595 research outputs found
On A two-variable p-adic l_q function
We prove that a two-variable p-adic l_q-function has the series p-adic
expansion which interpolates a linear combinations of terms of the generalized
q-Euler polynomials at non positive integers. The proof of this original
construction is due to Kubota and Leopoldt in 1964, although the method given
this note is due to WashingtonComment: 11S8
AAD-2004, a potent spin trapping molecule and microsomal prostaglandin E synthase-1 inhibitor, shows safety and efficacy in a mouse model of ALS
While free radicals and inflammation constitute major routes of neuronal injury occurring in neurodegenerative diseases, neither antioxidants nor nonsteroidal anti-inflammatory drugs (NSAIDs) have shown significant efficacy in human clinical trials. To explore the possibility that concurrent blockade of free radicals and PGE2-mediated inflammation might constitute a safe and effective therapeutic approach to certain neurodegenerative diseases, we have developed 2-hydroxy-5-[2-(4-trifluoromethylphenyl)-ethylaminobezoic acid (AAD-2004) as a derivative of aspirin. AAD-2004 completely removed free radicals at 50 nM as a potent spin trapping molecule and inhibited microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 230 nM. Oral administration of AAD-2004 blocked free radical formation, PGE2 formation, and microglial activation in the spinal motor neurons of SOD1G93A mice. As a consequence, AAD-2004 reduced autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and increasing life span. In these assays, AAD-2004 was superior to ibuprofen or riluzole. Gastric bleeding was not induced by AAD-2004 even at a dose 400-fold higher than that required to obtain maximal therapeutic efficacy in SOD1G93A mice. Targeting both mPGES-1 and free radicals may be a promising approach to reduce neurodegeneration in ALS and possibly other neurodegenerative diseases
Negotiating Asian American Identities: Collaborative Self-Study of Korean Immigrant Scholars’ Reading Group on AsianCri
The purpose of this study is to understand how Korean immigrant women early career scholars in higher education in the United States explore their Asian American identities in the identity-based community space. The study considered qualitative data generated by five authors in a collaborative reading group learning more about AsianCrit literature. Our analysis revealed that AsianCrit was used as a tool for revisiting our racialized experiences, negotiating tensions around key constructs of AsianCrit informed by transnational perspectives, and embracing Asian American identities in pursuit of solidarity. The findings contribute to expanding the scholarship of AsianCrit by highlighting its utility and possibilities to support transnational or first-generation Asian immigrants’ identity exploration in higher education. Moreover, the findings signify the identity-informed peer mentoring as a way to build Asian solidarity.
Includes Appendix A and Appendix B
Disentangled dimensionality reduction for noise-robust speaker diarisation
The objective of this work is to train noise-robust speaker embeddings
adapted for speaker diarisation. Speaker embeddings play a crucial role in the
performance of diarisation systems, but they often capture spurious information
such as noise and reverberation, adversely affecting performance. Our previous
work has proposed an auto-encoder-based dimensionality reduction module to help
remove the redundant information. However, they do not explicitly separate such
information and have also been found to be sensitive to hyper-parameter values.
To this end, we propose two contributions to overcome these issues: (i) a novel
dimensionality reduction framework that can disentangle spurious information
from the speaker embeddings; (ii) the use of a speech/non-speech indicator to
prevent the speaker code from representing the background noise. Through a
range of experiments conducted on four different datasets, our approach
consistently demonstrates the state-of-the-art performance among models without
system fusion.Comment: This paper was submitted to Interspeech202
Rethinking Session Variability: Leveraging Session Embeddings for Session Robustness in Speaker Verification
In the field of speaker verification, session or channel variability poses a
significant challenge. While many contemporary methods aim to disentangle
session information from speaker embeddings, we introduce a novel approach
using an additional embedding to represent the session information. This is
achieved by training an auxiliary network appended to the speaker embedding
extractor which remains fixed in this training process. This results in two
similarity scores: one for the speakers information and one for the session
information. The latter score acts as a compensator for the former that might
be skewed due to session variations. Our extensive experiments demonstrate that
session information can be effectively compensated without retraining of the
embedding extractor
- …