Meta-model-based multi-objective optimization for robust color reproduction using hybrid diffraction gratings

International audienceWe propose an efficient and versatile optimization scheme, based on the combination of multi-objective genetic algorithms and neural-networks, to reproduce specific colors through the optimization of the geometrical parameters of metal-dielectric diffraction gratings. To illustrate and assess the performance of this approach, we tailor the chromatic response of a structure composed of three adjacent hybrid V-groove diffraction gratings. To be close to the experimental situation, we include the feasibility constraints imposed by the fabrication process. The strength of our approach lies in the possibility to simultaneously optimize different contradictory objectives, avoiding time-consuming electromagnetic calculations

Insight into biological activities of chemically characterized extract from Marrubium vulgare L. in vitro, in vivo and in silico approaches

Aqueous extracts of Marrubium vulgare L. (M. vulgare) are widely used in traditional medicine for their therapeutic effects. Hence, this study aims to evaluate in vitro, in vivo, and in silico the biological activities of M. vulgare aqueous extract to further support their traditional use. Qualitative phytochemical tests of M. vulgare extracts showed the presence of primary and secondary metabolites, while quantitative analyses recorded revealed the contents of total phenols, flavonoids, and tannins, with values of 488.432 ± 7.825 mg/EAG gallic acid extract/g, 25.5326 ± 1.317 mg/EQ Quercetin extract/g and 23.966 ± 0.187 mg/EC catechin extract/g, respectively. Characterization of the phytochemical constituents of the extract revealed the presence of catechin and maleic acid as the most abundant while the evaluation of the antioxidant power revealed that the extract possesses significant antioxidant capacity, antimitotic potential, and antimicrobial properties against Streptococcus agalactiae and Staphylococcus epidermidis among many others. The antidiabetic activity of the extract showed a potent antihyperglycemic effect and a significant modulation of the pancreatic α-amylase activity as revealed by both in vitro and in vivo analysis, while an in silico evaluation showed that chemicals in the studied extract exhibited the aforementioned activities by targeting 1XO2 antimitotic protein, W93 antidiabetic protein and 1AJ6 antimicrobial protein, which revealed them as worthy of exploration in drug discovery odyssey. Conclusively, the result of this study demonstrates the numerous biological activities of M. vulgare and gives credence to their folkloric and traditional usage

Optimization of the Optical Response of Diffractive Metallic Gratings Applied to Optical Document Security

Les hologrammes de sécurité composés de structures sub-diffractives se développent à la croisée des besoins de protection des documents sensibles et de l'avènement des technologies modernes de reprographie servant la falsification grand public. L’objectif de ce travail est de concevoir des dispositifs de sécurité dont les effets visuels, basés sur la génération de couleurs structurales, soient facilement authentifiables, difficiles à contrefaire et compatibles avec la production de films holographiques. Nous étudions la réponse plasmonique de réseaux métalliques dissymétriques uni et bi-dimensionnels, fabriqués par lithographie interférentielle et transposés à grande échelle sur film polymère par des procédés de réplication roll-to-roll. L’analyse approfondie des mécanismes résonants observés dans les réseaux hybrides métal-diélectrique ouvre des perspectives nouvelles de conception et d’amélioration de la qualité des couleurs perçues. Les résultats montrent que l'utilisation de processus d'optimisation modernes, avant la fabrication, constitue une approche efficace permettant d'adapter et d'optimiser la réponse résonante des réseaux de diffraction. Nous démontrons que l’approche multi-objectifs surpasse les stratégies mono-objectif ouvrant la possibilité d'augmenter la complexité des structures employées pour la reproduction des couleurs. Enfin, nous montrons que le recours à des outils d’intelligence artificielle constitue une alternative efficace aux méthodes électromagnétiques traditionnelles.Security holograms based on sub-wavelength gratings (SWGs) are increasingly used not only to protect sensitive documents, but also to combat against the reprographic technologies used in counterfeiting.The aim of the present work is to design optical security devices to produce visual and chromatic effects, based on the generation of structural colors, easily recognizable but difficult to counterfeit and compatible with high-tech foil production. To this end, we study the optical response of one and two-dimensional asymmetric SWGs fabricated by laser interferometric lithography and scaled up to larger scales on polymer film using roll-to-roll replication processes. The in-depth physical analysis of the resonance mechanisms generated by metallic and hybrid metal-dielectric SWGs allows to understand and tailor their chromatic response. We also demonstrate that hybrid SWGs open new design perspectives and enhance the quality of the perceived colors. The research evidence presented in this contribution clearly shows that the use of modern optimization tools, prior to fabrication, provides an efficient way to tailor and to optimize the resonant response of diffraction gratings. We demonstrate that the multi-objective approach outperforms single-objective strategies and opens the possibility of increasing the complexity of the diffractive structures used for color reproduction. We emphasize that Artificial Intelligence tools constitute an efficient alternative to the traditional time-consuming electromagnetic methods

Hygrothermal Behavior of Earth-Based Materials: Experimental and Numerical Analysis

Bio-based building materials such as earth bricks are attracting renewed interest throughout the world due to their thermal and environmental properties. In this work, a numerical study of the hygrothermal behavior of building walls consist of compressed earth bricks (CEB) and stabilized earth bricks (SEB) was performed. A two-dimensional Luikov model for evaluating the temperature and the moisture migration in porous building materials was proposed. The coupled heat and moisture transfer problem was modeled. The governing equations of a mathematical model were solved numerically with the finite difference method. Input parameters in the model and their dependency on stabilizers content were determined by laboratory experiments. In order to specify the effect of chemical stabilization on the heat and mass transfer within studied materials, average moisture content and temperature were presented as a function of time. Results show that the addition of chemical stabilizers enhances the heat transfer through the earthen materials and reduces their water vapor permeability

Hygrothermal Behavior of Earth-Based Materials: Experimental and Numerical Analysis

Bio-based building materials such as earth bricks are attracting renewed interest throughout the world due to their thermal and environmental properties. In this work, a numerical study of the hygrothermal behavior of building walls consist of compressed earth bricks (CEB) and stabilized earth bricks (SEB) was performed. A two-dimensional Luikov model for evaluating the temperature and the moisture migration in porous building materials was proposed. The coupled heat and moisture transfer problem was modeled. The governing equations of a mathematical model were solved numerically with the finite difference method. Input parameters in the model and their dependency on stabilizers content were determined by laboratory experiments. In order to specify the effect of chemical stabilization on the heat and mass transfer within studied materials, average moisture content and temperature were presented as a function of time. Results show that the addition of chemical stabilizers enhances the heat transfer through the earthen materials and reduces their water vapor permeability

Refrigerant sub-cooling in radiative sky cooling panels in the UAE

International audienc

Metamodeling of high-contrast-index gratings for color reproduction

International audienceWe propose a metamodel-based optimization technique to tailor the chromatic response of high-contrast-index gratings. The algorithm, which couples a population-based metaheuristic with a neural network, is used to retrieve the optimal geometrical parameters of a grating to reproduce a prescribed color. By means of some examples, we assess the possibilities and limitations of our optimization scheme. The numerical evidence found shows that the metamodel approach offers an alternative to traditional metaheuristic techniques that not only provides the best solution for a given geometry and a material but also significantly improves the computing time required for the optimization process

Analysis of the Chemical Composition and Evaluation of the Antioxidant, Antimicrobial, Anticoagulant, and Antidiabetic Properties of <i>Pistacia lentiscus</i> from Boulemane as a Natural Nutraceutical Preservative

Pistacia lentiscus L. has traditionally been employed as a diuretic and stimulant in the treatment of hypertension. Our interest centered on analyzing the chemical profile of the plant’s leaves and its in vitro, in vivo, and in silico antioxidant, antimicrobial, anticoagulant, and antidiabetic effects in order to valorize this species and prepare new high-value products that can be used in the agro-food and pharmaceutical industries. When this species’ essential oil was hydrodistilled and subjected to GC-MS analysis, the results showed that the principal components were germacrene D (17.54%), spathulenol (17.38%), bicyclogermacrene (12.52%), and terpinen-4-ol (9.95%). The extraction of phenolic compounds was carried out by decoction and Soxhlet. The determination of total polyphenols, flavonoids, and tannins of aqueous and organic extracts by spectrophotometric methods demonstrated the richness of this species in phenolic compounds. Chromatographic analysis by HPLC/UV-ESI-MS of the aqueous extract of P. lentiscus revealed the presence of 3,5-di-O-galloyl quinic acid, gallic acid, and 3,4,5-tri-O-galloyl quinic acid specific to this species. The study of antioxidant activity by three methods (DPPH, FRAP, and Total Antioxidant Capacity) revealed that P. lentiscus is a very promising source of natural antioxidants. The antimicrobial activity of the essential oil and aqueous extract (E0) was studied by microdilution on the microplate. The results revealed the effectiveness of the aqueous extract compared to the essential oil against Gram-negative bacteria (K. pneumoniae, A. baumannii, E. aerogenes, E. cloacae, P. fluorescence, Salmonella sp., Shigella sp., and Y. enterolitica) and candidoses (C. krusei and C. albicans). The measurements of prothrombin time (PT) and activated partial thromboplastin time (aPTT) of the aqueous extract (E0) can significantly prolong these tests from concentrations of 2.875 and 5.750 mg/mL, respectively. The antihyperglycemic effect of the aqueous extract (E0) showed a strong in vitro inhibitory activity of α-amylase and α-glucosidase compared to acarbose. Thus, it significantly inhibited postprandial hyperglycemia in Wistar albino rats. The in-silico study of the major compounds of the essential oil and extract (E0) carried out using PASS, SwissADME, pkCSM, and molecular docking tools confirmed our in vitro and in vivo results. The studied compounds showed a strong ability to be absorbed by the gastrointestinal tract and to passively diffuse through the blood-brain barrier, a similarity to drugs, and water solubility. Molecular docking experiments deduced the probable mode of action of the identified compounds on their respective target proteins, such as NADPH oxidase, thrombin, α-amylase, and α-glucosidase. Furthermore, given the demonstrated antioxidant, antimicrobial, anticoagulant, and antidiabetic effects, we can affirm the richness of P. lentiscus in bioactive molecules and its use in traditional medicine as a source of preservative agent

DataSheet1_Insight into biological activities of chemically characterized extract from Marrubium vulgare L. in vitro, in vivo and in silico approaches.docx

Aqueous extracts of Marrubium vulgare L. (M. vulgare) are widely used in traditional medicine for their therapeutic effects. Hence, this study aims to evaluate in vitro, in vivo, and in silico the biological activities of M. vulgare aqueous extract to further support their traditional use. Qualitative phytochemical tests of M. vulgare extracts showed the presence of primary and secondary metabolites, while quantitative analyses recorded revealed the contents of total phenols, flavonoids, and tannins, with values of 488.432 ± 7.825 mg/EAG gallic acid extract/g, 25.5326 ± 1.317 mg/EQ Quercetin extract/g and 23.966 ± 0.187 mg/EC catechin extract/g, respectively. Characterization of the phytochemical constituents of the extract revealed the presence of catechin and maleic acid as the most abundant while the evaluation of the antioxidant power revealed that the extract possesses significant antioxidant capacity, antimitotic potential, and antimicrobial properties against Streptococcus agalactiae and Staphylococcus epidermidis among many others. The antidiabetic activity of the extract showed a potent antihyperglycemic effect and a significant modulation of the pancreatic α-amylase activity as revealed by both in vitro and in vivo analysis, while an in silico evaluation showed that chemicals in the studied extract exhibited the aforementioned activities by targeting 1XO2 antimitotic protein, W93 antidiabetic protein and 1AJ6 antimicrobial protein, which revealed them as worthy of exploration in drug discovery odyssey. Conclusively, the result of this study demonstrates the numerous biological activities of M. vulgare and gives credence to their folkloric and traditional usage.</p