The Netherlands retinopathy of prematurity study

Bij veel te vroeg geboren kinderen blijft prematurenretinopathie (ROP) een belangrijke oorzaak van blind- en slechtziendheid. Dit ondanks uitgebreid onderzoek. De oorzaak hiervan is, dat de leeftijd, waarop deze kinderen geboren en in leven gehouden kunnen worden daalt door een betere neonatologische behandeling. Het aantal kinderen, dat ernstige ROP kan oplopen neemt hierdoor toe. Een vroege opsporing en behandeling van ROP kan de kans op het ontwikkelen van een visuele beperking en de ernst daarvan verminderen. Een evidence-based richtlijn is een belangrijk hulpmiddel om de zorg voor deze hoog-risico prematuren te optimaliseren. Er is echter geen universeel screeningsprotocol op te stellen, omdat het niveau van de neonatologische zorg per land erg kan verschillen. Door middel van de NEDROP studie werden op nationaal niveau het screeningsproces, de invloed van overplaatsingen, de incidentie van ROP, de risicofactoren alsmede de behandelcriteria en de behandeling van ROP ge_nventariseerd. Dit heeft mede geresulteerd in een nieuwe richtlijn geschikt voor allen die betrokken zijn bij de screening (oogartsen, neonatologen, kinderartsen, verpleegkundigen en de ouders) en een uniforme, landelijke ouder-informatie folder. Het uiteindelijke doel van de NEDROP studie is om blind- en slechtziendheid door ROP te doen afnemen in Nederland.UBL - phd migration 201

Nationwide inventory on retinopathy of prematurity screening in the Netherlands

Purpose Provide up-to-date insight in incidence of retinopathy of prematurity (ROP), logistics of screening and treatment in the Netherlands and influence of the new national ROP guideline in which more stringent screening criteria were implemented and the early treatment for ROP criteria (ETROP) were emphasised. Methods Multicentre prospective nationwide study including all preterm infants, born in the Netherlands in 2017, and considered eligible for ROP screening. Anonymised data from ophthalmologists and paediatricians were merged. Outcome data were compared with the first national ROP inventory (NEDROP-1, 2009). Results In 2017, 1492 infants were live born with gestational age (GA) = 3, 3.3% (2009: 30/1662, 1.8%). In all infants, report on presence or absence of plus disease was provided, according to the ETROP criteria. Treatment was performed in 39 infants. Of infants with ROP stage >= 3, 3/49 (6.1%) progressed to retinal detachment (2009: 6/30, 20.0%). Conclusion The overall ROP incidence expressed as a percentage, remained stable but the number of infants that developed severe ROP nearly doubled. A near one-third reduction in screened infants shows satisfactory implementation of the new screening criteria. A notable decrease in retinal detachment delineates improved treatment outcome.Ophthalmic researc

Visual impairment due to retinopathy of prematurity and concomitant disabilities in the Netherlands

Aim: Determine incidence of visual impairment due to retinopathy of prematurity (ROP) and concomitant dis-abilities between 2009 and 2018 in the Netherlands and compare data to four former similar studies. Secondly, monitor if infants were missed for ROP-screening since the adoption of stricter, risk factor guided criteria (2013).Methods: Retrospective inventory on anonymous data of infants diagnosed with ROP from Dutch visual impairment-institutes. Data including: best corrected visual acuity, ROP-treatment and concomitant disabilities: bronchopulmonary dysplasia, behavioral abnormalities, epilepsy, hearing deficit, developmental delay, cerebral palsy and cerebral visual impairment. During the study period, lower age limit for neonatal life support (2010) and higher oxygen saturation targets (2014) were implemented.Results: Records of 53 infants were analyzed. Visual impairment incidence due to ROP was 2.02 per 100.000 live births (2000-2009: 1.84, p = 0.643). Compared to earlier periods (1975-2000), a significant decrease was observed. The incidence of concomitant disabilities remained stable. Mean gestational age (GA) continued to decrease to 26.6 & PLUSMN; 1.9 weeks (2000-2009: 27.4 & PLUSMN; 2.0 weeks, p = 0.047). All patients met the screening inclusion criteria.Conclusion: The incidence of visual impairment due to ROP and concomitant disabilities between 2009 and 2018 has not increased, despite lower GA and higher oxygen saturation targets. None of the infants were missed for ROP screening following introduction of more restricted screening inclusion criteria.Ophthalmic researc

Early collective expansion: Relativistic hydrodynamics and the transport properties of QCD matter

Relativistic hydrodynamics for ideal and viscous fluids is discussed as a tool to describe relativistic heavy-ion collisions and to extract transport properties of the quark-gluon plasma from experimentally measured hadron momentum spectra.Comment: Review article, 54 pages, 25 figure

Cost and effects of risk factor guided screening strategies for retinopathy of prematurity for different treatment strategies

Ophthalmic researc

Exposure keratopathy following silicone frontalis suspension in adult neuro- and myogenic ptosis

Ophthalmic researc

A translucent vascularised iris granuloma in a patient with secondary syphilis

Ophthalmic researc

Outcome and quality of screening in a nationwide survey on retinopathy of prematurity in The Netherlands

Ophthalmic researc

A translucent vascularised iris granuloma in a patient with secondary syphilis

Ophthalmic researc

Nationwide inventory of risk factors for retinopathy of prematurity in the Netherlands

Item does not contain fulltextOBJECTIVES: To study the incidence and risk factors for retinopathy of prematurity (ROP) in the Netherlands. STUDY DESIGN: Prospective, approximating population-based study that included infants with gestational age (GA) 28 days (OR 1.6, 95% CI 1.1-2.6, P = .03), and artificial ventilation >7 days (OR 1.6, 95% CI 1.1-2.5, P = .02). Prenatal glucocorticoids (OR 0.6, 95% CI 0.4-0.8, P 28 days, and artificial ventilation >7 days), treatment with iNO as risk factor for ROP is a novel finding