Multi-Objective Topology Optimization for Curved Arm of Multifunctional Billet Tong Based on Characterization of Working Conditions

A windlass driven heavy duty multifunctional billet tong was designed for large-scale forging and casting to reduce the number of auxiliary material handling devices in manufacturing workshops. To improve its mechanical performance and safety, a novel multi-objective topology optimization method for its curved arm is proposed in this paper. Firstly, the influence of different open angles and working frequencies for the curved arm was simplified to a multi-objective optimization problem. A comprehensive evaluation function was constructed using the compromise programming method, and a mathematical model of multi-objective topology optimization was established. Meanwhile, a radar chart was employed to portray the comparative measures of working conditions, the weight coefficient for each working condition was determined based on the corresponding enclosed areas, combining the stress indices, the displacement indices and the frequency indices of all working conditions. The optimization results showed that the stiffness and strength of the curved arm can be improved while its weight can be reduced by 10.77%, which shows that it is feasible and promising to achieve a lightweight design of the curved arm of a billet tong. The proposed method can be extended to other equipment with complex working conditions

Triangle mechanism in the decay process B0→J/ψK0f0(980)(a0(980))B_0 \to J/\psi K^0 f_0(980)(a_0(980))

The role of the triangle mechanism in the decay process $B_0\to J/\psi K^0f_0 \to J/\psi K^0\pi^+\pi^-$ and $B_0\to J\psi K^0a_0\to J/\psi K^0 \pi^0\eta$ is probed. In these process, the triangle singularity appears from the decay of $B^0$ into $J/\psi\phi K^0$ then $\phi$ decays into $K^0\bar{K^0}$ and $K^0\bar{K^0}$ merged into $f_0$ or $a_0$ which finally decay into $\pi^+\pi^-$ and $\pi^0\eta$ respectively. We find that this mechanism leads to a triangle singularity around $M_{\rm inv}(K^0f_0(a_0))\approx1520\ {\rm MeV}$, and gives sizable branching fractions ${\rm{Br}}(B_0\to J/\psi K^0f_0\to J/\psi K^0\pi^+\pi^-)=1.38\times10^{-6}$ and ${\rm{Br}}(B_0\to J/\psi K^0a_0\to J/\psi K^0\pi^0\eta)=2.56\times10^{-7}$. This potential investigation can help us obtain the information of the scalar meson $f_0(980)$ or $a_0(980)$.Comment: 8 pages, 6 figure

Pole determination of X(3960)X(3960) and X0(4140)X_0(4140) in decay B+→K+Ds+Ds−B^+\to K^+D_s^+D_s^-

Two near-threshold peaking structures with spin-parities $J^{PC}=0^{++}$ were recently discovered by the LHCb Collaboration in the $D_s^+D_s^-$ invariant mass distribution of the decay process $B^+\to D_s^+D_s^-K^+$. In our study, we employed a coupled-channel model to fit the experimental results published by the LHCb collaboration, simultaneously fitting the model to the invariant mass distributions of $M_{D_s^+D_s^-}$, $M_{D_s^+K^+}$, and $M_{D_s^-K^+}$. We utilized a coupled-channel model to search for the poles of $X(3960)$ and $X_0(4140)$. The determination of the poles is meaningful in itself, and it also lays an foundation for the future research on $X(3960)$ and $X_0(4140)$. Upon turning off the coupled-channel and performing another fit, we observed a change in the fitting quality, the effect was almost entirely due to the peak of $X(3960)$, so we suggest that $X(3960)$ may not be a kinematic effect.Comment: 6 pages, 7 figure

Multi-Objective Topology Optimization for Curved Arm of Multifunctional Billet Tong Based on Characterization of Working Conditions

A windlass driven heavy duty multifunctional billet tong was designed for large-scale forging and casting to reduce the number of auxiliary material handling devices in manufacturing workshops. To improve its mechanical performance and safety, a novel multi-objective topology optimization method for its curved arm is proposed in this paper. Firstly, the influence of different open angles and working frequencies for the curved arm was simplified to a multi-objective optimization problem. A comprehensive evaluation function was constructed using the compromise programming method, and a mathematical model of multi-objective topology optimization was established. Meanwhile, a radar chart was employed to portray the comparative measures of working conditions, the weight coefficient for each working condition was determined based on the corresponding enclosed areas, combining the stress indices, the displacement indices and the frequency indices of all working conditions. The optimization results showed that the stiffness and strength of the curved arm can be improved while its weight can be reduced by 10.77%, which shows that it is feasible and promising to achieve a lightweight design of the curved arm of a billet tong. The proposed method can be extended to other equipment with complex working conditions

MOPRD: A multidisciplinary open peer review dataset

Open peer review is a growing trend in academic publications. Public access to peer review data can benefit both the academic and publishing communities. It also serves as a great support to studies on review comment generation and further to the realization of automated scholarly paper review. However, most of the existing peer review datasets do not provide data that cover the whole peer review process. Apart from this, their data are not diversified enough as they are mainly collected from the field of computer science. These two drawbacks of the currently available peer review datasets need to be addressed to unlock more opportunities for related studies. In response to this problem, we construct MOPRD, a multidisciplinary open peer review dataset. This dataset consists of paper metadata, multiple version manuscripts, review comments, meta-reviews, author's rebuttal letters, and editorial decisions. Moreover, we design a modular guided review comment generation method based on MOPRD. Experiments show that our method delivers better performance indicated by both automatic metrics and human evaluation. We also explore other potential applications of MOPRD, including meta-review generation, editorial decision prediction, author rebuttal generation, and scientometric analysis. MOPRD is a strong endorsement for further studies in peer review-related research and other applications

Automated scholarly paper review: Technologies and challenges

Peer review is a widely accepted mechanism for research evaluation, playing a pivotal role in scholarly publishing. However, criticisms have long been leveled on this mechanism, mostly because of its inefficiency and subjectivity. Recent years have seen the application of artificial intelligence (AI) in assisting the peer review process. Nonetheless, with the involvement of humans, such limitations remain inevitable. In this review paper, we propose the concept and pipeline of automated scholarly paper review (ASPR) and review the relevant literature and technologies of achieving a full-scale computerized review process. On the basis of the review and discussion, we conclude that there is already corresponding research and implementation at each stage of ASPR. We further look into the challenges in ASPR with the existing technologies. The major difficulties lie in imperfect document parsing and representation, inadequate data, defective human-computer interaction and flawed deep logical reasoning. Moreover, we discuss the possible moral & ethical issues and point out the future directions of ASPR. In the foreseeable future, ASPR and peer review will coexist in a reinforcing manner before ASPR is able to fully undertake the reviewing workload from humans

A single-step preparation of carbohydrate functionalized monoliths for separation and trapping of polar compounds

A single-step copolymerization strategy was developed for the preparation of carbohydrate (glucose and maltose) functionalized monoliths using click reaction. Firstly, novel carbohydrate-functionalized methacrylate monomers were synthesized through Cu(I)-catalyzed 1,3-dipolar cycloaddition (alkyne-azide reaction) of terminal alkyne with azide of carbohydrate derivatives. The corresponding carbohydrate functionalized monolithic columns were then prepared through a single-step in-situ copolymerization. The physicochemical properties and performance of the fabricated monolithic columns were evaluated using scanning electron microscopy, Fourier-transform infrared spectroscopy, and nano-liquid chromatography. For the optimized monolithic column, satisfactory column permeability and good separation performance were demonstrated for polar compounds including nucleoside, phenolic compounds and benzoic acid derivatives. The monolithic column is also highly useful for selective and efficient enrichment of glycopeptides from human IgG tryptic digests. This study not only provided a novel hydrophilic column for separation and selective trapping of polar compounds, but also proposed a facile and efficient approach for preparing carbohydrate functionalized monoliths

fault gouge graphitization as evidence of past seismic slip

One moderate- to large-magnitude earthquake (M > 6) nucleates in Earth's crust every three days n average, but the geological record of ancient fault slip at meters-per-second seismic velocities (as opposed to subseismic slow-slip creep) remains debated because of the lack of established fault-zone evidence of seismic slip. Here we show that the irreversible temperature-dependent transformation of carbonaceous material (CM, a constituent of many fault gouges) into graphite is a reliable tracer of seismic fault slip. We sheared CM-bearing fault rocks in the laboratory at just above subseismic and at seismic velocities under both water-rich and water-deficient conditions and modeled the temperature evolution with slip. By means of micro-Raman spectroscopy and focused-ion beam transmission electron microscopy, we detected graphite grains similar to those found in the principal slip zone of the A.D. 2008 Wenchuan (Mw 7.9) earthquake (southeast Tibet) only in experiments conducted at seismic velocities. The experimental evidence presented here suggests that high-temperature pulses associated with seismic slip induce graphitization of CM. Importantly, the occurrence of graphitized fault-zone CM may allow us to ascertain the seismogenic potential of faults in areas worldwide with incomplete historical earthquake catalogues

A Humanized Anti-VEGF Rabbit Monoclonal Antibody Inhibits Angiogenesis and Blocks Tumor Growth in Xenograft Models

Rabbit antibodies have been widely used in research and diagnostics due to their high antigen specificity and affinity. Though these properties are also highly desirable for therapeutic applications, rabbit antibodies have remained untapped for human disease therapy. To evaluate the therapeutic potential of rabbit monoclonal antibodies (RabMAbs), we generated a panel of neutralizing RabMAbs against human vascular endothelial growth factor-A (VEGF). These neutralizing RabMAbs are specific to VEGF and do not cross-react to other members of the VEGF protein family. Guided by sequence and lineage analysis of a panel of neutralizing RabMAbs, we humanized the lead candidate by substituting non-critical residues with human residues within both the frameworks and the CDR regions. We showed that the humanized RabMAb retained its parental biological properties and showed potent inhibition of the growth of H460 lung carcinoma and A673 rhabdomyosarcoma xenografts in mice. These studies provide proof of principle for the feasibility of developing humanized RabMAbs as therapeutics