Axion Inflation and Gravity Waves in String Theory

The majority of models of inflation in string theory predict an absence of measurable gravitational waves, r << 10^{-3}. The most promising proposals for making string theoretic models that yield measurable tensor fluctuations involve axion fields with slightly broken shift symmetry. We consider such models in detail, with a particular focus on the N-flation scenario and on axion valley/natural inflation models. We find that in Calabi-Yau threefold compactifications with logarithmic Kahler potentials K it appears to be difficult to meet the conditions required for axion inflation in the supergravity regime. However, in supergravities with an (approximately) quadratic shift-symmetric K, axion inflation may be viable. Such Kahler potentials do arise in some string models, in specific limits of the moduli space. We describe the most promising classes of models; more detailed study will be required before one can conclude that working models exist.Comment: 30 + 16 pages, 5 figures. Added references, corrected typo

Parallel Longest Common SubSequence Analysis In Chapel

One of the most critical problems in the field of string algorithms is the longest common subsequence problem (LCS). The problem is NP-hard for an arbitrary number of strings but can be solved in polynomial time for a fixed number of strings. In this paper, we select a typical parallel LCS algorithm and integrate it into our large-scale string analysis algorithm library to support different types of large string analysis. Specifically, we take advantage of the high-level parallel language, Chapel, to integrate Lu and Liu's parallel LCS algorithm into Arkouda, an open-source framework. Through Arkouda, data scientists can easily handle large string analytics on the back-end high-performance computing resources from the front-end Python interface. The Chapel-enabled parallel LCS algorithm can identify the longest common subsequences of two strings, and experimental results are given to show how the number of parallel resources and the length of input strings can affect the algorithm's performance.Comment: The 27th Annual IEEE High Performance Extreme Computing Conference (HPEC), Virtual, September 25-29, 202

Nanoliposomal Nitroglycerin Exerts Potent Anti-Inflammatory Effects.

Nitroglycerin (NTG) markedly enhances nitric oxide (NO) bioavailability. However, its ability to mimic the anti-inflammatory properties of NO remains unknown. Here, we examined whether NTG can suppress endothelial cell (EC) activation during inflammation and developed NTG nanoformulation to simultaneously amplify its anti-inflammatory effects and ameliorate adverse effects associated with high-dose NTG administration. Our findings reveal that NTG significantly inhibits human U937 cell adhesion to NO-deficient human microvascular ECs in vitro through an increase in endothelial NO and decrease in endothelial ICAM-1 clustering, as determined by NO analyzer, microfluorimetry, and immunofluorescence staining. Nanoliposomal NTG (NTG-NL) was formulated by encapsulating NTG within unilamellar lipid vesicles (DPhPC, POPC, Cholesterol, DHPE-Texas Red at molar ratio of 6:2:2:0.2) that were ~155 nm in diameter and readily uptaken by ECs, as determined by dynamic light scattering and quantitative fluorescence microscopy, respectively. More importantly, NTG-NL produced a 70-fold increase in NTG therapeutic efficacy when compared with free NTG while preventing excessive mitochondrial superoxide production associated with high NTG doses. Thus, these findings, which are the first to reveal the superior therapeutic effects of an NTG nanoformulation, provide the rationale for their detailed investigation for potentially superior vascular normalization therapies

The norovirus NS3 protein is a dynamic lipid- and microtubule-associated protein involved in viral RNA replication

Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampered the development of appropriate antiviral therapies. Here we show that the NoV NS3 protein, derived from murine NoV (MNV), is intimately associated with the MNV replication complex and the viral replication intermediate double-stranded RNA (dsRNA). We observed that when expressed individually, MNV NS3 and NS3 encoded by human Norwalk virus (NV) induced the formation of distinct vesicle-like structures that did not colocalize with any particular protein markers to cellular organelles but localized to cellular membranes, in particular those with a high cholesterol content. Both proteins also showed some degree of colocalization with the cytoskeleton marker β-tubulin. Although the distribution of MNV and NV NS3s were similar, NV NS3 displayed a higher level of colocalization with the Golgi apparatus and the endoplasmic reticulum (ER). However, we observed that although both proteins colocalized in membranes counterstained with filipin, an indicator of cholesterol content, MNV NS3 displayed a greater association with flotillin and stomatin, proteins known to associate with sphingolipid- and cholesterol-rich microdomains. Utilizing time-lapse epifluorescence microscopy, we observed that the membrane-derived vesicular structures induced by MNV NS3 were highly motile and dynamic in nature, and their movement was dependent on intact microtubules. These results begin to interrogate the functions of NoV proteins during virus replication and highlight the conserved properties of the NoV NS3 proteins among the seven Norovirus genogroups

An Improved Analytical Solution for the Temperature Profile of Ice Sheets

An edited version of this paper was published by AGU. Copyright 2019 American Geophysical Union.The one‐dimensional steady state analytical solution of the energy conservation equation obtained by Robin (1955, https://doi.org/10.3189/002214355793702028) is frequently used in glaciology. This solution assumes a linear change in surface velocity from a minimum value equal to minus the mass balance at the surface to zero at the bed. Here we show that this assumption of a linear velocity profile leads to large errors in the calculated temperature profile and especially in basal temperature. By prescribing a nonlinear power function of elevation above the bed for the vertical velocity profile arising from use of the Shallow Ice Approximation, we derive a new analytical solution for temperature. We show that the solution produces temperature profiles identical to numerical temperature solutions with the Shallow Ice Approximation vertical velocity near ice divides. We quantify the importance of strain heating and demonstrate that integrating the strain heating and adding it to the geothermal heat flux at the bed is a reasonable approximation for the interior regions. Our analytical solution does not include horizontal advection components, so we compare our solution with numerical solutions of a two‐dimensional advection‐diffusion model and assess the applicability and errors of the analytical solution away from the ice divide. We show that several parameters and assumptions impact the spatial extent of applicability of the new solution including surface mass balance rate and surface temperature lapse rate. We delineate regions of Greenland and Antarctica within which the analytical solution at any depth is likely within 2 K of the actual temperatures with horizontal advection

The Non-BPS Black Hole Attractor Equation

We study the attractor mechanism for extremal non-BPS black holes with an infinite throat near horizon geometry, developing, as we do so, a physical argument as to why such a mechanism does not exist in non-extremal cases. We present a detailed derivation of the non-supersymmetric attractor equation. This equation defines the stabilization of moduli near the black hole horizon: the fixed moduli take values specified by electric and magnetic charges corresponding to the fluxes in a Calabi Yau compactification of string theory. They also define the so-called double-extremal solutions. In some examples, studied previously by Tripathy and Trivedi, we solve the equation and show that the moduli are fixed at values which may also be derived from the critical points of the black hole potential.Comment: 32 Pages, 2 Figures, LaTeX; v2: typos corrected, references adde

Molecular Dynamics Insights into the Structural and Water Transport Properties of a Forward Osmosis Polyamide Thin-Film Nanocomposite Membrane Modified with Graphene Quantum Dots

An approach combining molecular dynamics (MD) simulations and laboratory experiments was applied to provide new theoretical insights into the chemical structure of polyamide (PA) thin-film composite (TFC) membranes modified with graphene quantum dots (GQDs). Interaction energies, fractional free volumes, mean-square displacements, densities, and water diffusion coefficients were computed for PA and four likely chemical structures of the GQD-embedded PA membranes. These theoretical results aided with experimentally measured water fluxes allowed for determining the most likely structure of the GQD-PA membrane. The compatibility of the GQDs and PA chains was found to be due to the formation of hydrogen and covalent bonds to m-phenylenediamine units. The modified membrane has a higher water diffusivity but a lower overall free volume, compared to the pristine PA membrane. MD simulations in concert with laboratory experiments were found to provide a good understanding of the relationship between the microscopic characteristics and macroscopic transport properties of TFC membranes

Evaluation of response to preoperative chemotherapy versus surgery alone in gastroesophageal cancer: Tumor resectability, pathologic results and post-operative complications

Gastroesophageal cancer is one of the most common types of cancer worldwide. Despite significant developments in management, 5-year survival in the developing world is less than 20 percent. Due to restricted research about the impact of preoperative chemotherapy (POC) on tumor resection, pathological response and postoperative complications in Iran, we designed and implemented the present retrospective cross- sectional study on 156 patients with gastroesophageal cancer (GEc) between 2013 and 2015 at Shariati Hospital of Tehran. Two groups were included, the first group had previously received preoperative chemotherapy and the second group had only undergone surgery. All patients were followed for at least one year after the operation in terms of tumor recurrence, relapse free survival and one-year survival. The two groups were eventually compared regarding tumor resection, pathological response, postoperative complications, recurrence rate and survival. The mean age was 66.5± 7.3 years and 78 percent were male. The tumor resectability, pathological response and postoperative complications in the group which received POC were 93.5, 21.8 and 12.8, respectively, and in the surgery alone group figures for tumor resection and postoperative complications were 76 and 29.5, respectively. Also based on our study the 5-year survival in the POC group was better (79.5 vs. 66.5). Using standard neoadjuvant regimens (preoperative chemotherapy/ chemoradiotherapy) beforesurgery could increase tumor resectability, pathological response, and improve the general status of the patients. Therefore using POC may be recommended over surgery alone. © 2016, Asian Pacific Journal of Cancer Prevention