Medicinal Plants of the Indigenous Tribes in Peninsular Malaysia: Current and Future Perspectives

The main aim of this paper is to compile information on plant that is known to be medicinal to the indigenous tribes in Peninsular Malaysia. Information is compiled from various sources. Current trends on studies of medicinal plants of the indigenous tribes and threats to the sustainability of the plants are also discussed. Focus of future studies on medicinal plants utilized by the indigenous tribes will also be discussed

Assessment of predictive models for chlorophyll-a concentration of a tropical lake

<p>Abstract</p> <p>Background</p> <p>This study assesses four predictive ecological models; Fuzzy Logic (FL), Recurrent Artificial Neural Network (RANN), Hybrid Evolutionary Algorithm (HEA) and multiple linear regressions (MLR) to forecast chlorophyll- a concentration using limnological data from 2001 through 2004 of unstratified shallow, oligotrophic to mesotrophic tropical Putrajaya Lake (Malaysia). Performances of the models are assessed using Root Mean Square Error (RMSE), correlation coefficient (r), and Area under the Receiving Operating Characteristic (ROC) curve (AUC). Chlorophyll-a have been used to estimate algal biomass in aquatic ecosystem as it is common in most algae. Algal biomass indicates of the trophic status of a water body. Chlorophyll- a therefore, is an effective indicator for monitoring eutrophication which is a common problem of lakes and reservoirs all over the world. Assessments of these predictive models are necessary towards developing a reliable algorithm to estimate chlorophyll- a concentration for eutrophication management of tropical lakes.</p> <p>Results</p> <p>Same data set was used for models development and the data was divided into two sets; training and testing to avoid biasness in results. FL and RANN models were developed using parameters selected through sensitivity analysis. The selected variables were water temperature, pH, dissolved oxygen, ammonia nitrogen, nitrate nitrogen and Secchi depth. Dissolved oxygen, selected through stepwise procedure, was used to develop the MLR model. HEA model used parameters selected using genetic algorithm (GA). The selected parameters were pH, Secchi depth, dissolved oxygen and nitrate nitrogen. RMSE, r, and AUC values for MLR model were (4.60, 0.5, and 0.76), FL model were (4.49, 0.6, and 0.84), RANN model were (4.28, 0.7, and 0.79) and HEA model were (4.27, 0.7, and 0.82) respectively. Performance inconsistencies between four models in terms of performance criteria in this study resulted from the methodology used in measuring the performance. RMSE is based on the level of error of prediction whereas AUC is based on binary classification task.</p> <p>Conclusions</p> <p>Overall, HEA produced the best performance in terms of RMSE, r, and AUC values. This was followed by FL, RANN, and MLR.</p

Developing an ecological visualization system for biodiversity data

Data visualisation is essential for communicating and interpreting biodiversity data effectively. When compared to numerical values, visualising information with images is easier. Citizen Science has facilitated the collection of biodiversity data that can be used to conserve and preserve biodiversity sites. Google Earth provides a visualisation platform that can be used for biodiversity site monitoring. The latter has frequently been expressed in terms of biodiversity indices. The use of biodiversity indices for sites can be improved by incorporating visualisation elements. Previous studies that attempted to incorporate the calculation of biodiversity indices into biodiversity monitoring systems lacked the visualisation feature. This novel study aims to create an online module that combines biodiversity data from citizen science with a visualisation component. The observation data is imported from iNaturalist (https://www.inaturalist.org/) using the REST API method, which includes the species name and location. Species richness, Shannon-Wiener index, and Simpson index, as well as Hill Numbers, are automatically calculated and displayed on the Google Map alongside the green space area. The University of Malaya, which is located in an urban area, will be used as the study site for the demonstration of the developed prototype. The online biodiversity module prototype is available at http://www.umlivinglabsystem.com/Map/multipoly

Predicting 30-day mortality after an acute coronary syndrome (ACS) using machine learning methods for feature selection, classification and visualization

Hybrid combinations of feature selection, classification and visualisation using machine learning (ML) methods have the potential for enhanced understanding and 30-day mortality prediction of patients with cardiovascular disease using population-specific data. Identifying a feature selection method with a classifier algorithm that produces high performance in mortality studies is essential and has not been reported before. Feature selection methods such as Boruta, Random Forest (RF), Elastic Net (EN), Recursive Feature Elimination (RFE), learning vector quantization (LVQ), Genetic Algorithm (GA), Cluster Dendrogram (CD), Support Vector Machine (SVM) and Logistic Regression (LR) were combined with RF, SVM, LR, and EN classifiers for 30-day mortality prediction. ML models were constructed using 302 patients and 54 input variables from the Malaysian National Cardiovascular Disease Database. Validation of the best ML model was performed against Thrombolysis in Myocardial Infarction (TIMI) using an additional dataset of 102 patients. The Self-Organising Feature Map (SOM) was used to visualise mortality-related factors post-ACS. The performance of ML models using the area under the curve (AUC) ranged from 0.48 to 0.80. The best-performing model (AUC = 0.80) was a hybrid combination of the RF variable importance method, the sequential backward selection and the RF classifier using five predictors (age, triglyceride, creatinine, troponin, and total cholesterol). Comparison with TIMI using an additional dataset resulted in the best ML model outperforming the TIMI score (AUC = 0.75 vs. AUC = 0.60). The findings of this study will provide a basis for developing an online ML-based population-specific risk scoring calculator

A self organizing map (SOM) guided rule based system for freshwater tropical algal analysis and prediction

This paper describes the feasibility study of applying a hybrid combination of Kohonen self organizing feature maps (SOM) and a rule based system in predicting the biomass of selected algae division (Chlorophyta) at tropical Putrajaya Lake (Malaysia). The system was trained and tested on an over five years of limnological time-series data sampled from Putrajaya Lake. Results from trained SOM were used to extract rules of relationships between input variables and the Chlorophyta biomass which was used to construct a rule based system. Selected input variables were water temperature, Secchi depth and nitrate nitrogen (NO3-N). The rules extracted conformed to findings as postulated in literatures. The overall rule based system yielded an accuracy of 73%

Paediatric upper limb fracture healing time prediction using a machine learning approach

To analyse and predict the healing time of upper limb fractures in children, machine learning algorithms were used. Paediatric orthopaedic data was obtained from the University Malaya Medical Centre. The data set includes radiographs of upper limb fractures involving the radius, ulna, and humerus in children under the age of twelve, with ages recorded from the date and time of initial injury. Inputs assessment included: age, gender, bone type, the number of bones involved, fracture type, angulation and the distance of the fracture. Random Forest (RF) and Support Vector Regression (SVR) algorithms were used to predict and identify variables associated with fracture healing time. Self Organizing Maps was then used for visualization and ordination of factors associated with healing time. Algorithms performance was measured using root mean square error (RMSE). A significant determinant in fracture healing includes age, bone part, fracture angulation, and distance. The Wilcoxon signed ranked test reported there is a significant difference between the prediction result of the SVR model (RMSE = 2.56) and the RF model (RMSE =  2.66). Predicting healing time can be used in the treatment process and follow up period for general practitioners and medical officers. The algorithm is deployed online at https://kidsfractureexpert.com/

Determining hypertensive patients’ beliefs towards medication and associations with medication adherence using machine learning methods

Background This study assesses the feasibility of using machine learning methods such as Random Forests (RF), Artificial Neural Networks (ANN), Support Vector Regression (SVR) and Self-Organizing Feature Maps (SOM) to identify and determine factors associated with hypertensive patients’ adherence levels. Hypertension is the medical term for systolic and diastolic blood pressure higher than 140/90 mmHg. A conventional medication adherence scale was used to identify patients’ adherence to their prescribed medication. Using machine learning applications to predict precise numeric adherence scores in hypertensive patients has not yet been reported in the literature. Methods Data from 160 hypertensive patients from a tertiary hospital in Kuala Lumpur, Malaysia, were used in this study. Variables were ranked based on their significance to adherence levels using the RF variable importance method. The backward elimination method was then performed using RF to obtain the variables significantly associated with the patients’ adherence levels. RF, SVR and ANN models were developed to predict adherence using the identified significant variables. Visualizations of the relationships between hypertensive patients’ adherence levels and variables were generated using SOM. Result Machine learning models constructed using the selected variables reported RMSE values of 1.42 for ANN, 1.53 for RF, and 1.55 for SVR. The accuracy of the dichotomised scores, calculated based on a percentage of correctly identified adherence values, was used as an additional model performance measure, resulting in accuracies of 65% (ANN), 78% (RF) and 79% (SVR), respectively. The Wilcoxon signed ranked test reported that there was no significant difference between the predictions of the machine learning models and the actual scores. The significant variables identified from the RF variable importance method were educational level, marital status, General Overuse, monthly income, and Specific Concern. Conclusion This study suggests an effective alternative to conventional methods in identifying the key variables to understand hypertensive patients’ adherence levels. This can be used as a tool to educate patients on the importance of medication in managing hypertension

Random forest and Self Organizing Maps application for analysis of pediatric fracture healing time of the lower limb

In this study, we examined the lower limb fracture healing time in children using random forest (RF) and Self Organizing feature Maps (SOM) methods. The study sample was obtained from the pediatric orthopedic unit in University Malaya Medical Centre. Radiographs of long bones of lower limb fractures involving the femur, tibia and fibula from children ages 0–12 years, with ages recorded from the date and time of initial injury. Inputs assessment extracted from radiographic images included the following features: type of fracture, angulation of the fracture, contact area percentage of the fracture, age, gender, bone type, type of fracture, and number of bone involved. RF is initially used to rank the most important variables that effecting bone healing time. Then, SOM was applied for analysis of the relationship between the selected variables with fracture healing time. Due to the limitation of available dataset, leave one out technique was applied to enhance the reliability of RF. Results showed that age and contact area percentage of fracture were identified as the most important variables in explaining the fracture healing time. RF and SOM applications have not been reported in the field of pediatric orthopedics. We concluded that the combination of RF and SOM techniques can be used to assist in the analysis of pediatric fracture healing time efficiently

Validation of the general Framingham Risk Score (FRS), SCORE2, revised PCE and WHO CVD risk scores in an Asian population

Background: Cardiovascular risk prediction models incorporate myriad CVD risk factors. Current prediction models are developed from non-Asian populations, and their utility in other parts of the world is unknown. We validated and compared the performance of CVD risk prediction models in an Asian population. Methods: Four validation groups were extracted from a longitudinal community-based study dataset of 12,573 participants aged ≥18 years to validate the Framingham Risk Score (FRS), Systematic Coronary Risk Evaluation 2 (SCORE2), Revised Pooled Cohort Equations (RPCE), and World Health Organization cardiovascular disease (WHO CVD) models. Two measures of validation are examined: discrimination and calibration. Outcome of interest was 10-year risk of CVD events (fatal and non-fatal). SCORE2 and RPCE performances were compared to SCORE and PCE, respectively. Findings: FRS (AUC = 0.750) and RPCE (AUC = 0.752) showed good discrimination in CVD risk prediction. Although FRS and RPCE have poor calibration, FRS demonstrates smaller discordance for FRS vs. RPCE (298% vs. 733% in men, 146% vs. 391% in women). Other models had reasonable discrimination (AUC = 0.706-0.732). Only SCORE2-Low, -Moderate and -High (aged <50) had good calibration (X2 goodness-of-fit, P-value = 0.514, 0.189, 0.129, respectively). SCORE2 and RPCE showed improvements compared to SCORE (AUC = 0.755 vs. 0.747, P-value <0.001) and PCE (AUC = 0.752 vs. 0.546, P-value <0.001), respectively. Almost all risk models overestimated 10-year CVD risk by 3%-1430%. Interpretation: In Malaysians, RPCE are evaluated be the most clinically useful to predict CVD risk. Additionally, SCORE2 and RPCE outperformed SCORE and PCE, respectively. Funding: This work was supported by the Malaysian Ministry of Science, Technology, and Innovation (MOSTI) (Grant No: TDF03211036)