10 research outputs found
Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension
- Author
- Acary Souza Bulle Oliveira
- Adam Hart
- Adife Veske
- Aditya Kumar
- Aikaterini Dimitriou
- Akihiro Mukaino
- Akiko Kanzaki
- Akiyuki Uzawa
- Akshay Shah
- Alan Ross Berger
- Albert Hietala
- Alberta Locatelli
- Alejandra Dalila Garcia
- Alejandro Tobon Gonzalez
- Alessandro Filla
- Alex Fondaw
- Alexandre Guerreiro
- Alexandre Guerreiro
- Ali Malekniazi
- Aline de Cassia Santos
- Alzira Alves de Siqueira Carvalho
- Amaiak Chilingaryan
- Amanda Anderson
- Amelia Evoli
- Amna Shah
- Amy Saklad
- Amy Woodall
- Ana Carolina Amaral de Andrade
- Ana Lazaro
- Ana Paula Macagnan
- Ana Paula Melo
- Andrea Corse
- Andrea Kelley
- Andrea Swenson
- Angela Ardoin
- Angela Campanella
- Angela Marsili
- Angela Micheels
- Angiola Fasanaro
- Anh Tran
- Anita Mogensen
- Ann D'Hont
- Anna Gonzalez
- Anne Cooley
- Anne Mette Ostergaard Autzen
- Anneke van der Kooi
- Annelies Depreitere
- Annelies Vanhee
- Anthony Amato
- Antonella Di Pasquale
- Antonella Di Pasquale
- April McVey
- Arshira Seddigh
- Arzu Meherremova
- Ashley Mallon
- Aya Mizugami
- Ayse Kutlu
- Baki Dogan
- Barbara Lokaitis
- Barbora Kurkova
- Bengu Balkan
- Benison Keung
- Benjamin Brooks
- Beth DiSanzo
- Betsy Mosmiller
- Booth H. D. E.
- Brajesh Agrawal
- Brian Droker
- Brian Minton
- Brigitta Szabadosne
- Brittany Harvey
- Bruno Bezerra Rosa
- Bryan Kim
- Byoung Joon Kim
- Byung-Jo Kim
- Can Ebru Bekircan-Kurt
- Cansu Semiz
- Carlo Antozzi
- Carlos Casasnovas
- Carol Herbert
- Carolina Miranda
- Caroline Schotte
- Cecile Phan
- Celal Tuga
- Chae Won Shin
- Chafic Karam
- Chafic Karam
- Chang Nyoung Lee
- Charlene Hafer-Macko
- Charlotte Smetcoren
- Christian Homedes-Pedret
- Christopher Nance
- Claire Brown
- Clara Schommer
- Claudio Gabriel Mazia
- Colleen Pineda
- Craig Donahue
- Cristiani Fernanda Butinhao
- Csilla Rozsa
- Cynthia Bodkin
- Cynthia Carter
- Da Yoon Koh
- Dae Lim Koo
- Dai Matsuse
- Daiane da Cruz Pacheco
- Daisuke Yamamoto
- Dallas Forshew
- Daniel Ambrosio
- Daniel Dicapua
- Danielle Sheldon
- Dave Watling
- David Feder
- Debbie Davies
- Debora Dada Martineli Torres
- Dennis Jeffery
- Derrick Blackmore
- Diana Dimitrova
- Diego Lopergolo
- Donna Carnes
- Doreen Ho
- Délphine Mahieu
- Edina Varga
- Elaine Weiner
- Elena Bravver
- Elena Cortes Vicente
- Elena Giacomelli
- Eliana Reyes
- Elisabet Arribas-Ibar
- Elizabeth Watt
- Emanuela Onesti
- Emiko Tsuda
- Enrico Marano
- Eri Kobayashi
- Erica Nogueira Coelho
- Eriko Higuchi
- Eriko Miyawaki
- Eun Bi Hwang
- Eun Bin Cho
- Eun Haw Choi
- Exuperio Diez Tejedor
- Ezgi Yilmaz
- Fabio Barroso
- Faisal Sohail
- Fatima Maqsood
- Fernanda Carrara
- Fernanda Troili
- Filiz Muharrem
- Fiona Norwood
- Floyd Jones
- Francesco Saccà
- Francisco Javier Rodriguez de Rivera
- Frank Lin
- Fredrik Piehl
- Fujita K. P.
- Fumie Meguro
- Gabor Lovas
- Gabor Lovasamela César
- Gabriel Paiva
- Gabrielle Rico
- Gal Maier
- Gedeonne Jakab
- Gedeonne Jakab
- Giannis Sokratous
- Giorgia Camera
- Giorgia Puorro
- Giovanni Antonini
- Girija Sadalage
- Gisela Gili
- Gonzalo Mazuela
- Gonzalo Vidal
- Graziela Pinto
- Gulmohor Roy
- Gulsah Becerikli
- Gulsah Orsel
- Gustavo Duran
- Guy Van den Abeele
- Gyorgyi Szabo
- H James Jones
- Ha Young Shin
- Ha-Neul Jeong
- Hakan Cavus
- Harpreet Kaur
- Heena Olalde
- Heike Arndt
- Henning Andersen
- Henrique Mohr
- Hidekazu Suzuki
- Hirokazu Shiraishi
- Hiroyuki Murai
- Hisako Kobayashi
- Hong Vu
- Hoo Nam Kang
- Howard J. F.
- Hui Gong
- Huned Patwa
- Hung Youl Seok
- Husnu Efendi
- HyeJin Ra
- HyeLim Lee
- Hyung Seok Lee
- Iandra Souza
- Igor Dias Brockhausen
- Ihsan Sengun
- Ikuko Kamegamori
- Ikuko Yasuda
- Irene Yang
- Isabel Illa
- Ivana Jurajdova
- Iveta Novakova
- Jaana Eriksson
- Jae-Sung Lim
- Jaimin Shah
- Jakit Gollogly
- James Gilchrist
- Jan De Bleecker
- Jan Vynckier
- Jana Junkerova
- Jane Distad
- Jane Pedersen
- Janice Massey
- Jasmine Hewlett
- Jaya Trivedi
- Jayashri Srinivasan
- Jeffery Statland
- Jeffrey Guptill
- Jeffrey Narayan
- Jeffrey Rosenfeld
- Jenna Seelbach
- Jeri Sieren
- Jerry Locheke
- Ji Ye Hwang
- JiEun Lee
- Jinmyoung Seok
- JinWoo Jung
- Jiri Pitha
- Joan Højgaard
- Joan Nye
- Joanne Nemeth
- John Kincaid
- John Kissel
- John Loor
- John Vissing
- Jonathan Katz
- Jonathan McKinnon
- Jordan Jara
- Jordana Gonçalves Geraldo
- Jordi Diaz-Manera
- Josef Bednarik
- Josep Gamez Carbonell
- Joseph Chad Hoyle
- Ju-Hong Min
- Judit Matolcsi
- Juha-Pekka Erälinna
- Julie Agriesti
- Julie Khoury
- Julie Steele
- Juliet Saba
- Jun Kawamata
- Justin Kwan
- JuYoung Kwon
- Kaitlyn McKenna
- Kaori Osakada
- Kaori Uwasa
- Kara Patrick
- Karan Alcon
- Karen Callison
- Karen Zakalik
- Katarina Reguliova
- Kate Beck
- Katherine Amato
- Kathryn Johns
- Kathy de Koning
- Katrien De Mey
- Katsuhisa Masaki
- Kazumi Futono
- Kazumi Takada
- Keiko Kikutake
- Kelley Emmons
- Kendrick Henderson
- Kenichi Tsukita
- Kenkichi Nozaki
- Kerry Naunton
- Kevin Daniels
- Khema Sharma
- Kimberly Robeson
- Kimiaki Utsugisawa
- Koichi Narikawa
- Krishna Polaka
- Kristen Roe
- Kristin Huynh
- Lara Katzin
- Laszlo Vecsei
- Laura Diez Porras
- Laura Echevarria
- Laura Fionda
- Laura Fionda
- Laura Golden
- Laura Haar
- Laura Herbelin
- Lauren Wheeler
- Laurie Gutmann
- Lena Bjarbo
- Lesly Welsh
- Liang Lu
- Liene Duarte Silva
- Linda Wagemaekers
- Lindsay Zilliox
- Lisa Hobson-Webb
- Lisa Smith
- Livia Dezsi
- Lorenzo Maggi
- Lorraine Dishman
- Lotte Vinge
- Louisa Mezache
- Lucas Eduardo Pazetto
- Luciana Ferreira
- Luciana Renata Cubas Volpe
- Luciana Souza Duca
- Ludwig Gutmann
- Luis Antonio Querol Gutiérrez
- Luiz Augusto da Silva
- Luiz Otavio Maia Gonçalves
- Maeda Yasuko
- Magda Chmelikova
- Maki Jingu
- Makoto Samukawa
- Mamatha Pasnoor
- Manisha Chopra
- Mantegazza R.
- Marcela Silva
- Marcela Wolfova
- Marcelo Annes
- Marcelo Chaves
- Marcelo Rugiero
- Marek Cierny
- Marguerite Engel
- Maria Antonia Alberti Aguilo
- Maria da Penha Ananias Morita
- Maria Gabriele
- Maria Gori
- Maria Pasanisi
- Maria Salvado Figueras
- Maria Sastre
- Marianne de Visser
- Mariela Bettini
- Marina Pozo
- Martin Bilsker
- Mary Varghese
- Maryanne Burdette
- Masahiro Mori
- Masakatsu Motomura
- Masaki Saitoh
- Masako Tsurumaru
- Masanori Takahashi
- Masayuki Nakamori
- Matteo Garibaldi
- Maureen Walsh
- Maurer Pereira Martins
- Maurizio Inghilleri
- Maurício AndréGheller Friedrich
- Mayuko Noshiro
- Mazen Dimachkie
- Megan Kramer
- Megumi Koga
- Meinoshin Okumura
- Melanie Glenn
- Melinda Horvath
- Michael Benatar
- Michael Hehir
- Michael Pulley
- Michael Weiss
- Michaela Tyblova
- Michal Vytopil
- Miguel Wilken
- Mihoko Takada
- Miju Shin
- Mikko Laaksonen
- Mireya Fernandez-Fournier
- Mireya Fernandez-Fournier
- Miri Kim
- Miriam Freimer
- Misa Shimpo
- MiSong Choi
- Miwako Sato
- Miyuki Morikawa
- Mohamed Kazamel
- Mohamed Mahdi-Rogers
- Mohammad Alsharabati
- Mohammed Salajegheh
- Mohammed Sanjak
- Mollie Vanderhook
- Mona Elsayed
- Monika Konyane
- Muppidi S.
- Murat Terzi
- Murilo Santos Engel
- Musa Kazim Onar
- Muzeyyen Ugur
- Nadia Sattar
- Namie Taichi
- Namita Goyal
- Nanna Witting
- Naoki Kawaguchi
- Naoko Ishiyama
- Natalia Julia Palacios
- Natalia Prando
- Natália Assis
- Naya McKinnon
- Nazire Pinar Acar
- Neelam Goyal
- Nicholas Silvestri
- Nicholas Ventura
- Nicolas Vandenbussche
- Nicole Jenci
- Nicole Kressin
- Nivedita Jerath
- Nuria Vidal
- O'Brien F. L.
- Ohito Tano
- Olga Zapletalova
- Olivier Stevens
- Olli Oksaranta
- Ozlem Tun
- Paolo Emilio Alboini
- Patricia Padilla
- Patrícia Fernandes
- Pedro Lopez Ruiz
- Petra Tilkin
- Philip Van Damme
- Pilar Gomez Salcedo
- Pilar Sune
- Pinar Ozcelik
- Pravin Torane
- Pravin Torane
- Raffaele Iorio
- Ratna Bhavaraju-Sanka
- Rebecca Traub
- Rebekah Garcia
- Rekha Pillai
- Renata Martins Ribeiro
- Ricardo Rojas Garcia
- Richard Barohn
- Richard Nowak
- Rikako Kurihara
- Rikki Roderus
- Riley Snook
- Robert Miller
- Robert Pascuzzi
- Rosana Rocha
- Rudy Mercelis
- Rumi Takeyama
- Rup Tandan
- Sabrina Pol
- Sachiko Kamakura
- Said Beydoun
- Saiju Jacob
- Salma Akhter
- Sanaz Karimi
- Sandi Mumfrey-Thomas
- Sandra Guingrich
- SangAe Park
- Sara-Claude Michon
- Sarada Sakamuri
- Sarah Plevka
- Sarah Verjans
- Scott Cunningham
- Seda Aydinlik
- Sedat Sen
- Seiko Yoshida
- Seung Min Kim
- Sevim Erdem-Ozdamar
- Shachie Aranke
- Shannon Lucy
- Sharmeen Alam
- Sharon Chelnick
- Sharon Downing
- Sharon Nations
- Shin Hisahara
- Shirley Paulose
- Shirli Toska
- Shizuka Asada
- Shoko Amamoto
- Shuichiro Suzuki
- Shun Shimohama
- Shun Shimohama
- Shunsuke Yoshimura
- Sien Van Daele
- Silvia Bonanno
- Sivakumar Sathasivam
- So-Hyun Ahn
- Soichiro Funaka
- Sonia Garcia
- Stanislav Vohanka
- Stanislava Toncrova
- Stefania Morino
- Stephanie Kohlrus
- Stephanie Scala
- Steve Hopkins
- Susan Strom
- Susanne Krogh
- Tahseen Mozaffar
- Taira Uehara
- Takashi Hayashi
- Takashi Murahara
- Takuya Matsushita
- Tamar Gibson
- Tamires Cristina Gomes da Silva
- Taylor Darnell
- Teiichiro Miyazaki
- Teresa Costabile
- Terry McClain
- Terry McClain
- Tessa Marburger
- Tetsuya Akiyama
- Tetsuya Kanai
- Thabata Veiga
- Thomas Arnold
- Thomas Cochrane
- Thomas Harbo
- Tierney Scott
- Tina Liu
- Tiyonnoh Cash
- Tomihiro Imai
- Tomihiro Imai
- Tomohiro Kawamura
- Tomoko Tsuda
- Tomomi Kobashikawa
- Tomoya Hasuike
- Tomás Augusto Suriane Fialho
- Tuan Vu
- Tugce Kirbas Cavdar
- Tulio Bertorini
- Tuula Harrison
- Valentina D'Amato
- Valentina Velez Santamaria
- Valeria Cavalcante Lino
- Valerie Young
- Veena Mathew
- Vern Juel
- Victor Doan
- Vinay Chaudhry
- Vittorio Frasca
- Vittorio Frasca
- Waqar Waheed
- Wiendl H.
- Wladimir Pinto
- Wolfe G. I.
- Yagmur Caliskan
- Yasmeen Shabbir
- Yasmeen Shabbir
- Yasushi Suzuki
- Ye Liu
- Yoko Ishiyama
- Yoko Kaneko
- Yong Seo Koo
- Yool-Hee Kim
- Yoon-Ho Hong
- Yoshiko Sano
- Yuen T So
- Yuka Saito
- Yukiko Ozawa
- Yuko Fujii
- Yumi Yamashita
- Yumiko Nakamura
- Yunxia Wang
- Yuriko Nagane
- Yusuke Fukuda
- Zaeem Siddiqi
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo
Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab
- Author
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Andoin Angela
- André Gheller Friedrich Maurício
- Annes Marcelo
- Antonia Alberti Aguilo Maria
- Antonini Giovanni
- Antonio Querol Gutiérrez Luis
- Antozzi Carlo
- Aranke Shachie
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis Natália
- Augusto da Silva Luiz
- Augusto Suriane Fialho Tomás
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard
- Barroso Fabio
- Becerikli Gulsah
- Beck Kate
- Bednarik Josef
- Benatar Michael
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bi Hwang Eun
- Bilsker Martin
- Bin Cho Eun
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carolina Amaral de Andrade Ana
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chad Hoyle Joseph
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cristina Gomes da Silva Tamires
- Cunningham Scott
- César Pamela
- D'Amato Valentina
- D'Hont Ann
- da Cruz Pacheco Daiane
- da Penha Ananias Morita Maria
- Dada Martineli Torres Debora
- Dalila Garcia Alejandra
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- De Bleecker Jan
- de Cassia Santos Aline
- de Koning Kathy
- De Mey Katrien
- de Visser Marianne
- Depreitere Annelies
- Dezsi Livia
- Di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duarte Silva Liene
- Duran Gustavo
- Ebru Bekircan-Kurt Can
- Echevarria Laura
- Eduardo Pazetto Lucas
- Efendi Husnu
- Elsayed Mona
- Emilio Alboini Paolo
- Emmons Kelley
- Engel Marguerite
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- Erälinna Juha-Pekka
- Evoli Amelia
- Fasanaro Angiola
- Feder David
- Fernanda Butinhao Cristiani
- Fernandes Patrícia
- Fernandez-Fournier Mireya
- Fernandez-Fournier Mireya
- Ferreira Luciana
- Filla Alessandro
- Fionda Laura
- Fionda Laura
- Fondaw Alex
- Forshew Dallas
- Frasca Vittorio
- Frasca Vittorio
- Freimer Miriam
- Fujii Yuko
- Fukuda Yusuke
- Funaka Soichiro
- Futono Kazumi
- Gabriel Mazia Claudio
- Gabriele Maria
- Gamez Carbonell Josep
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gili Gisela
- Glenn Melanie
- Golden Laura
- Gollogly Jakit
- Gomez Salcedo Pilar
- Gong Hui
- Gonzalez Anna
- Gonçalves Geraldo Jordana
- Gori Maria Cristina
- Goyal Namita
- Goyal Neelam
- Guerreiro Alexandre
- Guinrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Haar Laura
- Hafer-Macko Charlene
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Harvey Brittany
- Hasuike Tomoya
- Haw Choi Eun
- Hayashi Takashi
- Hehir Michael
- Henderson Kendrick
- Herbelin Laura
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Ho Doreen
- Hobson-Webb Lisa
- Homedes-Pedret Christian
- Hong Yoon-Ho
- Hopkins Steve
- Horvath Melinda
- Howard Jr James
- Huynh Kristin
- Højgaard Joan
- Illa Isabel
- Imai Tomihiro
- Imai Tomihiro
- Inghilleri Maurizio
- Iorio Raffaele
- Ishiyama Naoko
- Ishiyama Yoko
- Jacob Saiju
- Jakab Gedeonne
- James Jones H
- Jara Jordan
- Javier Rodriguez de Rivera Francisco
- Jeffery Dennis
- Jenci Nicole
- Jeong Ha-Neul
- Jerath Nivedita
- Jingu Maki
- Johns Kathryn
- Jones Floyd
- Joon Kim Byoung
- Juel Vern
- Julia Palacios Natalia
- Jung JinWoo
- Junkerova Barbora Kurkova Jana
- Jurajdova Ivana
- Kamakura Sachiko
- Kamegamori Ikuko
- Kanai Tetsuya
- Kaneko Yoko
- Kanzaki Akiko
- Karam Chafic
- Karam Chafic
- Karimi Sanaz
- Katz Jonathan
- Katzin Lara
- Kaur Harpreet
- Kawaguchi Naoki
- Kawamata Jun
- Kawamura Tomohiro
- Kazamel Mohamed
- Kazim Onar Musa
- Kelley Andrea
- Keung Benison
- Khoury Julie
- Kikutake Keiko
- Kim Bryan
- Kim Byung-Jo
- Kim Miri
- Kim Yool-Hee
- Kincaid John
- Kirbas Cavdar Tugce
- Kissel John
- Kobashikawa Tomomi
- Kobayashi Eri
- Kobayashi Hisako
- Koga Megumi
- Kohlrus Stephanie
- Konyane Monika
- Kramer Megan
- Kressin Nicole
- Krogh Susanne
- Kumar Aditya
- Kurihara Rikako
- Kutlu Ayse
- Kwan Justin
- Kwon JuYoung
- Laaksonen Mikko
- Lazaro Ana
- Lee HyeLim
- Lee JiEun
- Lim Koo Dae
- Lim Jae-Sung
- Lin Frank
- Liu Tina
- Liu Ye
- Locatelli Alberta
- Locheke Jerry
- Lokaitis Barbara
- Loor John
- Lopergolo Diego
- Lopez Ruiz Pedro
- Lovas Gabor
- Lu Liang
- Lucy Shannon
- Maeda Yasuko
- Maggi Lorenzo
- Mahdi-Rogers Mohamed
- Mahieu Délphine
- Maier Gal
- Makamori Masayuki
- Malekniazi Ali
- Mallon Ashley
- Mantegazza Renato
- Maqsood Fatima
- Marano Enrico
- Marburger Tessa
- Marsili Angela
- Martins Ribeiro Renata
- Masaki Katsuhisa
- Massey Janice
- Mathew Veena
- Matolcsi Judit
- Matsuse Dai
- Matsushita Takuya
- Mazuela Gonzalo
- McClain Terry
- McClain Terry
- McKenna Kaitlyn
- McKinnon Jonathan
- McKinnon Naya
- McVey April
- Meguro Fumie
- Meherremova Arzu
- Mercelis Rudy
- Mette Ostergaard Autzen Anne
- Mezache Louisa
- Micheels Angela
- Michon Sara-Claude
- Miller Robert
- Min Kim Seung
- Min Ju-Hong
- Minton Brian
- Miranda Carolina
- Mitazaki Teiichiro
- Miyawaki Eriko
- Mizugami Aya
- Mogensen Anita
- Mohr Henrique
- Mori Masahiro
- Morikawa Miyuki
- Morino Stefania
- Mosmiller Betsy
- Motomura Masakatsu
- Mozaffar Tahseen
- Muharrem Filiz
- Mukaino Akihiro
- Mumfrey-Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Nagane Yuriko
- Nakamura Yumiko
- Nam Kang Hoo
- Nance Christopher
- Narayan Jeffrey
- Narikawa Koichi
- Nations Sharon
- Naunton Kerry
- Nemeth Joanne
- Nogueira Coelho Erica
- Norwood Fiona
- Noshiro Mayuko
- Novakova Iveta
- Nowak Richard
- Nozaki Kenkichi
- Nye Joan
- Nyoung Lee Chang
- Oksaranta Olli
- Okumura Meinoshin
- Olalde Heena
- Onesti Emanuela
- Orsel Gulsah
- Osakada Kaori
- Otavio Maia Gonçalves Luiz
- Ozawa Yukiko
- Ozcelik Pinar
- Padilla Patricia
- Paiva Gabriel
- Park SangAe
- Pasanisi Maria
- Pascuzzi Robert
- Pasnoor Mamatha
- Patrick Kara
- Patwa Huned
- Paula Macagnan Ana
- Paula Melo Ana
- Paulose Shirley
- Pedersen Jane
- Pereira Martins Maurer
- Phan Cecile
- Piehl Fredrik
- Pillai Rekha
- Pinar Acar Nazire
- Pineda Colleen
- Pinto Graziela
- Pinto Wladimir
- Pitha Jiri
- Plevka Sarah
- Pol Sabrina
- Polaka Krishna
- Pozo Marina
- Prando Natalia
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- Pulley Michael
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- Ra HyeJin
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- Robeson Kimberly
- Rocha Rosana
- Roderus Rikki
- Roe Kristen
- Rojas Garcia Ricardo
- Rosenfeld Jeffrey
- Ross Berger Alan
- Roy Gulmohor
- Rozsa Csilla
- Rugiero Marcelo
- Saba Juliet
- Saccà Francesco
- Sadalage Girija
- Saito Yuka
- Saitoh Masaki
- Sakamuri Sarada
- Saklad Amy
- Salajegheh Mohammed
- Salvado Figueras Maria
- Samukawa Makoto
- Sanjak Mohammad
- Sanjak Mohammed
- Sano Yoshiko
- Santos Engel Murilo
- Sastre Maria
- Sathasivam Sivakumar
- Sato Miwako
- Sattar Nadia
- Scala Stephanie
- Schommer Clara
- Schotte Caroline
- Seddigh Arshira
- Seelbach Jenna
- Semiz Cansu
- Sen Sedat
- Sengun Ihsan
- Seo Koo Yong
- Seok Lee Hyung
- Seok Jinmyoung
- Shabbir Yasmeen
- Shabbir Yasmeen
- Shah Akshay
- Shah Amna
- Shah Jaimin
- Sharma Khema
- Sheldon Danielle
- Shimohama Shun
- Shimohama Shun
- Shimpo Misa
- Shin Miju
- Shiraishi Hirokazu
- Siddiqi Zaeem
- Sieren Jeri
- Silva Marcela
- Silvestri Nicholas
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- Sohail Faisal
- Sokratous Giannis
- Souza Bulle Oliveira Acary
- Souza Duca Luciana
- Souza Iandra
- Srinivasan Jayashri
- Statland Jeffery
- Steele Julie
- Stevens Olivier
- Strom Susan
- Sub-Investigators
- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- T So Yuen
- Taichi Namie
- Takada Kazumi
- Takada Mihoko
- Takahashi Masanori
- Takeyama Rumi
- Tandan Rup
- Tano Ohito
- Terzi Murat
- Tilkin Petra
- Tinerney Scott
- Tobon Gonzalez Alejandro
- Toncrova Stanislava
- Torane Pravin
- Toska Shirli
- Tran Anh
- Traub Rebecca
- Trivedi Jaya
- Troili Fernanda
- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tsurumaru Masako
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uwasa Kaori
- Uzawa Akiyuki
- Van Daele Sien
- Van Damme Philip
- Van den Abeele Guy
- van der Kooi Anneke
- Vandenbussche Nicolas
- Vanderhook Mollie
- Vanhee Annelies
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Velez Santamaria Valentina
- Ventura Nicholas
- Verjans Sarah
- Veske Adife
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Vissing John
- Vohanka Stanislav
- Vu Hong
- Vu Tuan
- Vynckier Jan
- Vytopil Michael
- Wagemaekers Linda
- Waheed Waqar
- Walsh Maureen
- Wang Yunxia
- Watling Dave
- Watt Elizabeth
- Weiner Elaine
- Weiss Michael
- Welsh Lesly
- Wheeler Lauren
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Won Shin Chae
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Ye Hwang Ji
- Yilmaz Ezgi
- Yoon Koh Da
- Yoshida Seiko
- Yoshida Seiko
- Yoshimura Shunsuke
- Youl Seok Hung
- Young Shin Ha
- Young Valerie
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension
Consistent improvement with eculizumab across muscle groups in myasthenia gravis
- Author
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amaral de Andrade Ana Carolina
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Annes Marcelo
- Antonia Alberti Aguilo Maria
- Antonini Giovanni
- Antonio Querol Gutiérrez Luis
- Antozzi Carlo
- Aranke Shachie
- Ardoin Angela
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis Natália
- Augusto da Silva Luiz
- Augusto Suriane Fialho Tomás
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard
- Barroso Fabio
- Becerikli Gulsah
- Beck Kate
- Bednarik Josef
- Bekircan-Kurt Can Ebru
- Benatar Michael
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bi Hwang Eun
- Bilsker Martin
- Bin Cho Eun
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chad Hoyle Joseph
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cunningham Scott
- César Pamela
- da Cruz Pacheco Daiane
- da Penha Ananias Morita Maria
- Dalila Garcia Alejandra
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- de Bleecker Jan
- de Cassia Santos Aline
- de Koning Kathy
- de Mey Katrien
- de Visser Marianne
- Depreitere Annelies
- Dezsi Livia
- di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duarte Silva Liene
- Duran Gustavo
- D’Amato Valentina
- D’Hont Ann
- Echevarria Laura
- Eduardo Pazetto Lucas
- Efendi Husnu
- Elsayed Mona
- Emilio Alboini Paolo
- Emmons Kelley
- Engel Marguerite
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- Erälinna Juha-Pekka
- Evoli Amelia
- Fasanaro Angiola
- Feder David
- Fernanda Butinhao Cristiani
- Fernandes Patrícia
- Fernandez-Fournier Mireya
- Fernandez-Fournier Mireya
- Ferreira Luciana
- Filla Alessandro
- Fionda Laura
- Fionda Laura
- Fondaw Alex
- Forshew Dallas
- Frasca Vittorio
- Frasca Vittorio
- Freimer Miriam
- Friedrich Maurício André Gheller
- Fujii Yuko
- Fukuda Yusuke
- Funaka Soichiro
- Futono Kazumi
- Gabriel Mazia Claudio
- Gabriele Maria
- Gamez Carbonell Josep
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gili Gisela
- Glenn Melanie
- Golden Laura
- Gollogly Jakit
- Gomes da Silva Tamires Cristina
- Gomez Salcedo Pilar
- Gong Hui
- Gonzalez Anna
- Gonçalves Geraldo Jordana
- Gonçalves Luiz Otavio Maia
- Gori Maria
- Goyal Namita
- Goyal Neelam
- Guerreiro Alexandre
- Guingrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Haar Laura
- Hafer-Macko Charlene
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Harvey Brittany
- Hasuike Tomoya
- Haw Choi Eun
- Hayashi Takashi
- Hehir Michael
- Henderson Kendrick
- Herbelin Laura
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Ho Doreen
- Hobson-Webb Lisa
- Homedes-Pedret Christian
- Hong Yoon-Ho
- Hopkins Steve
- Horvath Melinda
- Howard James F.
- Huynh Kristin
- Højgaard Joan
- Illa Isabel
- Imai Tomihiro
- Imai Tomihiro
- Inghilleri Maurizio
- Iorio Raffaele
- Ishiyama Naoko
- Ishiyama Yoko
- Jacob Saiju
- Jakab Gedeonne
- James Jones H.
- Jara Jordan
- Jeffery Dennis
- Jenci Nicole
- Jeong Ha-Neul
- Jerath Nivedita
- Jingu Maki
- Johns Kathryn
- Jones Floyd
- Joon Kim Byoung
- Juel Vern
- Julia Palacios Natalia
- Jung JinWoo
- Junkerova Jana
- Jurajdova Ivana
- Kamakura Sachiko
- Kamegamori Ikuko
- Kanai Tetsuya
- Kaneko Yoko
- Kanzaki Akiko
- Karam Chafic
- Karam Chafic
- Karimi Sanaz
- Katz Jonathan
- Katzin Lara
- Kaur Harpreet
- Kawaguchi Naoki
- Kawamata Jun
- Kawamura Tomohiro
- Kazamel Mohamed
- Kazim Onar Musa
- Kelley Andrea
- Keung Benison
- Khoury Julie
- Kikutake Keiko
- Kim Bryan
- Kim Byung-Jo
- Kim Miri
- Kim Yool-hee
- Kincaid John
- Kirbas Cavdar Tugce
- Kissel John
- Kobashikawa Tomomi
- Kobayashi Eri
- Kobayashi Hisako
- Koga Megumi
- Koh Da Yoon
- Kohlrus Stephanie
- Konyane Monika
- Kramer Megan
- Kressin Nicole
- Krogh Susanne
- Kumar Aditya
- Kurihara Rikako
- Kurkova Barbora
- Kutlu Ayse
- Kwan Justin
- Kwon JuYoung
- Laaksonen Mikko
- Lazaro Ana
- Lee HyeLim
- Lee JiEun
- Lim Koo Dae
- Lim Jae-Sung
- Lin Frank
- Liu Tina
- Liu Ye
- Locatelli Alberta
- Locheke Jerry
- Lokaitis Barbara
- Loor John
- Lopergolo Diego
- Lopez Ruiz Pedro
- Lovas Gabor
- Lu Liang
- Lucy Shannon
- Maeda Yasuko
- Maggi Lorenzo
- Mahdi-Rogers Mohamed
- Mahieu D. lphine
- Maier Gal
- Malekniazi Ali
- Mallon Ashley
- Mantegazza Renato
- Maqsood Fatima
- Marano Enrico
- Marburger Tessa
- Marsili Angela
- Martins Ribeiro Renata
- Masaki Katsuhisa
- Massey Janice
- Mathew Veena
- Matolcsi Judit
- Matsuse Dai
- Matsushita Takuya
- Mazuela Gonzalo
- McClain Terry
- McClain Terry
- McKenna Kaitlyn
- McKinnon Jonathan
- McKinnon Naya
- McVey April
- Meguro Fumie
- Meherremova Arzu
- Mercelis Rudy
- Mette Ostergaard Autzen Anne
- Mezache Louisa
- Micheels Angela
- Michon Sara-Claude
- Miller Robert
- Min Kim Seung
- Min Ju-Hong
- Minton Brian
- Miranda Carolina
- Miyawaki Eriko
- Miyazaki Teiichiro
- Mizugami Aya
- Mogensen Anita
- Mohr Henrique
- Mori Masahiro
- Morikawa Miyuki
- Morino Stefania
- Mosmiller Betsy
- Motomura Masakatsu
- Mozaffar Tahseen
- Muharrem Filiz
- Mukaino Akihiro
- Mumfrey-Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Nagane Yuriko
- Nakamori Masayuki
- Nakamura Yumiko
- Nam Kang Hoo
- Nance Christopher
- Narayan Jeffrey
- Narikawa Koichi
- Nations Sharon
- Naunton Kerry
- Nemeth Joanne
- Nogueira Coelho Erica
- Norwood Fiona
- Noshiro Mayuko
- Novakova Iveta
- Nowak Richard
- Nozaki Kenkichi
- Nye Joan
- Nyoung Lee Chang
- O'Brien Fanny L.
- Oksaranta Olli
- Okumura Meinoshin
- Olalde Heena
- Onesti Emanuela
- Orsel Gulsah
- Osakada Kaori
- Ozawa Yukiko
- Ozcelik Pinar
- Padilla Patricia
- Paiva Gabriel
- Park SangAe
- Pasanisi Maria
- Pascuzzi Robert
- Pasnoor Mamatha
- Pasquale Antonella
- Patrick Kara
- Patwa Huned
- Paula Macagnan Ana
- Paula Melo Ana
- Paulose Shirley
- Pedersen Jane
- Pereira Martins Maurer
- Phan Cecile
- Piehl Fredrik
- Pillai Rekha
- Pinar Acar Nazire
- Pineda Colleen
- Pinto Graziela
- Pinto Wladimir
- Pitha Jiri
- Plevka Sarah
- Pol Sabrina
- Polaka Krishna
- Pozo Marina
- Prando Natalia
- Pulley Michael
- Puorro Giorgia
- Ra HyeJin
- Reguliova Katarina
- Renata Cubas Volpe Luciana
- Reyes Eliana
- Rico Gabrielle
- Robeson Kimberly
- Rocha Rosana
- Roderus Rikki
- Rodriguez de Rivera Francisco Javier
- Roe Kristen
- Rojas Garcia Ricardo
- Rosenfeld Jeffrey
- Ross Berger Alan
- Roy Gulmohor
- Rozsa Csilla
- Rugiero Marcelo
- Saba Juliet
- Saccà Francesco
- Sadalage Girija
- Saito Yuka
- Saitoh Masaki
- Sakamuri Sarada
- Saklad Amy
- Salajegheh Mohammed
- Salvado Figueras Maria
- Samukawa Makoto
- Sanjak Mohammed
- Sano Yoshiko
- Santos Engel Murilo
- Sastre Maria
- Sathasivam Sivakumar
- Sato Miwako
- Sattar Nadia
- Scala Stephanie
- Schommer Clara
- Schotte Caroline
- Scott Tierney
- Seddigh Arshira
- Seelbach Jenna
- Semiz Cansu
- Sen Sedat
- Sengun Ihsan
- Seo Koo Yong
- Seok Lee Hyung
- Seok Jinmyoung
- Shabbir Yasmeen
- Shabbir Yasmeen
- Shah Akshay
- Shah Amna
- Shah Jaimin
- Sharma Khema
- Sheldon Danielle
- Shimohama Shun
- Shimohama Shun
- Shimpo Misa
- Shin Miju
- Shiraishi Hirokazu
- Siddiqi Zaeem
- Sieren Jeri
- Silva Marcela
- Silvestri Nicholas
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- So Yuen T.
- Sohail Faisal
- Sokratous Giannis
- Souza Bulle Oliveira Acary
- Souza Duca Luciana
- Souza Iandra
- Srinivasan Jayashri
- Statland Jeffery
- Steele Julie
- Stevens Olivier
- Strom Susan
- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- Taichi Namie
- Takada Kazumi
- Takada Mihoko
- Takahashi Masanori
- Takeyama Rumi
- Tandan Rup
- Tano Ohito
- Terzi Murat
- Tilkin Petra
- Tobon Gonzalez Alejandro
- Toncrova Stanislava
- Torane Pravin
- Torres Debora Dada Martineli
- Toska Shirli
- Tran Anh
- Traub Rebecca
- Trivedi Jaya
- Troili Fernanda
- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tsurumaru Masako
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uwasa Kaori
- Uzawa Akiyuki
- van Daele Sien
- van Damme Philip
- van den Abeele Guy
- van der Kooi Anneke
- Vandenbussche Nicolas
- Vanderhook Mollie
- Vanhee Annelies
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Velez Santamaria Valentina
- Ventura Nicholas
- Verjans Sarah
- Veske Adife
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Vissing John
- Vohanka Stanislav
- Vu Hong
- Vu Tuan
- Vynckier Jan
- Vytopil Michal
- Wagemaekers Linda
- Waheed Waqar
- Walsh Maureen
- Wang Yunxia
- Watling Dave
- Watt Elizabeth
- Weiner Elaine
- Weiss Michael
- Welsh Lesly
- Wheeler Lauren
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Won Shin Chae
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Ye Hwang Ji
- Yilmaz Ezgi
- Yoshida Seiko
- Yoshimura Shunsuke
- Youl Seok Hung
- Young Shin Ha
- Young Valerie
- Yountz Marcus
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Wiley'
- Publication date
- 01/08/2020
- Field of study
Objective: To assess whether eculizumab, a terminal complement inhibitor, improves patient- and physician-reported outcomes (evaluated using the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale, respectively) in patients with refractory anti-acetylcholine receptor antibody-positive generalized myasthenia gravis across four domains, representing ocular, bulbar, respiratory, and limb/gross motor muscle groups. Methods: Patients with refractory anti-acetylcholine receptor antibody-positive generalized myasthenia gravis were randomized 1:1 to receive either placebo or eculizumab during the REGAIN study (NCT01997229). Patients who completed REGAIN were eligible to continue into the open-label extension trial (NCT02301624) for up to 4 years. The four domain scores of each of the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale recorded throughout REGAIN and through 130 weeks of the open-label extension were analyzed. Results: Of the 125 patients who participated in REGAIN, 117 enrolled in the open-label extension; 61 had received placebo and 56 had received eculizumab during REGAIN. Patients experienced rapid improvements in total scores and all four domain scores of both the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale with eculizumab treatment. These improvements were sustained through 130 weeks of the open-label extension. Interpretation: Eculizumab treatment elicits rapid and sustained improvements in muscle strength across ocular, bulbar, respiratory, and limb/gross motor muscle groups and in associated daily activities in patients with refractory anti-acetylcholine receptor antibody-positive generalized myasthenia gravis
Long-term safety and efficacy of eculizumab in generalized myasthenia gravis
- Author
- Acar Nazire Pinar
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alberti Aguilo Maria Antonia
- Alboini Paolo Emilio
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amaral Andrade Ana Carolina
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Ananias Morita Maria da Penha
- Andersen Henning
- Anderson Amanda
- Andoin Angela
- Annes Marcelo
- Antonini Giovanni
- Antozzi Carlo
- Aranke Shachie
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis Natália
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard J.
- Barroso Fabio
- Becerikli Gulsar
- Beck Kate
- Bednarik Josef
- Bekircan-Kurt Can Ebru
- Benatar Michael
- Berger Alan Ross
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bilsker Martin
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Burns Ted M.
- Butinhao Cristiani Fernanda
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Cho Eun Bin
- Choi Eun Hwa
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cunningham Scott
- César Pamela
- D'Amato Valentina
- D'Hondt Ann
- da Cruz Pacheco Daiane
- da Silva Luiz Augusto
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- de Bleecker Jan L.
- de Cassia Santos Aline
- de Koning Kathy
- de Mey Katrien
- de Visser Marianne
- Depreitere Annelies
- Dezsi Livia
- di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duarte Silva Liene
- Duran Gustavo
- Echevarria Laura
- Efendi Husnu
- Elsayed Mona
- Emmons Kelley
- Engel Marguerite
- Eralinna Juha-Pekka
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- Evoli Amelia
- Fasanaro Angiola
- Feder David
- Fernandes Patricia
- Fernandez-Fournier Mireya
- Ferreira Luciana
- Fialho Tomás Augusto Suriane
- Filla Allessandro
- Fionda Laura
- Fionda Laura
- Fondaw Alex
- Forshew Dallas
- Frasca Vittorio
- Frasca Vittorio
- Freimer Miriam
- Fujii Yuko
- Fujita Kenji P.
- Fukuda Yusuke
- Funaka Soichiro
- Futono Kazumi
- Gabriele Maria
- Gamez Josep
- Garcia Alejandra Dalila
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Gheller Friedrich Maurício André
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gili Gisela
- Glenn Melanie
- Golden Laura
- Gollogly Jakit
- Gomes da Silva Tamires Cristina
- Gomez Salcedo Pilar
- Gong Hui
- Gonzalez Anna
- Gonçalves Geraldo Jordana
- Gori Maria
- Goyal Namita
- Goyal Neelam
- Guerreiro Alexandre
- Guingrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Haar Laura
- Hafer-Macko Charlene
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Harvey Brittany
- Hasuike Tomoya
- Hayashi Takashi
- Hehir Michael
- Hendersen Kendrick
- Herbelin Laura
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Ho Doreen
- Hobson-Webb Lisa
- Homedes-Pedret Christian
- Hong Yoon-Ho
- Hopkins Steve
- Horvath Melinda
- Howard James F.
- Hoyle Joseph Chad
- Huynh Kristin
- Hwang Eun Bi
- Hwang Ji Ye
- Højgaard Joan
- Illa Isabel
- Imai Tomihiro
- Inghilleri Maurizio
- Iorio Raffaele
- Ishiyama Naoko
- Ishiyama Yoko
- Jacob Saiju
- Jakab Gedeonne
- Jara Jordan
- Jeffery Dennis
- Jenci Nicole
- Jeong Ha-Neul
- Jerath Nivedita
- Jingu Maki
- Johns Kathryn
- Jones Floyd
- Jones H. James
- Juel Vern
- Julia Palacios Natalia
- Jung JinWoo
- Junkerova Jana
- Jurajdova Ivana
- Kamakura Sachiko
- Kamegamori Ikuko
- Kanai Tetsuya
- Kaneko Yoko
- Kang Hoo Nam
- Kanzaki Akiko
- Karam Chafic
- Karam Chafic
- Karimi Sanaz
- Katz Jonathan
- Katzin Lara
- Kaur Harpreet
- Kawaguchi Naoki
- Kawamata Jun
- Kawamura Tomohiro
- Kazamel Mohamed
- Kelley Andrea
- Keung Benison
- Khoury Julie
- Kikutake Keiko
- Kim Bryan
- Kim Byoung Joon
- Kim Byung-Jo
- Kim Miri
- Kim Seung Min
- Kim Yool-hee
- Kincaid John
- Kirbas Cavdar Tugce
- Kissel John T.
- Kobashikawa Tomomi
- Kobayashi Eri
- Kobayashi Hisako
- Koga Megumi
- Koh Da Yoon
- Kohlrus Stephanie
- Konyane Monika
- Koo Dae Lim
- Koo Yong Seo
- Kramer Megan
- Kressin Nicole
- Krogh Susanne
- Kumar Aditya
- Kurihara Rikako
- Kurkova Barbora
- Kutlu Ayse
- Kwan Justin
- Kwon JuYoung
- Laaksonen Mikko
- Lazaro Ana
- Lee Chang Nyoung
- Lee HyeLim
- Lee Hyung Seok
- Lee JiEun
- Lim Jae-Sung
- Lin Frank
- Liu Tina
- Liu Ye
- Locatelli Alberta
- Locheke Jerry
- Lokaitis Barbara
- Loor John
- Lopergolo Diego
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- Lu Liang
- Lucy Shannon
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- Maggi Lorenzo
- Mahdi-Rogers Mohamed
- Mahieu D. lphine
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- Makamori Masayuki
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- McClain Terry
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- Min Ju-Hong
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- Miyawaki Eriko
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- Mori Masahiro
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- Mosmiller Betsy
- Motomura Masakatsu
- Mozaffar Tahseen
- Muharrem Filiz
- Mukaino Akihiro
- Mumfrey-Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Nagane Yuriko
- Nakamura Yumiko
- Nance Christopher
- Narayan Jeffrey
- Narikawa Koichi
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- Naunton Kerry
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- Nogueira Coelho Erica
- Norwood Fiona
- Noshiro Mayuko
- Novakova Iveta
- Nowak Richard J.
- Nozaki Kenkichi
- Nye Joan
- O'Brien Fanny L.
- Oksaranta Olli
- Okumura Meinoshin
- Olalde Heena
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- Orsel Gulsah
- Osakada Kaori
- Ostergaard Autzen Anne
- Otavio Maia Gonçalves Luiz
- Ozawa Yukiko
- Ozcelik Pinar
- Padilla Patricia
- Paiva Gabriel
- Park SangAe
- Pasanisi Maria
- Pascuzzi Robert
- Pasnoor Mamatha
- Patrick Kara
- Patwa Huned
- Paulose Shirley
- Pazetto Lucas Eduardo
- Pedersen Jane
- Pereira Martins Maurer
- Phan Cecile
- Piehl Fredrik
- Pillai Rekha
- Pineda Colleen
- Pinto Graziela
- Pinto Wladimir
- Pitha Jiri
- Plevka Sarah
- Pokala Krishna
- Pol Sabrina
- Pozo Marina
- Prando Natalia
- Pulley Michael
- Puorro Giorgia
- Querol Gutierrez Luis Antonio
- Ra HyeJin
- Reguliova Katarina
- Renata Cubas Volpe Luciana
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- Rico Gabrielle
- Robeson Kimberly
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- Roderus Rikki
- Rodriguez de Rivera Francisco Javier
- Roe Kristen
- Rojas Garcia Ricardo
- Rosenfeld Jeffrey
- Roy Gulmohor
- Rozsa Csilla
- Rugiero Marcelo
- Saba Juliet
- Saccà Francesco
- Sadalage Girija
- Saito Yuka
- Saitoh Masaki
- Sakamuri Sarada
- Saklad Amy
- Salajegheh Mohammed
- Salvado Maria
- Samukawa Makoto
- Sanjak Mohammad
- Sano Yoshiko
- Santos Engel Murilo
- Sastre Maria
- Sathasivam Sivakumar
- Sato Miwako
- Sattar Nadia
- Scala Stephanie
- Schommer Clara
- Schotte Caroline
- Seddigh Arshira
- Seelback Jenna
- Semiz Cansu
- Sen Sedat
- Sengun Ihsan
- Seok Hung Youl
- Seok Jinmyoung
- Shabbir Yasmeen
- Shah Akshay
- Shah Amna
- Shah Jaimin
- Sharma Khema
- Sheldon Danielle
- Shimohama Shun
- Shimpo Misa
- Shin Chae Won
- Shin Ha Young
- Shin Miju
- Shiraishi Hirokazu
- Siddiqi Zaeem
- Sieren Jeri
- Silva Marcela
- Silvestri Nicholas
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- So Yuen T.
- Sohail Faisal
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- Souza Duca Luciana
- Souza Iandra
- Srinivasan Jayashri
- Statland Jeffery
- Steele Julie
- Stevens Olivier
- Strom Susan
- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- Taichi Namie
- Takada Kazumi
- Takada Mihoko
- Takahashi Masanori
- Takeyama Rumi
- Tandan Rup
- Tano Ohito
- Terzi Murat
- Tierney Scott
- Tilkin Petra
- Tobon Gonzales Alejandro
- Toncrova Stanislava
- Torane Pravin
- Toska Shirli
- Tran Anh
- Traub Rebecca
- Trivedi Jaya
- Troili Fernanda
- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tsurumaru Masako
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uwasa Kaori
- Uzawa Akiyuki
- van Daele Sien
- van Damme Philip
- van den Abeele Guy
- van der Kooi Anneke
- Vandenbussche Nicolas
- Vanderhook Mollie
- Vanhee Annelies
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Velez Santamaria Valentina
- Ventura Nicholas
- Verjans Sarah
- Veske Adife
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Vissing John
- Vohanka Stanislav
- Vu Hong
- Vu Tuan H.
- Vynckier Jan
- Vytopil Michal
- Wagemaekers Linda
- Waheed Waqar
- Walsh Maureen
- Wang Jing Jing
- Wang Yunxia
- Watling Dave
- Watt Elizabeth
- Weiner Elaine
- Weiss Michael
- Welsh Lesly
- Wheeler Lauren
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Yilmaz Ezgi
- Yoshida Seiko
- Yoshimura Shunsuke
- Young Valerie
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Wiley'
- Publication date
- 01/07/2019
- Field of study
Introduction: Eculizumab is effective and well tolerated in patients with antiacetylcholine receptor antibody-positive refractory generalized myasthenia gravis (gMG; REGAIN; NCT01997229). We report an interim analysis of an open-label extension of REGAIN, evaluating eculizumab's long-term safety and efficacy. Methods: Eculizumab (1,200 mg every 2 weeks for 22.7 months [median]) was administered to 117 patients. Results: The safety profile of eculizumab was consistent with REGAIN; no cases of meningococcal infection were reported during the interim analysis period. Myasthenia gravis exacerbation rate was reduced by 75% from the year before REGAIN (P < 0.0001). Improvements with eculizumab in activities of daily living, muscle strength, functional ability, and quality of life in REGAIN were maintained through 3 years; 56% of patients achieved minimal manifestations or pharmacological remission. Patients who had received placebo during REGAIN experienced rapid and sustained improvements during open-label eculizumab (P < 0.0001). Discussion: These findings provide evidence for the long-term safety and sustained efficacy of eculizumab for refractory gMG. Muscle Nerve 2019
Recommended from our members
Eculizumab in refractory generalized myasthenia gravis previously treated with rituximab: subgroup analysis of REGAIN and its extension study
- Author
- Acar Nazire Pinar
- Agrawal Brajesh
- Agriesti Julie
- Aguilo Maria Antonia Alberti
- Ahn So‐Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alboini Paolo Emilio
- Alcon Karan
- Alsharabati Mohammad
- Amamoto Shoko
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Andrade Ana Carolina Amaral
- Annes Marcelo
- Antonini Giovanni
- Antozzi Carlo
- Aranke Shachie
- Ardoin Angela
- Arndt Heike
- Arnold Thomas
- Arribas‐Ibar Elisabet
- Asada Shizuka
- Assis Natália
- Autzen Anne Mette Ostergaard
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard
- Barroso Fabio
- Becerikli Gulsah
- Beck Kate
- Bednarik Josef
- Bekircan‐Kurt Can Ebru
- Benatar Michael
- Berger Alan Ross
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bhavaraju‐Sanka Ratna
- Bilsker Martin
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brockhausen Igor Dias
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Butinhao Cristiani Fernanda
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carbonell Josep Gamez
- Carnes Donna
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cassia Santos Aline
- Cavdar Tugce Kirbas
- Cavus Hakan
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Cho Eun Bin
- Choi Eun Haw
- Choi Mi Song
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Coelho Erica Nogueira
- Cooley Anne
- Corse Andrea
- Costabile Teresa
- Cruz Pacheco Daiane
- Cunningham Scott
- César Pamela
- D'Amato Valentina
- D'Hont Ann
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- De Bleecker Jan
- De Mey Katrien
- Depreitere Annelies
- Dezsi Livia
- Di Pasquale Antonella
- Di Pasquale Antonella
- Diaz‐Manera Jordi
- Dicapua Daniel
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duca Luciana Souza
- Duran Gustavo
- Echevarria Laura
- Efendi Husnu
- Elsayed Mona
- Emmons Kelley
- Engel Marguerite
- Engel Murilo Santos
- Erdem‐Ozdamar Sevim
- Eriksson Jaana
- Erälinna Juha‐Pekka
- Evoli Amelia
- Fasanaro Angiola
- Feder David
- Fernandes Patrícia
- Fernandez‐Fournier Mireya
- Fernandez‐Fournier Mireya
- Ferreira Luciana
- Fialho Tomás Augusto Suriane
- Figueras Maria Salvado
- Filla Alessandro
- Fionda Laura
- Fionda Laura
- Fondaw Alex
- Forshew Dallas
- Frasca Vittorio
- Frasca Vittorio
- Freimer Miriam
- Friedrich Maurício André Gheller
- Fujii Yuko
- Fukuda Yusuke
- Funaka Soichiro
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- Gabriele Maria
- Garcia Alejandra Dalila
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- Garcia Ricardo Rojas
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- Garibaldi Matteo
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- Min Ju‐Hong
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- Miyazaki Teiichiro
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- Mogensen Anita
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- Mori Masahiro
- Morikawa Miyuki
- Morino Stefania
- Mosmiller Betsy
- Motomura Masakatsu
- Mozaffar Tahseen
- Muharrem Filiz
- Mukaino Akihiro
- Mumfrey‐Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Nagane Yuriko
- Nakamori Masayuki
- Nakamura Yumiko
- Nance Christopher
- Narayan Jeffrey
- Narikawa Koichi
- Nations Sharon
- Naunton Kerry
- Nemeth Joanne
- Norwood Fiona
- Noshiro Mayuko
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- Nowak Richard J
- Nozaki Kenkichi
- Nye Joan
- O'Brien Fanny
- Oksaranta Olli
- Okumura Meinoshin
- Olalde Heena
- Oliveira Acary Souza Bulle
- Onar Musa Kazim
- Onesti Emanuela
- Orsel Gulsah
- Osakada Kaori
- Ozawa Yukiko
- Ozcelik Pinar
- Padilla Patricia
- Paiva Gabriel
- Palacios Natalia Julia
- Park Sang Ae
- Pasanisi Maria
- Pascuzzi Robert
- Pasnoor Mamatha
- Patrick Kara
- Patti Francesco
- Patwa Huned
- Paulose Shirley
- Pazetto Lucas Eduardo
- Pedersen Jane
- Penha Ananias Morita Maria
- Phan Cecile
- Piehl Fredrik
- Pillai Rekha
- Pineda Colleen
- Pinto Graziela
- Pinto Wladimir
- Pitha Jiri
- Plevka Sarah
- Pol Sabrina
- Polaka Krishna
- Porras Laura Diez
- Pozo Marina
- Prando Natalia
- Pulley Michael
- Puorro Giorgia
- Ra Hye Jin
- Reguliova Katarina
- Reyes Eliana
- Ribeiro Renata Martins
- Rico Gabrielle
- Rivera Francisco Javier Rodriguez
- Robeson Kimberly
- Rocha Rosana
- Roderus Rikki
- Roe Kristen
- Rosa Bruno Bezerra
- Rosenfeld Jeffrey
- Roy Gulmohor
- Rozsa Csilla
- Rugiero Marcelo
- Ruiz Pedro Lopez
- Saba Juliet
- Saccà Francesco
- Sadalage Girija
- Saito Yuka
- Saitoh Masaki
- Sakamuri Sarada
- Saklad Amy
- Salajegheh Mohammed
- Salcedo Pilar Gomez
- Samukawa Makoto
- Sanjak Mohammad
- Sanjak Mohammed
- Sano Yoshiko
- Santamaria Valentina Velez
- Sastre Maria
- Sathasivam Sivakumar
- Sato Miwako
- Sattar Nadia
- Scala Stephanie
- Schommer Clara
- Schotte Caroline
- Scott Tierney
- Seddigh Arshira
- Seelbach Jenna
- Semiz Cansu
- Sen Sedat
- Sengun Ihsan
- Seok Hung Youl
- Seok Jinmyoung
- Shabbir Yasmeen
- Shabbir Yasmeen
- Shah Akshay
- Shah Amna
- Shah Jaimin
- Sharma Khema
- Sheldon Danielle
- Shimohama Shun
- Shimohama Shun
- Shimpo Misa
- Shin Chae Won
- Shin Ha Young
- Shin Miju
- Shiraishi Hirokazu
- Siddiqi Zaeem A
- Sieren Jeri
- Silva Liene Duarte
- Silva Luiz Augusto
- Silva Marcela
- Silva Tamires Cristina Gomes
- Silvestri Nicholas
- Siqueira Carvalho Alzira Alves
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- So Yuen T
- Sohail Faisal
- Sokratous Giannis
- Souza Iandra
- Srinivasan Jayashri
- Statland Jeffery
- Steele Julie
- Stevens Olivier
- Strom Susan
- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- Taichi Namie
- Takada Kazumi
- Takada Mihoko
- Takahashi Masanori
- Takeyama Rumi
- Tandan Rup
- Tano Ohito
- Tejedor Exuperio Diez
- Terzi Murat
- the REGAIN Study Grp
- Tilkin Petra
- Toncrova Stanislava
- Torane Pravin
- Torres Debora Dada Martineli
- Toska Shirli
- Tran Anh
- Traub Rebecca
- Trivedi Jaya
- Troili Fernanda
- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tsurumaru Masako
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uwasa Kaori
- Uzawa Akiyuki
- Van Daele Sien
- Van Damme Philip
- Van den Abeele Guy
- Vandenbussche Nicolas
- Vanderhook Mollie
- Vanhee Annelies
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Ventura Nicholas
- Verjans Sarah
- Veske Adife
- Vicente Elena Cortes
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Visser Marianne
- Vissing John
- Vohanka Stanislav
- Volpe Luciana Renata Cubas
- Vu Hong
- Vu Tuan
- Vynckier Jan
- Vytopil Michal
- Wagemaekers Linda
- Waheed Waqar
- Walsh Maureen
- Wang Yunxia
- Watling Dave
- Watt Elizabeth
- Weiner Elaine
- Weiss Michael
- Welsh Lesly
- Wheeler Lauren
- Wilken Miguel
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Yilmaz Ezgi
- Yoshida Seiko
- Yoshida Seiko
- Yoshimura Shunsuke
- Young Valerie
- Yountz Marcus
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- John Wiley & Sons, Inc
- Publication date
- 01/12/2021
- Field of study
Introduction/Aims
Individuals with refractory generalized myasthenia gravis (gMG) who have a history of rituximab use and experience persistent symptoms represent a population with unmet treatment needs. The aim of this analysis was to evaluate the efficacy and safety of eculizumab in patients with refractory anti‐acetylcholine receptor antibody‐positive (AChR+) gMG previously treated with rituximab.
Methods
This post hoc subgroup analysis of the phase 3 REGAIN study (NCT01997229) and its open‐label extension (OLE; NCT02301624) compared baseline characteristics, safety, and response to eculizumab in participants who had previously received rituximab with those who had not. Rituximab use was not permitted within the 6 months before screening or during REGAIN/OLE.
Results
Of 125 REGAIN participants, 14 had received rituximab previously (7 received placebo and 7 received eculizumab). In the previous‐rituximab group, 57% had used at least four other immunosuppressants compared with 16% in the no‐previous‐rituximab group. Myasthenia Gravis Activities of Daily Living total scores from eculizumab baseline to week 130 of eculizumab treatment improved in both the previous‐rituximab and no‐previous‐rituximab groups (least‐squares mean −4.4, standard error of the mean [SEM] 1.0 [n = 9] and least‐squares mean −4.6, SEM 0.3 [n = 67], respectively; difference = 0.2, 95% confidence interval −1.88 to 2.22). In addition, in both groups, most patients who were treated with eculizumab for 130 weeks achieved a Myasthenia Gravis Foundation of America post‐intervention status of minimal manifestations (66.7% and 65.0%, respectively). The eculizumab safety profile was similar between groups and consistent with its established profile.
Discussion
Eculizumab is an effective therapy for patients with refractory AChR+ gMG, irrespective of whether they had received rituximab treatment previously
Correction to: Eculizumab improves fatigue in refractory generalized myasthenia gravis (Quality of Life Research, (2019), 28, 8, (2247-2254), 10.1007/s11136-019-02148-2)
- Author
- Acar Nazire Pinar
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alberti Aguilo Maria Antonia
- Alboini Paolo Emilio
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amaral Andrade Ana Carolina
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Andoin Angela
- Annes Marcelo
- Antonini Giovanni
- Antozzi Carlo
- Aranke Shachie
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis Natália
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard
- Barroso Fabio
- Becerikli Gulsar
- Beck Kate
- Bednarik Josef
- Bekircan-Kurt Can Ebru
- Benatar Michael
- Berger Alan Ross
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bilsker Martin
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Butinhao Cristiani Fernanda
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Cho Eun Bin
- Choi Eun Hwa
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cunningham Scott
- César Pamela
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- da Cruz Pacheco Daiane
- da Penha Ananias Morita Maria
- da Silva Luiz Augusto
- Depreitere Annelies
- Dezsi Livia
- de Bleecker Jan
- de Cassia Santos Aline
- de Koning Kathy
- de Mey Katrien
- de Visser Marianne
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
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- Dishman Lorraine
- Distad Jane
- di Pasquale Antonella
- Doan Victor
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- Ho Doreen
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- Hoyle Joseph Chad
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- Sen Sedat
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- Seok Hung Youl
- Seok Jinmyoung
- Shabbir Yasmeen
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- Sharma Khema
- Sheldon Danielle
- Shimohama Shun
- Shimpo Misa
- Shin ChaeWon
- Shin Ha Young
- Shin Miju
- Shiraishi Hirokazu
- Siddiqi Zaeem
- Sieren Jeri
- Silva Marcela
- Silvestri Nicholas
- Smetcoren Charlotte
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- Snook Riley
- So Yuen T.
- Sohail Faisal
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- Srinivasan Jayashri
- Statland Jeffery
- Steele Julie
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- Strom Susan
- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- Taichi Namie
- Takada Kazumi
- Takada Mihoko
- Takahashi Masanori
- Takeyama Rumi
- Tandan Rup
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- Tran Anh
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- Trivedi Jaya
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- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tsurumaru Masako
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uwasa Kaori
- Uzawa Akiyuki
- van den Abeele Guy
- van der Kooi Anneke
- Vandenbussche Nicolas
- Vanderhook Mollie
- Vanhee Annelies
- van Daele Sien
- van Damme Philip
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Velez Santamaria Valentina
- Ventura Nicholas
- Verjans Sarah
- Veske Adife
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Vissing John
- Vohanka Stanislav
- Vu Hong
- Vu Tuan
- Vynckier Jan
- Vytopil Michal
- Wagemaekers Linda
- Waheed Waqar
- Walsh Maureen
- Wang Jing Jing
- Wang Junxia
- Watling Dave
- Watt Elizabeth
- Weiner Elaine
- Weiss Michael
- Welsh Lesly
- Wheeler Lauren
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Yilmaz Ezgi
- Yoshida Seiko
- Yoshimura Shunsuke
- Young Valerie
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 15/08/2019
- Field of study
The article “Eculizumab improves fatigue in refractory generalized myasthenia gravis”, written by “Henning Andersen, Renato Mantegazza, Jing Jing Wang, Fanny O’Brien, Kaushik Patra, James F. Howard Jr. and The REGAIN Study Group” was originally published electronically on the publisher’s internet portal (currently SpringerLink) on 23 March 2019 without open access
Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study
- Author
- Acary Souza Bulle Oliveira
- Adam Hart
- Adife Veske
- Aditya Kumar
- Aikaterini Dimitriou
- Akihiro Mukaino
- Akiko Kanzaki
- Akiyuki Uzawa
- Akshay Shah
- Alan Ross Berger
- Albert Hietala
- Alberta Locatelli
- Alejandra Dalila Garcia
- Alejandro Tobon Gonzales
- Alex Fondaw
- Ali Malekniazi
- Allessandro Filla
- Alzira Alves de Siqueira Carvalho
- Amaiak Chilingaryan
- Amanda Anderson
- Amelia Evoli
- Amna Shah
- Amy Saklad
- Amy Woodall
- Ana Carolina Amaral Andrade
- Ana Lazaro
- Ana Paula Melo
- Andrea Corse
- Andrea Kelley
- Andrea Swenson
- Angela Andoin
- Angela Campanella
- Angela Marsili
- Angela Micheels
- Angiola Fasanaro
- Anh Tran
- Anita Mogensen
- Ann D'Hondt
- Anna Gonzalez
- Anne Cooley
- Anne Mette Ostergaard Autzen
- Anneke van der Kooi
- Annelies Depreitere
- Annelies Vanhee
- Anthony Amato
- Antonella Di Pasquale
- April McVey
- Arshira Seddigh
- Arzu Meherremova
- Ashley Mallon
- Aya Mizugami
- Ayse Kutlu
- Baki Dogan
- Barbara Lokaitis
- Barbora Kurkova
- Barohn
- Bengu Balkan
- Benison Keung
- Benjamin Brooks
- Beth DiSanzo
- Betsy Mosmiller
- Boscoe
- Brajesh Agrawal
- Brian Droker
- Brian Minton
- Brigitta Szabadosne
- Brittany Harvey
- Bruno Bezerra Rosa
- Bryan Kim
- Burns
- Burns
- Buzzard
- Can Ebru Bekircan-Kurt
- Cansu Semiz
- Carlo Antozzi
- Carlos Casasnovas
- Carol Herbert
- Carolina Miranda
- Caroline Schotte
- Cecile Phan
- Celal Tuga
- Chafic Karam
- Chafic Karam
- Charlene Hafer-Macko
- Charlotte Smetcoren
- Christian Homedes-Pedret
- Christopher Nance
- Claire Brown
- Clara Schommer
- Claudio Gabriel Mazia
- Colleen Pineda
- Conti-Fine
- Craig Donahue
- Cristiani Fernanda Butinhao
- Csilla Rozsa
- Cynthia Bodkin
- Cynthia Carter
- Dai Matsuse
- Daisuke Yamamoto
- Dallas Forshew
- Daniel Ambrosio
- Daniel Dicapua
- Danielle Sheldon
- Dave Watling
- David Feder
- Debbie Davies
- Debora Dada Martineli Torres
- Dennis Jeffery
- Derrick Blackmore
- Diana Dimitrova
- Donna Carnes
- Doreen Ho
- Délphine Mahieu
- Elaine Weiner
- Elena Bravver
- Elena Cortes Vicente
- Eliana Reyes
- Elisabet Arribas-Ibar
- Elizabeth Watt
- Emiko Tsuda
- Engel-Nitz
- Enrico Marano
- Eri Kobayashi
- Erica Nogueira Coelho
- Eriko Higuchi
- Eriko Miyawaki
- Exuperio Diez Tejedor
- Ezgi Yilmaz
- Fabio Barroso
- Faisal Sohail
- Fanny O’Brien
- Fatima Maqsood
- Fernanda Carrara
- Fernanda Troili
- Filiz Muharrem
- Fiona Norwood
- Floyd Jones
- Francesco Saccà
- Francisco Javier Rodriguez de Rivera
- Frank Lin
- Fredrik Piehl
- Fumie Meguro
- Gabor Lovas
- Gabriel Paiva
- Gabrielle Rico
- Gal Maier
- Gedeonne Jakab
- Giannis Sokratous
- Gil Wolfe
- Giorgia Camera
- Giorgia Puorro
- Giovanni Antonini
- Girija Sadalage
- Gisela Gili
- Gonzalo Mazuela
- Gonzalo Vidal
- Gulmohor Roy
- Gulsah Becerikli
- Gulsah Orsel
- Gustavo Duran
- Guy Van den Abeele
- Gyorgyi Szabo
- H. James Jones
- Hakan Cavus
- Harpreet Kaur
- Heena Olalde
- Heike Arndt
- Henning Andersen
- Hidekazu Suzuki
- Hillmen
- Hirokazu Shiraishi
- Hiroyuki Murai
- Hisako Kobayashi
- Hong Vu
- Howard
- Howard
- Hui Gong
- Huned Patwa
- Husnu Efendi
- Iandra Souza
- Igor Dias Brockhausen
- Ihsan Sengun
- Ikuko Kamegamori
- Ikuko Yasuda
- Irene Yang
- Isabel Illa
- Ivana Jurajdova
- Iveta Novakova
- Jaana Eriksson
- Jaimin Shah
- Jakit Gollogly
- James Gilchrist
- James Howard Jr
- Jan De Bleecker
- Jan Vynckier
- Jana Junkerova
- Jane Distad
- Jane Pedersen
- Janice Massey
- Jaretzki
- Jayashri Srinivasan
- Jeffery Statland
- Jeffrey Guptill
- Jeffrey Narayan
- Jeffrey Rosenfeld
- Jenna Seelback
- Jeri Sieren
- Jerry Locheke
- Jing-Jing Wang
- Jiri Pitha
- Joan Højgaard
- Joan Nye
- Joanne Nemeth
- John Kincaid
- John Kissel
- John Loor
- John Vissing
- Jonathan Katz
- Jonathan McKinnon
- Jordan Jara
- Jordana Gonçalves Geraldo
- Jordi Diaz-Manera
- Josep Gamez
- Joseph Chad Hoyle
- Judit Matolcsi
- Juha-Pekka Eralinna
- Julie Agriesti
- Julie Khoury
- Julie Steele
- Juliet Saba
- Jun Kawamata
- Justin Kwan
- Kaitlyn McKenna
- Kaori Osakada
- Kaori Uwasa
- Kara Patrick
- Karan Alcon
- Karen Callison
- Karen Zakalik
- Katarina Reguliova
- Kate Beck
- Katherine Amato
- Kathryn Johns
- Kathy de Koning
- Katrien De Mey
- Katsuhisa Masaki
- Kawaguchi
- Kazumi Futono
- Kazumi Takada
- Keiko Kikutake
- Kelley Emmons
- Kenichi Tsukita
- Kenji P. Fujita
- Kenkichi Nozaki
- Kerry Naunton
- Kevin Daniels
- Khema Sharma
- Kida
- Kimberly Robeson
- Kimiaki Utsugisawa
- Koichi Narikawa
- Krishna Pokala
- Kristen Roe
- Kristin Huynh
- Lara Katzin
- Laura Diez Porras
- Laura Echevarria
- Laura Fionda
- Laura Golden
- Laura Haar
- Laura Herbelin
- Laurie Gutmann
- Legendre
- Lena Bjarbo
- Lesly Welsh
- Liang Lu
- Licht
- Liene Duarte Silva
- Linda Wagemaekers
- Lindsay Zilliox
- Lisa Hobson-Webb
- Lisa Smith
- Lorenzo Maggi
- Lorraine Dishman
- Lotte Vinge
- Louisa Mezache
- Lucas Eduardo Pazetto
- Luciana Renata Cubas Volpe
- Luciana Souza Duca
- Ludwig Gutmann
- Luis Antonio Querol Gutierrez
- Luiz Augusto da Silva
- Luiz Otavio Maia Gonçalves
- Maki Jingu
- Makoto Samukawa
- Mamatha Pasnoor
- Manisha Chopra
- Marcela Silva
- Marcela Wolfova
- Marcelo Annes
- Marcelo Chaves
- Marcelo Rugiero
- Marguerite Engel
- Maria Antonia Alberti Aguilo
- Maria da Penha Ananias Morita
- Maria Pasanisi
- Maria Salvado
- Maria Sastre
- Marianne de Visser
- Mariela Bettini
- Marina Pozo
- Martin Bilsker
- Mary Varghese
- Maryanne Burdette
- Masahiro Mori
- Masakatsu Motomura
- Masaki Saitoh
- Masako Tsurumaru
- Masanori Takahashi
- Masayuki Makamori
- Matsuki
- Matteo Garibaldi
- Maureen Walsh
- Mayuko Noshiro
- Mazen Dimachkie
- Megan Kramer
- Megumi Koga
- Meinoshin Okumura
- Melanie Glenn
- Melinda Horvath
- Michael Benatar
- Michael Hehir
- Michael Pulley
- Michael Weiss
- Michaela Tyblova
- Michal Vytopil
- Miguel Wilken
- Mihoko Takada
- Mikko Laaksonen
- Mireya Fernandez-Fournier
- Miriam Freimer
- Misa Shimpo
- Miwako Sato
- Miyuki Morikawa
- Mohamed Kazamel
- Mohamed Mahdi-Rogers
- Mohammad Alsharabati
- Mohammad Sanjak
- Mohammed Salajegheh
- Mona Elsayed
- Muppidi
- Muppidi
- Murai
- Murai
- Murai
- Murat Terzi
- Murilo Santos Engel
- Musa Kazim Onar
- Muzeyyen Ugur
- Nadia Sattar
- Namie Taichi
- Namita Goyal
- Nanna Witting
- Naoki Kawaguchi
- Naoko Ishiyama
- Natalia Julia Palacios
- Natalia Prando
- Natália Assis
- Naya McKinnon
- Nazire Pinar Acar
- Neelam Goyal
- Nicholas Silvestri
- Nicholas Ventura
- Nicolas Vandenbussche
- Nicole Jenci
- Nicole Kressin
- Nivedita Jerath
- Nuria Vidal
- Ohito Tano
- Olga Zapletalova
- Olivier Stevens
- Olli Oksaranta
- Ozlem Tun
- Pamela César
- Paolo Emilio Alboini
- Patricia Fernandes
- Patricia Padilla
- Pedro Lopez Ruiz
- Petra Tilkin
- Pharmaceuticals and Medical Devices Agency Japan
- Philip Van Damme
- Pilar Gomez Salcedo
- Pilar Sune
- Pinar Ozcelik
- Pravin Torane
- Raffaele Iorio
- Ratna Bhavaraju-Sanka
- Rebecca Traub
- Rebekah Garcia
- Renata Martins Ribeiro
- Renato Mantegazza
- Ricardo Rojas Garcia
- Richard Barohn
- Richard Nowak
- Rikako Kurihara
- Rikki Roderus
- Riley Snook
- Robert Miller
- Robert Pascuzzi
- Rosana Rocha
- Rother
- Rudy Mercelis
- Rumi Takeyama
- Rup Tandan
- Sabrina Pol
- Sachiko Kamakura
- Said Beydoun
- Saiju Jacob
- Salma Akhter
- Sanaz Karimi
- Sanders
- Sandi Mumfrey-Thomas
- Sandra Guingrich
- Santos
- Sara-Claude Michon
- Sarada Sakamuri
- Sarah Plevka
- Sarah Verjans
- Scott Cunningham
- Scott Tierney
- Seda Aydinlik
- Sedat Sen
- Seiko Yoshida
- Sevim Erdem-Ozdamar
- Shachie Aranke
- Shannon Lucy
- Sharmeen Alam
- Sharon Chelnick
- Sharon Downing
- Shin Hisahara
- Shirley Paulose
- Shirli Toska
- Shizuka Asada
- Shoko Amamoto
- Shuichiro Suzuki
- Shun Shimohama
- Shunsuke Yoshimura
- Sien Van Daele
- Silvia Bonanno
- Sivakumar Sathasivam
- Soichiro Funaka
- Sonia Garcia
- Srikanth Muppidi
- Stefania Morino
- Stephanie Kohlrus
- Stephanie Scala
- Suh
- Susan Strom
- Susanne Krogh
- Tahseen Mozaffar
- Taira Uehara
- Takashi Hayashi
- Takashi Murahara
- Takuya Matsushita
- Tamar Gibson
- Tamires Cristina Gomes da Silva
- Taylor Darnell
- Teiichiro Mitazaki
- Teresa Costabile
- Terry McClain
- Terry McClain
- Tessa Marburger
- Tetsuya Akiyama
- Tetsuya Kanai
- Thabata Veiga
- Thomas Cochrane
- Thomas Harbo
- Tina Liu
- Tiyonnoh Cash
- Tomihiro Imai
- Tomohiro Kawamura
- Tomoko Tsuda
- Tomomi Kobashikawa
- Tomoya Hasuike
- Tomás Augusto Suriane Fialho
- Tuan Vu
- Tugce Kirbas Cavdar
- Tuula Harrison
- Tuzun
- Utsugisawa
- Utsugisawa
- Valentina D'Amato
- Valentina Velez Santamaria
- Valeria Cavalcante Lino
- Valerie Young
- Veena Mathew
- Vern Juel
- Victor Doan
- Vinay Chaudhry
- Waqar Waheed
- Wladimir Pinto
- Yagmur Caliskan
- Yasmeen Shabbir
- Yasuko Maeda
- Yasushi Suzuki
- Yoko Ishiyama
- Yoko Kaneko
- Yoshiko Sano
- Yuen T. So
- Yuka Saito
- Yukiko Ozawa
- Yuko Fujii
- Yumi Yamashita
- Yumiko Nakamura
- Yunxia Wang
- Yuriko Nagane
- Yusuke Fukuda
- Zaeem Siddiqi
- Zhang
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab's efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population
Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study
- Author
- Abramov Vladislav
- Acar Nazire Pinar
- Agopian Eliz
- Agriesti Julie
- Akhter Salma
- Akiyama Tetsuya
- Alberti Aguilo Maria
- Alboini Paolo Emilio
- Alcon Karan
- Alsharabati Mohammad
- Altiparmak Didem
- Alvermann Sascha
- Alves de Siqueira Carvalho Alzira
- Amaral de Andrade Ana Carolina
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
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- Tsuda Emiko
- Tsuda Tomoko
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- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
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- Vytopil Michael
- Wagemaekers Linda
- Waheed Waqar
- Wang Jing-Jing
- Wanschitz Julia
- Watanabe Masanori
- Watling Dave
- Weiner Elaine
- Weiss Michael
- Welsh Lesly Welsh
- Wenninger Stephan
- Wheeler Lauren
- Wielanek-Bachelet Anne-Cé
- Wilken Miguel
- Willlems Natasha
- Wilson Amy
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yarmoschuk Asya
- Yilmaz Ezgi
- Yoshida Seiko
- Yoshikawa Chieko
- Yoshimura Shunsuke
- Yuen T So
- Zakalik Karen
- Zampaki Martha
- Zapletalova Olga
- Zephir Hé
- Zilliox Lindsay
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Complement is likely to have a role in refractory generalised myasthenia gravis, but no approved therapies specifically target this system. Results from a phase 2 study suggested that eculizumab, a terminal complement inhibitor, produced clinically meaningful improvements in patients with anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis. We further assessed the efficacy and safety of eculizumab in this patient population in a phase 3 trial. Methods We did a phase 3, randomised, double-blind, placebo-controlled, multicentre study (REGAIN) in 76 hospitals and specialised clinics in 17 countries across North America, Latin America, Europe, and Asia. Eligible patients were aged at least 18 years, with a Myasthenia Gravis-Activities of Daily Living (MG-ADL) score of 6 or more, Myasthenia Gravis Foundation of America (MGFA) class II\ue2\u80\u93IV disease, vaccination against Neisseria meningitides, and previous treatment with at least two immunosuppressive therapies or one immunosuppressive therapy and chronic intravenous immunoglobulin or plasma exchange for 12 months without symptom control. Patients with a history of thymoma or thymic neoplasms, thymectomy within 12 months before screening, or use of intravenous immunoglobulin or plasma exchange within 4 weeks before randomisation, or rituximab within 6 months before screening, were excluded. We randomly assigned participants (1:1) to either intravenous eculizumab or intravenous matched placebo for 26 weeks. Dosing for eculizumab was 900 mg on day 1 and at weeks 1, 2, and 3; 1200 mg at week 4; and 1200 mg given every second week thereafter as maintenance dosing. Randomisation was done centrally with an interactive voice or web-response system with patients stratified to one of four groups based on MGFA disease classification. Where possible, patients were maintained on existing myasthenia gravis therapies and rescue medication was allowed at the study physician's discretion. Patients, investigators, staff, and outcome assessors were masked to treatment assignment. The primary efficacy endpoint was the change from baseline to week 26 in MG-ADL total score measured by worst-rank ANCOVA. The efficacy population set was defined as all patients randomly assigned to treatment groups who received at least one dose of study drug, had a valid baseline MG-ADL assessment, and at least one post-baseline MG-ADL assessment. The safety analyses included all randomly assigned patients who received eculizumab or placebo. This trial is registered with ClinicalTrials.gov, number NCT01997229. Findings Between April 30, 2014, and Feb 19, 2016, we randomly assigned and treated 125 patients, 62 with eculizumab and 63 with placebo. The primary analysis showed no significant difference between eculizumab and placebo (least-squares mean rank 56\uc2\ub76 [SEM 4\uc2\ub75] vs 68\uc2\ub73 [4\uc2\ub75]; rank-based treatment difference \ue2\u88\u9211\uc2\ub77, 95% CI \ue2\u88\u9224\uc2\ub73 to 0\uc2\ub796; p=0\uc2\ub70698). No deaths or cases of meningococcal infection occurred during the study. The most common adverse events in both groups were headache and upper respiratory tract infection (ten [16%] for both events in the eculizumab group and 12 [19%] for both in the placebo group). Myasthenia gravis exacerbations were reported by six (10%) patients in the eculizumab group and 15 (24%) in the placebo group. Six (10%) patients in the eculizumab group and 12 (19%) in the placebo group required rescue therapy. Interpretation The change in the MG-ADL score was not statistically significant between eculizumab and placebo, as measured by the worst-rank analysis. Eculizumab was well tolerated. The use of a worst-rank analytical approach proved to be an important limitation of this study since the secondary and sensitivity analyses results were inconsistent with the primary endpoint result; further research into the role of complement is needed. Funding Alexion Pharmaceuticals
Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study
- Author
- Acary Souza Bulle Oliveira
- Adam Hart
- Adife Veske
- Aditya Kumar
- Aikaterini Dimitriou
- Akihiro Mukaino
- Akiko Kanzaki
- Akiyuki Uzawa
- Akshay Shah
- Alan Ross Berger
- Albert Hietala
- Alberta Locatelli
- Alejandra Dalila Garcia
- Alejandro Tobon Gonzales
- Alex Fondaw
- Ali Malekniazi
- Allessandro Filla
- Alzira Alves de Siqueira Carvalho
- Amaiak Chilingaryan
- Amanda Anderson
- Amelia Evoli
- Amna Shah
- Amy Saklad
- Amy Woodall
- Ana Carolina Amaral Andrade
- Ana Lazaro
- Ana Paula Melo
- Andrea Corse
- Andrea Kelley
- Andrea Swenson
- Angela Andoin
- Angela Campanella
- Angela Marsili
- Angela Micheels
- Angiola Fasanaro
- Anh Tran
- Anita Mogensen
- Ann D'Hondt
- Anna Gonzalez
- Anne Cooley
- Anne Mette Ostergaard Autzen
- Anneke van der Kooi
- Annelies Depreitere
- Annelies Vanhee
- Anthony Amato
- Antonella Di Pasquale
- April McVey
- Arshira Seddigh
- Arzu Meherremova
- Ashley Mallon
- Aya Mizugami
- Ayse Kutlu
- Baki Dogan
- Barbara Lokaitis
- Barbora Kurkova
- Barohn
- Bengu Balkan
- Benison Keung
- Benjamin Brooks
- Beth DiSanzo
- Betsy Mosmiller
- Boscoe
- Brajesh Agrawal
- Brian Droker
- Brian Minton
- Brigitta Szabadosne
- Brittany Harvey
- Bruno Bezerra Rosa
- Bryan Kim
- Burns
- Burns
- Buzzard
- Can Ebru Bekircan-Kurt
- Cansu Semiz
- Carlo Antozzi
- Carlos Casasnovas
- Carol Herbert
- Carolina Miranda
- Caroline Schotte
- Cecile Phan
- Celal Tuga
- Chafic Karam
- Chafic Karam
- Charlene Hafer-Macko
- Charlotte Smetcoren
- Christian Homedes-Pedret
- Christopher Nance
- Claire Brown
- Clara Schommer
- Claudio Gabriel Mazia
- Colleen Pineda
- Conti-Fine
- Craig Donahue
- Cristiani Fernanda Butinhao
- Csilla Rozsa
- Cynthia Bodkin
- Cynthia Carter
- Dai Matsuse
- Daisuke Yamamoto
- Dallas Forshew
- Daniel Ambrosio
- Daniel Dicapua
- Danielle Sheldon
- Dave Watling
- David Feder
- Debbie Davies
- Debora Dada Martineli Torres
- Dennis Jeffery
- Derrick Blackmore
- Diana Dimitrova
- Donna Carnes
- Doreen Ho
- Délphine Mahieu
- Elaine Weiner
- Elena Bravver
- Elena Cortes Vicente
- Eliana Reyes
- Elisabet Arribas-Ibar
- Elizabeth Watt
- Emiko Tsuda
- Engel-Nitz
- Enrico Marano
- Eri Kobayashi
- Erica Nogueira Coelho
- Eriko Higuchi
- Eriko Miyawaki
- Exuperio Diez Tejedor
- Ezgi Yilmaz
- Fabio Barroso
- Faisal Sohail
- Fanny O’Brien
- Fatima Maqsood
- Fernanda Carrara
- Fernanda Troili
- Filiz Muharrem
- Fiona Norwood
- Floyd Jones
- Francesco Saccà
- Francisco Javier Rodriguez de Rivera
- Frank Lin
- Fredrik Piehl
- Fumie Meguro
- Gabor Lovas
- Gabriel Paiva
- Gabrielle Rico
- Gal Maier
- Gedeonne Jakab
- Giannis Sokratous
- Gil Wolfe
- Giorgia Camera
- Giorgia Puorro
- Giovanni Antonini
- Girija Sadalage
- Gisela Gili
- Gonzalo Mazuela
- Gonzalo Vidal
- Gulmohor Roy
- Gulsah Becerikli
- Gulsah Orsel
- Gustavo Duran
- Guy Van den Abeele
- Gyorgyi Szabo
- H. James Jones
- Hakan Cavus
- Harpreet Kaur
- Heena Olalde
- Heike Arndt
- Henning Andersen
- Hidekazu Suzuki
- Hillmen
- Hirokazu Shiraishi
- Hiroyuki Murai
- Hisako Kobayashi
- Hong Vu
- Howard
- Howard
- Hui Gong
- Huned Patwa
- Husnu Efendi
- Iandra Souza
- Igor Dias Brockhausen
- Ihsan Sengun
- Ikuko Kamegamori
- Ikuko Yasuda
- Irene Yang
- Isabel Illa
- Ivana Jurajdova
- Iveta Novakova
- Jaana Eriksson
- Jaimin Shah
- Jakit Gollogly
- James Gilchrist
- James Howard Jr
- Jan De Bleecker
- Jan Vynckier
- Jana Junkerova
- Jane Distad
- Jane Pedersen
- Janice Massey
- Jaretzki
- Jayashri Srinivasan
- Jeffery Statland
- Jeffrey Guptill
- Jeffrey Narayan
- Jeffrey Rosenfeld
- Jenna Seelback
- Jeri Sieren
- Jerry Locheke
- Jing-Jing Wang
- Jiri Pitha
- Joan Højgaard
- Joan Nye
- Joanne Nemeth
- John Kincaid
- John Kissel
- John Loor
- John Vissing
- Jonathan Katz
- Jonathan McKinnon
- Jordan Jara
- Jordana Gonçalves Geraldo
- Jordi Diaz-Manera
- Josep Gamez
- Joseph Chad Hoyle
- Judit Matolcsi
- Juha-Pekka Eralinna
- Julie Agriesti
- Julie Khoury
- Julie Steele
- Juliet Saba
- Jun Kawamata
- Justin Kwan
- Kaitlyn McKenna
- Kaori Osakada
- Kaori Uwasa
- Kara Patrick
- Karan Alcon
- Karen Callison
- Karen Zakalik
- Katarina Reguliova
- Kate Beck
- Katherine Amato
- Kathryn Johns
- Kathy de Koning
- Katrien De Mey
- Katsuhisa Masaki
- Kawaguchi
- Kazumi Futono
- Kazumi Takada
- Keiko Kikutake
- Kelley Emmons
- Kenichi Tsukita
- Kenji P. Fujita
- Kenkichi Nozaki
- Kerry Naunton
- Kevin Daniels
- Khema Sharma
- Kida
- Kimberly Robeson
- Kimiaki Utsugisawa
- Koichi Narikawa
- Krishna Pokala
- Kristen Roe
- Kristin Huynh
- Lara Katzin
- Laura Diez Porras
- Laura Echevarria
- Laura Fionda
- Laura Golden
- Laura Haar
- Laura Herbelin
- Laurie Gutmann
- Legendre
- Lena Bjarbo
- Lesly Welsh
- Liang Lu
- Licht
- Liene Duarte Silva
- Linda Wagemaekers
- Lindsay Zilliox
- Lisa Hobson-Webb
- Lisa Smith
- Lorenzo Maggi
- Lorraine Dishman
- Lotte Vinge
- Louisa Mezache
- Lucas Eduardo Pazetto
- Luciana Renata Cubas Volpe
- Luciana Souza Duca
- Ludwig Gutmann
- Luis Antonio Querol Gutierrez
- Luiz Augusto da Silva
- Luiz Otavio Maia Gonçalves
- Maki Jingu
- Makoto Samukawa
- Mamatha Pasnoor
- Manisha Chopra
- Marcela Silva
- Marcela Wolfova
- Marcelo Annes
- Marcelo Chaves
- Marcelo Rugiero
- Marguerite Engel
- Maria Antonia Alberti Aguilo
- Maria da Penha Ananias Morita
- Maria Pasanisi
- Maria Salvado
- Maria Sastre
- Marianne de Visser
- Mariela Bettini
- Marina Pozo
- Martin Bilsker
- Mary Varghese
- Maryanne Burdette
- Masahiro Mori
- Masakatsu Motomura
- Masaki Saitoh
- Masako Tsurumaru
- Masanori Takahashi
- Masayuki Makamori
- Matsuki
- Matteo Garibaldi
- Maureen Walsh
- Mayuko Noshiro
- Mazen Dimachkie
- Megan Kramer
- Megumi Koga
- Meinoshin Okumura
- Melanie Glenn
- Melinda Horvath
- Michael Benatar
- Michael Hehir
- Michael Pulley
- Michael Weiss
- Michaela Tyblova
- Michal Vytopil
- Miguel Wilken
- Mihoko Takada
- Mikko Laaksonen
- Mireya Fernandez-Fournier
- Miriam Freimer
- Misa Shimpo
- Miwako Sato
- Miyuki Morikawa
- Mohamed Kazamel
- Mohamed Mahdi-Rogers
- Mohammad Alsharabati
- Mohammad Sanjak
- Mohammed Salajegheh
- Mona Elsayed
- Muppidi
- Muppidi
- Murai
- Murai
- Murai
- Murat Terzi
- Murilo Santos Engel
- Musa Kazim Onar
- Muzeyyen Ugur
- Nadia Sattar
- Namie Taichi
- Namita Goyal
- Nanna Witting
- Naoki Kawaguchi
- Naoko Ishiyama
- Natalia Julia Palacios
- Natalia Prando
- Natália Assis
- Naya McKinnon
- Nazire Pinar Acar
- Neelam Goyal
- Nicholas Silvestri
- Nicholas Ventura
- Nicolas Vandenbussche
- Nicole Jenci
- Nicole Kressin
- Nivedita Jerath
- Nuria Vidal
- Ohito Tano
- Olga Zapletalova
- Olivier Stevens
- Olli Oksaranta
- Ozlem Tun
- Pamela César
- Paolo Emilio Alboini
- Patricia Fernandes
- Patricia Padilla
- Pedro Lopez Ruiz
- Petra Tilkin
- Pharmaceuticals and Medical Devices Agency Japan
- Philip Van Damme
- Pilar Gomez Salcedo
- Pilar Sune
- Pinar Ozcelik
- Pravin Torane
- Raffaele Iorio
- Ratna Bhavaraju-Sanka
- Rebecca Traub
- Rebekah Garcia
- Renata Martins Ribeiro
- Renato Mantegazza
- Ricardo Rojas Garcia
- Richard Barohn
- Richard Nowak
- Rikako Kurihara
- Rikki Roderus
- Riley Snook
- Robert Miller
- Robert Pascuzzi
- Rosana Rocha
- Rother
- Rudy Mercelis
- Rumi Takeyama
- Rup Tandan
- Sabrina Pol
- Sachiko Kamakura
- Said Beydoun
- Saiju Jacob
- Salma Akhter
- Sanaz Karimi
- Sanders
- Sandi Mumfrey-Thomas
- Sandra Guingrich
- Santos
- Sara-Claude Michon
- Sarada Sakamuri
- Sarah Plevka
- Sarah Verjans
- Scott Cunningham
- Scott Tierney
- Seda Aydinlik
- Sedat Sen
- Seiko Yoshida
- Sevim Erdem-Ozdamar
- Shachie Aranke
- Shannon Lucy
- Sharmeen Alam
- Sharon Chelnick
- Sharon Downing
- Shin Hisahara
- Shirley Paulose
- Shirli Toska
- Shizuka Asada
- Shoko Amamoto
- Shuichiro Suzuki
- Shun Shimohama
- Shunsuke Yoshimura
- Sien Van Daele
- Silvia Bonanno
- Sivakumar Sathasivam
- Soichiro Funaka
- Sonia Garcia
- Srikanth Muppidi
- Stefania Morino
- Stephanie Kohlrus
- Stephanie Scala
- Suh
- Susan Strom
- Susanne Krogh
- Tahseen Mozaffar
- Taira Uehara
- Takashi Hayashi
- Takashi Murahara
- Takuya Matsushita
- Tamar Gibson
- Tamires Cristina Gomes da Silva
- Taylor Darnell
- Teiichiro Mitazaki
- Teresa Costabile
- Terry McClain
- Terry McClain
- Tessa Marburger
- Tetsuya Akiyama
- Tetsuya Kanai
- Thabata Veiga
- Thomas Cochrane
- Thomas Harbo
- Tina Liu
- Tiyonnoh Cash
- Tomihiro Imai
- Tomohiro Kawamura
- Tomoko Tsuda
- Tomomi Kobashikawa
- Tomoya Hasuike
- Tomás Augusto Suriane Fialho
- Tuan Vu
- Tugce Kirbas Cavdar
- Tuula Harrison
- Tuzun
- Utsugisawa
- Utsugisawa
- Valentina D'Amato
- Valentina Velez Santamaria
- Valeria Cavalcante Lino
- Valerie Young
- Veena Mathew
- Vern Juel
- Victor Doan
- Vinay Chaudhry
- Waqar Waheed
- Wladimir Pinto
- Yagmur Caliskan
- Yasmeen Shabbir
- Yasuko Maeda
- Yasushi Suzuki
- Yoko Ishiyama
- Yoko Kaneko
- Yoshiko Sano
- Yuen T. So
- Yuka Saito
- Yukiko Ozawa
- Yuko Fujii
- Yumi Yamashita
- Yumiko Nakamura
- Yunxia Wang
- Yuriko Nagane
- Yusuke Fukuda
- Zaeem Siddiqi
- Zhang
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part one
- Author
- A. Berman
- A. Cochino
- A. De Jesus
- A. Groll
- A. Insalaco
- A. Jansson
- A. Kazmirchyk
- A. Kozlova
- A. Lazar
- A. Martini
- A. Martini
- A. Martini
- A. Martini
- A. Martini
- A. Ombrello
- A. Pistorio
- A. Ravelli
- A. Simon
- A. Simon
- A. Simon
- A. Simon
- A. Speziale
- A. Speziale
- A. Speziale
- A. Speziale
- A. Speziale
- A. Zeft
- A. Zeft
- A. Zeft
- Abdullah Alsonbul
- Abdullah Calıskan
- Achille Marino
- Acute-JIA Study Group
- Adel Al-Wahadneh
- Adele Civino
- Adele D’Amico
- Adrian Liston
- Adriana Ivonne Cespedes-Cruz
- Adriana Rodriguez Vidal
- Adriana S. Díaz-Maldonado
- Agneza Marija Pasini
- Ahmet B. Cekgeloglu
- Ahmet Gul
- Aki Hanaya
- Akihiro Yachie
- Akihiro Yachie
- Akihiro Yachie
- Alain Fischer
- Alan Salama
- Alberto Garaventa
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Tommasini
- Alberto Tommasini
- Alberto Tommasini
- Alberto Vieira
- Aleksandra Czajkowska
- Aleksandra Szabat
- Aleksandre Kajrishvili
- Aleksandre Kajrishvili
- Aleksey Kozhevnikov
- Alena Torbyak
- Alenka Gagro
- Alessandra Meneghel
- Alessandra Russo
- Alessandro Cafarotti
- Alessandro Consolaro
- Alessandro Consolaro
- Alessandro De Fanti
- Alessandro Ventura
- Alessia Omenetti
- Alessia Omenetti
- Alessia Omenetti
- Alexandre Belot
- Alexandre Belot
- Alexandre Belot
- Alexandre Belot
- Alexey Maschan
- Alfonso Ragnar Torres-Jimenez
- Alfred Mahr
- Alice Grossi
- Alice Grossi
- Alma Nunzia Olivieri
- Alma Olivieri
- Almira Ćosićkić
- Amanda Ombrello
- Amanda Radulescu
- Amanda Saracino
- Amit Rawat
- Amit Rawat
- Amit Rawat
- Amra Adrovic
- Amra Adrovic
- Amra Adrovic
- Amra Adrovic
- Amra Adrovic
- Amra Adrovic
- An Goris
- Ana F. Mourão
- Ana M. Marín Sánchez
- Ana V. Villarreal
- Ana V. Villarreal Treviño
- Ana V. Villarreal-Treviño
- Ana Vieira
- Ana Villarreal
- Anders Fasth
- Andrea Magnolato
- Andrea Pession
- Andrea Petretto
- Andrea Taddio
- Andrea Taddio
- Andrea Taddio
- Andressa G. Alves
- Andressa G. Alves
- Andrew Henrey
- Angel J. Flores-Pineda
- Angela Aquilani
- Angela C. Mosquera
- Angela C. Mosquera
- Angela Cox
- Angela Mauro
- Angela Mauro
- Angela Mauro
- Angela McArdle
- Angela Miniaci
- Angela Pistorio
- Angela Pistorio
- Angela Rösen-Wolff
- Angelika Thon
- Angelo Ravelli
- Angelo Ravelli
- Angelo Ravelli
- Angelo Ravelli
- Angelo Ravelli
- Angelo Ravelli
- Angelo Ravelli
- Angelo Ravelli
- Anita Dhanrajani
- Anju Gupta
- Anju Gupta
- Anju Gupta
- Anju Gupta
- Anju Gupta
- Ankur Kumar
- Ankur Kumar
- Anna C. Schulz
- Anna Gruenpeter
- Anna Kozlova
- Anna Mondino
- Anna Pogodina
- Anna Rubartelli
- Anna Shcherbina
- Anna Simon
- Anna Vermé
- Annacarin Horne
- Annalisa Chiocchetti
- Annalisa Salis
- Anne Grethe Jurik
- Anne H. Spannow
- Anne Hinks
- Anne Hulin
- Anne Lohse
- Anne Pagnier
- Anne Thorwarth
- Anne-Laure Mathieu
- Anneleen Avau
- Annemarie van Nieuwenhuijze
- Annemieke S. Littooij
- Annette Jansson
- Annette Keylock
- Annette von Scheven-Gête
- Antje Nimtz-Talaska
- Anton Hospach
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Petaccia
- Antonella Petaccia
- Antonella Petaccia
- Antonia Kienast
- Antonio Fernández-Nebro
- Antonio L. Urda Cardona
- Antonio L. Urda Cardona
- Antonio Novelli
- Antonio Urda-Cardona
- Ariane Klein
- Ariane Standing
- Arinna Bertoni
- Arinna Bertoni
- Arinna Bertoni
- Arne Hørlyck
- Aygen Yılmaz
- Aysenur Pac Kısaarslan
- Aysenur Pac Kisaarslan
- Ayşen Bingöl
- Ayşenur Kısaarslan
- B. Flato
- B. Lauwerys
- B. Lauwerys
- Bahar Muezzinoglu
- Balahan Makay
- Balahan Makay
- Balahan Makay
- Banu Acar
- Banu Orak
- Barbara Stanimirovic
- Belinda Hernandez
- Belkisa Čolić
- Berenice Sanchez-Jara
- Berent Prakken
- Berent Prakken
- Beril Talim
- Berit Flato
- Berna E. Fidanci
- Berna Eren Fidanci
- Berta Lopez Montesinos
- Betul Sozeri
- Betul Sozeri
- Betul Sozeri
- Betül Sozeri
- Betül Sözeri
- Beverley Almeida
- Biagio Castaldi
- Bianca Lattanzi
- BIKER collaborative group
- Bilade Cherqaoui
- Biljana Djurdjevic-Banjac
- Biman Saikia
- Biman Saikia
- Birgitte T. Mahler
- Bita Arabshahi
- Bo Magnusson
- Bo Magnusson
- Board of the Swedish Pediatric Rheumatology Registry
- Bogumiła Szponar
- Boris Huegle
- Boris Hugle
- Brenden Dufault
- Brent Adler
- Brian M. Feldman
- Brigitte Bader-Meunier
- Brigitte Bader-Meunier
- Brigitte Bader-Meunier
- Brigitte Bader-Meunier
- Brigitte Bader-Meunier
- Bruno Charbit
- Bruno Dallapiccola
- Butsabong Lerkvaleekul
- Butsabong Lerkvaleekul
- Bénédicte Neven
- Bénédicte Neven
- C H. Spencer
- C. C. Barbosa Sandoval de Souza
- C. H. Spencer
- C. Wang
- C. Wouters
- Cagla Kaymakamgil
- Calin Lazar
- Calin Lazar
- Calin Lazar
- Camilla Celani
- Camilo Vargas
- CAPS
- Carine H. Wouters
- Carine Wouters
- Carine Wouters
- Carine Wouters
- Carla Aguilar Blancafort
- Carla Maldini
- Carlos Eduardo Ramalho
- Carolin Pretzer
- Carolina Uggenti
- Carolina Uggenti
- Caroline Freychet
- Caroline M. Andreasen
- Carsten W. Heuck
- Casper Schoemaker
- Caterina Di Battista
- Caterina Pellecchia
- Catherine Adamsbaum
- Catherine Orzechowski
- Cathryn E. Harkness
- Cecilia Lazea
- Chack-Yung Yu
- Chantal Deslandre
- Chantal Job Deslandre
- Charalampia Papadopoulou
- Charlotte Eijkelboom
- Chiara Lavarello
- Chiara Marini
- Chiara Passarelli
- Chiara Passarelli
- Chiara Trentin
- Chloe M. Stephenson
- Chris Pruunsild
- Chris Wallace
- Chris Williams
- Christelle Sordet
- Christiaan Scott
- Christian Høst
- Christian Pagnoux
- Christina Boros
- Christina Boros
- Christina Boros
- Christina Boros
- Christina Peterson
- Christine Arango
- Christine Barnerias
- Christine Bodemer
- Christine Bodemer
- Christine Bodemer
- Christine Bodemer
- Christine Nirschl
- Christine Seib
- Christine Soler
- Christoph Kessel
- Christoph Kessel
- Christopher Piper
- Chung-Yung Yu
- Ciaran Duffy
- Claas Hinze
- Claas Hinze
- Claas Hinze
- Claas Hinze
- Claire Grimwood
- Claire Hoyoux
- Claire Murphy
- Claire T. Deakin
- Clara Gimenez Roca
- Clara Giménez Roca
- Clara Malagon
- Clara Malagon
- Clara Malattia
- Clara Malattia
- Clara Malattia
- Clare Pain
- Clarissa Pilkington
- Clarissa pilkington
- Clarissa Pilkington
- Claudia Bracaglia
- Claudia Mauri
- Claudia Pastorino
- Claudia Pastorino
- Claudia Pastorino
- Claudia Poloni
- Claudio Lavarello
- Claudio Lavarello
- Clotilde Alizzi
- Clotilde Alizzi
- Consuelo Modesto
- Consuelo Modesto Caballero
- Consuelo Modesto Caballero
- Consuelo Modesto Caballero
- Cosimo Giannini
- Coskun F. Ozkececi
- Coskun F. Ozkececi
- Craig Kinnear
- Cristina Battagliotti
- Cristina Battagliotti
- Cristina Battagliotti
- Cristina de Min
- Cyril Gitiaux
- Cécile Gaujoux-Viala
- D. A. Williams
- D. Arikan
- D. J. Lovell
- D. J. Lovell
- D. Lovell
- D. Lovell
- D. Rigante
- Daiva Gorczyca
- Damien Bentayou
- Damien Noone
- Dan Cosma
- Dan Vasilescu
- Dan Ø. Pradsgaard
- Dana Nemcova
- Dana Nemcova
- Dana Nemcova
- Dana Nemcova
- Dana Němcová
- Daniel J. Lovell
- Daniel Kelberman
- Daniel L. Kastner
- Daniel L. Kastner
- Daniel Lovell
- Daniel Windschall
- Daniel Álvarez de la Sierra
- Daniela Chroustová
- Daria Augustyniak
- Darragh Duffy
- Darragh Duffy
- David Isenberg
- David Jayne
- David Moreno Romo
- Davide Gatti
- Deborah Stone
- Deepthi R. Abraham
- Deepti Suri
- Deepti Suri
- Delphine Regnard
- Demet Kartal
- Denise Ferrera
- Denise Lasigliè
- Denise Pires Marafon
- Denise Pires Marafon
- Denise Pires Marafon
- Denise Pires Marafon
- Denise Pires Marafon
- Denise Pires-Marafón
- Deniz Dogru
- Despina Eleftheriou
- Despina Eleftheriou
- Despina Eleftheriou
- Despina Eleftheriou
- Despina Eleftheriou
- Despina Eleftheriou
- Despina Eleftheriou
- Despina Moshous
- Despoina Maritsi
- Despoina Maritsi
- Diana Sueiro Delgado
- Diane Hebert
- Didier Bessis
- Diego R. Salinas-Encinas
- Diego Vozzi
- Dilek Konukbay
- Dilek Yıldız
- Dilek Yildiz
- Dilek Yılmaz
- Dirk Foell
- Dirk Foell
- Dirk Foell
- Dirk Foell
- Dirk Foell
- Dirk Foell
- Dirk Föll
- Dirk Föll
- Dirk Holzinger
- Dirk Holzinger
- Dirk Holzinger
- Dirk Holzinger
- Dita Cebecauerová
- Do Young Kim
- Dogan Simsek
- Dogan Simsek
- Dogan Simsek
- Dogan Simsek
- Domenico Biasi
- Donatella Vairo
- Donato Rigante
- Donato Rigante
- Donato Rigante
- Donato Rigante
- Dong Soo Kim
- Dorota Rowczenio
- Doğan Simsek
- Duarte Alves
- E. Alekseeva
- E. Alexeeva
- E. Ben-Chetrit
- E. Ben-Chetrit
- E. Ben-Chetrit
- E. Castagnola
- E. Demirkaya
- E. Hachulla
- E. Haddad
- E. Nasonov
- E. Papadopoulou-Alataki
- E. Solau-Gervais
- E. Tsitami
- E. Vritzali
- Ebru Yalcin
- Ebru Yilmaz
- Ebun Omoyinmi
- Edel R. Rodea-Montero
- Edi Paleka Bosak
- Edita Kabíčková
- Edyta Olesińska
- EH Pieter Van Dijkhuizen
- Eileen Baildem
- Eileen Hoal
- Ekaterina Alexeeva
- Ekaterina Alexeeva
- Ekaterina Alexeeva
- Ekaterina Kulesh
- Elaine F. Remmers
- Elaine F. Remmers
- Elena Raikina
- Elena Reffo
- Eleonora Fanti
- Elif Comak
- Elisa Fazzi
- Elisa Patrone
- Elisa Pisaneschi
- Elisabeth Solau-Gervais
- Elisabeth Weissbarth-Riedel
- Elisabetta Cortis
- Elisabetta Traggiai
- Elizabeth Candell Chalom
- Elizabeth D. Mellins
- Elizabeth Jury
- Elizabeth Legger
- Ellen Brisse
- Ellen-Margrethe Hauge
- Elvira Inglese
- Elzbieta Smolewska
- Emediong S. Asuka
- Emiliano Marasco
- Emiliano Marasco
- Emilie Georget
- Emilio Inarejos Clemente
- Emily Robinson
- Emine Sonmez
- Emma Henry
- Ender Terzioğlu
- Enrica Balza
- Enrique Faugier
- Enrique Faugier
- Enrique Faugier Fuentes
- Enrique Faugier-Fuentes
- EPOCA Study Group
- Erbil Unsal
- Erbil Unsal
- Erbil Ünsal
- Erdal Sag
- Eric Jeziorski
- Eric Legius
- Erica Valencic
- Erika Scoccimarro
- Erkan Demirkaya
- Erkan Demirkaya
- Erkan Demirkaya
- Erkan Demirkaya
- Erkan Demirkaya
- Erkan Demirkaya
- Erkan Demirkaya
- Esmeralda Nuñez-Cuadros
- Esmeralda Núñez Cuadros
- Esmeralda Núñez Cuadros
- Esra Kurt
- Esra Kurt
- Estefania Quesada-Masachs
- Estefania Quesada-Masachs
- Esther Hoppenreijs
- Estibaliz Iglesias Jimenez
- Estíbaliz Iglesias
- Eszter Dzsida
- Eszter Dzsida
- Etienne Merlin
- Eunice M. Okuda
- Eunice M. Okuda
- Eunice Solis-Vallejo
- Eva Seipelt
- Eve Smith
- Evgeniy Melchenko
- Ezgi D. Batu
- Ezgi D. Batu
- Ezgi D. Batu
- Ezgi Deniz Batu
- Ezgi Deniz Batu
- Ezgi Deniz Batu
- F. Avila-Zapata
- F. Boris
- F. De Benedetti
- F. De Benedetti
- F. De Benedetti
- F. De Benedetti
- F. De Benedetti
- F. Dedeoglu
- F. Gohar
- F. Sztajnbok
- F. Uettwiller
- Fabian Speth
- Fabian Speth
- Fabian Speth
- Fabian Speth
- Fabio Voller
- Fabiola Almeida
- Fabiola D. Almeida
- Fabrizia Corona
- Fabrizia Corona
- Fabrizia Corona
- Fabrizia Corona
- Fabrizia Corona
- Fabrizio De Benedetti
- Fabrizio De Benedetti
- Fabrizio De Benedetti
- Fabrizio De Benedetti
- Fabrizio De Benedetti
- Fabrizio De Benedetti
- Fabrizio De Benedetti
- Fabrizio De Benedetti
- Fabrizio Debenedetti
- Faekah Gohar
- Fahrija Skokić
- Fatemeh F. Mehregan
- Fatih Kelesoglu
- Fatih Ozaltin
- Fatma Dedeoglu
- Fatos Yalcinkaya
- Faysal Gok
- Faysal Gok
- Faysal Gok
- Faysal Gök
- Federica Del Chierico
- Federica Penco
- Federica Penco
- Federica Penco
- Federica Penco
- Federica Vanoni
- Federico Annoni
- Federico Bertini
- Federico Marchetti
- Ferah Sönmez
- Ferhat Demir
- Fernanda Falcini
- Fernando Garcia
- Fernando Garcia-Rodriguez
- Fernando N. Arita
- Filipa O. Ramos
- Fiona Price-Kuehne
- Flavio Faletra
- Flavio Sztajnbok
- Flavio Sztajnbok
- Flavio Sztajnbok
- Florence A. Aeschlimann
- For Pediatric Rheumatology International Trials Organization (PRINTO)/Pediatric Rheumatology Collaborative Study Group (PRCSG)
- For the FMF Arthritis Vasculitis and Orphan Disease Research in Paediatric Rheumatology (FAVOR)
- Franca Fagioli
- Franca Rusconi
- Francesca Bovis
- Francesca Kalli
- Francesca Magnaguagno
- Francesca Minoia
- Francesca Orlando
- Francesca Orlando
- Francesca Ricci
- Francesca Schena
- Francesca Schena
- Francesca Schena
- Francesca Soscia
- Francesca Sperotto
- Francesco Baldo
- Francesco Baldo
- Francesco Caroli
- Francesco Chiarelli
- Francesco La Torre
- Francesco La Torre
- Francesco Zulian
- Francesco Zulian
- Francesco Zulian
- Francisca Aguiar
- Frank Dressler
- Frank Weller-Heinemann
- François-Jérôme Authier
- Frederic Rieux-Laucat
- Frederick W. Miller
- Fredy Hermógenes Prada Martínez
- Frédéric Rieux-Laucat
- Funda Bastug
- G. Amaryan
- G. Berbers
- G. Espada
- G. Fabio
- G. Giancane
- G. Horneff
- G. Horneff
- G. Horneff
- G. Horneff
- G. Junge
- G. Mjasnikov
- G. Pileggi
- G. Simonini
- G. Susic
- G. Vega-Cornejo
- Gabriele Simoni
- Gabriele Simonini
- Gabriele Simonini
- Gabriella Giancane
- Gabriella Giancane
- Gaetana Minnone
- Galina Lyskina
- Galina Lyskina
- Galina Lyskina
- Gary Sterba
- Gemma Lepri
- Geneviève Lapeyre
- GENIAL Investigators UK JSLE Study Group
- Gennadiy Novik
- Georg Otto
- Georges Leclercq
- Georgina Tiller
- Gerd Ganser
- Gerd Ganser
- Gerd Ganser
- Gerd Horneff
- Gerd Horneff
- Gerd Horneff
- Gerd Horneff
- Gerd Horneff
- Giampietro Farronato
- Giampietro Farronato
- Gian Marco Moneta
- Gian Marco Moneta
- Giancarla Di Landro
- Giancarla Di Landro
- Gianluca Damonte
- Gianmarco Moneta
- Gilberto Filaci
- Gillian I. Rice
- Gillian Rice
- Giorgia Martini
- Giovanna Ferrara
- Giovanna Ferrara
- Giovanna Ferrara
- Giovanni Alighieri
- Giovanni Conti
- Giovanni Corsello
- Giovanni Filocamo
- Giovanni Filocamo
- Giovanni Filocamo
- Giovanni Filocamo
- Giovanni Filocamo
- Gisela Diaz-Cordovés
- Gisela Díaz-Cordovés Rego
- Gisela Díaz-Cordovés Rego
- Giulia Amico
- Giulia Zani
- Giuseppe Lapergola
- Giusi Prencipe
- Giusi Prencipe
- Glenda Durrheim
- Gloria Dallagiacoma
- Gokalp Basbozkurt
- Gokalp Basbozkurt
- Gokcen Dilsa Tugcu
- Goran Radunovic
- Goran Roic
- Gordana Susic
- Graciela Espada
- GRIP study group
- Guilhem Cros
- Guillaume Bassez
- Gulsev Kale
- Gur Akansel
- Gülşah Kaya Aksoy
- H. H. Tilson
- H. Hoffman
- H. Hoffman
- H. I. Brunner
- H. I. Brunner
- H. I. Brunner
- H. I. Huppertz
- H. I. Huppertz
- H. Lachmann
- H. Lachmann
- H. Lachmann
- H. Lachmann
- H. M. Hoffman
- H. M. Hoffman
- H. M. Hoffman
- Hafize E. Sönmez
- Hafize Emine Sonmez
- Hafize Emine Sonmez
- Hafize Uzun
- Hakan Kisaoglu
- Hakan Poyrazoglu
- Hakan Poyrazoglu
- Hal M. Hoffman
- Haluk Topaloglu
- Hans-Iko Huppertz
- Hans-Iko Huppertz
- Harsha Gunawardena
- Hartwig Lehmann
- Harun Çakmak
- Hasmik Sargsyan
- Hasmik Sargsyan
- Hayde G. Hernández-Huirache
- Helen Foster
- Helen J. Lachmann
- Helen Lachmann
- Helen Lachmann
- Helen Lachmann
- Helen Lachmann
- Hella Luksch
- Helmut Wittkowski
- Helmut Wittkowski
- Helmut Wittkowski
- Hema Chaplin
- Hermann Girschick
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- Umberto Garagiola
- Umberto Garagiola
- V. Chasnyk
- V. Hentgen
- V. Paes Leme Ferriani
- V. Panaviene
- V. Stanevicha
- Vahid Ziaee
- Valda Stanevicha
- Valda Stanevicha
- Valda Stanevicha
- Valda Stanevicha
- Valda Stanevicha
- Valentina Leone
- Valentina Litta Modignani
- Valentino Conter
- Valeria Gerloni
- Valeria Gerloni
- Valérie Devauchelle-Pensec
- Vanessa Smith
- Vanessa Smith
- Vanessa Smith
- Vasiliy Burlakov
- Vera Milic
- Veronique Hentgen
- Victoria Arthur
- Victoria B. Nikolayenko
- Vimal Prajapati
- Vincent Bondet
- Violetta Opoka-Winiarska
- Virginia Messia
- Virginia Messia
- Vitor A. Teixeira
- Vladimir Kenis
- Vladimír Tesař
- Véronique Hentgen
- W.-Alberto Sifuentes-Giraldo
- W.-Alberto Sifuentes-Giraldo
- W.-Alberto Sifuentes-Giraldo
- Wafa A. Madan
- Walter Ferlin
- Wanxia Tsai
- Wendy Costello
- Wendy Thomson
- Wendy Thomson
- Wendy Thomson
- Wendy Thomson
- Wilco de Jager
- William Fahy
- Wineke Armbrust
- Witaya Sungkarat
- Working Group of Behçet’s Disease Pediatric Rheumatology Association of Japan (PRAJ)
- Working Group “Juvenile Dermatomyositis” of the German Society for Paediatric and Adolescent Rheumatology (GKJR)
- Working Group “Juvenile Dermatomyositis” of the German Society for Paediatric and Adolescent Rheumatology (GKJR)
- X. Li
- X. Wei
- X. Xu
- Xiaomin Yu
- Y. Joubert
- Y. Joubert
- Y. Joubert
- Y. Joubert
- Y. Uziel
- Yanick Crow
- Yanick Crow
- Yanick Crow
- Yanick Crow
- Yanick J. Crow
- Yasar Karaaslan
- Yasin Bulut
- Yasuo Nakagishi
- Yasushi Kawaguchi
- Yavuz Tokgöz
- Yelda Bilginer
- Yelda Bilginer
- Yelda Bilginer
- Yelda Bilginer
- Yelda Bilginer
- Yiannis Ioannou
- Yiannis Ioannou
- Ying Hong
- Ying Hong
- Yoann Rose
- Yoann Rose
- Yonatan Butbul
- Yosef Uziel
- Yosef Uziel
- Yosef Uziel
- Yosef Uziel
- Yosuke Fujii
- Yukie Saito
- Yuksel Aliyazicioglu
- Yulia Kostina
- Yulia Kostina
- Yumi Tani
- Yunus Arıkan
- Yuridiana Ramirez
- Yuridiana Ramirez Loyola
- Yuridiana Ramírez
- Yvonne Kusche
- Z. Serap Arıcı
- Zehra Serap Arici
- Zelal Ekinci
- Zelal Ekinci
- Zelal Ekinci
- Zelal Ekinci Ekinci
- Zeno Sparchez
- Zeyad El-Habahbeh
- Zeynep Birsin Özçakar
- Zubeyde Gunduz
- Zubeyde Gunduz
- Zübeyde Gunduz
- Özge A. Gücenmez
- Özge Basaran
- Şebnem Sara Kılıc
- Publication venue
- place:236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
- Publication date
- 01/01/2017
- Field of study