Use of SMOS L3 soil moisture data: validation and drought assessment for Pernambuco State, Northeast Brazil

The goal of this study was to validate soil moisture data from Soil Moisture Ocean Salinity (SMOS) using two in situ databases for Pernambuco State, located in Northeast Brazil. The validation process involved two approaches, pixel-station comparison and areal average, for three regions in Pernambuco with different climatic characteristics. After validation, the SMOS data were used for drought assessment by calculating soil moisture anomalies for the available period of data. Four statistical criteria were used to verify the quality of the satellite data: Pearson correlation coefficient, Willmott index of agreement, BIAS, and root mean squared difference (RMSD). The average RMSD calculated from the daily time series in the pixel and the areal assessment were 0.071 m3m-3 and 0.04 m3m-3, respectively. Those values are near to the expected 0.04 m3m-3 accuracy of the SMOS mission. The analysis of soil moisture anomalies enabled the assessment of the dry period between 2012 and 2017 and the identification of regions most impacted by the drought. The driest year for all regions was 2012, when the anomaly values achieved -50% in some regions. The use of SMOS data provided additional information that was used in conjunction with the precipitation data to assess drought periods. This may be particularly relevant for planning in agriculture and supporting decision makers and farmers.Peer ReviewedPostprint (published version

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo

Use of SMOS L3 soil moisture data: validation and drought assessment for Pernambuco State, Northeast Brazil

The goal of this study was to validate soil moisture data from Soil Moisture Ocean Salinity (SMOS) using two in situ databases for Pernambuco State, located in Northeast Brazil. The validation process involved two approaches, pixel-station comparison and areal average, for three regions in Pernambuco with different climatic characteristics. After validation, the SMOS data were used for drought assessment by calculating soil moisture anomalies for the available period of data. Four statistical criteria were used to verify the quality of the satellite data: Pearson correlation coefficient, Willmott index of agreement, BIAS, and root mean squared difference (RMSD). The average RMSD calculated from the daily time series in the pixel and the areal assessment were 0.071 m3m-3 and 0.04 m3m-3, respectively. Those values are near to the expected 0.04 m3m-3 accuracy of the SMOS mission. The analysis of soil moisture anomalies enabled the assessment of the dry period between 2012 and 2017 and the identification of regions most impacted by the drought. The driest year for all regions was 2012, when the anomaly values achieved -50% in some regions. The use of SMOS data provided additional information that was used in conjunction with the precipitation data to assess drought periods. This may be particularly relevant for planning in agriculture and supporting decision makers and farmers.Peer Reviewe

Política, atores e interesses no processo de mudança institucional: a criação do Ministério da Saúde em 1953 Politics, actors, and interests in the process of institutional change: the creation of the Brazilian Ministry of Health in 1953

Este trabalho analisa a criação do Ministério da Saúde, em 1953, por meio da identificação dos principais agentes envolvidos, seus interesses e estratégias utilizadas para atingir seus objetivos e influenciar o processo de mudança institucional. Relacionando este processo às características particulares do contexto político da época, identificaremos, entre as arenas de decisão, aquela que ganhou relevância; apresentaremos as variáveis políticas que interferiram no surgimento dessa nova agência estatal autônoma para a saúde pública.<br>This analysis of the 1953 creation of the Ministry of Health identifies the main actors involved, their interests, and the strategies they employed to reach their goals and influence the process of institutional change. Placing the process within the context of the era's specific political characteristics, the article identifies the predominant decision-making arena as well as the political variables that influenced the emergence of this new, autonomous government agency for public health