50 research outputs found
Practical aspects of the use of phosphate binding materials in refractory mixtures, mortars and putties
Phosphate binders, particularly acidic phosphates of Al and Cr, are used for binding Al silicate refractories used for lining of burners, SiC refractories, and refractory mortars. The binders have apparent d. 2.13-2.18 g/cu cm, porosity 21.4-23.8%, compressive strength 223 71 kg/ sq cm, total shrinkage 0.2-0.8%, and refractoriness 1240 deg
Corrigendum to Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci
Neuroticism is a personality trait of fundamental importance for psychological well-being and public health. It is strongly associated with major depressive disorder (MDD) and several other psychiatric conditions. Although neuroticism is heritable, attempts to identify the alleles involved in previous studies have been limited by relatively small sample sizes. Here we report a combined meta-analysis of genome-wide association study (GWAS) of neuroticism that includes 91 370 participants from the UK Biobank cohort, 6659 participants from the Generation Scotland: Scottish Family Health Study (GS:SFHS) and 8687 participants from a QIMR (Queensland Institute of Medical Research) Berghofer Medical Research Institute (QIMR) cohort. All participants were assessed using the same neuroticism instrument, the Eysenck Personality Questionnaire-Revised (EPQ-R-S) Short Form’s Neuroticism scale. We found a single-nucleotide polymorphism-based heritability estimate for neuroticism of ~15% (s.e.=0.7%). Meta-analysis identified nine novel loci associated with neuroticism. The strongest evidence for association was at a locus on chromosome 8 (P=1.5 × 10−15) spanning 4 Mb and containing at least 36 genes. Other associated loci included interesting candidate genes on chromosome 1 (GRIK3 (glutamate receptor ionotropic kainate 3)), chromosome 4 (KLHL2 (Kelch-like protein 2)), chromosome 17 (CRHR1 (corticotropin-releasing hormone receptor 1) and MAPT (microtubule-associated protein Tau)) and on chromosome 18 (CELF4 (CUGBP elav-like family member 4)). We found no evidence for genetic differences in the common allelic architecture of neuroticism by sex. By comparing our findings with those of the Psychiatric Genetics Consortia, we identified a strong genetic correlation between neuroticism and MDD and a less strong but significant genetic correlation with schizophrenia, although not with bipolar disorder. Polygenic risk scores derived from the primary UK Biobank sample captured ~1% of the variance in neuroticism in the GS:SFHS and QIMR samples, although most of the genome-wide significant alleles identified within a UK Biobank-only GWAS of neuroticism were not independently replicated within these cohorts. The identification of nine novel neuroticism-associated loci will drive forward future work on the neurobiology of neuroticism and related phenotypes
Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci
Neuroticism is a personality trait of fundamental importance for psychological well-being and public health. It is strongly associated with major depressive disorder (MDD) and several other psychiatric conditions. Although neuroticism is heritable, attempts to identify the alleles involved in previous studies have been limited by relatively small sample sizes. Here we report a combined meta-analysis of genome-wide association study (GWAS) of neuroticism that includes 91 370 participants from the UK Biobank cohort, 6659 participants from the Generation Scotland: Scottish Family Health Study (GS:SFHS) and 8687 participants from a QIMR (Queensland Institute of Medical Research) Berghofer Medical Research Institute (QIMR) cohort. All participants were assessed using the same neuroticism instrument, the Eysenck Personality Questionnaire-Revised (EPQ-R-S) Short Form’s Neuroticism scale. We found a single-nucleotide polymorphism-based heritability estimate for neuroticism of ~15% (s.e.=0.7%). Meta-analysis identified nine novel loci associated with neuroticism. The strongest evidence for association was at a locus on chromosome 8 (P=1.5 × 10−15) spanning 4 Mb and containing at least 36 genes. Other associated loci included interesting candidate genes on chromosome 1 (GRIK3 (glutamate receptor ionotropic kainate 3)), chromosome 4 (KLHL2 (Kelch-like protein 2)), chromosome 17 (CRHR1 (corticotropin-releasing hormone receptor 1) and MAPT (microtubule-associated protein Tau)) and on chromosome 18 (CELF4 (CUGBP elav-like family member 4)). We found no evidence for genetic differences in the common allelic architecture of neuroticism by sex. By comparing our findings with those of the Psychiatric Genetics Consortia, we identified a strong genetic correlation between neuroticism and MDD and a less strong but significant genetic correlation with schizophrenia, although not with bipolar disorder. Polygenic risk scores derived from the primary UK Biobank sample captured ~1% of the variance in neuroticism in the GS:SFHS and QIMR samples, although most of the genome-wide significant alleles identified within a UK Biobank-only GWAS of neuroticism were not independently replicated within these cohorts. The identification of nine novel neuroticism-associated loci will drive forward future work on the neurobiology of neuroticism and related phenotypes
Safety and Immunogenicity of an AMA-1 Malaria Vaccine in Malian Adults: Results of a Phase 1 Randomized Controlled Trial
The objective was to evaluate the safety, reactogenicity and immunogenicity of the AMA-1-based blood-stage malaria vaccine FMP2.1/AS02A in adults exposed to seasonal malaria.A phase 1 double blind randomized controlled dose escalation trial was conducted in Bandiagara, Mali, West Africa, a rural town with intense seasonal transmission of Plasmodium falciparum malaria. The malaria vaccine FMP2.1/AS02A is a recombinant protein (FMP2.1) based on apical membrane antigen-1 (AMA-1) from the 3D7 clone of P. falciparum, adjuvanted with AS02A. The comparator vaccine was a cell-culture rabies virus vaccine (RabAvert). Sixty healthy, malaria-experienced adults aged 18-55 y were recruited into 2 cohorts and randomized to receive either a half dose or full dose of the malaria vaccine (FMP2.1 25 microg/AS02A 0.25 mL or FMP2.1 50 microg/AS02A 0.5 mL) or rabies vaccine given in 3 doses at 0, 1 and 2 mo, and were followed for 1 y. Solicited symptoms were assessed for 7 d and unsolicited symptoms for 30 d after each vaccination. Serious adverse events were assessed throughout the study. Titers of anti-AMA-1 antibodies were measured by ELISA and P. falciparum growth inhibition assays were performed on sera collected at pre- and post-vaccination time points. Transient local pain and swelling were common and more frequent in both malaria vaccine dosage groups than in the comparator group. Anti-AMA-1 antibodies increased significantly in both malaria vaccine groups, peaking at nearly 5-fold and more than 6-fold higher than baseline in the half-dose and full-dose groups, respectively.The FMP2.1/AS02A vaccine had a good safety profile, was well-tolerated, and was highly immunogenic in malaria-exposed adults. This malaria vaccine is being evaluated in Phase 1 and 2 trials in children at this site
Bordonein-L, a new L-amino acid oxidase from Crotalus durissus terrificus snake venom: isolation, preliminary characterization and enzyme stability
Analysis and assessment of the Podkarpackie voivodship socio-economic development
Zagadnienie rozwoju społeczno-gospodarczego to zjawisko o charakterze
złożonym, wielokryteriowym. Związane jest zarówno z aspektem
ekonomicznym, demograficznym jak i przyrodniczym. Rozwój wiąże się
bezpośrednio ze wzrostem liczby inwestycji, z zainteresowaniem turystycznym,
z rozbudową infrastruktury technicznej oraz społecznej. Nie
można także zapomnieć o kapitale ludzkim. Dodatkowy odpływ ludności
z terenów słabo zaludnionych powoduje bowiem regres w rozwoju społeczno-
gospodarczym. Przemiany społeczno-gospodarcze po 1990 roku
były bezpośrednią przyczyną reorganizacji struktury przestrzennej kraju
oraz powiązań regionalnych. Województwa tzw. „ściany wschodniej” są
postrzegane jako obszary rolnicze, słabiej rozwinięte. Wciąż aktualne pozostaje
pytanie czy należy podejmować próby hamowania niekorzystnych
procesów na obszarach słabiej rozwiniętych (rolniczych), wspierać je i dążyć
do ich rozwoju, czy może wspierać te obszary, które same posiadają już
zdolności rozwojowe. Artykuł przedstawia analizę i próbę oceny warunków
rozwoju społeczno-gospodarczego województwa podkarpackiego,
przyjmując jako pole podstawowej oceny powiat. Na potrzeby oceny zróżnicowania
przestrzennego badanego województwa zastosowano metodę
taksonomii wrocławskiej. Materiały źródłowe stanowiące podstawę badań
dotyczyły stanu na 2011 r. Dane pochodzą ze źródeł statystyki publicznej
Głównego Urzędu Statystycznego. W wyniku przeprowadzonych analiz wydzielono typy przestrzenne warunków rozwoju społeczno-gospodarczego
w województwie podkarpackim oraz dokonano ich charakterystyki.The issue of socio-economic development is a phenomenon with
a complex analysis. It is associated with both the economic aspect, demographic
and natural. The development is directly related to the increase
in investment, with interest tourism, the development of technical
and social infrastructure. It cannot be forget the human capital. The outflow
causes a decline in socio-economic development. Social and economic
changes after 1990 were the direct cause of the reorganization of
the spatial structure of the country and regional links. Province called
„Eastern wall” are seen as agricultural areas, less developed. Question
remains whether to attempt to inhibit the unfavorable processes in less
developed areas (agricultural), to support them and strive for their development,
or support these areas, which themselves already have development
potential. The article presents the analysis the socio-economic
development of Podkarpackie, taking as a primary field assessment district.
Analysis was performed according to the state for the year 2011,
the data come from sources of official statistics of the Central Statistical
Office. These analyzes gave the zone set for the differentiation of
areas for the socio-economic development. The testing method used
to analysis was the taxonomy, created by the researcher in Wrocław