Ferulic acid-loaded polymeric nanoparticles prepared from nano-emulsion templates facilitate internalisation across the blood?brain barrier in model membranes

Ferulic acid-loaded PLGA NPs were synthesised via low-energy emulsification methods utilising nano-emulsion templating including permeabilisation efficiency assessed using an in vitro organ-on-a-chip system that simulates the blood-brain barrier

Ethylcellulose Nanoparticles prepared from Nano-emulsion templates as Ferulic Acid Nanocarriers

Ferulic acid (FA), a natural antioxidant, has been encapsulated in nanoparticles (NPs) made from ethylcellulose (EC), a biocompatible polymer, using nano-emulsions prepared via phase-inversion composition (PIC) method. To control film forming and release properties, Tributyl citrate (TBC) and Miglyol812 (a mixture of medium-chain triglycerides) have been utilized as EC plasticizers. The EC nanoparticles exhibited diameters in the range of 100-130 nm and appropriate colloidal stability. The EC NPs featured high FA encapsulation efficiencies, and sustained FA release, that can be fitted to kinetic models such as first-order and Peppas-Salhin. EC NPs did not show cytotoxicity when incubated with HeLa cells. These results are promising for cosmetic and pharmaceutical applications.Peer reviewe