7 research outputs found
Padina boergessenii ameliorates carbon tetrachloride induced nephrotoxicity in Wistar rats
AbstractThis research investigates the ameliorative effect of brown alga Padina boergessenii against CCl4-induced nephrotoxicity in rats. Twenty-four Wistar albino rats were divided into four groups as follows: control group (saline), CCl4 group, CCl4+P. boergessenii extract group and P. boergessenii extract alone group. At the end of the experimental period, the animals are sacrificed and tissue samples (kidney) were collected. CCl4 at a dose of 2mL/kg, administered subcutaneously, produced significantly decreased activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT). Histopathological examinations showed massive centrilobular necrosis and fat accumulation in CCl4-induced animals. In the protective test, especially in animals pretreated with P. boergessenii (150mg/kg) extract, there was a significant increase in antioxidant enzyme levels although there was no sign of abnormality in the kidney of rats pretreated with extract as evidenced by histopathological sections against CCl4-induced decrease of lipid peroxidation (TBARS). The ameliorative effect may be due to the presence of various bioactive compounds in alga. These results suggest that an extract of P. boergessenii is able to significantly alleviate the nephrotoxicity induced by CCl4 in Wistar rats
A Clinico-Genotypic Prognostic Index for De Novo Composite Diffuse Large B-Cell Lymphoma Arising from Follicular Lymphoma in Asian patients treated in the Rituximab Era
10.1038/s41598-020-61378-4Scientific Reports101437
Successful therapeutic rechallenge after a severe episode of high dose methotrexate-induced choreoathetosis: A case report
10.3892/mco.2019.1898Molecular and Clinical Oncology114354-35
A clinicohaematological prognostic model for nasal-type natural killer/T-cell lymphoma: A multicenter study
10.1038/s41598-019-51522-0Scientific Reports911496
Padina boergessenii ameliorates carbon tetrachloride induced nephrotoxicity in Wistar rats
Whole exome sequencing identifies recessive germline mutations in FAM160A1 in familial NK/T cell lymphoma
10.1038/s41408-018-0149-5Blood Cancer Journal81111