Modelling the incremental value of personality facets: the domains-incremental facets-acquiescence bifactor showmodel

Personality can be described at different levels of abstraction. Whereas the Big Five domains are the dominant level of analysis, several researchers have called for more fine-grained approaches, such as facet-level analysis. Personality facets allow more comprehensive descriptions, more accurate predictions of outcomes, and a better understanding of the mechanisms underlying trait–outcome relationships. However, several methodological issues plague existing evidence on the added value of facet-level descriptions: Manifest facet scale scores differ with respect to their reliability, domain-level variance (variance that is due to the domain factor) and incremental facet-level variance (variance that is specific to a facet and not shared with the other facets). Moreover, manifest scale scores overlap substantially, which affects associations with criterion variables. We suggest a structural equation modelling approach that allows domain-level variance to be separated from incremental facet-level variance. We analysed data from a heterogeneous sample of adults in the USA (N = 1193) who completed the 60-item Big Five Inventory-2. The results illustrate how the variance of manifest personality items and scale scores can be decomposed into domain-level and incremental facet-level variance. The association with criterion variables (educational attainment, income, health, and life satisfaction) further demonstrates the incremental predictive power of personality facets

Binding of ethidium to DNA measured using a 2D diffusion-modulated gradient COSY NMR experiment

AbstractThe binding of ethidium bromide to a DNA hairpin (dU5-hairpin) was investigated using a novel 2D diffusion-modulated gradient correlation spectroscopy (DMG-COSY) experiment to evaluate the applicability of this technique for studying the binding of drugs to DNA. The DMG-COSY experiment includes a preparation period during which coherent magnetization is attenuated due to molecular self-diffusion. Magnetization then evolves due to scalar coupling during an evolution delay, and is detected using gradient pulses for coherence selection. The time-domain data are processed in an analogous manner as for gradient-selected COSY experiments. The diffusion coefficient for uridine in DMSO solution was determined from the H5–H6 crosspeak intensities for a series of 2D DMG-COSY experiments that differed in the magnitude of the gradient pulses applied during the preparation period of the DMG-COSY experiment. The diffusion coefficient for uridine calculated from the DMG-COSY experiments was identical (within experimental error) to that determined from 1D diffusion experiments (5.24×10−6 cm2/s at 26°C). The diffusion coefficients for ethidium bromide and for the dU5-hairpin were first measured separately using the DMG-COSY experiment, and then measured in the putative complex. The diffusion coefficient for free ethidium bromide (4.15×10−6 cm2/s at 26°C) was considerably larger than for the dU5-hairpin (1.60×10−6 cm2/s at 26°C), as expected for the smaller molecule. The diffusion coefficient for ethidium was markedly decreased upon addition of the dU5-hairpin, consistent with complex formation (1.22×10−6 cm2/s at 26°C). Complex formation of 1:1 stoichiometry between ethidium and the stem of the dU5-hairpin was verified independently by fluorescence spectroscopy. These results demonstrate the utility of the DMG-COSY experiment for investigating the binding of drugs to DNA in aqueous solution

The Behavioral, Emotional, and Social Skills Inventory (BESSI): Psychometric Properties of a German-Language Adaptation, Temporal Stabilities of the Skills, and Associations with Personality and Intelligence

Social, emotional, and behavioral (SEB) skills comprise a broad set of abilities that are essential for building and maintaining relationships, regulating emotions, selecting and pursuing goals, or exploring novel stimuli. Toward an improved SEB skill assessment, Soto and colleagues recently introduced the Behavioral, Emotional, and Social Skills Inventory (BESSI). Measuring 32 facets from 5 domains with 192 items (assessment duration: ~15 min), BESSI constitutes the most extensive SEB inventory to date. However, so far, BESSI exists only in English. In three studies, we comprehensively validated a novel German-language adaptation, BESSI-G. Moreover, we expanded evidence on BESSI in three ways by (1) assessing the psychometric properties of the 32 individual skill facets, in addition to their domain-level structure; (2) providing first insights into the temporal stabilities of the 32 facets over 1.5 and 8 months; and (3) investigating the domains' and facets' associations with intelligence, in addition to personality traits. Results show that BESSI-G exhibits good psychometric properties (unidimensionality, reliability, factorial validity). Its domain-level structure is highly similar to that of the English-language source version. The facets show high temporal stabilities, convergent validity with personality traits, and discriminant validity with fluid and crystallized intelligence. We discuss implications for research on SEB skills.Soziale, emotionale und selbstregulatorischer Fähigkeiten (SEB) umfassen ein breites Spektrum von Fähigkeiten, die für den Aufbau und die Pflege von Beziehungen, die Regulierung von Emotionen, die Auswahl und Verfolgung von Zielen oder für die Erkundung neuer Reize unerlässlich sind. Auf dem Weg zu einer verbesserten Bewertung der SEB-Fähigkeiten haben Soto und Kolleg*innen vor kurzem das "Behavioral, Emotional, and Social Skills Inventory (BESSI)" eingeführt. Es misst 32 Facetten aus 5 Domänen mit 192 Items

Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99623/1/glia22549.pd

The developmental psychometrics of big five self-reports: Acquiescence, factor structure, coherence, and differentiation from ages 10 to 20.

How do youths ’ personality reports differ from those of adults? To identify the year-by-year timing of developmental trends from late childhood (age 10) to early adulthood (age 20), the authors examined Big Five self-report data from a large and diverse Internet sample. At younger ages within this range, there were large individual differences in acquiescent responding, and acquiescence variability had pronounced effects on psychometric characteristics. Beyond the effects of acquiescence, self-reports generally became more coherent within domains, and better differentiated across domains, at older ages. Impor-tantly, however, different Big Five domains showed different developmental trends. Extraversion showed especially pronounced age gains in coherence but no gains in differentiation. In contrast, Agreeableness and Conscientiousness showed large age gains in differentiation but only trivial gains in coherence. Neuroticism and Openness showed moderate gains in both coherence and differentiation. Comparisons of items that were relatively easy versus difficult to comprehend indicated that these patterns were not simply due to verbal comprehension. These findings have important implications for the study of personality characteristics and other psychological attributes in childhood and adolescence

NOTES ON THE NEST, BREEDING SEASON, AND ELEVATIONAL RANGE OF A RARE HUMMINGBIRD, THE PURPLE-BACKED SUNBEAM (AGLAEACTIS ALICIAE)

Abstract The breeding biology and phenology of the endangered hummingbird Purple-backed Sunbeam (Aglaeactis aliciae) are not well known. We report observations of nesting A. aliciae near El Molino, in La Libertad Department, Peru. On 11 March 2018, we found a female building a nest while on 10 March 2019 we found an incubating female. We describe specific characteristics of the nest and breeding behavior of nesting females. Based on our observations and that of others, the timing of nesting for this species seems to correspond to the mid-to-late rainy season, extending from at least March to May. Additionally, our sightings suggest a higher upper elevational range limit for this range-restricted Andean hummingbird than previously reported; the elevational range should be considered to be 2900–3700 m a.s.l.Resumen ∙ Notas sobre el nido, temporada reproductiva y rango elevacional del Colibrí de Alicia (Aglaeactis aliciae) La biología reproductiva y la fenología del Colibrí de Alicia (Aglaeactis aliciae) – una especie de colibrí amenazada – son poco conocidas. Aquí reportamos observaciones de nidificación de A. aliciae en El Molino, Departamento La Libertad, Perú. El 11 de marzo de 2018 encontramos una hembra construyendo un nido, mientras que el 10 de marzo de 2019 encontramos a una hembra incubando. Describimos las características del nido y el comportamiento reproductivo de las hembras. En base a nuestras observaciones e información previa sugerimos que la temporada de nidificación se desarrolla desde mediados a fines de la temporada húmeda, extendiéndose desde marzo a mayo. Nuestras observaciones también indican que la especie se encuentra a mayores altitudes que lo reportado previamente y que su rango altitudinal seria 2900–3700 m s.n.m

The Last Eight-Billion Years of Intergalactic CIV Evolution

We surveyed the HST UV spectra of 49 low-redshift quasars for z < 1 CIV candidates, relying solely on the characteristic wavelength separation of the doublet. After consideration of the defining traits of CIV doublets (e.g., consistent line profiles, other associated transitions, etc.), we defined a sample of 38 definite (group G = 1) and five likely (G = 2) doublets with rest equivalent widths W_r for both lines detected at >= 3 sigma. We conducted Monte-Carlo completeness tests to measure the unblocked redshift (dz) and co-moving pathlength (dX) over which we were sensitive to CIV doublets of a range of equivalent widths and column densities. The absorber line density of (G = 1+2) doublets is dN/dX = 4.1+0.7/-0.6 for log N(C^+3) >= 13.2, and dN/dX has not evolved significantly since z = 5. The best-fit power-law to the G = 1 frequency distribution of column densities f(N(C^+3)) = k(N(C^+3)/N_0)^alpha_N has coefficient k = (0.67+0.18/-0.16) x 10^-14 cm^2 and exponent alpha_N = -1.50+0.17/-0.19, where N_0 = 10^14 cm^-2. Using the power-law model of f(N(C^+3)), we measured the C^+3 mass density relative to the critical density: Omega(C^+3) = (6.20+1.82/-1.52) x 10^-8 for 13 <= log N(C^+3) <= 15. This value is a 2.8+/-0.7 increase in Omega(C^+3) compared to the error-weighted mean from several 1 < z < 5 surveys for CIV absorbers. A simple linear regression to Omega(C^+3) over the age of the Universe indicates that Omega(C^+3) has slowly but steadily increased from z = 5 --> 0, with dOmega(C^+3)/dt_age = (0.42+/-0.2) x 10^-8 Gyr^-1.Comment: 61 pages; accepted by ApJ; includes changes based on referee repor

A validation of the Japanese adaptation of the Big Five Inventory-2

The purpose of this study was to adapt a Japanese version of the Big Five Inventory-2 (BFI-2-J) to examine its factor structure, reliability, validity, and measurement invariance. The BFI-2-J assesses five domains and 15 facets of the Big Five personality traits. We analyzed two datasets: 487 Japanese undergraduates and 500 Japanese adults. The results of the principal component analysis and confirmatory factor analysis revealed that the domain-facet structure of the BFI-2-J was similar to that of other language versions. The reliability of the BFI-2-J is sufficient. The correlation coefficients between the BFI-2-J and the other Big Five and self-esteem measures supported convergent and discriminant validity. Moreover, we confirmed measurement invariance across age and sex groups in domain-level and facet-level models. The results suggest that the BFI-2-J is a good instrument for measuring the Big Five personality traits and their facets in Japan. The BFI-2-J is expected to be useful in Japanese personality research and international comparative research

Investigating the biological properties of carbohydrate derived fulvic acid (CHD-FA) as a potential novel therapy for the management of oral biofilm infections.

Background: A number of oral diseases, including periodontitis, derive from microbial biofilms and are associated with increased antimicrobial resistance. Despite the widespread use of mouthwashes being used as adjunctive measures to control these biofilms, their prolonged use is not recommended due to various side effects. Therefore, alternative broad-spectrum antimicrobials that minimise these effects are highly sought after. Carbohydrate derived fulvic acid (CHD-FA) is an organic acid which has previously demonstrated to be microbiocidal against Candida albicans biofilms, therefore, the aims of this study were to evaluate the antibacterial activity of CHD-FA against orally derived biofilms and to investigate adjunctive biological effects.&lt;p&gt;&lt;/p&gt; Methods: Minimum inhibitory concentrations were evaluated for CHD-FA and chlorhexidine (CHX) against a range of oral bacteria using standardised microdilution testing for planktonic and sessile. Scanning electron microscopy was also employed to visualise changes in oral biofilms after antimicrobial treatment. Cytotoxicity of these compounds was assessed against oral epithelial cells, and the effect of CHD-FA on host inflammatory markers was assessed by measuring mRNA and protein expression.&lt;p&gt;&lt;/p&gt; Results: CHD-FA was highly active against all of the oral bacteria tested, including Porphyromonas gingivalis, with a sessile minimum inhibitory concentration of 0.5%. This concentration was shown to kill multi-species biofilms by approximately 90%, levels comparable to that of chlorhexidine (CHX). In a mammalian cell culture model, pretreatment of epithelial cells with buffered CHD-FA was shown to significantly down-regulate key inflammatory mediators, including interleukin-8 (IL-8), after stimulation with a multi-species biofilm.&lt;p&gt;&lt;/p&gt; Conclusions: Overall, CHD-FA was shown to possess broad-spectrum antibacterial activity, with a supplementary function of being able to down-regulate inflammation. These properties offer an attractive spectrum of function from a naturally derived compound, which could be used as an alternative topical treatment strategy for oral biofilm diseases. Further studies in vitro and in vivo are required to determine the precise mechanism by which CHD-FA modulates the host immune response.&lt;p&gt;&lt;/p&gt

Treatment of trigeminal ganglion neurons in vitro with NGF, GDNF or BDNF: effects on neuronal survival, neurochemical properties and TRPV1-mediated neuropeptide secretion

BACKGROUND: Nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) all play important roles in the development of the peripheral sensory nervous system. Additionally, these growth factors are proposed to modulate the properties of the sensory system in the adult under pathological conditions brought about by nerve injury or inflammation. We have examined the effects of NGF, GDNF and BDNF on adult rat trigeminal ganglion (TG) neurons in culture to gain a better understanding of how these growth factors alter the cytochemical and functional phenotype of these neurons, with special attention to properties associated with nociception. RESULTS: Compared with no growth factor controls, GDNF, at 1 and 100 ng/ml, significantly increased by nearly 100% the number of neurons in culture at 5 days post-plating. A significant, positive, linear trend of increasing neuron number as a function of BDNF concentration was observed, also peaking at nearly 100%. NGF treatment was without effect. Chronic treatment with NGF and GDNF significantly and concentration-dependently increased 100 nM capsaicin (CAP)-evoked calcitonin gene-related peptide (CGRP) release, reaching approximately 300% at the highest concentration tested (100 ng/ml). Also, NGF and GDNF each augmented anandamide (AEA)- and arachidonyl-2-chloroethylamide (ACEA)-evoked CGRP release, while BDNF was without effect. Utilizing immunohistochemistry to account for the proportions of TRPV1- or CGRP-positive neurons under each growth factor treatment condition and then standardizing evoked CGRP release to these proportions, we observed that NGF was much more effective in enhancing CAP- and 50 mM K(+)-evoked CGRP release than was GDNF. Furthermore, NGF and GDNF each altered the concentration-response function for CAP- and AEA-evoked CGRP release, increasing the E(max )without altering the EC(50 )for either compound. CONCLUSIONS: Taken together, our results illustrate that NGF, GDNF and BDNF differentially alter TG sensory neuron survival, neurochemical properties and TRPV1-mediated neuropeptide release in culture. In particular, our findings suggest that GDNF and NGF differentially modulate TRPV1-mediated neuropeptide secretion sensitivity, with NGF having a much greater effect on a per neuron basis than GDNF. These findings are discussed in relation to possible therapeutic roles for growth factors or their modulators in pathological pain states, especially as these relate to the trigeminal system