- Blumenfeld Barry
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- Boutemeur Madjid
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- Breedon Richard
- Breuker Horst
- Brew Christopher
- Brigljevic Vuko
- Broccolo Giuseppe
- Brom Jean-Marie
- Brooke James John
- Broutin Clementine
- Brown Robert M.
- Brownson Eric
- Brun Hugues
- Bruno Giacomo
- Buchmuller Oliver
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- De Almeida Dias Flavia
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- Diaz Merino Irma
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- Lyons Louis
- Ma Teng
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- MacEvoy Barry C.
- Mackay Catherine Kirsty
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- Neumeister Norbert
- Newbold Dave M.
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- Newman-Holmes Catherine
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- Re Daniele Del
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- Rovelli Chiara
- Rovelli Tiziano
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- Ruchti Randy
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- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoon Sungho
- York Andrew
- Yumiceva Francisco
- Yun Jae Chul
- Zabi Alexandre
- Zachariadou Aikaterini
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatzerklyaniy Andriy
- Zeidler Clemens
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zinonos Zinonas
- Zito Giuseppe
- Zoeller Marc Henning
- Zotto Pierluigi
- Zuranski Andrzej
- Publication venue
- Publication date
- 04/02/2010
- Field of study
Measurements of inclusive charged-hadron transverse-momentum and pseudorapidity distributions are presented for proton-proton collisions at sqrt(s) = 0.9 and 2.36 TeV. The data were collected with the CMS detector during the LHC commissioning in December 2009. For non-single-diffractive interactions, the average charged-hadron transverse momentum is measured to be 0.46 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 0.9 TeV and 0.50 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 2.36 TeV, for pseudorapidities between -2.4 and +2.4. At these energies, the measured pseudorapidity densities in the central region, dN(charged)/d(eta) for |eta| < 0.5, are 3.48 +/- 0.02 (stat.) +/- 0.13 (syst.) and 4.47 +/- 0.04 (stat.) +/- 0.16 (syst.), respectively. The results at 0.9 TeV are in agreement with previous measurements and confirm the expectation of near equal hadron production in p-pbar and pp collisions. The results at 2.36 TeV represent the highest-energy measurements at a particle collider to date
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at s = 7 TeV
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Actis Oxana
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alexander James
- Aliev Takhmasib
- Allfrey Philip
- Almeida Nuno
- Altsybeev Igor
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Ambroglini Filippo
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Asaadi Jonathan
- Asghar Muhammad Irfan
- Askew Andrew
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Aumeyr Thomas
- Autermann Christian
- Avery Paul
- Avetisyan Aram
- Ayhan Aydin
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ballin Jamie
- Ban Yong
- Bandurin Dmitry
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
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- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
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- Reyes-Santos Marco A.
- Rhee Han-Bum
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- Shepherd-Themistocleous Claire
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- Xiao Hong
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- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoon Sungho
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- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatzerklyaniy Andriy
- Zeidler Clemens
- Zeinali Maryam
- Zeise Manuel
- Zennamo Joseph
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zinonos Zinonas
- Zito Giuseppe
- Zoeller Marc Henning
- Zorbilmez Caglar
- Zumerle Gianni
- Zuranski Andrzej
- Önengüt Gülsen
- Özbek Melih
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 19/05/2010
- Field of study
Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at s=7~TeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit-pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity \dnchdeta|_{|\eta| < 0.5} = 5.78\pm 0.01\stat\pm 0.23\syst for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from s=0.9 to 7~TeV is 66.1\%\pm 1.0\%\stat\pm 4.2\%\syst. The mean transverse momentum is measured to be 0.545\pm 0.005\stat\pm 0.015\syst\GeVc. The results are compared with similar measurements at lower energies.Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at sqrt(s) = 7 TeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit-pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity, dN(charged)/d(eta), for |eta| < 0.5, of 5.78 +/- 0.01 (stat) +/- 0.23 (syst) for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from sqrt(s) = 0.9 to 7 TeV is 66.1% +/- 1.0% (stat) +/- 4.2% (syst). The mean transverse momentum is measured to be 0.545 +/- 0.005 (stat) +/- 0.015 (syst) GeV/c. The results are compared with similar measurements at lower energies
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