Evolution of red wines II. An assessment of the role of acetaldehyde

Factors influencing formation and utilisation of acetaldehyde during red vinification have been examined, with emphasis on its production during primary fermentation and depletfon during early maturation.Acetaldehyde concentrations in new wines were controlled at predictably low levels by addition of SO2 at 30- 50 mg/l before fermentation. There was no appreciable effect from yeast strain, pH or temperature on acetaldehyde production. Significant decrease in acetaldehyde, a-ketoglutaric acid and pyruvic acid, with release of free SO2, occurred during malolactic fermentation. The rate of acetaldehyde consumption in sterile-filtered wine was increased at higher te·mperature and decreased by the presence of free SO2 at high levels. Progressive change in pigment composition of new wines was not influenced by variation in bound acetaldehyde within the range 2-103 mg/l.Acetaldehyde concentration also decreased in a majority of red wines during conservation in commercial cellars. Increases were attributed to abnormal conditions of wine exposure to air. lt was concluded that acetaldehyde formation in wine is probably a surface phenomenon, involving autoxidation of ethanol at the wine interface with atmospheric oxygen. Increase in acetaldehyde during vinification was considered to be adverse in relation to sensory properties and stability of red wine

Student Perspectives on how Trauma Experiences Manifest in the Classroom: Engaging Court-Involved Youth in the Development of a Trauma-Informed Teaching Curriculum

This study explores how the lived experience of court-involved youth impacts learning and school culture, and solicits youth voice in creating a trauma-informed intervention to improve student educational well-being. Thirty-nine female students, ages 14 to 18, participated in focus groups to describe externalizing behaviors that they have both witnessed and personally struggled with in the classroom, discuss the perceived causes of these behaviors, and their suggestions for improving school culture to reduce these behavior manifestations in the classroom. Two major categories of behavior were identified, including: “anger emotions” and “aggressive actions.” Students described the causes of behavior as, “environmental influences” and “triggers.” The most common solutions that students gave to reduce externalizing behaviors in school settings included “encouraging respect of others” and “improving behavior management to enhance student engagement.” An additional solution suggested by the students included the “monarch room as support.” The Monarch Room is an alternative intervention to traditional suspension/expulsion polices that provides students in need of specific emotional support an opportunity to redirect/de-escalate externalizing behavior or mood in the school setting. This study highlights the need for trauma-informed approaches in school settings, and the importance of the inclusion of a youth voice in developing and implementing these intervention models

Confirmation of co-denitrification in grazed grassland

peer-reviewedPasture-based livestock systems are often associated with losses of reactive forms of nitrogen (N) to the environment. Research has focused on losses to air and water due to the health, economic and environmental impacts of reactive N. Di-nitrogen (N2) emissions are still poorly characterized, both in terms of the processes involved and their magnitude, due to financial and methodological constraints. Relatively few studies have focused on quantifying N2 losses in vivo and fewer still have examined the relative contribution of the different N2 emission processes, particularly in grazed pastures. We used a combination of a high 15N isotopic enrichment of applied N with a high precision of determination of 15N isotopic enrichment by isotope-ratio mass spectrometry to measure N2 emissions in the field. We report that 55.8 g N m−2 (95%, CI 38 to 77 g m−2) was emitted as N2 by the process of co-denitrification in pastoral soils over 123 days following urine deposition (100 g N m−2), compared to only 1.1 g N m−2 (0.4 to 2.8 g m−2) from denitrification. This study provides strong evidence for co-denitrification as a major N2 production pathway, which has significant implications for understanding the N budgets of pastoral ecosystems.The authors are grateful for the funding that was provided through the Research Stimulus Fund Program administered by the Department of Agriculture & Food under the National Development Plan 2007–2013 RSF 07536. The first author is grateful for the funding provided by Teagasc through the Walsh Fellowship Scheme

Short-Term Memory for Space and Time Flexibly Recruit Complementary Sensory-Biased Frontal Lobe Attention Networks

The frontal lobes control wide-ranging cognitive functions; however, functional subdivisions of human frontal cortex are only coarsely mapped. Here, functional magnetic resonance imaging reveals two distinct visual-biased attention regions in lateral frontal cortex, superior precentral sulcus (sPCS) and inferior precentral sulcus (iPCS), anatomically interdigitated with two auditory-biased attention regions, transverse gyrus intersecting precentral sulcus (tgPCS) and caudal inferior frontal sulcus (cIFS). Intrinsic functional connectivity analysis demonstrates that sPCS and iPCS fall within a broad visual-attention network, while tgPCS and cIFS fall within a broad auditory-attention network. Interestingly, we observe that spatial and temporal short-term memory (STM), respectively, recruit visual and auditory attention networks in the frontal lobe, independent of sensory modality. These findings not only demonstrate that both sensory modality and information domain influence frontal lobe functional organization, they also demonstrate that spatial processing co-localizes with visual processing and that temporal processing co-localizes with auditory processing in lateral frontal cortex. Michalka et al. report four interleaved vision-biased and auditory-biased attention regions bilaterally in human lateral frontal cortex. Short-term memory for space and for time recruits the frontal visual and auditory networks, respectively across sensory modalities

A Form of Inherited Cerebellar Ataxia with Saccadic Intrusions, Increased Saccadic Speed, Sensory Neuropathy, and Myoclonus

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72602/1/j.1749-6632.2002.tb02850.x.pd

Auditory Spatial Attention Representations in the Human Cerebral Cortex

Auditory spatial attention serves important functions in auditory source separation and selection. Although auditory spatial attention mechanisms have been generally investigated, the neural substrates encoding spatial information acted on by attention have not been identified in the human neocortex. We performed functional magnetic resonance imaging experiments to identify cortical regions that support auditory spatial attention and to test 2 hypotheses regarding the coding of auditory spatial attention: 1) auditory spatial attention might recruit the visuospatial maps of the intraparietal sulcus (IPS) to create multimodal spatial attention maps; 2) auditory spatial information might be encoded without explicit cortical maps. We mapped visuotopic IPS regions in individual subjects and measured auditory spatial attention effects within these regions of interest. Contrary to the multimodal map hypothesis, we observed that auditory spatial attentional modulations spared the visuotopic maps of IPS; the parietal regions activated by auditory attention lacked map structure. However, multivoxel pattern analysis revealed that the superior temporal gyrus and the supramarginal gyrus contained significant information about the direction of spatial attention. These findings support the hypothesis that auditory spatial information is coded without a cortical map representation. Our findings suggest that audiospatial and visuospatial attention utilize distinctly different spatial coding schemes. © 2012 The Author

Characterization of Spray A flame structure for parametric variations in ECN constant-volume vessels using chemiluminescence and laser-induced fluorescence

The transient and quasi-steady flame structure of reacting fuel sprays produced by single-hole injectors has been studied using chemiluminescence imaging and Planar Laser-Induced Fluorescence (PLIF) in various constant-volume facilities at different research institutes participating in the Engine Combustion Network (ECN). The evolution of the high-temperature flame has been followed based on chemiluminescence imaging of the excited-state hydroxyl radical (OH*), and PLIF of ground-state OH. Regions associated with low-temperature chemical reactions are visualized using formaldehyde (CH2O) PLIF with 355-nm excitation. We compare the results obtained by different research institutes under nominally identical experimental conditions and fuel injectors. In spite of design differences among the various experimental facilities, the results are consistent. This lends confidence to studies of transient behavior and parameter variations performed by individual research groups. We present results of the transient flame structures at Spray A reference conditions, and include parametric variations around this baseline, involving ambient temperature, oxygen concentration and injection pressure. Key results are the observed influence of an entrainment wave on the transient flame behavior, model-substantiated explanations for the high-intensity OH* lobes at the lift-off length and differences with OH PLIF, and a general analogy of the flame structures with a spray cone along which the flame tends to locate for the applied parametric variations

Geriatric pharmacotherapy : optimisation through integrated approach in the hospital setting

Since older patients are more vulnerable to adverse drug-related events, there is a need to ensure appropriate prescribing in these patients in order to prevent misuse, overuse and underuse of drugs. Different tools and strategies have been developed to reduce inappropriate prescribing; the available measures can be divided into medication assessment tools, and specific interventions to reduce inappropriate prescribing. Implicit criteria of inappropriate prescribing focus on appropriate dosing, search for drug-drug interactions, and increase adherence. Explicit criteria are consensus-based standards focusing on drugs and diseases and include lists of drugs to avoid in general or lists combining drugs with clinical data. These criteria take into consideration differences between patients, and stand for a medication review, by using a systematic approach. Different types of interventions exist in order to reduce inappropriate prescribing in older patients, such as: educational interventions, computerized decision support systems, pharmacist-based interventions, and geriatric assessment. The effects of these interventions have been studied, sometimes in a multifaceted approach combining different techniques, and all types seem to have positive effects on appropriateness of prescribing. Interdisciplinary teamwork within the integrative pharmaceutical care is important for improving of outcomes and safety of drug therapy. The pharmaceutical care process consists offour steps, which are cyclic for an individual patient. These steps are pharmaceutical anamnesis, medication review, design and follow-up of a pharmaceutical care plan. A standardized approach is necessary for the adequate detection and evaluation of drug-related problems. Furthermore, it is clear that drug therapy should be reviewed in-depth, by having full access to medical records, laboratory values and nursing notes. Although clinical pharmacists perform the pharmaceutical care process to manage the patient’s drug therapy in every day clinical practice, the physician takes the ultimate responsibility for the care of the patient in close collaboration with nurses

Considering Physical Well-Being, Self-perceptions, and Support Variables in Understanding Youth Academic Achievement

The purpose of this study was to examine the relation between measures of students’ physical well-being and self-perception and their academic achievement. Specifically, we look at students’ social support for physical activity, physical activity perceptions, self-concept, self-efficacy, health behaviors, and cardiorespiratory fitness (as measured by the progressive aerobic cardiovascular endurance run [PACER] test). Students (n = 697 fifth graders) were surveyed at the beginning of the school year. A two-group path analysis revealed notable relationships between the predictor variables and proximal and distal outcomes, with some paths moderated by sex. One relationship that was significant for both sexes was cardiorespiratory fitness, as it was the only significant predictor of achievement. This effect was moderate to large for the female students (R2Math=36%; R2Read=15%) and small to large for the male students (R2Math=26%; R2Math=10%). These findings can be used to guide future research and educational prevention and intervention efforts