Axion Inflation and Gravity Waves in String Theory

The majority of models of inflation in string theory predict an absence of measurable gravitational waves, r << 10^{-3}. The most promising proposals for making string theoretic models that yield measurable tensor fluctuations involve axion fields with slightly broken shift symmetry. We consider such models in detail, with a particular focus on the N-flation scenario and on axion valley/natural inflation models. We find that in Calabi-Yau threefold compactifications with logarithmic Kahler potentials K it appears to be difficult to meet the conditions required for axion inflation in the supergravity regime. However, in supergravities with an (approximately) quadratic shift-symmetric K, axion inflation may be viable. Such Kahler potentials do arise in some string models, in specific limits of the moduli space. We describe the most promising classes of models; more detailed study will be required before one can conclude that working models exist.Comment: 30 + 16 pages, 5 figures. Added references, corrected typo

The Non-BPS Black Hole Attractor Equation

We study the attractor mechanism for extremal non-BPS black holes with an infinite throat near horizon geometry, developing, as we do so, a physical argument as to why such a mechanism does not exist in non-extremal cases. We present a detailed derivation of the non-supersymmetric attractor equation. This equation defines the stabilization of moduli near the black hole horizon: the fixed moduli take values specified by electric and magnetic charges corresponding to the fluxes in a Calabi Yau compactification of string theory. They also define the so-called double-extremal solutions. In some examples, studied previously by Tripathy and Trivedi, we solve the equation and show that the moduli are fixed at values which may also be derived from the critical points of the black hole potential.Comment: 32 Pages, 2 Figures, LaTeX; v2: typos corrected, references adde

The norovirus NS3 protein is a dynamic lipid- and microtubule-associated protein involved in viral RNA replication

Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampered the development of appropriate antiviral therapies. Here we show that the NoV NS3 protein, derived from murine NoV (MNV), is intimately associated with the MNV replication complex and the viral replication intermediate double-stranded RNA (dsRNA). We observed that when expressed individually, MNV NS3 and NS3 encoded by human Norwalk virus (NV) induced the formation of distinct vesicle-like structures that did not colocalize with any particular protein markers to cellular organelles but localized to cellular membranes, in particular those with a high cholesterol content. Both proteins also showed some degree of colocalization with the cytoskeleton marker β-tubulin. Although the distribution of MNV and NV NS3s were similar, NV NS3 displayed a higher level of colocalization with the Golgi apparatus and the endoplasmic reticulum (ER). However, we observed that although both proteins colocalized in membranes counterstained with filipin, an indicator of cholesterol content, MNV NS3 displayed a greater association with flotillin and stomatin, proteins known to associate with sphingolipid- and cholesterol-rich microdomains. Utilizing time-lapse epifluorescence microscopy, we observed that the membrane-derived vesicular structures induced by MNV NS3 were highly motile and dynamic in nature, and their movement was dependent on intact microtubules. These results begin to interrogate the functions of NoV proteins during virus replication and highlight the conserved properties of the NoV NS3 proteins among the seven Norovirus genogroups

Nanoliposomal Nitroglycerin Exerts Potent Anti-Inflammatory Effects.

Nitroglycerin (NTG) markedly enhances nitric oxide (NO) bioavailability. However, its ability to mimic the anti-inflammatory properties of NO remains unknown. Here, we examined whether NTG can suppress endothelial cell (EC) activation during inflammation and developed NTG nanoformulation to simultaneously amplify its anti-inflammatory effects and ameliorate adverse effects associated with high-dose NTG administration. Our findings reveal that NTG significantly inhibits human U937 cell adhesion to NO-deficient human microvascular ECs in vitro through an increase in endothelial NO and decrease in endothelial ICAM-1 clustering, as determined by NO analyzer, microfluorimetry, and immunofluorescence staining. Nanoliposomal NTG (NTG-NL) was formulated by encapsulating NTG within unilamellar lipid vesicles (DPhPC, POPC, Cholesterol, DHPE-Texas Red at molar ratio of 6:2:2:0.2) that were ~155 nm in diameter and readily uptaken by ECs, as determined by dynamic light scattering and quantitative fluorescence microscopy, respectively. More importantly, NTG-NL produced a 70-fold increase in NTG therapeutic efficacy when compared with free NTG while preventing excessive mitochondrial superoxide production associated with high NTG doses. Thus, these findings, which are the first to reveal the superior therapeutic effects of an NTG nanoformulation, provide the rationale for their detailed investigation for potentially superior vascular normalization therapies

BRST Quantization of Noncommutative Gauge Theories

In this paper, the BRST symmetry transformation is presented for the noncommutative U(N) gauge theory. The nilpotency of the charge associated to this symmetry is then proved. As a consequence for the space-like non-commutativity parameter, the Hilbert space of physical states is determined by the cohomology space of the BRST operator as in the commutative case. Further, the unitarity of the S-matrix elements projected onto the subspace of physical states is deduced.Comment: 20 pages, LaTeX, no figures, one reference added, to appear in Phys. Rev.

Noncommutative Topological Half-flat Gravity

We formulate a noncommutative description of topological half-flat gravity in four dimensions. BRST symmetry of this topological gravity is deformed through a twisting of the usual BRST quantization of noncommutative gauge theories. Finally it is argued that resulting moduli space of instantons is characterized by the solutions of a noncommutative version of the Plebanski's heavenly equation.Comment: 12+1 pages, revtex4, no figure

Nanolaminate structures fabricated by ALD for reducing propagation losses and enhancing the third-order optical nonlinearities

We demonstrate a novel atomic layer deposition (ALD) process to make high quality nanocrystalline titanium dioxide (TiO2) and zinc oxide (ZnO) with intermediate Al2O3 layers to limit the crystal size. The waveguide losses of TiO2/Al2O3 nanolaminates measured using the prism coupling method for both 633 nm and 1551 nm wavelengths are as low as 0.2 ± 0.1 dB/mm with the smallest crystal size. We also show that the third-order optical nonlinearity in ZnO/Al2O3 nanolaminates can be enhanced by nanoscale engineering of the thin film structure.Peer reviewe

Effective superpotentials for compact D5-brane Calabi-Yau geometries

For compact Calabi-Yau geometries with D5-branes we study N=1 effective superpotentials depending on both open- and closed-string fields. We develop methods to derive the open/closed Picard-Fuchs differential equations, which control D5-brane deformations as well as complex structure deformations of the compact Calabi-Yau space. Their solutions encode the flat open/closed coordinates and the effective superpotential. For two explicit examples of compact D5-brane Calabi-Yau hypersurface geometries we apply our techniques and express the calculated superpotentials in terms of flat open/closed coordinates. By evaluating these superpotentials at their critical points we reproduce the domain wall tensions that have recently appeared in the literature. Finally we extract orbifold disk invariants from the superpotentials, which, up to overall numerical normalizations, correspond to orbifold disk Gromov-Witten invariants in the mirror geometry.Comment: 55 pages; v2: references added, typos correcte

The Hamiltonian BRST quantization of a noncommutative nonabelian gauge theory and its Seiberg-Witten map

We consider the Hamiltonian BRST quantization of a noncommutative non abelian gauge theory. The Seiberg-Witten map of all phase-space variables, including multipliers, ghosts and their momenta, is given in first order in the noncommutative parameter $\theta$. We show that there exists a complete consistence between the gauge structures of the original and of the mapped theories, derived in a canonical way, once we appropriately choose the map solutions.Comment: 10 pages, Latex. Address adde