La discriminazione di genere più diffusa nei prodotti d’intrattenimento in Cina

Il presente lavoro nasce dall'inquietudine per quanto riguarda la situazione peggiorata della discriminazione di genere manifestata nei prodotti d'intrattenimento negli ultimi anni in Cina, la quale in realtà, è una conseguenza causata dal continuo rafforzamento della censura. L’obiettivo di questa tesi è di scoprire i pregiudizi di genere insiti nei prodotti d’intrattenimenti e nelle regole governative che limitano la creatività di ideare e produrre le nuove opere. Questa tesi, utilizzando la teoria di Laura Mulvey, cerca anche di analizzare la fonte di questi pregiudizi presentati nei prodotti d’intrattenimento e nelle regole aggiornate dal governo cinese

Research on dedicated rail power supply system for electric cars

in order to improve the endurance capacity and driving safety of electric vehicles, a special track power supply system for electric cars on expressways is studied. The working principle of the main components of the system, such as sliding contact charging track and mechanical charging arm, is simulated and analyzed by using SolidWorks software. The results show that the charging function of the contact track can provide unlimited endurance for electric vehicles, and the guidance function of the track can also ensure the safety of highspeed driving

Presleep focusing on positive spontaneous thoughts enhanced the possibility of dreaming of them

IntroductionDreaming is the subjective experience during sleep. A spontaneous thought is a thought that comes to one’s mind involuntarily. This study investigated whether presleep focusing on a positive spontaneous thought enhanced the possibility of dreaming of the thought.MethodsNinety-seven participants were quasi-randomly assigned to an expression condition (focus on an spontaneous thought for 5-Min before sleeping; N = 45) and a control condition (think about anything for 5-Min before sleeping; N = 45). Participants completed a dream diary upon waking. Then, both participants themselves (the selfrating method) and external judges (the external-rating method) rated the correlation between the positive spontaneous thought and the dream.ResultsThe result of the external-rating method indicated that presleep focusing on positive spontaneous thoughts enhanced the possibility of dreaming of the thoughts. In addition, the external-rating method found that presleep focusing on positive spontaneous thoughts enhanced the possibility of dreaming of thoughts that were related to the positive spontaneous thoughts but not the positive spontaneous thoughts themselves.DiscussionThese results supported the current concern theory which suggests that one’s current concerns increase responses to cues related to the concerns implicitly. In addition, these results supported the continuity hypothesis which states that dreaming is in continuous with waking life, and thus the intensity of a daily concern may be related to the possibility of dreaming of the daily concern

Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling

Inflammatory responses induced by chronic cerebral hypoperfusion (CCH) play a critical role in the progression of vascular dementia. Stimulator of interferon genes (STING) signaling function as a key mediator of inflammation and immunological responses in the central nervous system (CNS), and resveratrol (RES) exerts potent anti-inflammatory effects. However, the role of STING signaling and the relationship between RES and STING signaling in persistent hypoperfusion-induced cerebral inflammation remain unclear. In this study, Sprague–Dawley rats were subjected to either Sham or bilateral common carotid artery occlusion (2VO) surgery and received RES or vehicle daily by intraperitoneal injection for 4 or 8 weeks. Morris’s water maze was used for the analysis of cognitive function. The neuroinflammatory responses in white matter and hippocampus of the rat brain were assessed by Western blot, Immunofluorescence staining, and qRT-PCR analyses. Myelin integrity, neutrophil infiltration, and microglia proliferation were assessed by Immunohistochemistry and histologic analysis. We demonstrated that after CCH, neurons, microglia, and astrocyte under endoplasmic reticulum (ER) stress upregulated the expression of STING, TANK-binding kinase 1 (TBK1), and the transcription factor interferon regulatory factor 3 (IRF3), as well as translocation of IRF3 into the nucleus. These were accompanied by infiltration of neutrophils, activation of microglia, and overproduction of proinflammatory mediators. Improvements in cognitive deficits were related to reduced hippocampal neuronal cell death and increased myelin integrity in RES-treated rats. The neuroprotective effects of RES were associated with suppression of the expression of tumor necrosis factor-alpha (TNF-α), intercellular adhesion molecule 1 (ICAM-1), VCAM-1, interferon-β (IFN-β), and IL-1β, likely through mitigation of the STING/TBK1/IRF3 pathway. These inhibitory effects exerted by RES also inhibited the levels of myeloperoxidase, reduced excess expression of reactive astrocytes, and activated microglia. In conclusion, the STING/TBK1/IRF3 axis may be critical for proinflammatory responses in cerebral tissue with persistent hypoperfusion, and RES exerts its anti-inflammatory effects by suppressing STING/TBK1/IRF3 signaling

Artificial intelligence for reducing the radiation burden of medical imaging for the diagnosis of coronavirus disease.

Medical imaging has been intensively employed in screening, diagnosis and monitoring during the COVID-19 pandemic. With the improvement of RT-PCR and rapid inspection technologies, the diagnostic references have shifted. Current recommendations tend to limit the application of medical imaging in the acute setting. Nevertheless, efficient and complementary values of medical imaging have been recognized at the beginning of the pandemic when facing unknown infectious diseases and a lack of sufficient diagnostic tools. Optimizing medical imaging for pandemics may still have encouraging implications for future public health, especially for long-lasting post-COVID-19 syndrome theranostics. A critical concern for the application of medical imaging is the increased radiation burden, particularly when medical imaging is used for screening and rapid containment purposes. Emerging artificial intelligence (AI) technology provides the opportunity to reduce the radiation burden while maintaining diagnostic quality. This review summarizes the current AI research on dose reduction for medical imaging, and the retrospective identification of their potential in COVID-19 may still have positive implications for future public health

Case report: Synchronous tumors of the female reproductive tract in systemic lupus erythematosus: report of two cases and review of the literature

BackgroundSystemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple systems. Patients with SLE are prone to a variety of malignancies, especially neoplasms of the female reproductive tract. Synchronous tumors, considered to involve multiple sites, are rare in the female reproductive tract. There are hardly any reports of SLE with synchronous reproductive tract tumors.Case presentationWe report the occurrence of two to three reproductive tract tumors in two women with SLE. A 52-year-old woman was diagnosed with vulvar cancer and cervical cancer. Another woman, aged 67, was diagnosed with concurrent vulvar cancer, vaginal cancer, and cervical cancer and also presented with a suspected lung cancer.ConclusionThe presence of synchronous tumors of the reproductive tract in patients with SLE is uncommon and can be easily disregarded. It is crucial to highlight that SLE patients with multiple primary malignancies exhibit notable late-stage presentation at the time of diagnosis, inadequate disease-free survival, poor overall survival, rapid progression rates, and mortality. Consequently, greater awareness must be raised regarding synchronous reproductive tract tumors in patients with SLE. Regular comprehensive cancer screening and management should be implemented for individuals diagnosed with SLE

Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced Colitis

Nuclear magnetic resonance (NMR)-based metabolomics, which comprehensively measures metabolites in biological systems and investigates their response to various perturbations, is widely used in research to identify biomarkers and investigate the pathogenesis of underlying diseases. However, further applications of high-field superconducting NMR for medical purposes and field research are restricted by its high cost and low accessibility. In this study, we applied a low-field, benchtop NMR spectrometer (60 MHz) employing a permanent magnet to characterize the alterations in the metabolic profile of fecal extracts obtained from dextran sodium sulfate (DSS)-induced ulcerative colitis model mice and compared them with the data acquired from high-field NMR (800 MHz). Nineteen metabolites were assigned to the 60 MHz 1H NMR spectra. Non-targeted multivariate analysis successfully discriminated the DSS-induced group from the healthy control group and showed high comparability with high-field NMR. In addition, the concentration of acetate, identified as a metabolite with characteristic behavior, could be accurately quantified using a generalized Lorentzian curve fitting method based on the 60 MHz NMR spectra.journal articl

Using domain knowledge for robust and generalizable deep learning-based CT-free PET attenuation and scatter correction.

Despite the potential of deep learning (DL)-based methods in substituting CT-based PET attenuation and scatter correction for CT-free PET imaging, a critical bottleneck is their limited capability in handling large heterogeneity of tracers and scanners of PET imaging. This study employs a simple way to integrate domain knowledge in DL for CT-free PET imaging. In contrast to conventional direct DL methods, we simplify the complex problem by a domain decomposition so that the learning of anatomy-dependent attenuation correction can be achieved robustly in a low-frequency domain while the original anatomy-independent high-frequency texture can be preserved during the processing. Even with the training from one tracer on one scanner, the effectiveness and robustness of our proposed approach are confirmed in tests of various external imaging tracers on different scanners. The robust, generalizable, and transparent DL development may enhance the potential of clinical translation