Pharmaceutical care in patients with Coronavirus disease 2019 (COVID-19) in a private hospital in Salvador-BA: Cuidados farmacêuticos a pacientes com doença por Coronavírus 2019 (COVID-19) em um hospital privado de Salvador-BA

Coronavirus Disease-19 (COVID-19) is characterized as a new highly contagious pandemic disease that has been challenging health managers, professionals and the entire population to face and control this infection. Many alternative compassionate-use therapies were used in patients, although the results of their studies had not been published. From this perspective, the present study aims to describe the pharmaceutical care provided to patients with suspected or diagnosed COVID-19, in line with the protocols, guidelines and clinical studies that have been developed during this period. This is a descriptive, retrospective and observational study, carried out from March to June 2020, in a tertiary hospital in Salvador, Bahia. Data related to clinical activities provided by the clinical pharmacist were assessed, such as drug reconciliations, pharmaceutical interventions, pharmacotherapeutic follow-up, as well as problems related to medications identified in the medical records and prescriptions to hospitalized patients. Of the 241 assessed patients, approximately 75% received some pharmaceutical care that contributed to a positive outcome in the patients’ clinical condition. The clinical pharmacist’s performance brings benefits to the care provided to the patient and, thus, the development of their activities together with the multidisciplinary team in health services is essential

Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-02-25T18:45:25Z No. of bitstreams: 1 Baccan G. C Hormone levels are....pdf: 724792 bytes, checksum: b4ecb4200c89a92c7e3a758264aa1baa (MD5)Made available in DSpace on 2014-02-25T18:45:25Z (GMT). No. of bitstreams: 1 Baccan G. C Hormone levels are....pdf: 724792 bytes, checksum: b4ecb4200c89a92c7e3a758264aa1baa (MD5) Previous issue date: 2011Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biofunção. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biofunção. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilLeishmaniasis is a serious health problem in several parts of the world, and localized cutaneous leishmaniasis (LCL) is the most frequent presentation of the tegumentary form of this disease cluster. Clinical presentations of leishmaniasis are influenced by both parasite and host factors, with emphasis on the host immune response. Alterations in plasma hormone levels have been described in many infections, and changes in hormone levels could be related to an imbalanced cytokine profile. In the present work, we evaluated a group of patients with LCL to determine changes in plasma hormone levels (cortisol, DHEA-S, estradiol, prolactin and testosterone) and their association with clinical markers of disease (lesion size, dose used to reach cure and time to cure) and with cytokines produced by PBMC stimulated by SLA (IFN-γ, IL-10 and TNF-α). Individuals with LCL exhibited lower plasma levels of DHEA-S, prolactin and testosterone compared with sex-matched controls, whereas levels of cortisol and estradiol were similar between patients and controls. Plasma levels of cortisol, estradiol or prolactin positively correlated with at least one clinical parameter. Cortisol and prolactin levels exhibited a negative correlation with levels of IFN-γ, whereas no correlation was observed with IL-10 or TNF-α levels. A decrease in DHEA-S levels was observed in male LCL patients when compared to male healthy controls. No other differences between the sexes were observed. Our results indicate a role for neuroendocrine regulation that restricts Th1 responses in human LCL. It is possible that, although impairing parasite killing, such neuroimmunomodulation may contribute to limiting tissue damage

Brain, Behavior, and Immunity

texto completo: acesso restrito. p. 548–554.Leishmaniasis is a serious health problem in several parts of the world, and localized cutaneous leishmaniasis (LCL) is the most frequent presentation of the tegumentary form of this disease cluster. Clinical presentations of leishmaniasis are influenced by both parasite and host factors, with emphasis on the host immune response. Alterations in plasma hormone levels have been described in many infections, and changes in hormone levels could be related to an imbalanced cytokine profile. In the present work, we evaluated a group of patients with LCL to determine changes in plasma hormone levels (cortisol, DHEA-S, estradiol, prolactin and testosterone) and their association with clinical markers of disease (lesion size, dose used to reach cure and time to cure) and with cytokines produced by PBMC stimulated by SLA (IFN-c, IL-10 and TNF-a). Individuals with LCL exhibited lower plasma levels of DHEA-S, prolactin and testosterone compared with sex-matched controls, whereas levels of cortisol and estradiol were similar between patients and controls. Plasma levels of cortisol, estradiol or prolactin positively correlated with at least one clinical parameter. Cortisol and prolactin levels exhibited a negative correlation with levels of IFN-c, whereas no correlation was observed with IL-10 or TNF-a levels. A decrease in DHEA-S levels was observed in male LCL patients when compared to male healthy controls. No other differences between the sexes were observed. Our results indicate a role for neuroendocrine regulation that restricts Th1 responses in human LCL. It is possible that, although impairing parasite killing, such neuroimmuno-modulation may contribute to limiting tissue damage