2,131 research outputs found
Numerical experiments on short-term meteorological effects on solar variability
A set of numerical experiments was conducted to test the short-range sensitivity of a large atmospheric general circulation model to changes in solar constant and ozone amount. On the basis of the results of 12-day sets of integrations with very large variations in these parameters, it is concluded that realistic variations would produce insignificant meteorological effects. Any causal relationships between solar variability and weather, for time scales of two weeks or less, rely upon changes in parameters other than solar constant or ozone amounts, or upon mechanisms not yet incorporated in the model
Thirteen-year wear rate comparison of highly crosslinked and conventional polyethylene in total hip arthroplasty: long-term follow-up of a prospective randomized controlled trial
The Evolution of Early-type Field Galaxies Selected from a NICMOS Map of the Hubble Deep Field North
The redshift distribution of well-defined samples of distant early-type
galaxies offers a means to test the predictions of monolithic and hierarchical
galaxy formation scenarios. NICMOS maps of the entire Hubble Deep Field North
in the F110W and F160W filters, when combined with the available WFPC2 data,
allow us to calculate photometric redshifts and determine the morphological
appearance of galaxies at rest-frame optical wavelengths out to z ~ 2.5. Here
we report results for two subsamples of early-type galaxies, defined primarily
by their morphologies in the F160W band, which were selected from the NICMOS
data down to H160_{AB} < 24.0. The observed redshift distributions of our two
early-type samples do not match that predicted by a monolithic collapse model,
which shows an overabundance at z > 1.5. A hierarchical formation model better
matches the redshift distribution of the HDF-N early-types at z > 1.5, but
still does not adequately describe the observed early-types. The hierarchical
model predicts significantly bluer colors on average than the observed
early-type colors, and underpredicts the observed number of early-types at z <
1. [abridged]Comment: Accepted for publication in the Astronomical Journal; 54 pages, 21
figures. Figures 10 and 11 are included separately in JPEG forma
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The Medial Prefrontal Cortex and the Emergence of Self-Conscious Emotion in Adolescence
In the present study, we examined the relationship between developmental modulation of socioaffective brain systems and adolescents’ preoccupation with social evaluation. Child, adolescent, and adult participants viewed cues indicating that a camera was alternately off, warming up, or projecting their image to a peer during the acquisition of behavioral-, autonomic-, and neural-response (functional MRI) data. Believing that a peer was actively watching them was sufficient to induce self-conscious emotion that rose in magnitude from childhood to adolescence and partially subsided into adulthood. Autonomic arousal was uniquely heightened in adolescents. These behavioral patterns were paralleled by emergent engagement of the medial prefrontal cortex (MPFC) and striatum-MPFC connectivity during adolescence, which are thought to promote motivated social behavior in adolescence. These findings demonstrate that adolescents’ self-consciousness is related to age-dependent sensitivity of brain systems critical to socioaffective processes. Further, unique interactions between the MPFC and striatum may provide a mechanism by which social-evaluation contexts influence adolescent behavior.Psycholog
Simulations of Dust in Interacting Galaxies I: Dust Attenuation
A new Monte-Carlo radiative-transfer code, Sunrise, is used in conjunction
with hydrodynamic simulations of major galaxy mergers to calculate the effects
of dust in such systems. The simulations are in good agreement with
observations of dust absorption in starburst galaxies, and the dust has a
profound effect on their appearance. The dust attenuation increases with
luminosity such that at peak luminosities ~90% of the bolometric luminosity is
absorbed by dust. In general, the detailed appearance of the merging event
depends on the stage of the merger and the geometry of the encounter. The
fraction of bolometric energy absorbed by the dust, however, is a robust
quantity that can be predicted from the intrinsic properties bolometric
luminosity, baryonic mass, star-formation rate, and metallicity of the system.
This paper presents fitting formulae, valid over a wide range of masses and
metallicities, from which the absorbed fraction of luminosity (and consequently
also the infrared dust luminosity) can be predicted. The attenuation of the
luminosity at specific wavelengths can also be predicted, albeit with a larger
scatter due to the variation with viewing angle. These formulae for dust
attenuation appear to be valid for both isolated and interacting galaxies, are
consistent with earlier studies, and would be suitable for inclusion in
theoretical models, e.g. semi-analytic models of galaxy formation.Comment: 12 pages, 10 figures, submitted to Ap
Identification and characterization of a galacturonic acid transporter from Neurospora crassa and its application for Saccharomyces cerevisiae fermentation processes
BACKGROUND: Pectin-rich agricultural wastes potentially represent favorable feedstocks for the sustainable production of alternative energy and bio-products. Their efficient utilization requires the conversion of all major constituent sugars. The current inability of the popular fermentation host Saccharomyces cerevisiae to metabolize the major pectic monosaccharide D-galacturonic acid (D-GalA) significantly hampers these efforts. While it has been reasoned that the optimization of cellular D-GalA uptake will be critical for the engineering of D-GalA utilization in yeast, no dedicated eukaryotic transport protein has been biochemically described. Here we report for the first time such a eukaryotic D-GalA transporter and characterize its functionality in S. cerevisiae. RESULTS: We identified and characterized the D-GalA transporter GAT-1 out of a group of candidate genes obtained from co-expression analysis in N. crassa. The N. crassa Δgat-1 deletion strain is substantially affected in growth on pectic substrates, unable to take up D-GalA, and impaired in D-GalA-mediated signaling events. Moreover, expression of a gat-1 construct in yeast conferred the ability for strong high-affinity D-GalA accumulation rates, providing evidence for GAT-1 being a bona fide D-GalA transport protein. By recombinantly co-expressing D-galacturonate reductase or uronate dehydrogenase in yeast we furthermore demonstrated a transporter-dependent conversion of D-GalA towards more reduced (L-galactonate) or oxidized (meso-galactaric acid) downstream products, respectively, over a broad concentration range. CONCLUSIONS: By utilizing the novel D-GalA transporter GAT-1 in S. cerevisiae we successfully generated a transporter-dependent uptake and catalysis system for D-GalA into two products with high potential for utilization as platform chemicals. Our data thereby provide a considerable first step towards a more complete utilization of biomass for biofuel and value-added chemicals production
X-Ray Detected Active Galactic Nuclei in Dwarf Galaxies At 0 \u3c Z \u3c 1
We present a sample of accreting supermassive black holes (SMBHs) in dwarf galaxies at z\lt 1. We identify dwarf galaxies in the NEWFIRM Medium Band Survey with stellar masses of {M}\star \lt 3× {10}9 {M}⊙ that have spectroscopic redshifts from the DEEP2 survey and lie within the region covered by deep (flux limit of ˜ 5× {10}-17{--}6× {10}-16 {erg} {{cm}}-2 {{{s}}}-1) archival Chandra X-ray data. From our sample of 605 dwarf galaxies, 10 exhibit X-ray emission consistent with that arising from active galactic nucleus (AGN) activity. If black-hole mass scales roughly with stellar mass, then we expect that these AGNs are powered by SMBHs with masses of ˜ {10}5{--}{10}6 {M}⊙ and typical Eddington ratios of ˜ 5 % . Furthermore, we find an AGN fraction consistent with extrapolations of other searches of ˜ 0.6 % {--}3 % for {10}9 {M}⊙ ≤slant {M}\star ≤slant 3× {10}9 {M}⊙ and 0.1\lt z\lt 0.6. Our AGN fraction is in good agreement with a semi-analytic model, suggesting that, as we search larger volumes, we may use comparisons between observed AGN fractions and models to understand seeding mechanisms in the early universe
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