116 research outputs found

    TOWARDS COHERENT MARINE SPATIAL PLANNING ACROSS THE EUROPEAN MACARONESIA

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    The biogeographic region known as European Macaronesia comprises the archipelagos of the Azores, Canary Islands and Madeira in the Atlantic Ocean. The collective exclusive economic zones surrounding the archipelagos is a vast area of approximately two million km2. The Directive 2014/89/EU of the European Union (EU) obliged EU Member States, including their archipelagos, to pursue sustainable use of their waters through Marine Spatial Planning (MSP). Planning the large marine areas of the Macaronesia is not an easy endeavour, particularly when establishing the domestic frameworks for MSP implies sharing of competences among national and subnational authorities and is dependent on inter-departmental collaboration. Furthermore, the complexity of MSP arrangements, including legislation, governance, planning processes and documentation, is a barrier to coherent regional MSP and the application of the ecosystem approach, due to a lack of understanding across borders. This paper reviews and synthetises the national and subnational frameworks for MSP in the Macaronesian archipelagos. It also compares the principles guiding MSP in each archipelago to determine the coherence across the region, with the aim of outlining the basis for transboundary cooperation in the European Macaronesia.En prens

    Knot-isomers of Moebius Cyclacene: How Does the Number of Knots Influence the Structure and First Hyperpolarizability?

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    Four large ring molecules composed by 15 nitrogen-substituted benzene rings, named as "knot-isomers of Moebius cyclacene", i.e. non-Moebius cyclacenes without a knot (0), Moebius cyclacenes with a knot (1), non-Moebius cyclacenes with two knots (2), and Moebius cyclacenes with three knots (3), are systematically studied for their structures and nonlinear optical properties. The first hyperpolarizability (beta_0) values of these four knot-isomers structures are 4693 (0) < 10484 (2) < 25419 (3) < 60846 au (1). The beta_0 values (60846 for 1, 10484 for 2 and 25419 au for 3) of the knot-isomers with knot(s) are larger than that (4693 au for 0) of the knot-isomer without a knot. It shows that the beta_0 value can be dramatically increases (13 times) by introducing the knot(s) to the cyclacenes structures. It is found that introducing knots to cyclacenes is a new means to enhance the first hyperpolarizability.Comment: 12 pages, 4 figure

    Role of cellular senescence and NOX4-mediated oxidative stress in systemic sclerosis pathogenesis.

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    Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and numerous internal organs and a severe fibroproliferative vasculopathy resulting frequently in severe disability and high mortality. Although the etiology of SSc is unknown and the detailed mechanisms responsible for the fibrotic process have not been fully elucidated, one important observation from a large US population study was the demonstration of a late onset of SSc with a peak incidence between 45 and 54 years of age in African-American females and between 65 and 74 years of age in white females. Although it is not appropriate to consider SSc as a disease of aging, the possibility that senescence changes in the cellular elements involved in its pathogenesis may play a role has not been thoroughly examined. The process of cellular senescence is extremely complex, and the mechanisms, molecular events, and signaling pathways involved have not been fully elucidated; however, there is strong evidence to support the concept that oxidative stress caused by the excessive generation of reactive oxygen species may be one important mechanism involved. On the other hand, numerous studies have implicated oxidative stress in SSc pathogenesis, thus, suggesting a plausible mechanism in which excessive oxidative stress induces cellular senescence and that the molecular events associated with this complex process play an important role in the fibrotic and fibroproliferative vasculopathy characteristic of SSc. Here, recent studies examining the role of cellular senescence and of oxidative stress in SSc pathogenesis will be reviewed

    Corrigendum: Illness perceptions of COVID-19 in Europe: Predictors, impacts and temporal evolution

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    A corrigendum on Illness perceptions of COVID-19 in Europe: predictors, impacts and temporal evolution by Dias Neto, D., Nunes da Silva, A., Roberto, M. S., Lubenko, J., Constantinou, M., Nicolaou, C., Lamnisos, D., Papacostas, S., Höfer, S., Presti, G., Squatrito, V., Vasiliou, V. S., McHugh, L., Monestès, J. L., Baban, A., Alvarez-Galvez, J., Paez-Blarrina, M., Montesinos, F., Valdivia-Salas, S., Ori, D., Lappalainen, R., Kleszcz, B., Gloster, A., Karekla, M., and Kassianos, A. P. (2021). Front. Psychol. 12:640955. doi: 10.3389/fpsyg.2021.640955info:eu-repo/semantics/publishedVersio
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