Evaluation of Cases Who Underwent Reconstruction Through Pectoralis Major Myocutaneous Flap after Laryngopharyngectomy

Objective: In this retrospective study, we discussed the results of patients who underwent hypopharynx reconstruction through a pectoralis major myocutaneous flap (PMMF) after laryngopharyngectomy.Methods: Twenty-three patients who underwent total laryngectomy, subtotal pharyngectomy, and/ or esophagus upper segment resection due to advanced- stage (T3 and T4) laryngeal, hypopharyngeal, and esophagus upper segment-located squamous cell carcinoma and subsequent reconstruction with PMMF were retrospectively evaluated. While the minor complications were determined to be wound site infection, hemorrhage, and disruption of suture at the donor site, major complications were determined to be anastomotic line disruption, fistula, and dysphagia.Results: Eighteen (78.2%) patients were male and five (21.7%) were female; their ages varied between 33 and 72 years (mean: 60.1). According to lesion localization, 11 patients were evaluated as having laryngeal cancer, seven as having hypopharyngeal cancer, and five as having esophagus upper segment-located cancer. The rate of minor complications was 30.4%: fistula was observed in 11 (47.8%) patients and 13 (56.5%) patients mentioned difficulty swallowing only solid foods. The total follow-up period ranged from 4 to 60 (mean: 31.6) months.Conclusion: PMMF is continuing to be a good alternative reconstruction method for the reconstruction of partial hypopharyngeal defects because it is easily obtainable, one surgical team is sufficient when using the flap, and it is associated with low morbidity and mortality rates

Hypertrophic Lingual Thyroid Causing Sleep Apnea

Ectopic lingual thyroid disorder, developing as a consequence of thyroid gland migration during early embryogenesis, is a rarely seen congenital anomaly. In this paper, we report a 39-year-old male patient with snoring and moderate-level obstructive sleep apnea who received the diagnosis of lingual thyroid at our clinic. We treated the patient with thyroxin suppression therapy. During our clinical follow-ups, the amount of lingual thyroid tissue significantly decreased, and the symptoms of obstructive sleep apnea disappeared

Evaluation of iron and zinc levels in recurrent tonsillitis and tonsillar hypertrophy

WOS: 000372213200012PubMed ID: 26954864Objectives: The aim of this study is to look into the roles of iron and zinc metals in etiopathogenesis of recurrent tonsillitis and tonsillar hypertrophy by evaluating the levels of iron and zinc elements in the palatine tonsillar tissue. Methods: In total, 40 patients who underwent a tonsillectomy to treat recurrent tonsillitis and tonsillar hypertrophy were included in the study. Patients were classified into two groups, recurrent tonsillitis and tonsillar hypertrophy, determined by the results of clinical and histopathological examination. The levels of iron and zinc elements were determined for each tonsillar tissue sample. Results: There was a significant difference in the iron and zinc concentrations (p < 0.001) between the tonsillar hypertrophy and recurrent tonsillitis groups. The levels of iron and zinc were significantly lower in the recurrent tonsillitis group. Conclusions: This study suggests that low tissue concentrations of iron and zinc may lead to recurrent tonsillitis. (C) 2016 Elsevier Inc. All rights reserved

Radyoterapi sonrası iki taraflı dış kulak yolu kolesteatomu

Bu yazıda, nazofarenks karsinomu nedeniyle radyoterapi ile tedavi edilen ve radyoterapiden dört yıl sonra iki taraflı dış kulak yolu kolesteatomu saptanan 55 yaşında bir kadın olgu sunuldu. Hastada inatçı otore vardı ve tanı otoskopik bulguların yanı sıra, temporal kemik tomografisinde dış kulak yolu ön duvarını aşındıran yumuşak doku kitlesinin görülmesi ile konuldu. Cerrahi tedavi olarak kanaloplasti ve kolesteatom eksizyonu yapıldı.In this article, we report a 55-year-old female case was treated with radiotherapy due to nasopharynx carcinoma and diagnosed with bilateral external auditory canal cholesteatoma four years after radiotherapy. Persistent otorrhea was present in the patient and the diagnosis was established through noticing a soft tissue mass eroding external auditory canal anterior wall in temporal bone tomography as well as the otoscopic findings. Canaloplasty and cholesteatoma excision were administered as the surgical treatment

A Unique Case of Intranasal Metastasis from Occult Poorly Differentiated Thyroid Carcinoma

Background: Poorly differentiated thyroid carcinomas (PDTCs) lie, both morphologically and behaviorally, between well-differentiated and undifferentiated carcinomas. Metastasis of poorly differentiated thyroid carcinoma to the intranasal cavity has not been reported previously in the literature. Case Report: A 48-year-old male patient presented with massive epistaxis and nasal obstruction. On nasal examination, a bleeding, vascular mass was seen filling the left nasal cavity. The histopathological report of the nasal mass was well-differentiated thyroid carcinoma metastasis. Whole body scintigraphy, ultrasonography and positron emission tomography were done to rule out other possible metastases in the body and determine the origin of the tumor, which was identified as the left lobe of the thyroid gland, and there were multiple metastases involving the lung, sacroiliac area, and left humerus. Histopathological examination of a thyroidectomy specimen revealed PDTC consisting of insular, follicular, and papillary components. Postoperatively, the patient received radioactive iodine ablation therapy (iodine-131) and a course of external beam radiation therapy to the sacroiliac area and other metastatic regions. No recurrences were observed in a follow-up period of 5 years after surgery. Conclusion: The metastasis of differentiated thyroid carcinoma as a component of PDTC to the intranasal cavity has not been reported before. It is interesting that the well-differentiated component of the tumor was metastasized in our patient. Due to the aggressiveness of PDTC and the poor survival rates in patients who undergo surgery alone, a multidisciplinary treatment approach is required

Endoskopik ve Eksternal Dakriyosistorinostomi Sonuçlarının Karşılaştırılması ve Hasta Memnuniyetinin Analizi

Amaç: Endoskopik ve eksternal dakriyosistorinostomi (DSR) ameliyat sonuçlarımızın karşılaştırılması ve hasta memnuniyetinin değerlendirilmesi. Yöntemler: Çalışmaya 46 (35 kadın, 11 erkek) endoskopik DSR ve 43 (37 kadın, 6 erkek) eksternal-DSR uygulanan hasta dahil edildi. Ameliyat başarısı objektif ve subjektif olarak değerlendirildi. Nazolakrimal kanaldan verilen salin solüsyonun endoskopi ile objektif olarak burundan gelişi değerlendirildi. Subjektif değerlendirme hastaların epiforalarının sorgulanması ile değerlendirildi. Ameliyat başarısının değerlendirilmesine ilaveten her iki hasta grubuna sonuç değerlendirme ve memnuniyet anketi uygulandı. Bulgular: Yaş ve cinsiyet açısından her iki grup arasında istatistiksel açıdan anlamlı bir fark yoktu (sırasıyla p=0.486, p=0.23). Ancak her iki grupta kadınların sayısı erkeklere göre daha yüksekti ve bu istatistiksel açıdan anlamlıydı (endoskopik DSR p=0.01, eksternal DSR p=0.001). Postoperatif kanama ve punktum hasarı açısından karşılaştırıldığında her iki grup arasında istatistiksel açıdan anlamlı bir fark saptanmadı. Başarı oranı endoskopik DSR grubunda %84.7 iken eksternal DSR grubunda %90.6 idi, ancak her iki grup arasında istatistiksel açıdan anlamlı fark yoktu (p=0.397). Her iki gruba yöneltilen anket sonucunda; ameliyattan genel memnuniyet oranı açısından gruplar arasında anlamlı bir fark bulunmadı (p=0.397). Sonuç: Literatürdeki birçok çalışmada iki grup için verilen sonuçlar çalışmamızda elde edilenlere benzerdir. Her iki tekniğin avantajları ve dezavantajları mevcuttur. Hangi yöntem tercih edilirse edilsin çalış- mamıza göre fonksiyonel başarı elde edilmesi hasta memnuniyetini belirleyen esas faktördür.Objective: Comparison of endoscopic and external dacryocystorhinostomy (DCR) results and evaluation of patients’ satisfaction. Methods: Forty six (35 females and 11 males) patients who underwent endoscopic DCR and 43 (37 females and six males) who underwent external DCR were included. Surgical success was objectively and subjectively assessed. The nasolacrimal duct was irrigated by a saline solution, and the saline solution was objectively visualized by endoscopy from the nose. Subjective assessment was performed asking the patients' epiphora. In addition to evaluating the success of the operation, satisfaction and result surveys were administered to the two groups. Results: There was no statistically significant difference between the two groups in terms of age and sex (respectively p=0.486, p=0.23). However, the number of females was higher than the number of males in the two groups, and the difference was statistically significant (endoscopic-DCR p=0.01, external-DCR p=0.001). There was no statistically significant difference between the two groups in terms of postoperative bleeding and punctum damage. The success rate was 84.7% in the endoscopic DCR group and 90.6% in the external DCR group. There was no statistically significant difference in the success rate between the two groups (p=0.397). The survey results revealed that there was no statistically significant difference between the two groups in terms of patient satisfaction (p=0.397). Conclusion: The results of many studies in the literature show operation success rates between the two groups that are similar to ours. Both techniques have advantages and disadvantages. Independent of the preferred procedure, our results show that functional success mainly determines patient satisfaction

Comparison of Endoscopic and External Dacryocystorhinostomy Results and Analysis of Patients' Satisfaction

WOS: 000386244200003PubMed ID: 29392027Objective: Comparison of endoscopic and external dacryocystorhinostomy (DCR) results and evaluation of patients' satisfaction. Methods: Forty six (35 females and 11 males) patients who underwent endoscopic DCR and 43 (37 females and six males) who underwent external DCR were included. Surgical success was objectively and subjectively assessed. The nasolacrimal duct was irrigated by a saline solution, and the saline solution was objectively visualized by endoscopy from the nose. Subjective assessment was performed asking the patients' epiphora. In addition to evaluating the success of the operation, satisfaction and result surveys were administered to the two groups. Results: There was no statistically significant difference between the two groups in terms of age and sex (respectively p=0.486, p=0.23). However, the number of females was higher than the number of males in the two groups, and the difference was statistically significant (endoscopic-DCR p=0.01, external-DCR p=0.001). There was no statistically significant difference between the two groups in terms of postoperative bleeding and punctum damage. The success rate was 84.7% in the endoscopic DCR group and 90.6% in the external DCR group. There was no statistically significant difference in the success rate between the two groups (p=0.397). The survey results revealed that there was no statistically significant difference between the two groups in terms of patient satisfaction (p=0.397). Conclusion: The results of many studies in the literature show operation success rates between the two groups that are similar to ours. Both techniques have advantages and disadvantages. Independent of the preferred procedure, our results show that functional success mainly determines patient satisfaction

MBL, P2X7, and SLC11A1 gene polymorphisms in patients with oropharyngeal tularemia

WOS: 000386069300016PubMed ID: 27223255Conclusion: A significant association was found of oropharyngeal tularemia with SLC11A1 allele polymorphism (INT4G/C) and MBL2 C+4T (P/Q). These results indicate C allele and Q allele might be a risk factor for the development of oropharyngeal tularemia.Aim: This study aimed to investigate the relationship of SLC11A1, MBL, and P2X(7) gene polymorphism with oropharyngeal tularemia.Methods: The study included totally 120 patients who were diagnosed with oropharyngeal tularemia. Frequencies of polymorphisms in the following genes were analyzed both in the patient and control groups in the study: SLC11A1 (5'(GT)(n) Allele 2/3, Int4G/C, 3' UTR, D543N G/A), MBL (MBL2 C+4T (P/Q), and P2X(7) (-762 C/T and 1513 A/C).Results: Among all polymorphisms that were investigated in this study, SLC11A1 gene showed a significance in the distriburtion of polymorphism allelle frequency at the INT4 region. Frequency of C allele was 54 (28%) in patients with oropharyngeal tularemia, and 31 (13%) in the control group (p=0.006 and OR = 1.96 (1.21-3.20)). An association was detected between MBL2 C+4T (P/Q) gene polymorphism and oropharyngeal tularemia (p0.05).Gaziosmanpasa UniversityGaziosmanpasa University [2014/14]This study was supported by the Gaziosmanpasa University (project no: 2014/14)