8,846 research outputs found

    Pregnancy-associated breast cancer - Special features in diagnosis and treatment

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    For obvious psychological reasons it is difficult to associate pregnancy - a life-giving period of our existence with life-threatening malignancies. Symptoms pointing to malignancy are often ignored by both patients and physicians, and this, together with the greater difficulty of diagnostic imaging, probably results in the proven delay in the detection of breast cancers during pregnancy. The diagnosis and treatment of breast cancer are becoming more and more important, as the fulfillment of the desire to have children is increasingly postponed until a later age associated with a higher risk of carcinoma, and improved cure rates of solid tumors no longer exclude subsequent pregnancies. The following article summarizes the special features of the diagnosis and primary therapy of pregnancy-associated breast cancer with particular consideration of cytostatic therapy

    Investigating the impact of changes in iteration-likelihoods on design process performance

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    Research on changes in design has mainly focused on the product domain, which is the manifestation of the design process. This article investigates changes in the process domain, which describes the execution of coordinated and concurrent design activities through interdisciplinary teams. More specifically, this article focuses on changes in the iterative behavior of activities as one of the key levers determining the performance of complex concurrent design processes. In activity network–based models of design processes, the occurrence of such behavior is often expressed probabilistically through iteration-likelihoods. First, the impact of iteration-likelihood changes on the effort and duration of both individual activities and the overall design process is examined through stochastic analysis. Consequently, a method for the investigation of such changes is developed, which grounds on an experimental approach using Monte Carlo simulation of activity network–based process models. The method is applied to the design process of a high-speed machining device for the manufacturing of planetary-ball-bearing housings. This analysis results in a two-dimensional criticality ranking of potential iteration-likelihood changes and in the identification of the most affected individual activities. The article concludes with managerial implications for process planning and improvement and discusses which design activities need to be targeted by project management to prevent and react to critical iteration-likelihood changes. This is the author accepted manuscript. The final version is available from SAGE via http://dx.doi.org/10.1177/1063293X1558820

    High efficiency thermionic converter studies

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    Research in thermionic energy conversion technology is reported. The objectives were to produce converters suitable for use in out of core space reactors, radioisotope generators, and solar satellites. The development of emitter electrodes that operate at low cesium pressure, stable low work function collector electrodes, and more efficient means of space charge neutralization were investigated to improve thermionic converter performance. Potential improvements in collector properties were noted with evaporated thin film barium oxide coatings. Experiments with cesium carbonate suggest this substance may provide optimum combinations of cesium and oxygen for thermionic conversion

    Physical Nucleon Properties from Lattice QCD

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    We demonstrate that the extremely accurate lattice QCD data for the mass of the nucleon recently obtained by CP-PACS, combined with modern chiral extrapolation techniques, leads to a value for the mass of the physical nucleon which has a systematic error of less than one percent.Comment: 4 pages, 2 figure

    Driver Drowsiness Immediately before Crashes – A Comparative Investigation of EEG Pattern Recognition

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    Periodogram and other spectral power estimation methods are established in quantitative EEG analysis. Their outcome in case of drowsy subjects fulfilling a sustained attention task is difficult to interpret. Two novel kind of EEG analysis based on pattern recognition were proposed recently, namely the microsleep (MS) and the alpha burst (AB) pattern recognition. We compare both methods by applying them to the same experimental data and relating their output variables to two independent variables of driver drowsiness. The latter was an objective lane tracking performance variable and the first was a subjective variable of self-experienced sleepiness. Results offer remarkable differences between both EEG analysis methodologies. The expected increase with time since sleep as well as with time on task, which also exhibited in both independent variables, was not identified after applying AB recognition. The EEG immediately before fatigue related crashes contained both patterns. MS patterns were remarkably more frequent before crashes; almost every crash (98.5 %) was preceded by MS patterns, whereas less than 64 % of all crashes had AB patterns within a 10 sec pre-crash interval

    Carbon Stars and other Luminous Stellar Populations in M33

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    The M33 galaxy is a nearby, relatively metal-poor, late-type spiral. Its proximity and almost face-on inclination means that it projects over a large area on the sky, making it an ideal candidate for wide-field CCD mosaic imaging. Photometry was obtained for more than 10^6 stars covering a 74' x 56' field centered on M33. Main sequence (MS), supergiant branch (SGB), red giant branch (RGB) and asymptotic giant branch (AGB) populations are identified and classified based on broad-band V and I photometry. Narrow-band filters are used to measure spectral features allowing the AGB population to be further divided into C and M-star types. The galactic structure of M33 is examined using star counts, colour-colour and colour-magnitude selected stellar populations. We use the C to M-star ratio to investigate the metallicity gradient in the disk of M33. The C/M-star ratio is found to increase and then flatten with increasing galactocentric radius in agreement with viscous disk formation models. The C-star luminosity function is found to be similar to M31 and the SMC, suggesting that C-stars should be useful distance indicators. The ``spectacular arcs of carbon stars'' in M33 postulated recently by Block et al. (2004) are found in our work to be simply an extension of M33's disk.Comment: 20 pages, 20 figures. Accepted for publication in The Astronomical Journa

    Nonperturbative improvement and tree-level correction of the quark propagator

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    We extend an earlier study of the Landau gauge quark propagator in quenched QCD where we used two forms of the O(a)-improved propagator with the Sheikholeslami-Wohlert quark action. In the present study we use the nonperturbative value for the clover coefficient c_sw and mean-field improvement coefficients in our improved quark propagators. We compare this to our earlier results which used the mean-field c_sw and tree-level improvement coefficients for the propagator. We also compare three different implementations of tree-level correction: additive, multiplicative, and hybrid. We show that the hybrid approach is the most robust and reliable and can successfully deal even with strong ultraviolet behavior and zero-crossing of the lattice tree-level expression. We find good agreement between our improved quark propagators when using the appropriate nonperturbative improvement coefficients and hybrid tree-level correction. We also present a simple extrapolation of the quark mass function to the chiral limit.Comment: 12 pages, 18 figures, RevTeX4. Some clarifications and corrections. Final version, to appear in Phys.Rev.

    Youth Single-Sport Specialization in Professional Baseball Players.

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    Background: An increasing number of youth baseball athletes are specializing in playing baseball at younger ages. Purpose: The purpose of our study was to describe the age and prevalence of single-sport specialization in a cohort of current professional baseball athletes. In addition, we sought to understand the trends surrounding single-sport specialization in professional baseball players raised within and outside the United States (US). Study Design: Cross-sectional study; Level of evidence, 3. Methods: A survey was distributed to male professional baseball athletes via individual team athletic trainers. Athletes were asked if and at what age they had chosen to specialize in playing baseball at the exclusion of other sports, and data were then collected pertaining to this decision. We analyzed the rate and age of specialization, the reasons for specialization, and the athlete\u27s perception of injuries related to specialization. Results: A total of 1673 professional baseball athletes completed the survey, representing 26 of the 30 Major League Baseball (MLB) organizations. Less than half (44.5%) of professional athletes specialized in playing a single sport during their childhood/adolescence. Those who reported specializing in their youth did so at a mean age of 14.09 ± 2.79 years. MLB players who grew up outside the US specialized at a significantly earlier age than MLB players native to the US (12.30 ± 3.07 vs 14.89 ± 2.24 years, respectively; Conclusion: This study challenges the current trends toward early youth sport specialization, finding that the majority of professional baseball athletes studied did not specialize as youth and that those who did specialize did so at a mean age of 14 years. With the potential cumulative effects of pitching and overhead throwing on an athlete\u27s arm, the trend identified in this study toward earlier specialization within baseball is concerning
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