58 research outputs found
Contribution of microscopy for understanding the mechanism of action against trypanosomatids
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs. Thus, it has been observed that sesquiterpene lactones induce diverse ultrastructural alterations in both T. cruzi and Leishmania spp., such as cytoplasmic vacuolization, appearance of multilamellar structures, condensation of nuclear DNA, and, in some cases, an important accumulation of lipid vacuoles. This accumulation could be related to apoptotic events. Some of the sesquiterpene lactones (e.g., psilostachyin) have also been demonstrated to cause an intense mitochondrial swelling accompanied by a visible kinetoplast deformation as well as the appearance of multivesicular bodies. This mitochondrial swelling could be related to the generation of oxidative stress and associated to alterations in the ergosterol metabolism. The appearance of multilamellar structures and multiple kinetoplasts and flagella induced by the sesquiterpene lactone psilostachyin C indicates that this compound would act at the parasite cell cycle level, in an intermediate stage between kinetoplast segregation and nuclear division. In turn, the diterpene lactone icetexane has proved to induce the external membrane budding on T. cruzi together with an apparent disorganization of the pericellar cytoskeleton. Thus, ultrastructural TEM studies allow elucidating the possible mechanisms and the subsequent identification of molecular targets for the action of natural compounds on trypanosomatids.Fil: Lozano, Esteban SebastiĂĄn. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de Medicina y BiologĂa Experimental de Cuyo; ArgentinaFil: Spina Zapata, Renata MarĂa. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Barrera, Patricia Andrea. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - San Luis. Instituto de Investigaciones en TecnologĂa QuĂmica. Universidad Nacional de San Luis. Facultad de QuĂmica, BioquĂmica y Farmacia. Instituto de Investigaciones en TecnologĂa QuĂmica; ArgentinaFil: Sosa Escudero, Miguel Angel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; Argentin
A endogamia explicaria a elevada prevalĂȘncia de deficiĂȘncias em populaçÔes do Nordeste brasileiro?
Determinação de resveratrol e caracterĂsticas quĂmicas em sucos de uvas produzidas em sistemas orgĂąnico e convencional
Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil
The Impact of Imbalanced training Data on Local matching learning of ontologie
International audienceMatching learning corresponds to the combination of ontology matching and machine learning techniques. This strategy has gained increasing attention in recent years. However, state-of-the-art approaches implementing matching learning strategies are not well-tailored to deal with imbalanced training sets. In this paper, we address the problem of the imbalanced training sets and their impacts on the performance of the matching learning in the context of aligning biomedical ontologies. Our approach is applied to local matching learning, which is a technique used to divide a large ontology matching task into a set of distinct local sub-matching tasks. A local matching task is based on a local classifier built using its balanced local training set. Thus, local classifiers discover the alignment of the local sub-matching tasks. To validate our approach, we propose an experimental study to analyze the impact of applying conventional resampling techniques on the quality of the local matching learning
Rethinking normative literacy practices, behaviors, and interactions: Learning from young immigrant boys
Angioma em tufo e sĂndrome dolorosa miofascial Tufted angioma and myofascial pain syndrome
O Angioma em tufo Ă© considerado um raro tumor vascular cutĂąneo adquirido. Caracteriza-se por mĂĄculas purpĂșrico-violĂĄceas, dolorosas que podem evoluir para placas com pĂĄpulas angiomatosas. Tem natureza benigna, mas o envolvimento extenso Ă© comum, gerando alteração funcional do membro afetado em caso de dor. Os autores relatam um caso de angioma em tufo associado Ă sĂndrome dolorosa miofascial, em que o elemento predisponente foi a presença deste tumor desde a infĂąncia. A dor local prejudicou a utilização da musculatura e possibilitou o surgimento da sĂndrome relatada. A realização de bloqueio anestĂ©sico de pontos-gatilhos no membro afetado, levou Ă melhora total dos sintomas.<br>Tufted angioma is a rare acquired vascular tumor. It is characterized by painful purplish macules that may progress to plaques containing angiomatous papules. The condition is benign; however, it often affects extensive areas of the skin, leading to functional disability of the affected limb if painful. The present report describes a case of a tufted angioma associated with myofascial pain syndrome in which the predisposing element was the presence of this tumor since childhood. Pain at the site of the lesion affected muscle use and led to the onset of the associated syndrome. Complete relief from symptoms was achieved by blocking the trigger points of the affected limb with anesthesia
âTumour Perplexâ called pilomatricoma â Report of a case with confounding chest wall mass in an adult male and its literature review
- âŠ