7 research outputs found
Sustainable Ecotourism through Cutting-Edge Technologies
Tourism is a phenomenon that dates back to ancient times. Ancient Greek philosophers recognised, adopted, and promoted the concept of rest-based tourism. Ecotourism is a particular type of tourism that connects with activities that take place in nature, without harming it, along with the herbal and animal wealth. According to estimates, the global ecotourism industry is currently booming due to various reasons, and it is becoming an important factor of sustainable regional development. This article presents the vision, work, and outcomes of project AdVENt, a project focusing natively in sustainable ecotourism through natural science and technological innovation. AdVENt’s study area includes the National Parks of Oiti (or Oeta) and Parnassus in Central Greece, where there is a remarkable native flora with a high endemism rate integrated with areas of cultural value and national and European hiking routes and paths of varying difficulty
Sustainable Ecotourism through Cutting-Edge Technologies
Tourism is a phenomenon that dates back to ancient times. Ancient Greek philosophers recognised, adopted, and promoted the concept of rest-based tourism. Ecotourism is a particular type of tourism that connects with activities that take place in nature, without harming it, along with the herbal and animal wealth. According to estimates, the global ecotourism industry is currently booming due to various reasons, and it is becoming an important factor of sustainable regional development. This article presents the vision, work, and outcomes of project AdVENt, a project focusing natively in sustainable ecotourism through natural science and technological innovation. AdVENt’s study area includes the National Parks of Oiti (or Oeta) and Parnassus in Central Greece, where there is a remarkable native flora with a high endemism rate integrated with areas of cultural value and national and European hiking routes and paths of varying difficulty
Bone Marrow Ribonucleotide Reductase mRNA Levels and Methylation Status As a Prognostic Factor in Patients with Myelodysplastic Syndrome Treated with 5-Azacytidine
Bone marrow ribonucleotide reductase mRNA levels and methylation status as prognostic factors in patients with myelodysplastic syndrome treated with 5-Azacytidine
Ribonucleotide Reductase (RNR) is a two-subunit (RRM1, RRM2) enzyme,
responsible for the conversion of ribonucleotides to
deoxyribonucleotides required for DNA replication. To evaluate RNR as a
biomarker of response to 5-azacytidine, we measured RNR mRNA levels by a
quantitative real-time PCR in bone marrow samples of 98 patients with
myelodysplastic syndrome (MDS) treated with 5-azacytidine with parallel
quantification of the gene promoter's methylation. Patients with low
RRM1 levels had a high RRM1 methylation status (p = 0.005) and a better
response to treatment with 5-azacytidine (p = 0.019). A next-generation
sequencing for genes of interest in MDS was also carried out in a subset
of 61 samples. Splicing factor mutations were correlated with lower RRM1
mRNA levels (p = 0.044). Our results suggest that the expression of RNR
is correlated with clinical outcomes, thus its expression could be used
as a prognostic factor for response to 5-azacytidine and a possible
therapeutic target in MDS