Tunable resistivity of correlated VO2(A) and VO2(B) via tungsten doping

Applications of correlated vanadium dioxides VO2(A) and VO2(B) in electrical devices are limited due to the lack of effective methods for tuning their fundamental properties. We find that the resistivity of VO2(A) and VO2(B) is widely tunable by doping them with tungsten ions. When x < 0.1 in V1−xWxO2(A), the resistivity decreases drastically by four orders of magnitude with increasing x, while that of V1−xWxO2(B) shows the opposite behaviour. Using spectroscopic ellipsometry and X-ray photoemission spectroscopy, we propose that correlation effects are modulated by either chemical-strain-induced redistribution of V−V distances or electron-doping-induced band filling in V1−xWxO2(A), while electron scattering induced by disorder plays a more dominant role in V1−xWxO2(B). The tunable resistivity makes correlated VO2(A) and VO2(B) appealing for next-generation electronic devices. © 2020, The Author(s).1

Polymer Micelle Formulation for the Proteasome Inhibitor Drug Carfilzomib: Anticancer Efficacy and Pharmacokinetic Studies in Mice

Carfilzomib (CFZ) is a peptide epoxyketone proteasome inhibitor approved for the treatment of multiple myeloma (MM). Despite the remarkable efficacy of CFZ against MM, the clinical trials in patients with solid cancers yielded rather disappointing results with minimal clinical benefits. Rapid degradation of CFZ in vivo and its poor penetration to tumor sites are considered to be major factors limiting its efficacy against solid cancers. We previously reported that polymer micelles (PMs) composed of biodegradable block copolymers poly(ethylene glycol) (PEG) and poly(caprolactone) (PCL) can improve the metabolic stability of CFZ in vitro. Here, we prepared the CFZ-loaded PM, PEG-PCL-deoxycholic acid (CFZ-PM) and assessed its in vivo anticancer efficacy and pharmacokinetic profiles. Despite in vitro metabolic protection of CFZ, CFZ-PM did not display in vivo anticancer efficacy in mice bearing human lung cancer xenograft (H460) superior to that of the clinically used cyclodextrin-based CFZ (CFZ-CD) formulation. The plasma pharmacokinetic profiles of CFZ-PM were also comparable to those of CFZ-CD and the residual tumors that persisted in xenograft mice receiving CFZ-PM displayed an incomplete proteasome inhibition. In summary, our results showed that despite its favorable in vitroperformances, the current CFZ-PM formulation did not improve in vivo anticancer efficacy and accessibility of active CFZ to solid cancer tissues over CFZ-CD. Careful consideration of the current results and potential confounding factors may provide valuable insights into the future efforts to validate the potential of CFZ-based therapy for solid cancer and to develop effective CFZ delivery strategies that can be used to treat solid cancers

From Peripheral to Central: The Role of ERK Signaling Pathway in Acupuncture Analgesia

Despite accumulating evidence of the clinical effectiveness of acupuncture, its mechanism remains largely unclear. We assume that molecular signaling around the acupuncture needled area is essential for initiating the effect of acupuncture. To determine possible bio-candidates involved in the mechanisms of acupuncture and investigate the role of such bio-candidates in the analgesic effects of acupuncture, we conducted 2 stepwise experiments. First, a genome-wide microarray of the isolated skin layer at the GB34-equivalent acupoint of C57BL/6 mice 1 hour after acupuncture found that a total of 236 genes had changed and that extracellular signal–regulated kinase (ERK) activation was the most prominent bio-candidate. Second, in mouse pain models using formalin and complete Freund adjuvant, we found that acupuncture attenuated the nociceptive behavior and the mechanical allodynia; these effects were blocked when ERK cascade was interrupted by the mitogen-activated protein kinase kinase (MEK)/mitogen-activated protein kinase (MAPK) inhibitor U0126 (.8 μg/μL). Based on these results, we suggest that ERK phosphorylation following acupuncture needling is a biochemical hallmark initiating the effect of acupuncture including analgesia

Prediction on Compressive and Split Tensile Strengths of GGBFS/FA Based GPC

Based on rate constant concept, empirical models were presented for the predictions of age-dependent development of compressive and split tensile strengths of geopolymer concrete composite (GPCC) with fly ash (FA) blended with ground granulated blast furnace slag (GGBFS). The models were empirically developed based on a total of 180 cylindrical test results of GPCC. Six different independent factors comprising of curing temperature, the weight ratios of GGBFS/binder, the aggregate/binder, the alkali solution/binder, the Na2SiO3/NaOH, and the NaOH concentration were considered as the variables. The ANOVA analyses performed on Taguchi orthogonal arrays with six factors in three levels showed that the curing temperature and ratio of GGBFS to binder were the main contributing factors to the development of compressive strength. The models, functionalized with these contributing factors and equivalent age, reflect the level of activation energy of GPCC similar to that of ordinary Portland cement concrete (OPC) and a higher frequency of molecular collisions during the curing period at elevated temperature. The model predictions for compressive and split tensile strength showed good agreements with tested results

Sharp contrast in the electrical and optical properties of vanadium Wadsley (VmO2m+1, m > 1) epitaxial films selectively stabilized on (111)-oriented Y-stabilized ZrO2

Four oxidation states (V2+, V3+, V4+, and V5+) in vanadium oxides and the conversion between them have attracted attention for application to batteries and electronics. Compared to single-valence counterparts, however, there have been few reports on the fundamental properties of mixed-valence vanadium oxide films, as their complexity and closeness in thermodynamic phase diagrams hinder the formation of pure phases in film. Here, using an epitaxial growth technique with precise control of oxygen partial pressure (20-100 mTorr) on (111)-oriented Y-stabilized ZrO2, we selectively stabilize pure phases of VO2(B) (m = infinity), V6O13 (m = 6), and V2O5 (m = 2), so-called Wadsley phases (VmO2m+1, m > 1) in which V4+ and/or V5+ can coexist. Fractional increase of V4+ changes the electrical ground state, insulating VO2 (B) and V2O5, metallic V6O13 transition into insulators below 150 K. While VO2 (B) and V(6)O(13 )exhibit strong spectral weights at low photon energy in the room-temperature extinction coefficients, the band-edge absorption shifts toward higher photon energy for smaller m, opening an indirect band gap of 2.6 eV in V2O5 . The sharp contrast of electrical and optical properties between vanadium Wadsley phases highlights the importance of precisely controlling the oxidation state of vanadium. ©2019 American Physical Societ

Modeling of Bond Stress–Slip Relationships of a Strand in Concrete during Steam Curing

Abstract The restrained thermal expansion of a pretensioned strand causes thermal prestress loss during steam curing until sufficient bond strength develops. The amount of thermal prestress loss is directly related to the characteristics of the interfacial bond stress–slip relationship at different maturity phases of concrete. For a rational assessment, the bond stress–slip relationship needs to be investigated experimentally at different maturity phases. In this study, a total of 12 pull-out tests were performed using seven-wire strand of 12.7 mm diameter, at different concrete equivalent ages of 7.8, 23.5, 53.8 and 85.2 h. Based on the test results, an empirical model of the bond stress–slip relationship was developed. The model comprised four segments: a curvilinear ascending region, a constant maximum region, a linearly descending region, and a region of constant frictional bond stress. The characteristic values in the model were expressed as functions of equivalent age. The model was able to predict the test results with reasonable accuracy

Willingness to Pay for the Public Electric Bus in Nepal: A Contingent Valuation Method Approach

The rapid increase in conventional diesel and gasoline vehicles in developing countries draws attention to clean energy vehicles, including electric buses. From socioeconomic and environmental perspectives, the benefits of electric buses are well described; however, there is a lack of studies to analyze the willingness to pay (WTP). This study aims to estimate 500 residents’ WTP in Pokhara Metropolitan City in Nepal, based on a contingent valuation method (CVM). The survey results show that 78% of respondents are willing to pay a special monthly tax for introducing electric buses in the city primarily due to the fact that electric buses are likely to be helpful to the environment (82.3%). Using the logistic regression analysis, it is estimated that the mean WTP is 758.6 NPR per person, with the most influencing factors of ‘willingness to ride electric buses for free’ and ‘the average usage of the main transportation per week’. The variables that show a positive relationship with the WTP are ‘the average usage of the main transportation per week’, ‘willingness to ride electric buses for free’, and ‘age’. The variable that negatively correlates with the WTP is ‘age’. The study’s findings provide references for developing funding options and budgeting plans for local policymakers

Binary Mixtures of Some Active Pharmaceutical Ingredients with Fatty Alcohols—The Criteria of Successful Eutectic Formation and Dissolution Improvement

Pharmaceutical eutectics are solid mixtures, where the crystals of active pharmaceutical ingredients (APIs) are finely divided in the phase-separated microstructures. The size reduction makes the eutectic formation a viable option to improve the dissolution rate of the poorly soluble APIs. In the present study, ibuprofen, naproxen, and sorafenib were investigated in terms of their phase behaviors with fatty alcohols, such as tetradecanol, octadecanol, and docosanol. Among the studied APIs, only ibuprofen was able to form eutectics with the fatty alcohols, and this was in agreement with the feasibility prediction based on the van ’t Hoff equation and solubility parameters. In vitro release behavior was significantly improved for the ibuprofen/octadecanol eutectic mixture, although the practical insolubility of octadecanol in water was the opposite of the outstanding hydrophilicity of usual eutectic formers. The feasibility prediction and the choice of eutectic formers in the present study will be useful in advancing the utility of the pharmaceutical eutectics

Effect of Fermented Red Ginseng Concentrate Intake on Stool Characteristic, Biochemical Parameters, and Gut Microbiota in Elderly Korean Women

Fermented red ginseng (FRG) has been used as a general stimulant and herbal medicine for health promotion in Asia for thousands of years. Few studies have investigated the effects of FRG containing prebiotics on the gut microbiota. Here, 29 Korean women aged ≥ 50 years were administered FRG for three weeks to determine its effect on stool characteristics, biochemical parameters, and gut microbiome. Gut microbial DNA was subjected to 16S rRNA V3–V4 region sequencing to assess microbial distribution in different stages. Additionally, the stool consistency, frequency of bowel movements, and biochemical parameters of blood were evaluated. We found that FRG intake improved stool consistency and increased the frequency of bowel movements compared to before intake. Biochemical parameters such as glucose, triglyceride, cholesterol, low-density lipoprotein cholesterol, creatinine, alkaline phosphatase, and lactate dehydrogenase decreased and high-density lipoprotein cholesterol increased with FRG intake. Gut microbiome analysis revealed 20 specific bacteria after three weeks of FRG intake. Additionally, 16 pathways correlated with the 20 specific bacteria were enhanced after red ginseng intake. In conclusion, FRG promoted health in elderly women by lowering blood glucose levels and improving bowel movement frequency. The increase in bacteria observed with FRG ingestion supports these findings